CN103610887B - A kind of Chinese medicine for the treatment of necrotizing fasciitis - Google Patents
A kind of Chinese medicine for the treatment of necrotizing fasciitis Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine for the treatment of necrotizing fasciitis, it is prepared from by the raw medicinal material of following weight proportion: Thalictrum thumbergii D C 3 parts, poinsettia 3 parts, clock root 2 parts of looking up to heaven, Herba Tropaeoli 4 parts, Herba Sambuci Chiensis 5 parts, Aloe 5 parts, Radix Stephaniae hemandifoliae 3 parts, Folium daturae 0.3 part, Viola arcuata 5 parts, Tibet chicken feet showy flowers of herbaceous plants 5 parts, celestial Pennisetum centrasiaticum Tzvel 5 parts, Radix Sophorae Alopecuroidis 5 parts, Ramulus et Folium Phyllodii Pulchelli 4 parts, west place in Hubei Herba Hydrocotyles 3 parts, Ramulus Euonymi 3 parts, Rhizoma Acori Graminei 4 parts, Radix Et Rhizoma Rhei 6 parts, Cortex Phellodendri 6 parts, Rhizoma Coptidis 6 parts, 12 parts, Radix Glycyrrhizae.Clinical trial certificate, the present invention can safe and effective treatment necrotizing fasciitis.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine for the treatment of necrotizing fasciitis.
Background technology
Necrotizing fasciitis is the downright bad soft tissue infection for feature of a kind of extensively and rapidly subcutaneous tissue and fascia, often suffers a shock with general toxicity.Current necrotizing fasciitis treatment mainly applies antibiotic and operative therapy, and curative effect is low, and side effect is large.Therefore the Chinese medicine researching and developing a kind of safe and effective treatment necrotizing fasciitis very has value for clinical application.
Involved by Chinese medicine of the present invention, the present Research of medical material is as follows:
Thalictrum thumbergii D C: be the root of cohosh East Asia Thalictrum aquilegifolium L. var. sibiricum Regel.[nature and flavor] are bitter, cold, slightly poisonous.[function cures mainly] " heat-clearing and toxic substances removing.Control toothache, acute dermatitis, eczema.[usage and dosage] 2 ~ 3g.
Poinsettia: the dry body of this product Euphorbiaceae painted euphorbia.[nature and flavor] are bitter, puckery, cold.Poisonous.[function cures mainly] regulating menstruation, hemostasis, cough-relieving, synthetism, detumescence.Cure mainly menorrhagia, cough due to wind and cold, traumatic injury, traumatic hemorrhage, fracture.[usage and dosage] 2 ~ 3g.
To look up to heaven clock root: this product is the root of Melastomateae plants Osbeckia crinita Benth. Ex Triana.[nature and flavor] bitter in the mouth; Puckery; Cold nature.[return through] returns spleen; Kidney; Lung; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Regulating menstruation, hemostasis.Main hematodiarrhoea; Watery diarrhea; Drench pain; Edema; Hepatitis; Cholecystitis; Rheumatalgia; Cough with asthma; Chronic cough; Spitting of blood; Have blood in stool; Metrorrhagia; Menoxenia; Amenorrhea; Leukorrhagia; Skin infection; Hemorrhoid.[usage and dosage] 6-10g.
Herba Tropaeoli: this product is the herb of Tropaeolaceae plant nasturtium.[nature and flavor] acrid in the mouth; Acid; Cool in nature.[return through] heart; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main conjunctival congestion and swelling pain; Furuncle; Spit blood; Spitting of blood.[usage and dosage.5-10g。
Herba Sambuci Chiensis: this product is the flower of caprifoliaceae plant Herba sambuci chinensis.[nature and flavor] sweet light, micro-hardship, flat.[function cures mainly] dissipating blood stasis for subsidence of swelling, dispelling, collateral-activating.For traumatic injury, sprain and swell and ache, fracture pain, rheumatic arthritis.Inducing diuresis to remove edema, promoting blood circulation and stopping pain.[usage and dosage] 6-10g.
