CN103610853B - Angelica sinensis and ligusticum wallichii tablet for regulating menstruation and preparation method of angelica sinensis and ligusticum wallichii tablet - Google Patents
Angelica sinensis and ligusticum wallichii tablet for regulating menstruation and preparation method of angelica sinensis and ligusticum wallichii tablet Download PDFInfo
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Abstract
The invention relates to the field of a traditional Chinese medicine composition, and particularly relates to an angelica sinensis and ligusticum wallichii tablet for regulating menstruation and a preparation method of the angelica sinensis and ligusticum wallichii tablet. The preparation method of the angelica sinensis and ligusticum wallichii tablet for regulating menstruation comprises the following steps: distilling the angelica sinensis and the ligusticum wallichii to obtain essential oil and dregs; mixing the essential oil with beta-cyclodextrine and water, and homogenizing, so as to obtain suspension liquid; orderly precipitating, filtering, drying and crushing the suspension liquid, so as to obtain an essential oil inclusion compound; mixing the dregs with radix bupleuri, radix paeoniae alba, bighead atractylodes rhizome, tuckahoe and rhizoma alismatis; decocting, so as to obtain a mixed solution; orderly filtering, concentrating and pelletizing the mixed solution, so as to obtain drug particles; mixing the essential oil inclusion compound with the drug particles, and then tabletting, so as to obtain the angelica sinensis and ligusticum wallichii tablet for regulating menstruation. By adopting the angelica sinensis and ligusticum wallichii tablet for regulating menstruation and the preparation method of the angelica sinensis and ligusticum wallichii tablet, the viscosity of the drug particles is increased, tabletting is easier, the difficulty of the production technology is reduced, the stability of the drug is improved, the quality guarantee period is prolonged, and disintegration of the drug is facilitated, so that the dissolution and absorption rate of the drug is improved.
Description
Technical field
The present invention relates to Chinese medicine composition field, in particular to Guishaotiaojing tablets and preparation method thereof.
Background technology
Guishaotiaojing tablets is a kind of Chinese medicine composition being used for the treatment of menoxenia, and its main component comprises: Radix Bupleuri, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Rhizoma Alismatis be totally seven taste Chinese crude drugs.
In correlation technique, the preparation method of Guishaotiaojing tablets is: first by Radix Angelicae Sinensis and Rhizoma Chuanxiong distillation, obtain volatile oil and medicinal residues; Again these medicinal residues and other gomi herbs are merged and decoct, then the solution obtained filtered successively, concentrate, precipitate with ethanol, recovery ethanol, drying, pulverizing, granulation, obtain drug particles; Finally volatile oil is above sprayed directly on drug particles, then adds other adjuvant, carry out tabletting, finally obtained Guishaotiaojing tablets.
There are the following problems for above preparation method: be directly sprayed on drug particles by volatile oil, not only can reduce the viscosity of drug particles, and then cause tabletting difficulty; And the volatile surface to tablet of volatile oil, and then the stability of medicine is reduced, also can make medicine disintegration difficulty.
Summary of the invention
The object of the present invention is to provide Guishaotiaojing tablets and preparation method thereof, to solve the above problems.
Provide the preparation method of Guishaotiaojing tablets in an embodiment of the present invention, comprise the following steps:
By Radix Angelicae Sinensis and Rhizoma Chuanxiong distillation, obtain volatile oil and medicinal residues;
Volatile oil is mixed with cycloheptaamylose, water, and homogenizing, obtain suspension;
Suspension is precipitated successively, filters, dry, pulverize, obtain volatile oil clathrate compound;
Medicinal residues are mixed with Radix Bupleuri, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria and Rhizoma Alismatis, then decocts, obtain mixed liquor;
Mixed liquor is filtered successively, concentrate, granulate, obtain drug particles;
Volatile oil clathrate compound is mixed with drug particles, then tabletting, obtain Guishaotiaojing tablets;
Wherein, the volume ratio of volatile oil, cycloheptaamylose and water three kinds of compositions is: 1:4.5-7.5:13.5-22.5.
Provide Guishaotiaojing tablets in an embodiment of the present invention, it adopts the preparation method of above-described embodiment to prepare.
