CN103623327A - Traditional Chinese medicine for acupoint application to treat child anorexia and preparation method and application method thereof - Google Patents

Traditional Chinese medicine for acupoint application to treat child anorexia and preparation method and application method thereof Download PDF

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CN103623327A
CN103623327A CN201310507162.XA CN201310507162A CN103623327A CN 103623327 A CN103623327 A CN 103623327A CN 201310507162 A CN201310507162 A CN 201310507162A CN 103623327 A CN103623327 A CN 103623327A
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parts
spleen
chinese medicine
parched
fructus
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CN103623327B (en
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邵秀英
贾晓
宋金芳
张倩
贾琳
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Qingdao Huangdao District Healthcare Hospital For Women Children
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Qingdao Huangdao District Healthcare Hospital For Women Children
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Abstract

The invention discloses a traditional Chinese medicine for acupoint application to treat child anorexia. The traditional Chinese medicine comprises the following components in parts by weight: 3 parts of roasted white atractylodes rhizome, 2 parts of fructus amomi, 2 parts of amomum cardamomum, 1 part of scorched hawthorn fruit, 1 part of roasted malt and 1 part of raw gizzard lining. The principle that 'Spleen tonifying lies in movement rather than supplement' is taken as a guiding principle in treatment of the disease. The traditional Chinese medicine can be used for strengthening the spleen and harmonizing the stomach as main functions and cannot tonify too much or simply cure indigestion. The roasted roasted white atractylodes rhizome has the effects of tonifying qi and tonifying the spleen as a monarch drug; the fructus amomi and the amomum cardamomum are sweet, have the effects of refreshing the mind, warming the middle warmer and promoting circulation of qi as ministerial drugs, and help the roasted white atractylodes rhizome tonify the spleen, so that the spleen can be transformed; the scorched hawthorn fruit, the roasted malt and the raw gizzard lining have the effects of helping digestion and invigorating the stomach as adjuvant drugs, and can help the roasted white atractylodes rhizome transform water and grain. The overall formula has the effects of tonifying the spleen, warming the middle warmer and promoting circulation of qi, helping digestion and invigorating the stomach in common. Thus, the traditional Chinese medicine has the effects of strengthening the temperament, enhancing the appetite and enhancing the orexia, is flavorous in taste, and is the source of qi and blood.

Description

Point-application Chinese medicine for the treatment of infantile anorexia and preparation method thereof and using method
Technical field
The present invention relates to a kind of external application Chinese medicine, particularly a kind of sticking in the Chinese medicine that is used for the treatment of infantile anorexia at Pishu (bilateral), bl (bilateral), SHENQUE acupoint place.
Background technology
Infantile anorexia (disorders of digestive function) claim again loss of appetite that digestive functional disturbance, clinical manifestation take the long term even refusing to eat be principal character.Be apt to occur in 1 ~ 6 years old child, especially more common with city children's, only child's sickness rate is higher.Morbidity is without obviously seasonal, but summer heat-damp in summer in season, can make symptom increase the weight of.Clinically, often there is head of a family's private prosecution child appetite bad, obtain " apositia "? in fact, be not to be just diagnosed as " apositia " with " inappetence ", so-called apositia, must first get rid of baby and whether suffer from flu or internal medicine chronic disease (for example: have loose bowels for a long time, chronic hepatitis, pulmonary tuberculosis), if because above-mentioned reason, anorexia is now naturally, and after disease recovery from illness by the time, anorexia should be able to be improved; Apositia truly must be after eliminating children's suffers from the physiological disorders such as flu, internal medicine chronic disease or digestive tract disease, over a long time inappetence, see that food do not want to eat, even refuse to eat yet, this situation is general continuous more than two months, so, just meet so-called " anorexia ".