Aloe: this product is the dry product of juice through concentrating in the leaf of liliaceous plant Aloe vulgaris, Aloe ferox Miller or stripe aloe vera.[nature and flavor] are bitter, cold.[return through] returns liver, stomach, large intestine channel.[function cures mainly] removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.[usage and dosage] 2 ~ 5g.
Radix Stephaniae hemandifoliae: this product is the root of menispermaceous plants Radix Stephaniae hemandifoliae.[nature and flavor] are bitter; Cold in nature.[return through] heart; Liver; Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing, eliminating stasis to stop pain.。Main flu, pharyngalgia, diarrhoea, dysentery, cellulitis toxic swelling, stomachache, wind syndrome of head pain, rheumatic arthralgia, traumatic injury.[usage and dosage] 9-15g.
Folium daturae: this product is the leaf of plant of Solanaceae datura metel or datura innoxia etc.[nature and flavor] bitter in the mouth; Pungent; Warm in nature; Poisonous.[function cures mainly] antitussive and antiasthmatic; Pain relieving is drawn out the pus.Master breathes with cough; Arthralgia pain; Foot gas; Proctoptosis; Carbuncle furuncle.[usage and dosage] 0.3-0.6g.
Viola arcuata: this product is the herb of Violaceae plant Viola arcuata.[nature and flavor] pungent fiber crops; Micro-acid; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Loose block up hemostasis.Main sore swollen toxin; Acute mastitis; Traumatic injury; Open fracture; Traumatic hemorrhage; Snakebite.[usage and dosage] 9-15g.
Tibet chicken feet showy flowers of herbaceous plants: this product is the flower of ranunculaceae plant Flos Trollii ranunculoidis.[nature and flavor] acrid in the mouth; Micro-hardship; Cold.[function cures mainly] is antipyretic; Evacuation of pus.Main irritable feverish sensation in the chest; Wound is suppurated.[usage and dosage] 3-6g.
Celestial Pennisetum centrasiaticum Tzvel: be root or the herb of the celestial BAICAO of feverfew.[nature and flavor] acrid in the mouth; Puckery; Warm in nature.[function cures mainly] antidotes against snake bite.Main venom.[usage and dosage] 15-30g.
Radix Sophorae Alopecuroidis: this product is the root of leguminous plant Herba Sophorae alopecuroidis.[nature and flavor] are bitter, cold.[function cures mainly] heat-clearing and toxic substances removing.Control dysentery, eczema, toothache, cough.[usage and dosage] 3-6g.
Ramulus et Folium Phyllodii Pulchelli: be the aerial parts of leguminous plant board Qian Shu.[nature and flavor] are lightly seasoned; Bitter; Property is put down; Mild toxicity.[return through] lung; Spleen; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Expelling wind and promoting diuresis; Promoting blood circulation and detumescence.Main cold, fever; Laryngopharynx swelling and pain; Ulcerative gingivitis; Rheumatic arthralgia; Edema; Expand; Hepatosplenomegaly; Treating swelling and pain by traumatic injury; Insect-bite.[usage and dosage] 6-15g.
West place in Hubei Herba Hydrocotyles: this product is the herb of the large Herba Coriandri of samphire west place in Hubei.[nature and flavor] bitter in the mouth; Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances is invigorated blood circulation.Main jaundice due to damp-heat; Dysentery; Pyretic stranguria; Stranguria caused by urinary stone; Aphtha; Boil of the external auditory meatus; Traumatic injury.[usage and dosage] 6-15g.
Ramulus Euonymi: be branch or the aliform appurtenance of the tool fin of Celastraceae plant winged euonymus.[nature and flavor] are bitter; Pungent; Cold.[return through] Liver Channel.[function cures mainly] removing blood stasis stimulates the menstrual flow; Removing toxic substances and promoting subsidence of swelling; Parasite killing.Primary symptom abdominal mass is lumpd; Trusted subordinate's pain; Amenorrhea; Dysmenorrhea; Metrorrhagia and metrostaxis; The stagnant stomachache of the stasis of blood in puerperal; Retention of lochia; Hernia; Severe and migratory arthralgia arthralgia pain; Skin ulcer swells; Traumatic pain; Abdominal pain due to worm stagnation; Burn and scald; Venom.[usage and dosage] 4-9g.
