CN103623108A - Application of poplar flower extract on reducing blood fat - Google Patents
Application of poplar flower extract on reducing blood fat Download PDFInfo
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- CN103623108A CN103623108A CN201310691878.XA CN201310691878A CN103623108A CN 103623108 A CN103623108 A CN 103623108A CN 201310691878 A CN201310691878 A CN 201310691878A CN 103623108 A CN103623108 A CN 103623108A
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Abstract
The invention relates to novel application of a poplar flower extract, and in particular relates to the application in preparation of flood fat reducing products. The poplar flower extract is able to regulate the abnormal change of serum total cholesterol, total triglyceride, low density lipoprotein cholesterin and high density lipoprotein cholesterol caused by high fat diet, is wide in distribution of raw material sources, and has a wide application prospect in preparation of blood fat reducing products, health foods and drugs.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, relates to a kind of novel use for decreasing blood fat of poplar flower extract.
Background technology
In people's blood, contained lipid is called blood fat in blood plasma, comprise cholesterol, cholesterol ester, triglyceride, phospholipid and not esterified fat acid etc. several, mainly refer to cholesterol and triglyceride in serum.Cholesterol and triglyceride are all the nutrient substance of needed by human, but Healthy People has certain standard level, cholesterol < 5.172mmol/L, triglyceride < 2.032mmol/L.When the averages such as cholesterol, triglyceride surpass normal value, be referred to as hyperlipemia.Blood lipid level is too high, can directly cause the disease of some serious harm healths, as atherosclerosis, coronary heart disease, pancreatitis etc.
Hyperlipemia is person in middle and old age's commonly encountered diseases and frequently-occurring disease.Along with the raising of people's living standard and the change of living habit, this sick sickness rate obviously increases, and the age of morbidity also shifts to an earlier date to some extent.The caused atherosclerosis of hyperlipemia is to cause the main cause of coronary heart disease, hypertension and cerebrovascular disease, and the whole world approximately has 1,200 ten thousand people to die from cardiovascular diseases and apoplexy every year.So the treatment of hyperlipemia is extremely important, this has caused showing great attention to of the whole mankind.The final purpose for the treatment of hyperlipemia is to suppress arteriosclerotic further developing, thereby prevents the death that caused by cardio-cerebrovascular diseases.
Flower of poplar is Salicaceous Plants eugene poplar
populus eanadensis Moeneh, Cortex Populi Tomentosae
p. tomentosa Carror belong to the dry staminate inflorescence of other various plants together.Be distributed in the ground such as Liaoning, Hebei, Shanxi, Shaanxi, Gansu, Jiangsu, Anhui, Zhejiang, Henan.China is except all introducing a fine variety in Guangdong, Hainan, Yunnan, Wai， various places, Tibet.When spring, the flowers are in blossom, gather, remove impurity, dry.Main as veterinary drug.It is cold in nature, and bitter in the mouth is returned liver, gallbladder, large intestine channel.There is heat-clearing and toxic substances removing, removing dampness antidiarrheal efficacy.Cure mainly damp-heat diarrhea, newborn animal is had loose bowels.Its effective ingredient comprises: flavone, organic acid, aminoacid, saccharide and alkaloid etc.Clinical practice is mainly used in control man avian escherichia coli, Salmonella, the poultry digestive tract infection that various bacteria, the viruses such as duck pasteurellosis bacillus, Bacillus proteus, staphylococcus cause.
Do not see at present the relevant report of relevant flower of poplar and extract blood fat reducing aspect thereof, the hypolipidemic activity of flower of poplar and extract thereof belongs to first to be found.
Summary of the invention
The new purposes that the object of this invention is to provide a kind of poplar flower extract.
The new purposes of poplar flower extract provided by the present invention is its application in preparing blood fat-reducing product.
Described product is food, health food and medicine.
Poplar flower extract of the present invention is prepared by following method:
(1) flower of poplar, gathered when spring, the flowers are in blossom, removed impurity, dried;
(2) get drying sample, with 5 ~ 20 times of water or ethanol water, extract;
(3) filter, extracting solution dry, pulverize, and packs and get final product.
The specific embodiment
For more detailed description the present invention, provide the following example of preparing.But scope of the present invention is not limited to this.