The cause of disease of infantile anorexia has a lot, and bad dietary habit is often the main cause of anorexia, and the diet of high protein, high sugar declines appetite; Between two meal, arbitrarily eat the snacks such as confection, dessert, Semen arachidis hypogaeae, Semen Benincasae, and the variable interval of having a meal, the irregular appetite that all affects of living, add the head of a family to the spoiling of only child, overflow into nourishing, taste biochemical function of a specified duration is not normal.Some father and mother are also eager to excel and feed, curse and beat, and more cause children's's psychentonia, and nutrition is disorderly, occurs that body is more weak, and natural fibre line of meat sweating due to debility is many, lustreless complexion symptom.Through examining, find that the clean tongue of the most tongue of infant is few, the soft nothing of abdomen is long-pending, defecates hard, heating easy to catch cold.Primary disease can not get alleviating for a long time, can complication infantile malnutrition, even cause dysplasia etc.Children's is in continuous growth promoter, and the adult that compares needs more various allowance of nutrients.If various allowance of nutrients are not enough, the normal growth that not only can affect children's is grown, and makes growth promoter stagnate when serious, and internal organs of the body atrophy will inevitably affect children's's normal immune system like this.As due to anorexia caused serious protein--heat energy is not enough malnutrition infant, can occur that Cellular Immune Disturbances and serum antibody reduce, thereby the infection such as various antibacterials, virus and fungus easily occur, and infect often lasting, protracted course of disease, even threat to life.Clinical manifestation is repeated cold, fever, or recurrent cough, do not eat, not active, body weight does not increase, size is not long.
According to the theory of Chinese medical science of China, infantile anorexia belongs to " indigestion and loss of appetite " of the traditional Chinese medical science, " anorexia " category, the traditional Chinese medical science thinks that The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, The spleen has the function to transport and transform nutrients, stomach receiving food and drink, The spleen has the function to transport and transform nutrients water paddy, The spleen has the function to transport and transform nutrients water liquid, temper is healthy and vigorous, and stomach is received officials, famine is full often to be had, and QI and blood biochemistry is active.Children's is the body of the young sun of young the moon, and internal organs are tender and lovely, and children's is due to eating and drinking without temperance usually, improper feeding, and long-term monophagia or hungry full immoderate injuring in taste, cause taste impaired, dysfunction of the spleen in transportation, stomach loses and is received, and produces anorexia, food and tasteless apositia.Primary disease treatment take " spleen strong be valued for fortune and do not mending " be guideline, main with invigorating the spleen and regulating the stomach, can not cross with tonification or food stagnation removing merely.
Treating clinically at present infantile anorexia is all generally to adopt medicine for oral administration to treat, and Western medicine kind for oral administration is a lot, but major part not only price is partially expensive but also effect is mostly not obvious, can not effect a radical cure, side effect is large, life-time service even can impair one's health, and the Chinese medicine of existing treatment infantile anorexia, be mostly oral medicine, the good Chinese patent medicine of some mouthfeel, JIANWEI XIAOSHI PIAN for example, mostly just play appetizing and digestive effect, cure the symptoms, not the disease, and the Chinese medicine effecting a permanent cure, mostly mouthfeel is not good enough, the patent of invention that for example patent No. is 200710068406.3 discloses a kind of medicine for the treatment of infantile anorexia and preparation method thereof, method, its component has: 21-29 parts of Massa Medicata Fermentata, Jiaoshan Hill is planted 18-26 parts, 15-25 parts, Fructus Hordei Germinatus, 20-27 parts of Endothelium Corneum Gigeriae Galli, 15 1 20 parts of Radix Puerariaes, 12 1 16 parts of Rhizoma Zingiberiss, 14 1 19 parts of Flos Loniceraes, 20 parts of astragalus 15-, fry 10 1 13 parts of Fructus Aurantii, preparation method: Massa Medicata Fermentata water is steamed to limit steam distillation method and extract volatile oil, 8 kinds of medical materials of medicinal residues and residue merge, decoct with water 2-3 time, each 25-35 minute, collecting decoction, be evaporated to thick paste, put to room temperature, with ethanol, precipitate, gained concentrated solution mixes with Massa Medicata Fermentata volatile oil, add white sugar and starch, mix homogeneously, drying under reduced pressure, packing, sterilizing, sealing, make.This medicine is complicated components not only, and dosage is many and preparation method is complicated.This medicine is oral medicine, and children's itself, with regard to anorexia, with regard to unwilling even more oral drugs, adopts this kind of method treatment, and infant is often mismatched, and may also can play minus effect.