Guishaotiaojing tablets of the above embodiment of the present invention and preparation method thereof, carries out enclose by volatile oil, then the volatile oil clathrate compound obtained is mixed obtained Guishaotiaojing tablets with drug particles.After enclose, volatile oil is wrapped in the inside of clathrate, and clathrate outside is the cycloheptaamylose with better viscosity, therefore, volatile oil clathrate compound is mixed with drug particles, not only can not reduce the viscosity of drug particles, the viscosity of drug particles can be increased on the contrary, thus easier tabletting, reduces the difficulty of production technology; And not easily evaporate because volatile oil is wrapped in inside, thus the stability of medicine improves, and shelf lives extends, and also avoid the problem that volatile oils to medical surfaces makes medicine disintegration difficulty.In addition, because the cycloheptaamylose added in medicine has good water absorption and dilatancy, be therefore more conducive to the disintegrate of medicine, the solution absorption speed of medicine is improved.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail.
Embodiment one
A preparation method for Guishaotiaojing tablets, comprises the following steps:
Step 101: by Radix Angelicae Sinensis and Rhizoma Chuanxiong distillation, obtain volatile oil and medicinal residues;
Step 102: mixed with cycloheptaamylose, water by volatile oil, and homogenizing, obtain suspension;
Step 103: suspension is precipitated successively, filters, dry, pulverize, obtain volatile oil clathrate compound;
Step 104: medicinal residues are mixed with Radix Bupleuri, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria and Rhizoma Alismatis, then decocts, obtain mixed liquor;
Step 105: mixed liquor is filtered successively, concentrate, granulate, obtain drug particles;
Step 106: mixed with drug particles by volatile oil clathrate compound, then tabletting, obtain Guishaotiaojing tablets;
Wherein, the volume ratio of volatile oil, cycloheptaamylose and water three kinds of compositions is: 1:4.5-7.5:13.5-22.5.
Volatile oil is carried out enclose by above preparation method, then the volatile oil clathrate compound obtained is mixed obtained Guishaotiaojing tablets with drug particles.After enclose, volatile oil is wrapped in the inside of clathrate, and clathrate outside is the cycloheptaamylose with better viscosity, therefore, this volatile oil clathrate compound is mixed with drug particles, not only can not reduce the viscosity of drug particles, the viscosity of drug particles can be increased on the contrary, thus easier tabletting, reduces the difficulty of production technology; And not easily evaporate because volatile oil is wrapped in inside, thus the stability of medicine improves, and shelf lives extends, and also avoid the problem that volatile oils to medical surfaces makes medicine disintegration difficulty.In addition, because the cycloheptaamylose added in medicine has good water absorption and dilatancy, be therefore more conducive to the disintegrate of medicine, the solution absorption speed of medicine is improved.
Due to the Guishaotiaojing tablets more easy disintegrating that above-mentioned preparation method obtains, therefore, do not need to add disintegrating agent again, therefore both decrease supplementary product consumption, turn avoid the side effect adding disintegrating agent and may bring.
In addition, above-mentioned preparation method can also be improved further, to reach more technique effect, such as:
Preferably, concentrated in step 105 method is:
Obtaining filtrate after being filtered by mixed liquor, to be concentrated into relative density be 1.10-1.12, obtains clear paste;
In clear paste, add ethanol, then leave standstill, after get supernatant;
Reclaim the ethanol in supernatant, obtain residual liquid simultaneously;
Filter residual liquid, and the filtrate obtained to be concentrated into relative density be 1.30-1.35.
The purity of medicine can be improved by above method for concentration.
Preferably, also comprise after step volatile oil clathrate compound mixed with drug particles He before tabletting: add Pulvis Talci.Pulvis Talci has fluidizer effect, therefore the recess of drug particle surface can fill up and fill by interpolation Pulvis Talci, lower the roughening of drug particle surface, reach in the past and reduce frictional force between drug particles, improve drug particles and to flow past object, thus easier tabletting.
Preferably, also comprise after step volatile oil clathrate compound mixed with drug particles He before tabletting: add magnesium stearate.Magnesium stearate has lubrication, therefore the recess of drug particle surface can fill up and fill by interpolation magnesium stearate, lower the roughening of drug particle surface, reach in the past and reduce frictional force between drug particles, improve drug particles and to flow past object, thus easier tabletting.In addition, because magnesium stearate is hydrophobic substance, therefore in order to more fully improve lubricity and mobility, magnesium stearate and Pulvis Talci can also be added in medicine simultaneously, making both action compensatings, increase progressively.