Embodiment 1: the preparation of poplar flower extract
Flower of poplar, gathered when spring, the flowers are in blossom, removed impurity, dried; With 10 times of amount 95% ethanol waters, extract; Filter, extracting solution dry, pulverize, and packs and get final product; This contains total flavones 82%, total phenols 8.5% in extracting.
Embodiment 2: hypolipidemic activity
1 experiment material
Positive control drug: certain XUEZHIKANG JIAONANG (lot number: 121206).Serum total cholesterol (TC); Triglyceride (TG); HDL-C (HDL – cho) and low-density lipoprotein cholesterol (LDL – cho) assay test kit, build up Bioengineering Research Institute by Nanjing and produce.
210 of KM SPF level mices, 18-22g, purchased from institute of biological products, Changchun Co., Ltd, credit number: SCXK(is lucky) 2011-0003, after conforming, minute cage monoculture, be divided at random experimental group (poplar flower extract high and low dose group, positive controls, model group) and blank group, 10 every group.Preventative to 30 days given the test agent time, therapeutic was to 30 days given the test agent time.
High lipid food: 78.8% normal feedstuff, 1% cholesterol, 10% yolk powder and 10% Adeps Sus domestica, 0.2% cholate.
2 test methods
2.1 hyperlipoidemia method-preventive administrations
Under experimental situation, mice feed normal feedstuff is observed 5d, carry out random packet, experimental group gives the given the test agent of various dose when giving high lipid food, blank group gives the distilled water that conventional feed gives same volume simultaneously, regularly weigh in, in experiment, finish fasting 16 hours, survey serum TC, TG, HDL-C, LDL-C level.
2.2 hyperlipoidemia method-therapeutic administrations
Under experimental situation, mice feed normal feedstuff is observed 5d, after formal experiment starts to use high lipid food feed 10d instead except each experimental group animal of blank group (normal feedstuff of feeding), starts administration.Given the test agent per os gavage, model group and blank group give the distilled water of same volume, and regularly weigh in, and in experiment, finish fasting 16 hours, measure serum TC, TG, HDL-C, LDL-C level.
3 experimental results
3.1 preventive administration
Preventive administration experimental result is in Table 1.
Each index situation of table 1 mice preventive administration lipid-lowering test (
± SD, n=8)
With model group comparison: *
p﹤ 0.05, * *
p﹤ 0.01, * * *
p﹤ 0.001
By table 1 data, can be drawn:
(1) T-CHOL: through the high fat of 30 days, raise, the TC content of model group mice be significantly higher than blank group (
p﹤ 0.01), illustrate and successfully set up hypercholesterolemia mouse model; Poplar flower extract high dose group (
p﹤ 0.01), middle dosage group (
p﹤ 0.001), low dose group (
p﹤ 0.001) and positive drug group (
p﹤ 0.05) TC content is all significantly lower than model group, illustrate that each dosage group of poplar flower extract and positive drug all have the effect that reduces TC, and each dosage group of poplar flower extract is all better than positive drug group.
(2) triglyceride: feed through the high lipid foods of 30 days, the TG content of model group mice is apparently higher than blank group, but not statistically significant; Each dosage group of poplar flower extract and positive drug group TG content is all lower than model group, but respectively organizes equal not statistically significant.
(3) HDL-C: between the HDL-cho content of each dosage group, there is certain difference, but equal not statistically significant.
(4) low-density lipoprotein cholesterol: through the high fat of 30 days, raise, the LDL-cho content of model group mice be significantly higher than Normal group (
p﹤ 0.05), illustrate and successfully set up high/low density lipoprotein cholesterol mouse model; Each dosage group of poplar flower extract and positive drug group (
p﹤ 0.01) LDL-cho content is all significantly lower than model group, illustrate that each dosage group of poplar flower extract and positive drug all have the effect that reduces LDL-cho, and each dosage group of poplar flower extract is all better than positive drug group.
3.2 therapeutic administrations
Therapeutic administration experimental result is in Table 2.
Each index situation of table 2 mice therapeutic administration lipid-lowering test (
± SD, n=8)
With model group comparison: *
p﹤ 0.05, * *
p﹤ 0.01, * * *
p﹤ 0.001
By table 2 data, can be drawn:
(1) T-CHOL: through the high fat of 30 days, raise, the TC content of model group mice be significantly higher than blank group (
p﹤ 0.001), illustrate and successfully set up hypercholesterolemia mouse model; Poplar flower extract high dose group (
p﹤ 0.001), middle dosage group (
p﹤ 0.01), low dose group (
p﹤ 0.01) and positive drug group (
p﹤ 0.001) TC content is all significantly lower than model group, illustrates that each dosage group of poplar flower extract and positive drug all have the effect that reduces TC.