Now also there are some by external application, to treat the medicine of infantile anorexia, the patent of invention that for example patent No. is 201210047599.5 discloses a kind of ointment for the treatment of infantile anorexia, by Fructus Gardeniae 25-35 gram, Fructus Crataegi 25-35 gram, Semen Arecae 25-35 gram, raw Semen Armeniacae Amarum 25-35 gram, make with azone for Borneolum Syntheticum 8-12 gram, wherein, by Fructus Gardeniae, Fructus Crataegi, Semen Arecae and raw Semen Armeniacae Amarum are dried to mix and are ground, cross 80-120 mesh sieve and become fine powder A, again Borneolum Syntheticum is ground, cross 80-120 mesh sieve and become fine powder B, fine powder A and fine powder B are mixed into medicamental pulverata, add again azone by the equal even ointment that mixes of medicamental pulverata, the pill of spheronizing, every ball adds 2.5-3g azone to make by 15-20g medicamental pulverata.What in this medicine, transdermal penetrating agent was used is azone, and it is the low stimulation of low toxicity during for normal skin, and it can also promote the absorption of skin to medicine, and dosage is reduced.But it can produce obvious stimulation for damaged skin place.Children's may be due to medicine in application process in other component produce and stimulate, and then grab richly, may cause drug of topical application place skin injury, adding the further chafe of effect meeting of azone, produce the irritated reaction that waits.And this process for preparing medicine is more complicated, standby after azone and medicine directly mix, be not only difficult to preserve, and the preservable time is short.
The patent No. is that 200810190917.7 patent of invention discloses a kind of external prescription for the treatment of infantile anorexia, and the weight proportion of its each component is: Fructus Hordei Germinatus (parched) 8-10, Jiaoshan Hill quarrel 10-15, Massa Medicata Fermentata preparata 8-12, fry Endothelium corneum 5-10, fry Semen Raphani 7-12, flour 9-14.Remaining is distilled water.Preparation method: by Fructus Hordei Germinatus (parched), Jiaoshan Hill quarrel, Massa Medicata Fermentata preparata, stir-fry, fry Semen Raphani pulverize, add flour and distilled water furnishing pasty state to be applied on gauze, at infant, spread on just before going to bed umbilicus place at every turn.In this medicine component, there is no the composition that promotes that skin absorbs the drug, so this medicine using dosage is large.Due in embryo period, umbilical part is that fetus is communicated with parent, obtains unique passage of blood, oxygen and nutrition supply, though this passage is broken off after birth, umbilical part and whole body meridian, the vital organs of the human body still have very close relationship.Umbilicus is the place that stomach wall is the thinnest, there is no subcutaneous fat, and blood vessel is very abundant, so being affixed on umbilicus place, this medicine can play therapeutical effect, and other point skins that can treat infantile anorexia of health are thicker, if this plaster is spread on to other places, acupuncture point, curative effect can be poor.
Summary of the invention
The present invention is directed to the deficiency of prior art, provide that a kind of formula that can treat infantile anorexia is simple, dosage is few, be convenient to preparation preserve with use, be easy to that infiltration and absorption, therapeutic effect are good, instant effect, the point-application Chinese medicine that avoids having an injection and take medicine.
Technical scheme of the present invention is: a kind of point-application Chinese medicine for the treatment of infantile anorexia, is grouped into by the one-tenth of following mass fraction: 3 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 2 parts of Fructus Amomis, 2 parts of Fructus Amomi Rotunduss, 1 part of Fructus Crataegi (parched to brown), 1 part of Fructus Hordei Germinatus (parched), 1 part of live chickens Endothelium corneum.
The preparation method of the point-application Chinese medicine of above-described treatment infantile anorexia, is characterized in that: comprise the following steps:
(1), according to mass fraction, take 3 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 2 parts of Fructus Amomis, 2 parts of Fructus Amomi Rotunduss, 1 part of Fructus Crataegi (parched to brown), 1 part of Fructus Hordei Germinatus (parched), 1 part of live chickens Endothelium corneum;
(2), above-mentioned load weighted component is pulverized respectively after, cross 100 mesh sieves, obtain satisfactory powder;
(3), by after above-mentioned powder mixing and stirring, pack in sealed container and preserve.