Rhizoma Acori Graminei: this product is the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott.[nature and flavor] are pungent, bitter, temperature.[return through] GUIXIN, stomach warp.[function cures mainly] removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.[usage and dosage] 3 ~ 9g.
Radix Et Rhizoma Rhei: this product is the rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.[nature and flavor] are bitter, cold.[return through] returns spleen, stomach, large intestine, liver, pericardium channel.[function cures mainly] purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.[usage and dosage] 3 ~ 30g
Cortex Phellodendri: be the bark of rutaceae Cortex Phellodendri or wampee.[return through] returns kidney, urinary bladder channel.[function cures mainly] heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.[usage and dosage] 3 ~ 12g.
Rhizoma Coptidis: this product is the rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao, coptis omeiensis or Coptis teeta.[nature and flavor] are bitter, cold.[return through] GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.[usage and dosage] 2 ~ 5g.
Radix Glycyrrhizae: this product is root and the root stock of glycyrrhizic legume.[nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.[usage and dosage] 1.5 ~ 15g.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine for the treatment of necrotizing fasciitis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing necrotizing fasciitis.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine for the treatment of necrotizing fasciitis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Thalictrum thumbergii D C 3 parts, poinsettia 3 parts, clock root 2 parts of looking up to heaven, Herba Tropaeoli 4 parts, Herba Sambuci Chiensis 5 parts, Aloe 5 parts, Radix Stephaniae hemandifoliae 3 parts, Folium daturae 0.3 part, Viola arcuata 5 parts, Tibet chicken feet showy flowers of herbaceous plants 5 parts, celestial Pennisetum centrasiaticum Tzvel 5 parts, Radix Sophorae Alopecuroidis 5 parts, Ramulus et Folium Phyllodii Pulchelli 4 parts, west place in Hubei Herba Hydrocotyles 3 parts, Ramulus Euonymi 3 parts, Rhizoma Acori Graminei 4 parts, Radix Et Rhizoma Rhei 6 parts, Cortex Phellodendri 6 parts, Rhizoma Coptidis 6 parts, 12 parts, Radix Glycyrrhizae.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects 50 routine necrotizing fasciitis patients between in August ,-2013 in February, 2009 altogether, age 17-72 year, course of disease 1-30 days.Be divided at random: treatment group 25 example, matched group 25 example.Two groups of data there was no significant differences such as sex, age, have comparability.
2, test method
2.1 Therapeutic Method
Matched group Effect of Oral Metronidazole and rocephin, by specification is taken, 20 days courses for the treatment of.
The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 1, every day 2 times.10 days courses for the treatment of.
2.2 observation items: before and after experiment, to pain, suppuration, body temperature and biochemical indicator chemical examination record.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, test chamber inspection is normal, has no recurrence in half a year.Take a turn for the better: clinical symptom relief, lab testing improvement or normal.Invalid: clinical symptoms, lab testing are without being clearly better or increasing the weight of.
3.2 treatment statistical results are in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Untoward reaction example | Total effective rate (%) |
| Treatment group | 25 | 9 | 10 | 6 | 2（8%） | 76% |
| Matched group | 25 | 3 | 9 | 13 | 5（20%） | 48% |
Visible, the medicine that the present invention obtains can safe and effective treatment necrotizing fasciitis.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take Thalictrum thumbergii D C 3g, poinsettia 3g, look up to heaven clock root 2g, Herba Tropaeoli 4g, Herba Sambuci Chiensis 5g, Aloe 5g, Radix Stephaniae hemandifoliae 3g, Folium daturae 0.3g, Viola arcuata 5g, Tibet chicken feet showy flowers of herbaceous plants 5g, celestial Pennisetum centrasiaticum Tzvel 5g, Radix Sophorae Alopecuroidis 5g, Ramulus et Folium Phyllodii Pulchelli 4g, west place in Hubei Herba Hydrocotyles 3g, Ramulus Euonymi 3g, Rhizoma Acori Graminei 4g, Radix Et Rhizoma Rhei 6g, Cortex Phellodendri 6g, Rhizoma Coptidis 6g, Radix Glycyrrhizae 12g; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, the capsule of adult normal's one day consumption must be met.