Preferably, also comprise before distillation: by Radix Angelicae Sinensis and Rhizoma Chuanxiong mixing, and add water wherein, infiltrate 2-4h.By infiltrating, Radix Angelicae Sinensis and Rhizoma Chuanxiong are softened, thus more easily distill, and by infiltrating a part of active ingredient dissolving Radix Angelicae Sinensis and Rhizoma Chuanxiong, thus the extraction efficiency of volatile oil can be improved.In addition, in order to further improve extraction efficiency, can also before infiltration, first Radix Angelicae Sinensis is cut into lamellar, Rhizoma Chuanxiong is pulverized, is especially cut into oblique thin slice (thickness is 1-2mm), the medical material specific surface area of this shape is large, thus the extraction ratio of volatile oil and extraction efficiency all higher.
The present invention also with volatile oil recovery rate for inspection target is tested, prove: Radix Angelicae Sinensis is made oblique thin slice, Rhizoma Chuanxiong power is broken into coarse powder, extract volatile oil, result volatile oil is drawn effect is better than Radix Angelicae Sinensis, traditional handicraft that Rhizoma Chuanxiong is cataclasm.
Preferably, the method for granulation is: dry granulation.Adopt wet granulation in traditional preparation methods more, due in wet-granulation process, need to add water, and when adding water heating, collapsing easily appears in material, and (material should be fluidized state to a pot phenomenon in pot body under normal circumstances, because process parameter control is improper, material is not dry in time, cause materials from bonding serious, sink to the bottom of a pan, can not seethe with excitement, this phenomenon is called the pot that collapses, and also means and granulates unsuccessfully).And adopt dry granulation not need to add water, therefore there will not be above-mentioned phenomenon, the yield rate thus prepared is higher.
Preferably, in Guishaotiaojing tablets, the proportioning of Radix Bupleuri, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Rhizoma Alismatis is: by weight, Radix Bupleuri 1-2 part, Radix Paeoniae Alba 1-4 part, Rhizoma Atractylodis Macrocephalae 1.2-2.8 part, Poria 1.2-2.8 part, Radix Angelicae Sinensis 1-2 part, Rhizoma Chuanxiong 0.8-1.2 part and Rhizoma Alismatis 1-2 part.Above-mentioned seven flavor medicine material can adopt any part within the scope of its number.
Preferably, mixed by volatile oil with cycloheptaamylose, water, and the method for homogenizing is further: cycloheptaamylose and water are joined in colloid mill, then limit adds volatile oil in colloid mill, lateral dominance colloid mill carries out homogenizing.Adopt this homogenizing method more easily to make to interpenetrate between material evenly.
Preferably, ethanol used is above: volumetric concentration is the ethanol of 95%.Found by test, adopt the ethanol enclose effect of this concentration better.
In addition, after tabletting, conventional film coating operation can also be carried out again, such as sugar coating.And when preparing volatile oil clathrate compound, before adding cycloheptaamylose, water, first can also dilute volatile oil with 95% ethanol (volumetric concentration), easier like this enclose.
Relative density hereinafter refers to the density relative to water.
Implement two
A preparation method for Guishaotiaojing tablets, comprises the following steps:
Dried cream powder: according to prescription, Radix Angelicae Sinensis medical material is cut into oblique thin slice, Ligusticum chuanxiong Hort is ground into fine powder, and other medical material (Radix Bupleuri, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Alismatis) is given as one thinks fit cataclasm, for subsequent use.Radix Angelicae Sinensis, Rhizoma Chuanxiong added suitable quantity of water infiltration after 2-4 hour, then used steam distillation 7h, extract volatile oil, and it were for subsequent use to obtain medicinal residues; Medicinal residues and all the other gomi herbs decoct with water secondary, each 2 hours, merge and decoct, filter, be the clear paste of 1.10-1.12 (60 DEG C) by filtrate and Radix Angelicae Sinensis, Rhizoma Chuanxiong concentration of liquid medicine to relative density, add ethanol and make its content reach 50%, stir evenly, hold over night, get supernatant, filter, reclaim the ethanol in filtrate, and filtrate is concentrated into the thick paste that relative density is 1.30-1.35 (60 DEG C), less than 70 DEG C, vacuum is dry, be ground into fine powder, for subsequent use.
Volatile oil clathrate compound: volatile oil adds 6 times of beta-cyclodextrin inclusion compounds and 18 times of water grinding enclose, less than 45 DEG C dryings, is ground into segmentation.
Finally, by dried cream powder, volatile oil clathrate compound mix homogeneously, dry granulation, adds magnesium stearate, Pulvis Talci in granule, mixing, tabletting, film coating, obtains product.