The using method of the point-application Chinese medicine of above-described treatment infantile anorexia, is characterized in that: during use, gets medicine powder and is placed in clean container, with after Rhizoma Zingiberis Recens juice furnishing pasty state, be made into the medicine cake of 2cm * 2cm, and standby.
The invention has the beneficial effects as follows: according to the theory of Chinese medical science of China, infantile anorexia belongs to " indigestion and loss of appetite " of the traditional Chinese medical science, " anorexia " category, the traditional Chinese medical science thinks that The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, The spleen has the function to transport and transform nutrients, stomach receiving food and drink, The spleen has the function to transport and transform nutrients water paddy, The spleen has the function to transport and transform nutrients water liquid, temper is healthy and vigorous, and stomach is received officials, famine is full often to be had, and QI and blood biochemistry is active.Children's is the body of the young sun of young the moon, and internal organs are tender and lovely, and children's is due to eating and drinking without temperance usually, improper feeding, and long-term monophagia or hungry full immoderate injuring in taste, cause taste impaired, dysfunction of the spleen in transportation, stomach loses and is received, and produces anorexia, food and tasteless apositia.
Primary disease treatment take " spleen strong be valued for fortune and do not mending " be guideline, main with invigorating the spleen and regulating the stomach, can not cross with tonification or food stagnation removing merely.In side, the Rhizoma Atractylodis Macrocephalae is bitter, sweet, warm, returns spleen, stomach warp.There is the effect of air making-up and spleen enlivening.< < book on Chinese herbal medicine converges says > >: " Rhizoma Atractylodis Macrocephalae, is assignment taste, and wet dissipation eliminating impediment, helps digestion except the key medicine of painful abdominal mass.Insufficiency of the spleen unstrong, art can be mended it, and insufficiency of stomach is not received, and art can help it." Rhizoma Atractylodis Macrocephalae power of mending stomach spleen invigorating through parching with earth or parched with bran is stronger.
Fructus Amomi is pungent, warm, returns spleen, stomach warp.There is the effect that warming middle-JIAO to promote flow of QI fragrance is amusing.< < property of medicine opinion > >: " main cold air stomachache ....The digesting and absorbing the essence of foodstuff that disappears, warm taste." modern pharmacological research Fructus Amomi volatile oil has fragrant digestion promoting function, can promote gastric secretion, can get rid of digestive tract pneumatosis, therefore can relieving distension by promoting circulation of QI.Fructus Amomi Rotundus property is pungent, warm, returns spleen, stomach, lung meridian.There is removing dampness circulation of qi promoting, the effect that warming middle-JIAO is amusing.< < Kaibao Bencao > >: " main accumulation of pathogenic cold gas, emesis regurgitation, the rapid digestion of food therapeutic method to keep the adverse QI flowing downwards." pharmacological research this product is containing volatile oil now, wherein main component is dextro Borneolum Syntheticum and gum camphor.This product can promote gastric secretion, promotes gastrointestinal peristalsis, prevents enteral abnormal fermentation, drives away gastrointestinal pneumatosis, therefore there is good fragrant digestion promoting function.
Fructus Crataegi property is sour, sweet, tepor is returned taste Liver Channel, has the effect of promoting digestion and removing stagnation circulation of qi promoting dissipating blood stasis.< < Compendium of Materia Medica > >: " dissipating fluid-retention food.The meat Ji , mass in the abdomen phlegm retention that disappears, feeling of fullness acid regurgitation, stagnant blood pain with distension." modern pharmacological research Fructus Crataegi can increase the secretion of digestive enzyme in stomach, facilitating digestion.Contained lipase can promote steatolysis.Contained multiple organic acid can improve the activity of protease, and food meat is easily digested.
Fructus Hordei Germinatus is sweet flat, returns spleen, stomach, Liver Channel.There is promoting digestion and invigorating the stomach, the effect of galactopoiesis relieving distension.< < Compendium of Materia Medica > >: " digest all fruit food stagnations of all rice and flour." modern pharmacological research this product amylase-containing, transform carbohydrase, proteolytic enzyme, vitamin B, maltose, glucose, phospholipid and micro-hordenine etc.Its contained digestive enzyme and the peptic effect of vitamin B.
