CN103611012A

CN103611012A - Medicine for treating vitamin D deficiency rickets and preparation method thereof

Info

Publication number: CN103611012A
Application number: CN201310685160.XA
Authority: CN
Inventors: 苏振华
Original assignee: Individual
Current assignee: Xu Shikui
Priority date: 2013-12-16
Filing date: 2013-12-16
Publication date: 2014-03-05
Anticipated expiration: 2033-12-16
Also published as: CN103611012B

Abstract

The invention discloses a medicine for treating vitamin D deficiency rickets and a preparation method thereof. The medicine is mainly prepared from turtle carapace, gallus gallus domesticus brisson, fossil fragments, malt, rhizoma polygonati and Chinese dates according to a certain weight ratio. The medicine has the function of tonifying middle-jiao and qi and takes effect quickly, has good curative effects and does not have side effects when being used for treating vitamin D deficiency rickets.

Description

A kind of medicine for the treatment of vitamin D deficiency and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of vitamin D deficiency and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Vitamin D deficiency, be again osteomalacia, be that bone mineralising is not enough, for the new bone matrix calcification obstacle forming, to cause with vitamin D deficiency the disease that calcium, disorders of phosphorus metabolism and clinical calcification obstacle of take skeleton are principal character, vitamin D is to maintain the necessary nutrient of higher mammal life, and it is one of most important biological regulation factor of calcium metabolism.The rickets that vitamin d insufficiency causes, is a kind of chronic Deficiency disease, and morbidity slowly, affects growth promoter.Multiplely be born in 3 months～children's of 2 years old.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, has finally found the medicine of effective treatment vitamin D deficiency, thereby has completed the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment vitamin D deficiency.

Another object of the present invention has just been to provide the preparation method of this Chinese medicine composition.

Medicine of the present invention is to select Carapax Trionycis, Ovum Gallus domesticus crusta, Os Draconis, Fructus Hordei Germinatus, Rhizoma Polygonati, Fructus Jujubae, Monopteri albi, Cortex Eucommiae medicine to combine preparation, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat vitamin D deficiency.Wherein select Carapax Trionycis to be because its nature and flavor are salty, flat, enter liver, spleen channel, there is replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, the function of hard masses softening and resolving, controls consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly ， mass in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, little Jing Epilepsy.Select Ovum Gallus domesticus crusta to be because it is controlled and stops drinking gastralgia, regurgitation, rickets of child, various hemorrhage, the nebula of looking unfamiliar film, a body furuncle, Ting discharging ear.Select Os Draconis to be because its property sweet-puckery flavor is flat, be included into the heart, liver, kidney, large intestine channel, have tranquillizing the mind by relieving convulsion, the function of arresting sweating controlling nocturnal emission with astringent drugs, controls frightened Epilepsy demented, and palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating.Select Fructus Hordei Germinatus to be because its nature and flavor are sweet, tepor, enters spleen, stomach warp, and have and help digestion, and in, the function of the therapeutic method to keep the adverse QI flowing downwards, controls food stagnation and does not disappear, distension and fullness in the abdomen, and inappetence, vomiting is had loose bowels, and mammary swelling does not disappear.Select Rhizoma Polygonati to be because its nature and flavor are sweet flat, enter spleen, lung, kidney channel, have invigorating the spleen and replenishing QI, profit cardiopulmonary, the function of bone and muscle strengthening, controls deficient cold and heat, pulmonary tuberculosis hemoptysis, the empty lack of appetite of body after being ill, muscles and bones is weak, rheumatalgia, wind favus disease.Select Fructus Jujubae to be because its nature and flavor are sweet, temperature, enters spleen, stomach warp, has spleen reinforcing stomach function regulating, and supplementing QI for promoting the production of body fluid adjusts battalion to defend, and separates the function of poison of drug, controls insufficiency of stomach lack of appetite, the weak loose stool of spleen, and qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select Monopteri albi to be because its nature and flavor are sweet, temperature, has tonifying deficiency, except rheumatism, the function of bone and muscle strengthening, controls consumptive disease wound, anemofrigid-damp arthralgia, puerperal stranguria drop, dysentery pus and blood, hemorrhoid complicated by anal fistula, ecthyma.Select the Cortex Eucommiae to be because its nature and flavor are sweet micro-pungent, temperature, enters liver, kidney channel, has invigorating the liver and kidney, bone and muscle strengthening, and antiabortive function, controls spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, and vaginal bleeding during pregnancy is wanted to fall, hypertension.