(2) triglyceride: through the high lipid foods of 30 days, feed, the TG content of model group mice be significantly higher than blank group (
p﹤ 0.05), illustrate and successfully set up high triglyceride mouse model; Each dosage group of poplar flower extract and positive drug group TG content is all lower than model group, but respectively organizes equal not statistically significant.
(3) HDL-C: feed through the high lipid foods of 30 days, the HDL-cho content of model group mice is starkly lower than blank group, but does not have statistical significance; Each dosage group of poplar flower extract and positive drug group HDL-cho content is all higher than model group, but respectively organizes equal not statistically significant.
(4) low-density lipoprotein cholesterol: through the high fat of 30 days, raise, the LDL-cho content of model group mice be significantly higher than Normal group (
p﹤ 0.001), illustrate and successfully set up high/low density lipoprotein cholesterol mouse model; Each dosage group of poplar flower extract and positive drug group (
p﹤ 0.01) LDL-cho content is all significantly lower than model group, illustrate that each dosage group of poplar flower extract and positive drug all have the effect that reduces LDL-cho, and each dosage group of poplar flower extract is all better than positive drug group.
4 experiment conclusion
Preventative and the therapeutic lipid-lowering test interpretation of result of mice shows: poplar flower extract (100mg/kg ~ 400mg/kg) can suppress the TC of mice and the rising of LDL level significantly, is conducive to the Control and prevention atherosclerosis of blood fat; Poplar flower extract has the effect of removing T-CHOL in blood vessel wall, and this is significant for the incidence rate that reduces cardiovascular and cerebrovascular disease.Therefore, fully develop flower of poplar resource, turn waste into wealth, the food, health food and the medicine that utilize poplar flower extract exploitation to have effect for reducing blood fat have good prospect.
Claims (2)
1. the blood fat reducing purposes of poplar flower extract, is characterized in that the application of poplar flower extract in preparing blood fat-reducing product.
2. blood fat-reducing product claimed in claim 1 is food, health food or medicine.
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| CN201310691878.XA CN103623108A (en) | 2013-12-17 | 2013-12-17 | Application of poplar flower extract on reducing blood fat |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421197A (en) * | 2016-10-26 | 2017-02-22 | 泉州市惠安闽投商贸有限公司 | Traditional Chinese medicine preparation for reducing blood fat and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020063734A (en) * | 2001-01-30 | 2002-08-05 | 주식회사 한국의과학연구소 | Drugs sampling method for nutrition and robustness |
| CN101736030A (en) * | 2010-01-08 | 2010-06-16 | 河南科技大学 | Acyl-acyl carrier protein thioesterase gene RNAi carrier in poplar and application thereof |
| CN103120726A (en) * | 2013-02-28 | 2013-05-29 | 河南科技大学 | Traditional Chinese medicine composition for improving weaned pig growth performance and preparation method thereof |
-
2013
- 2013-12-17 CN CN201310691878.XA patent/CN103623108A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020063734A (en) * | 2001-01-30 | 2002-08-05 | 주식회사 한국의과학연구소 | Drugs sampling method for nutrition and robustness |
| CN101736030A (en) * | 2010-01-08 | 2010-06-16 | 河南科技大学 | Acyl-acyl carrier protein thioesterase gene RNAi carrier in poplar and application thereof |
| CN103120726A (en) * | 2013-02-28 | 2013-05-29 | 河南科技大学 | Traditional Chinese medicine composition for improving weaned pig growth performance and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 心静闻妙香: "摘杨树花", 《HTTP://BLOG.SINA.COM.CN/WUGUIRONG》 * |
| 李丽: "复方杨树花预混剂对产蛋鸡生产性能的影响", 《饲料研究》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421197A (en) * | 2016-10-26 | 2017-02-22 | 泉州市惠安闽投商贸有限公司 | Traditional Chinese medicine preparation for reducing blood fat and preparation method and application thereof |
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Application publication date: 20140312 |