Endothelium Corneum Gigeriae Galli, sweet, flat, returns spleen, stomach, small intestinal, urinary bladder channel, has the effect of promoting digestion and invigorating the stomach.< < Compendium of Materia Medica > >: " control children's's intermittent fever due to retention of food; treat the dripping regurgitation of adult, the wine that disappears is long-pending ... " modern pharmacological research this product is containing gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.After oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Live chickens Endothelium corneum is better than the food digesting action of Endothelium Corneum Gigeriae Galli (parched).
Rhizoma Atractylodis Macrocephalae (parched) air making-up and spleen enlivening is monarch drug, Fructus Amomi, and the roud cardamon seed fragrance warming middle-JIAO to promote flow of QI of being amusing is ministerial drug, helps Rhizoma Atractylodis Macrocephalae (parched) spleen invigorating, makes spleen energy transporting; Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched), live chickens Endothelium corneum promoting digestion and invigorating the stomach is adjuvant drug, can help Rhizoma Atractylodis Macrocephalae (parched) spleen invigorating transporting and transforming nutrients from foodstuff.Full side plays spleen invigorating warming middle-JIAO to promote flow of QI, the merit of promoting digestion and invigorating the stomach altogether.Temper is healthy and vigorous like this, and stomach is received enhancing, and appetite strengthens, and food has a taste like this, and QI and blood biochemistry is active.
The unwilling even more oral drugs of the anorexia of children's own.And children's's skin is tender, visceral-qi is agile, and point-application effect is rapid, to skin zero damage, therefore extensive in paediatric applications, and especially in treatment children's digestive system disease, application is maximum.Acupuncture points on the human body be internal organs meridian qi and blood infusion in the privileged sites of body outside, be also the stimulation point of the method for the treatment of such as the reflecting point of disease and acupuncture.Point-application method, is that Chinese medicine is made to ointment or medicine cake, is attached on selected acupuncture point, and doing so existingly has again the osmosis of medicine to the stimulation at acupuncture point (being similar to acupuncture), is one of method of inner disease outer treat.Back shu points is that qi of zang-fu viscera infusion is in the acupuncture points on the human body of back of the body waist.The back shu points that Pishu (bilateral), bl (bilateral) are taste.Pishu is at back, and under eleventh dorsal vertebra spinous process, side is opened 1.5 cun.Cure mainly indigestion and loss of appetite, dyspepsia, abdominal distention, has loose bowels.Bl is at back, and under twelfth dorsal vertebra spinous process, side is opened 1.5 cun.Cure mainly abdominal distention, indigestion and loss of appetite.SHENQUE acupoint is positioned at umbilicus, and in embryo period, umbilical part is that fetus is communicated with parent, obtains unique passage of blood, oxygen and nutrition supply.Though this passage is broken off after birth, umbilical part and whole body meridian, the vital organs of the human body still have very close relationship.Umbilicus is the place that stomach wall is the thinnest, there is no subcutaneous fat, but blood vessel is very abundant, so medicine is easy to infiltration, absorbs, add that medicine is not subject to hindering and damaging of gastric enzyme, so dosage is few, instant effect.The medication that cooperatively interacts of a plurality of acupuncture points, can be multi-pronged, in the Shorten the Treatment Process cycle, reaches the object of rapid healing.
The specific embodiment
Embodiment
Treat a point-application Chinese medicine for infantile anorexia, by the one-tenth of following mass fraction, be grouped into: 3 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 2 parts of Fructus Amomis, 2 parts of Fructus Amomi Rotunduss, 1 part of Fructus Crataegi (parched to brown), 1 part of Fructus Hordei Germinatus (parched), 1 part of live chickens Endothelium corneum.
The preparation method of the point-application Chinese medicine of above-described treatment infantile anorexia, comprises the following steps:
(1), according to mass fraction, take Rhizoma Atractylodis Macrocephalae (parched) 30g, Fructus Amomi 20g, Fructus Amomi Rotundus 20g, Fructus Crataegi (parched to brown) 10g, Fructus Hordei Germinatus (parched) 10g, live chickens Endothelium corneum 1g;
(2), above-mentioned load weighted component is pulverized respectively after, cross 100 mesh sieves, obtain satisfactory powder;
(3), by after above-mentioned powder mixing and stirring, pack in sealed container and preserve.
