CN103638415B - The Chinese medicine for the treatment of chronic obstructive pulmonary disease - Google Patents
The Chinese medicine for the treatment of chronic obstructive pulmonary disease Download PDFInfo
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Abstract
The present invention relates to pharmaceutical formulation field, a kind of Chinese medicine treating chronic obstructive pulmonary disease, it is characterized in that raw material composition is by weight percentage: Rhizoma Acori Calami 10～14%, Herba Schizonepetae 8～12%, Radix Cynanchi Atrati 6～10%, Flos Farfarae 2～6%, Semen Lepidii (Semen Descurainiae) 5～7%, Semen Sinapis Albae 2～6%, Semen Coicis 2～6%, Fructus Chebulae 5～7%, Rhizoma Kaempferiae 6～10%, Chinese juniper beach wormwood 5～7%, Radix Ilicis Pubescentis 2～6%, Semen Cuscutae 6～10%, Herba Lycopodii 2～5%, Rhizoma Paridis 2～6%, Radix Stephaniae Tetrandrae 2～6%, Rhizoma Belamcandae 6～10%, above-mentioned raw materials medicine is soaked, remove slag after decocting to obtain filtered juice.The present invention is with low cost, have no side effect, and treatment chronic obstructive pulmonary disease curative effect is high.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, a kind of chronic obstructive pulmonary disease for the treatment of
Chinese medicine.
Background technology
It is known that chronic obstructive pulmonary disease is the commonly encountered diseases of a kind of serious harm human health, multiple
Sick.In more than 40 years old crowd of China, chronic obstructive pulmonary disease prevalence is up to 8.2%.COPD acute exacerbation is slow resistance
The key factor of lung death.The at present diagnosis of AECOPD places one's entire reliance upon clinical manifestation, still lacks
Single effective biomarker is used for clinical diagnosis and the assessment of AECOPD, therefore finds simple and effective
And the biomarker that can accurately reflect COPD change of illness state is the important topic of COPD research field.LPA
It is a kind of multi-functional " phospholipid courier ".It mainly by activated blood platelet, fibroblast, adipose cell,
Endotheliocyte, inflammatory cell and cancerous cell produce, and are platelet activation in antimer, hypercoagulability and blood
Bolt forms preferable molecular marked compound.Its significant biological effect include stimulating cellular proliferation with survive,
Promote platelet aggregation, increase the permeability of vascular endothelial cell, smooth muscle cell contraction, tumor cell
Invade profit etc..Hs-CRP is the inflammation reliably label of sensitivity in antimer, and Fbg is thrombotic
Key factor, is also one of the label of airway inflammation.Phospholipid as biomembranous key component to maintenance
Integrity and the function of film are most important, are cell hypoxia ischemia and the product of oxidativestress damage caudacoria cracking
Thing.Low molecular heparin (LMWH) has obvious anticoagulin xa activity.Low dosage LMWH has solely
Stand on the antiinflammatory property outside anticoagulation.By the neutrophilic granulocyte in in-vitro simulated COPD pathogenesis
Release elastin laminin enzyme process, Brown etc. confirms, LMWH stops the gathering of neutrophilic granulocyte and suppresses
The expression of the elastoser of its induction, thus play antiinflammatory action.Blood plasma LPA, PLs, hs-CRP
And Fbg significantly raises in AECOPD patient.Diagnosis AECOPD is had the highest by blood plasma PLs level
Sensitivity, is expected to become blood plasma biomarker new for AECOPD.Should further clear and definite triple combination detection
The COPD patient of different times, the different order of severity is improved specificity and the meaning of sensitivity.Slowly
Property obstructive pulmonary disease be a kind of important chronic respiratory system diseases, number of patients is many, and case fatality rate is high.
Owing to its slow Progressive symmetric erythrokeratodermia develops, have a strong impact on work capacity and the quality of life of patient.COPD patient
After acute attack stage, though clinical symptoms has been alleviated, but its pulmonary function is still continuing deterioration, and
Due to self-defense and the reduction of immunologic function and the impact of extraneous various harmful factor, the most repeatedly send out
Make, and gradually produce various Cardiopulmonary Complications.
Summary of the invention
The purpose of the present invention is contemplated to overcome above-mentioned existing technical deficiency, it is provided that one treats chronic resistance
The Chinese medicine of plug property lung disease, with low cost, have no side effect, treatment chronic obstructive pulmonary disease curative effect is high.