Be used for the treatment of necrotizing fasciitis.Oral, every bu is taken for twice sooner or later.
Specific embodiment 2
Take Thalictrum thumbergii D C 3g, poinsettia 3g, look up to heaven clock root 2g, Herba Tropaeoli 4g, Herba Sambuci Chiensis 5g, Aloe 5g, Radix Stephaniae hemandifoliae 3g, Folium daturae 0.3g, Viola arcuata 5g, Tibet chicken feet showy flowers of herbaceous plants 5g, celestial Pennisetum centrasiaticum Tzvel 5g, Radix Sophorae Alopecuroidis 5g, Ramulus et Folium Phyllodii Pulchelli 4g, west place in Hubei Herba Hydrocotyles 3g, Ramulus Euonymi 3g, Rhizoma Acori Graminei 4g, Radix Et Rhizoma Rhei 6g, Cortex Phellodendri 6g, Rhizoma Coptidis 6g, Radix Glycyrrhizae 12g; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of necrotizing fasciitis.Oral, once a day.
Specific embodiment 3
Take Thalictrum thumbergii D C 3g, poinsettia 3g, look up to heaven clock root 2g, Herba Tropaeoli 4g, Herba Sambuci Chiensis 5g, Aloe 5g, Radix Stephaniae hemandifoliae 3g, Folium daturae 0.3g, Viola arcuata 5g, Tibet chicken feet showy flowers of herbaceous plants 5g, celestial Pennisetum centrasiaticum Tzvel 5g, Radix Sophorae Alopecuroidis 5g, Ramulus et Folium Phyllodii Pulchelli 4g, west place in Hubei Herba Hydrocotyles 3g, Ramulus Euonymi 3g, Rhizoma Acori Graminei 4g, Radix Et Rhizoma Rhei 6g, Cortex Phellodendri 6g, Rhizoma Coptidis 6g, Radix Glycyrrhizae 12g; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, then adds appropriate dextrin and correctives, granulates according to this area common process, and packaging, can obtain the granule meeting adult normal's one day consumption.
Be used for the treatment of necrotizing fasciitis.Oral, every bu morning, noon and afternoon take for three times.
Claims (1)
1. treat the Chinese medicine of necrotizing fasciitis for one kind, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Thalictrum thumbergii D C 3 parts, poinsettia 3 parts, clock root 2 parts of looking up to heaven, Herba Tropaeoli 4 parts, Herba Sambuci Chiensis 5 parts, Aloe 5 parts, Radix Stephaniae hemandifoliae 3 parts, Folium daturae 0.3 part, Viola arcuata 5 parts, Tibet chicken feet showy flowers of herbaceous plants 5 parts, celestial Pennisetum centrasiaticum Tzvel 5 parts, Radix Sophorae Alopecuroidis 5 parts, Ramulus et Folium Phyllodii Pulchelli 4 parts, west place in Hubei Herba Hydrocotyles 3 parts, Ramulus Euonymi 3 parts, Rhizoma Acori Graminei 4 parts, Radix Et Rhizoma Rhei 6 parts, Cortex Phellodendri 6 parts, Rhizoma Coptidis 6 parts, 12 parts, Radix Glycyrrhizae.
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| 中西医结合治疗急性坏死性筋膜炎的临床研究;刘宝生!300193等;《天津中医》;20011012;第18卷(第05期);4-6 * |
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