The specific embodiment

The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight

Carapax Trionycis 6-12 gram of Ovum Gallus domesticus crusta 10-18 cron bone 6-15 gram

Fructus Hordei Germinatus 12-20 gram of Rhizoma Polygonati 10-20 gram of Fructus Jujubae 15-25 piece

Monopteri albi 15-25 gram of Cortex Eucommiae 12-22 gram

Be preferably

8 grams, 8 grams of Ovum Gallus domesticus crustas of Carapax Trionycis, 12 cron bone

20 pieces, 12 grams of Fructus Jujubaes of 15 grams of Rhizoma Polygonatis of Fructus Hordei Germinatus

15 grams of 18 grams of Cortexs Eucommiae of Monopteri albi

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Carapax Trionycis: be soaked in water, remove skin and flesh, clean, dry;

2, Ovum Gallus domesticus crusta: clean;

3, Os Draconis: get the Os Draconis of outwash, forge and be popular on smokeless stove fire or in crucible, take out, cool, pulverize;

4, Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior micro-stir-fry to yellow, taking-up cools;

5, Rhizoma Polygonati: clean earth, slightly profit, cuts into slices, and dries;

6, Fructus Jujubae: Fructus Jujubae: choose clean impurity, dry;

7, Monopteri albi: clean and remove haslet;

8, the Cortex Eucommiae: remove rough bark, clean, run through, be cut into strand, dry.

Two, preparation

1, the Ovum Gallus domesticus crusta of described weight is dried to pulverization;

2, by the Os Draconis pulverization of described weight;

3, the Fructus Hordei Germinatus of described weight is fried to rear pulverization;

4, by the Monopteri albi of described weight watt on roast ripe pulverization;

5, the Cortex Eucommiae of described weight, Carapax Trionycis are soaked 3 days in Chinese liquor, then watt on roast ripe grinding as smalls;

6, the Rhizoma Polygonati water of described weight is steamed nine times, then dry pulverization;

7, by the Removing Kernel for Date of described weight, smash into mud shape and make little cake, on Linesless charcoal, process dry, pulverization;

8, each medicine smalls preparing is mixed and stirred, make powder and get final product.

Medicine of the present invention has the function of invigorating the spleen and replenishing QI, is used for the treatment of vitamin D deficiency instant effect, good effect.By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get 30 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.By pure medicine 0.1:1(weight) adding distil water dilution is mixed liquor, overdose test group is 25ml/kg, normal amount is 10ml/kg, administering mode is administration by gavage administration, every day, secondary, serve on 7 days, observed administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 50 examples for medical treatment.

2, diagnostic criteria

The clinical change of skeleton, the of flaccid muscles and nonspecific Spirit nerve symptoms of disease of being mainly of vitamin D deficiency.Serious symptom rickets patient can affect digestive system, respiratory system, blood circulation and immune system, simultaneously also influential to children's's intelligent development.Be divided into clinically the initial stage, swash phase, convalescent period and sequela stage.Initial stage, sharp phase and convalescent period, be referred to as active stage.

3, Therapeutic Method

Select described drug powder, to patient, take, every day 2 times, cold boiled water is taken after mixing it with water, each consumption be 6 months to 1 years old 0.5 gram, 1 gram of 1-2 year 30 days is a course for the treatment of, takes continuously 2 courses for the treatment of.

4, efficacy assessment standard

Effective: the recovery from illness of vitamin D deficiency symptom, recovers normal.

Take a turn for the better: vitamin D deficiency symptom alleviates, and the state of an illness progressively takes a turn for the better.

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

Figure 201310685160X100002DEST_PATH_IMAGE001

In above-mentioned treatment, by Drug therapy vitamin D deficiency patient of the present invention 50 examples, effective 41 examples of result, obvious effective rate is 82%, 5 examples that take a turn for the better, and improvement rate is 10%, invalid 8 examples, total effective rate is 92%.

Claims

1. a medicine for the treatment of vitamin D deficiency, is characterized in that: it is to be made by the crude drug in following weight range:

Monopteri albi 15-25 gram of Cortex Eucommiae 12-22 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

15 grams of 18 grams of Cortexs Eucommiae of Monopteri albi.

3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Carapax Trionycis: be soaked in water, remove skin and flesh, clean, dry;

(2) Ovum Gallus domesticus crusta: clean;

(3) Os Draconis: get the Os Draconis of outwash, forge and be popular on smokeless stove fire or in crucible, take out, cool, pulverize;

(4) Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior micro-stir-fry to yellow, taking-up cools;

(5) Rhizoma Polygonati: clean earth, slightly profit, cuts into slices, and dries;

(6) Fructus Jujubae: Fructus Jujubae: choose clean impurity, dry;

(7) Monopteri albi: clean and remove haslet;

(8) Cortex Eucommiae: remove rough bark, clean, run through, be cut into strand, dry;

(2) preparation

(1) Ovum Gallus domesticus crusta of described weight is dried to pulverization;

(2) by the Os Draconis pulverization of described weight;

(3) Fructus Hordei Germinatus of described weight is fried to rear pulverization;

(4) by the Monopteri albi of described weight watt on roast ripe pulverization;

(5) Cortex Eucommiae of described weight, Carapax Trionycis are soaked 3 days in Chinese liquor, then watt on roast ripe grinding as smalls;

(6) the Rhizoma Polygonati water of described weight is steamed nine times, then dry pulverization;

(7) by the Removing Kernel for Date of described weight, smash into mud shape and make little cake, on Linesless charcoal, process dry, pulverization;

(8) each medicine smalls preparing is mixed and stirred, make powder and get final product.