This embodiment, except can reaching the beneficial effect of operation referred to above, can also produce following technique effect:
Medicinal residues and other gomi herbs have decocted twice, improve the extraction ratio of active ingredient.
In decoction, filter, concentrated after add ethanol again, thus the hydrophobic active ingredient in medicine is dissolved out more fully.Wherein, concentrated relative density is that the clear paste of 1.10-1.12 more easily precipitates, and thus separating effect is better, and pharmaceutical purity is higher.
Last drying less than 70 DEG C, can ensure to obtain high-quality medicine because: baking temperature more than 70 DEG C after, active ingredient peoniflorin easily decomposes.
Dry below 45 DEG C when preparing volatile oil clathrate compound, the problems such as volatile oil decomposition at high temperature can be avoided.
Embodiment three
A preparation method for Guishaotiaojing tablets, comprises the following steps:
Dried cream powder: according to prescription, makes sheet by Radix Angelicae Sinensis, Rhizoma Chuanxiong, and other medical material (Radix Bupleuri, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Alismatis) is given as one thinks fit cataclasm, for subsequent use.Radix Angelicae Sinensis, Rhizoma Chuanxiong added suitable quantity of water infiltration after 2-4 hour, used steam distillation 7h, extracted volatile oil, for subsequent use; The gomi herbs such as medicinal residues and all the other Radix Paeoniae Albas decoct with water secondary, each 2 hours, merge and decoct, filter, be the clear paste of 1.10-1.12 (60 DEG C) by filtrate and Radix Angelicae Sinensis, Rhizoma Chuanxiong concentration of liquid medicine to relative density, add ethanol and make its content reach 50%, stir evenly, hold over night, get supernatant, filter, filtrate recycling ethanol, is concentrated into the thick paste of relative density 1.30-1.35 (60 DEG C), and less than 70 DEG C, vacuum is dry, be ground into fine powder, for subsequent use.
Volatile oil clathrate compound: volatile oil adds 6 times of beta-cyclodextrin inclusion compounds and 18 times of water grinding enclose, less than 45 DEG C dryings, is ground into segmentation.
Finally, by dried cream powder, volatile oil clathrate compound mix homogeneously, dry granulation, adds magnesium stearate, Pulvis Talci 4.4g in granule, mixing, tabletting, film coating, to obtain final product.
This embodiment can reach the beneficial effect of all process steps related to above.
Following examples four to six provide three kinds of Guishaotiaojing tablets, and these three kinds of Guishaotiaojing tablets all adopt preparation method provided above to prepare.
Embodiment four
A kind of Guishaotiaojing tablets consists of the following composition: by weight, Radix Bupleuri 1 part, the Radix Paeoniae Alba 1 part, the Rhizoma Atractylodis Macrocephalae 1.2 parts, 1.2 parts, Poria, Radix Angelicae Sinensis 1 part, Rhizoma Chuanxiong 0.8 part and Rhizoma Alismatis 1 part.
Embodiment five
A kind of Guishaotiaojing tablets consists of the following composition: by weight, Radix Bupleuri 2 parts, the Radix Paeoniae Alba 4 parts, the Rhizoma Atractylodis Macrocephalae 2.8 parts, 2.8 parts, Poria, Radix Angelicae Sinensis 2 parts, Rhizoma Chuanxiong 1.2 parts and Rhizoma Alismatis 1-2 part.
Embodiment six
A kind of Guishaotiaojing tablets consists of the following composition: by weight, Radix Bupleuri 1.5 parts, the Radix Paeoniae Alba 2.5 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 2 parts, Poria, Radix Angelicae Sinensis 1.5 parts, Rhizoma Chuanxiong 1 part and Rhizoma Alismatis 1.5 parts.
Embodiment seven
A kind of Guishaotiaojing tablets consists of the following composition: Radix Bupleuri 882g, Radix Paeoniae Alba 1470g, Rhizoma Atractylodis Macrocephalae 1176g, Poria 1176g, Radix Angelicae Sinensis 882g, Rhizoma Chuanxiong 588g, Rhizoma Alismatis 882g.When adopting this formula to prepare medicine, the magnesium stearate of adding, Pulvis Talci be 4.4g altogether.
Test example
The enclose effect test of volatile oil
Capital equipment: colloid mill, bottle,suction, vacuum drying oven, volatile oil determination apparatus.