The present invention solves above-mentioned technical problem and the technical scheme is that one treats chronic obstructive pulmonary
The Chinese medicine of disease, it is characterized in that raw material composition be by weight percentage: Rhizoma Acori Calami 10～14%, Herba Schizonepetae 8～
12%, Radix Cynanchi Atrati 6～10%, Flos Farfarae 2～6%, Semen Lepidii (Semen Descurainiae) 5～7%, Semen Sinapis Albae 2～6%, Semen Coicis 2～
6%, Fructus Chebulae 5～7%, Rhizoma Kaempferiae 6～10%, Chinese juniper beach wormwood 5～7%, Radix Ilicis Pubescentis 2～6%, Semen Cuscutae 6～10%,
Herba Lycopodii 2～5%, Rhizoma Paridis 2～6%, Radix Stephaniae Tetrandrae 2～6%, Rhizoma Belamcandae 6～10%, above-mentioned raw materials medicine is added water logging
Bubble, remove slag after decocting to obtain filtered juice.
The invention has the beneficial effects as follows, with low cost, have no side effect, treat chronic obstructive pulmonary disease
Curative effect is high.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
First in following ratio (weight %) take cleaning crude drug, often take medicine into, Rhizoma Acori Calami 12, chaste tree
Mustard 10, Radix Cynanchi Atrati 8.1, Flos Farfarae 6.1, Semen Lepidii (Semen Descurainiae) 4, Semen Sinapis Albae 4, Semen Coicis 4, Fructus Chebulae 6.1,
Rhizoma Kaempferiae 8.1, Chinese juniper beach wormwood 6.1, Radix Ilicis Pubescentis 4, Semen Cuscutae 8.1, Herba Lycopodii 3.3, Rhizoma Paridis 4, Radix Stephaniae Tetrandrae 4,
Rhizoma Belamcandae 8.1.Take above-mentioned 16 kinds of crude drug gross weights 248 grams.At room temperature 16 taste Chinese herbal medicine are added water
To 700～900ml, soak 6～8 hours, then torture about 90～120 minutes with slow fire, remove slag
Obtaining filtrate about 200ml, medicinal residues add water 300～400ml, torture 40～60 minutes, remove slag and to obtain filter
Liquid 60～100ml, there are 260～about 300ml medicine soup, i.e. prepares treatment chronic obstructive pulmonary disease
Chinese medicine.Loading in sterile glass vials, seal bottle cap is standby.Every day, potion was administered orally at twice, the most empty
Abdomen takes 130～150ml, takes continuously 6 months, until clinical symptom disappearance.
Rhizoma Acori Calami waking up the patient from unconsciousness by dissipating phlegm of the present invention, dehumidify stomach invigorating, killing parasites for relieving itching.Main coma due to phlegm syncope, apoplexy, insane
Epilepsy, palpitates with fear forgetful, Hiccough and deaf, abdominal pain due to retention of food, and dysentery is had loose bowels, rheumatalgia, eczema, scabies；
Herba Schizonepetae delivers scattered wind, and rash disappears skin ulcer, hemostasis.Cure mainly flu, headache, wind heat conjunctival congestion, measles without adequate eruption,
Rubella pruritus, skin infection is from the beginning of, metrostaxis, hemorrhoidal bleeding of having blood in stool, puerperal blood faints；Radix Cynanchi Atrati is called: Radix Tylophorae arenicolae,
Hundred swing grass, Radix Alangii, Baima common vetch, clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment.Seek for pathogenic warmth wound
Heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug；Coltsfoot
Flower acrid, sweet, warm.Enter lung meridian.Nourishing the lung to arrest cough, the expectorant therapeutic method to keep the adverse QI flowing downwards；Semen Lepidii (Semen Descurainiae) acrid in the mouth, bitter, cold in nature.Merit
Effect: drink, inducing diuresis to remove edema are exempted from eliminating the pathogens from the lung.Curing mainly phlegm retention to stop amassing, fullness in the chest is stopped up stagnant, cough；Semen Sinapis Albae is warm in nature, taste
Pungent.Enter lung, stomach two warp.Tool promoting the circulation of QI eliminating phlegm, the effect of reducing swelling and alleviating pain；Semen Coicis is the most cold and cool, and diuretic oozes
Wet, can dry except wind, clearing away heat and discharging pus, eliminating impediment pain relieving, to dysuria, edema, tinea pedis and rheumatism
The effects such as pain are notable；Fructus Chebulae's refreshing and detoxicating, cures mainly chronic diarrhea, chronic dysentery, proctoptosis, phlegmatic cough of breathing with cough, chronic cough
Aphonia；Rhizoma Kaempferiae warming middle-JIAO, helps digestion, pain relieving.Control trusted subordinate's cold type of pain, stop dyspepsia, traumatic injury, toothache.
For septum pectorale distension, coldness and pain in the epigastrium, diet does not disappears；Chinese juniper beach wormwood is called: sky is removed, Fructus Momordicae charantiae, mountain gold gourd, medicine
Melon skin, clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, intestine moistening.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia,
Acute mastitis, lung abscess, acute appendicitis swell and ache；Radix Ilicis Pubescentis mildly bitter flavor is sweet, and property is put down, nontoxic.Return lung, liver, large intestine channel.
Blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, expelling phlegm for arresting cough；Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight,
Antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, tire of suffering from a deficiency of the kidney
Leakage, frequent fetal movement, spleen are suffered from a deficiency of the kidney and are rushed down；Herba Lycopodii relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping.For rheumatic arthralgia, sit
Osteoneuralgia, lumbar muscle strain, traumatic injury；Rhizoma Paridis heat-clearing and toxic substances removing, reducing swelling and alleviating pain, there is stronger resisting
Cancer and resistant effect, blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle；Radix Stephaniae Tetrandrae is cold in nature, bitter in the mouth, pungent, return bladder, kidney,
Spleen channel.There is effect of inducing diuresis to remove edema, wind-expelling pain-stopping.Harness the river swollen tympanites, hygropyretic beriberi, brothers' spasm and pain；
Rhizoma Belamcandae is bitter, cold.Enter lung, Liver Channel.Heat-clearing and toxic substances removing, throat, expectorant saliva.For experiencing wind heat, or
Expectorant heat stops up the diseases such as the laryngopharynx swelling and pain caused by containing.For diseases such as accumulation and obstruction of sputum, cough and asthmas.Can clearing away lung-heat and
Expectorant saliva, controls cough phlegm dyspnea.
The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize.
Its processing technique is same as in Example 1.
The present invention is made further by the clinical trial carried out below in conjunction with my Yuan Ji Wendeng Central Hospital, Weihai City
Describe in detail:
1, diagnostic criteria: meet the chronic obstructive of respirology branch of Chinese Medical Association formulation in 1997
Pneumonopathy diagnostic criteria.
2, case selection: selected 80 examples are being in hospital of the court's in January, 2008～in December, 2012 and suffer from
Person, diagnosis meets the chronic obstructive pulmonary disease diagnosis mark of respirology branch of Chinese Medical Association formulation in 1997
Accurate.MethodsThe cases enrolled is in acute attack stage, the outer disease of other lungs of nonjoinder, does not uses tea within 1 week
Bases medicine and whole body application corticosteroid medication.The maleest 53 examples, female 27 example, the age 46.1～
88.2 years old, average 65.4 ± 22.1 years old. selected case get rid of: hormone dependant person, have severe cardiac, liver,
Renal insufficiency and patients of acute myocardial infarction, Pregnant and lactant women.
3, Therapeutic Method: every day, potion was administered orally at twice, (medicine) being taken before meal 130～150ml, take continuously sooner or later
With 6 months.
4, treatment standard:
Effective: breathe, wheezing symptoms substantially alleviates or disappears, and does not affect daily life；Pulmonary's wheezing sound
It is wholly absent or significantly reduces；FEV1, FEV1/FVC, PEF and PO2 increase ＞ 25%, PCO2 and reduce ＞ 25%.
Take a turn for the better: cough, wheezing symptoms alleviate, but be not wholly absent, and can tolerate；Pulmonary's wheezing sound subtracts
Few, but be not wholly absent；FEV1, FEV1/FVC, PEF and PO2 increase by 15%～24%, and PCO2 reduces
15%～24%.
Invalid: to cough, pant without alleviating or increasing the weight of；Pulmonary's wheezing sound does not reduces or increases；FEV1、
FEV1/FVC, PEF and PO2 increase ＜ 15%, PC02 and reduce ＜ 15%.
5, therapeutic effect: 80 examples treated altogether by the Chinese medicine using the present invention to treat chronic obstructive pulmonary disease,
Effective 57 examples of result, take a turn for the better 21 examples, invalid 2 examples, and total effective rate is 97.5%, and inefficiency is 2.5%.
Claims (1)
1. treat a Chinese medicine for chronic obstructive pulmonary disease, it is characterized in that: raw material forms with weight hundred
Proportion by subtraction is calculated as, Rhizoma Acori Calami 10～14%, Herba Schizonepetae 8～12%, Radix Cynanchi Atrati 6～10%, Flos Farfarae 2～6%, Roripa
Li 5～7%, Semen Sinapis Albae 2～6%, Semen Coicis 2～6%, Fructus Chebulae 5～7%, Rhizoma Kaempferiae 6～10%, Chinese juniper beach wormwood
5～7%, Radix Ilicis Pubescentis 2～6%, Semen Cuscutae 6～10%, Herba Lycopodii 2～5%, Rhizoma Paridis 2～6%, Radix Stephaniae Tetrandrae 2～
6%, Rhizoma Belamcandae 6～10%, above-mentioned raw materials medicine is soaked, remove slag after decocting to obtain filtered juice.
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| 四参五子汤治疗慢性肺胀124例疗效观察;罗再生;《陕西中医》;19881231;第9卷(第12期);第535-536页 * |
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