The using method of the point-application Chinese medicine of above-described treatment infantile anorexia, during use, gets medicine powder and is placed in clean container, with after Rhizoma Zingiberis Recens juice furnishing pasty state, is made into the medicine cake of 2cm * 2cm, standby.
Allow infant to be treated get seat acupoint selection, partly sterilised, is attached to Pishu (bilateral), bl (bilateral) and SHENQUE acupoint by the medicine cake making, and with gauze, covers, and Breathable adhesive tape is fixed.General reservation 6-12 hours.Skin sensitivity person can shorten the time, and the good people of skin-tolerant can proper extension, but is preferably no more than 24 hours, 7 days courses for the treatment of.
By some chronic disease of clinical eliminating, as the infant of the reason of the apositia such as peptic ulcer, chronic hepatitis, tuberculosis, dyspepsia and prolonged constipation is divided into experimental group 40 examples and matched group 36 examples at random.2-6 years old experimental group ages, 2-6 years old matched group ages.Male's 18 examples in experimental group, women's 22 examples; Male's 16 examples in matched group, women's 20 examples, two groups of situations, without significant difference, have comparability.Experimental group is used and applies Qizhong medicine, and matched group adopts a day twice once a bag of bacillus subtilis bigeminy enzyme alive.It within 7 days, is a course for the treatment of.Statistics t check.Final result is as shown in the table:
Group Number of cases Cure Effective Effectively Invalid Total effective rate
Experimental group 40 22 13 5 0 100%
Matched group 36 2 3 26 5 86.2%
Two groups of differences have statistical significance (P<0.05)

Claims (3)

1. a point-application Chinese medicine for the treatment of infantile anorexia, is characterized in that: the one-tenth by following mass fraction is grouped into: 3 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 2 parts of Fructus Amomis, 2 parts of Fructus Amomi Rotunduss, 1 part of Fructus Crataegi (parched to brown), 1 part of Fructus Hordei Germinatus (parched), 1 part of live chickens Endothelium corneum.
2. the preparation method of the point-application Chinese medicine for the treatment of infantile anorexia according to claim 1, is characterized in that: comprise the following steps:
(1), according to mass fraction, take 3 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 2 parts of Fructus Amomis, 2 parts of Fructus Amomi Rotunduss, 1 part of Fructus Crataegi (parched to brown), 1 part of Fructus Hordei Germinatus (parched), 1 part of live chickens Endothelium corneum;
(2), above-mentioned load weighted component is pulverized respectively after, cross 100 mesh sieves, obtain satisfactory powder;
(3), by after above-mentioned powder mixing and stirring, pack in sealed container and preserve.
3. the using method of the point-application Chinese medicine for the treatment of infantile anorexia according to claim 1, is characterized in that: during use, gets medicine powder and is placed in clean container, with after Rhizoma Zingiberis Recens juice furnishing pasty state, be made into the medicine cake of 2cm * 2cm, and standby.
CN201310507162.XA 2013-10-24 2013-10-24 Point-application Chinese medicine for the treatment of infantile anorexia and preparation method thereof Expired - Fee Related CN103623327B (en)

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CN104548005A (en) * 2014-12-19 2015-04-29 王建玲 Traditional Chinese medicine composition for treating child anorexia and preparation method of traditional Chinese medicine composition
CN109730981A (en) * 2019-03-07 2019-05-10 张春梅 For treating anorexia, dyspeptic Traditional Chinese medicine composition patch, preparation and its application

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Publication number Priority date Publication date Assignee Title
CN104548005A (en) * 2014-12-19 2015-04-29 王建玲 Traditional Chinese medicine composition for treating child anorexia and preparation method of traditional Chinese medicine composition
CN104548005B (en) * 2014-12-19 2018-06-05 宿州市徽腾知识产权咨询有限公司 A kind of Chinese medicine composition of baby anorexia and its preparation method of preparation
CN109730981A (en) * 2019-03-07 2019-05-10 张春梅 For treating anorexia, dyspeptic Traditional Chinese medicine composition patch, preparation and its application

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