Test method:
Extract volatile oil: the oblique thin slice 88.2kg of Radix Angelicae Sinensis, Rhizoma Chuanxiong coarse powder 58.8kg, drop in 3m3 multi-function extractor, add 1.5 times of water infiltrations 4 hours, pass into Steam Heating medical material from bottom, steam volatile oil, the vapours with volatile oil passes through chiller, cooling, enter oil water separator, volatile oil retains in oil water separator, and water liquid passes back into multi-function extractor, so extracts 7 hours, divide and get volatile oil, for subsequent use.
Enclose volatile oil: the enclose of volatile oil adopts orthogonal design to test, and experimental factor and level are in table 1.Take beta-schardinger dextrin-in clean bucket, add purified water stirring and dissolving, pour in the colloid mill that run well, adjusting gap is 5 μm, ON cycle.Get Radix Angelicae Sinensis, Rhizoma Chuanxiong volatile oil 120ml, adding dissolve with ethanol (1:1) slowly adds in colloid mill (about 3 minutes) afterwards, grind below 40 DEG C, close closed loop, open discharging opening, clathrate aqueous solution is placed in clean bucket, freezer places 24 hours, and sucking filtration, collecting precipitation, 45 DEG C of dryings, obtain volatile oil clathrate compound, weigh, calculate clathrate yield.Clathrate is pressed Chinese Pharmacopoeia version in 2010 annex and measure item Carapax et Plastrum Testudinis method mensuration volatile oil content.
Inspection target: inclusion essential oil rate.
Table 1 enclose experimental factor water-glass
Table 2 EXPERIMENTAL DESIGN and result of the test
Table 3 significance test
F
0.10（2，1）=49.5 F
0.025（2，1）=799.5
Table 4 range analysis
| A | B | C | |
| Ⅰj | 2.190 | 1.641 | 2.051 |
| Ⅱj | 2.096 | 2.432 | 2.262 |
| Ⅲj | 2.092 | 2.305 | 2.065 |
| R | 0.033 | 0.264 | 0.070 |
Conclusion: as shown in Table 2-4, analysis shows result, and factor B has the impact of highly significant to result of the test, and factor C has appreciable impact to result of the test; Within the scope of investigation, factor A is little on result of the test impact.Be B2C2 according to the best clathrate process parameter of range analysis volatile oil, when result of the test is more or less the same, select less supplementary product consumption A.Therefore determine that the best clathrate process parameter of volatile oil is A3B2C2.
Take the beta-schardinger dextrin-of 6 times of volatile oil weight, add the purified water stirring and dissolving of 3 times of beta-schardinger dextrin-weight, pour in the colloid mill that run well, adjusting gap is 5 μm, ON cycle.Get Radix Angelicae Sinensis, Rhizoma Chuanxiong volatile oil add 95% dissolve with ethanol after (volatile oil: 95% ethanol=1:1), slowly add in colloid mill (volatile oil has added rear beginning timing), grind 20 minutes below 40 DEG C, close closed loop, open discharging opening, taking-up clathrate aqueous solution is placed freezer in clean bucket and is placed 24 hours, and sucking filtration, collecting precipitation, 45 DEG C of dryings, obtain volatile oil clathrate compound.
Stability test
The sample that Example 2-3 and matched group obtain, carries out accelerated stability according to " Chinese medicine, natural drug stability study technological guidance principle " and long-time stability are investigated.
In this test, the embodiment 2-3 formula used formula used with matched group is identical, all as follows:
Radix Bupleuri 882g, Radix Paeoniae Alba 1470g, Rhizoma Atractylodis Macrocephalae 1176g, Poria 1176g, Radix Angelicae Sinensis 882g, Rhizoma Chuanxiong 588g, Rhizoma Alismatis 882g.
The preparation method of matched group is as follows:
By prescription seven flavor medicine material, give as one thinks fit cataclasm, get Radix Angelicae Sinensis, Rhizoma Chuanxiong adds suitable quantity of water and infiltrate after 2-4 hour, use steam distillation 7h, extract volatile oil, for subsequent use; The gomi herbs such as medicinal residues and all the other Radix Paeoniae Albas decoct with water secondary, each 2 hours, merge and decoct, filter, be the clear paste of 1.10-1.12 (60 DEG C) by filtrate and Radix Angelicae Sinensis, Rhizoma Chuanxiong concentration of liquid medicine to relative density, add ethanol and make alcohol content reach 50%, stir evenly, hold over night, get supernatant, filter, filtrate recycling ethanol, is concentrated into the thick paste of relative density 1.30-1.35 (60 DEG C), and less than 90 DEG C, vacuum is dry, pulverize, for subsequent use; By dried cream powder and dextrine powder mixing, use one-step palletizing, add magnesium stearate, Pulvis Talci 4.4g, carboxymethyl starch sodium 4.4g, mixing, tabletting, film coating, to obtain final product.
Stability test result as shown in Table 5 and 6, peoniflorin is wherein the main pharmacodynamics composition of Guishaotiaojing tablets, as seen from the experiment, the stability of the volatile oil of the medicine that preparation method of the present invention obtains significantly improves, content is also high than matched group, and the content of effective ingredient peoniflorin is apparently higher than matched group.
The investigation result of table 5 accelerated stability test
The investigation result of table 6 long-term stable experiment
Adopt enclose volatile oil to have appreciable impact to sample stability, in its enclose process, oil, beta-schardinger dextrin-, the ratio of water, milling time affect enclose effect; Dry granulation has evaded that the dry cream of fluidized bed granulation is heated, moisture increases, the unfavorable factor become sticky of feeling like jelly, and improves stability and the product quality of medicine, simplifies production technology, improve production efficiency.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. the preparation method of Guishaotiaojing tablets, is characterized in that, comprises the following steps:
By Radix Angelicae Sinensis and Rhizoma Chuanxiong distillation, obtain volatile oil and medicinal residues;
Described volatile oil is mixed with cycloheptaamylose, water, and homogenizing, obtain suspension;
Described suspension is precipitated successively, filters, dry, pulverize, obtain volatile oil clathrate compound;
Described medicinal residues are mixed with Radix Bupleuri, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria and Rhizoma Alismatis, then decocts, obtain mixed liquor;
Described mixed liquor is filtered successively, concentrates, dry granulation, obtain drug particles;
Described volatile oil clathrate compound is mixed with described drug particles, then tabletting, obtain described Guishaotiaojing tablets;
Wherein, the volume ratio of described volatile oil, described cycloheptaamylose and described water three kinds of compositions is: 1:4.5-7.5:13.5-22.5;
Also comprise before described distillation: by described Radix Angelicae Sinensis and the mixing of described Rhizoma Chuanxiong, and add water wherein, infiltrate 2-4h, also comprise before described Radix Angelicae Sinensis and the mixing of described Rhizoma Chuanxiong: described Radix Angelicae Sinensis is cut into lamellar, described Rhizoma Chuanxiong is pulverized;
Wherein, in described Guishaotiaojing tablets, the proportioning of Radix Bupleuri, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Rhizoma Alismatis is: by weight, Radix Bupleuri 1-2 part, Radix Paeoniae Alba 1-4 part, Rhizoma Atractylodis Macrocephalae 1.2-2.8 part, Poria 1.2-2.8 part, Radix Angelicae Sinensis 1-2 part, Rhizoma Chuanxiong 0.8-1.2 part and Rhizoma Alismatis 1-2 part.
2. the preparation method of Guishaotiaojing tablets according to claim 1, is characterized in that, also comprises after the described step mixed with described drug particles by described volatile oil clathrate compound He before described tabletting:
Add Pulvis Talci; And/or, add magnesium stearate.
3. the preparation method of Guishaotiaojing tablets according to claim 1, is characterized in that, described concentrated method is:
It is 1.10-1.12 that the filtrate obtained after being filtered by described mixed liquor is concentrated into relative density, obtains clear paste;
In described clear paste, add ethanol, then leave standstill, after get supernatant;
Reclaim the ethanol in described supernatant, obtain residual liquid simultaneously;
Filter described residual liquid, and the filtrate obtained to be concentrated into relative density be 1.30-1.35.
4. the preparation method of Guishaotiaojing tablets according to claim 1, is characterized in that, is mixed by described volatile oil with cycloheptaamylose, water, and the method for homogenizing is further:
Cycloheptaamylose and water are joined in colloid mill, then limit adds described volatile oil in described colloid mill, the described colloid mill of lateral dominance carries out homogenizing.
5. the preparation method of Guishaotiaojing tablets according to claim 3, is characterized in that, described ethanol is: volumetric concentration is the ethanol of 95%.
6. Guishaotiaojing tablets, is characterized in that, the Guishaotiaojing tablets of described Guishaotiaojing tablets for utilizing the preparation method of the Guishaotiaojing tablets described in any one of claim 1-5 obtained.
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