CN103599279A - Traditional Chinese medicinal preparation for treating diabetes - Google Patents
Traditional Chinese medicinal preparation for treating diabetes Download PDFInfo
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- CN103599279A CN103599279A CN201310518943.9A CN201310518943A CN103599279A CN 103599279 A CN103599279 A CN 103599279A CN 201310518943 A CN201310518943 A CN 201310518943A CN 103599279 A CN103599279 A CN 103599279A
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Abstract
A traditional Chinese medicinal preparation for treating diabetes relates to the technical field of Chinese herbal medicines. The traditional Chinese medicinal preparation comprises the following bulk drugs: by weight, 35-45 parts of rhizoma atractylodis, 35-45 parts of rhizoma alismatis, 55-65 parts of Radix Astragali, 15-25 parts of Cornus officinalis, 25-35 parts of gypsum, 25-35 parts of Ligusticum wallichii, 25-35 parts of root of kudzu vine, 25-35 parts of biota orientalis, 5-15 parts of Chinese angelica and 15-25 parts of red sage root. Selection and compatibility of traditional Chinese medicinal materials accord with dialectical theories in Chinese Medicine, and a preparation method of the traditional Chinese medicinal preparation is simple. After compatibility, a water decoction is prepared. The traditional Chinese medicinal preparation has a remarkable effect of treating diabetic patients and has no toxic or side effect. Complementary purpose in traditional Chinese medicine compatibility is achieved.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine preparation for the treatment of diabetes.
Background technology
When during medically empty stomach (sugar-free and any sugary food intake in 8 hours), blood glucose is higher than normal range, (fasting glucose normal value 4.0-6.1mmol/L) is referred to as hyperglycemia, if two hours blood glucoses are higher than 7.8mmol/L after the meal, also can be called hyperglycemia.Diabetes are a kind of endocrinopathyes that carbohydrate metabolism disturbance is cardinal symptom of take, pathogenesis is hypoinsulinism or Insulin receptor INSR dysfunction in patient body, clinical manifestation is empty stomach or post-prandial glycemia rising, glycosuria and hyperlipemia, and its sickness rate is just being the trend rising year by year.Although hyperglycemia is not a kind of disease, also be not exclusively equal to diabetes, but hyperglycemia and diabetes have inevitable internal relation, hyperglycemia easy induced Diabetic really clinically, and suffer from for a long time hyperglycemia and also may damage eyes, kidney, blood vessel, heart, nerve etc.
Still lack at present the specific drug for the treatment of diabetes.The drug main of western medical treatment diabetes will comprise orally-taken blood sugar reducing class medicine and insulin, and orally-taken blood sugar reducing medicine comprises sulphanylureas, biguanides, meals glucose regulator etc.Although above these medicines have certain curative effect to the treatment of diabetes, but in clinical, its effect is not clearly, and some medicine also has toxic and side effects to patient, and side effect as the most serious in biguanides is to cause lactic acidosis, after occurring, mortality rate is 50%, unsuitable long-term taking.
In Chinese medicine, the category of diabetes ownership diabetes.Traditional Chinese medical science ancient books early has description to its cause of disease, diagnosis and treatment, and proposes many effective sides of quenching one's thirst, and is still applied to so far clinical.Chinese medicinal formulae treatment diabetes, because it is cheap, the features such as convenience, low toxic and side effects and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of drawing materials, than Western medicine, have irreplaceable superiority.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of cure rate high, the Chinese medicine preparation of safe and reliable treatment diabetes.
Technical problem to be solved by this invention realizes by the following technical solutions:
Treat a Chinese medicine preparation for diabetes, the medicament of being made by the crude drug of following weight portion:
Rhizoma Atractylodis 35-45 part, Rhizoma Alismatis 35-45 part, Radix Astragali 55-65 part, Fructus Corni 15-25 part, Gypsum Fibrosum 25-35 part, Rhizoma Chuanxiong 25-35 part, Radix Puerariae 25-35 part, Cacumen Platycladi 25-35 part, Radix Angelicae Sinensis 5-15 part, Radix Salviae Miltiorrhizae 15-25 part.
Preferred weight part of each crude drug is:
40 parts of Rhizoma Atractylodis, 40 parts of Rhizoma Alismatis, 60 parts of the Radixs Astragali, 20 parts of Fructus Corni, 30 parts of Gypsum Fibrosum, 30 parts of Rhizoma Chuanxiongs, 30 parts of Radix Puerariaes, 30 parts of Cacumen Platycladis, 10 parts of Radix Angelicae Sinensis, 20 parts of Radix Salviae Miltiorrhizaes.
The present invention's crude drug used can be bought and obtain from common Chinese shop, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required while preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., with conventional method of Chinese medicinal, be prepared into any conventional oral formulations, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method of preparing the present composition, comprises the steps,
1) by following parts by weight, take each crude drug: 40 parts of Rhizoma Atractylodis, 40 parts of Rhizoma Alismatis, 60 parts of the Radixs Astragali, 20 parts of Fructus Corni, 30 parts of Gypsum Fibrosum, 30 parts of Rhizoma Chuanxiongs, 30 parts of Radix Puerariaes, 30 parts of Cacumen Platycladis, 10 parts of Radix Angelicae Sinensis, 20 parts of Radix Salviae Miltiorrhizaes.
2) above-mentioned each taste material medicine is mixed be placed on and in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction, can in decoction, add after the conventional adjuvant of preparation or carrier, preparations shaping, obtains pill, capsule or tablet.
Usage and consumption:
The present invention more than 9.1 mM/ls, and did not use the patient of other medicines with headache mainly for fasting glucose, and the dosage of medicine of the present invention depends on concrete dosage form, and the factor such as patient's age, body weight, health status.Instruction: decoction, get a pair and take herb liquid, each oral 120-150 milliliter, one day twice, sub-service sooner or later, 7 days was a course for the treatment of; Pill, a ball, twice, 7 day on the one is a course for the treatment of.
The traditional Chinese medical science, the category of diabetes ownership diabetes, thinks that diabetes is YIN fluid deficiency, scorching inclined to one side Sheng, and take the deficiency of YIN as this, scorching is mark, both reciprocal causations; Chinese medicine composition of the present invention is compared with existing medicine, and the effectiveness of Chinese medicine composition of the present invention is high, and duration of efficacy is long, and in animal or mammal, does not produce uncomfortable side effect.
Pharmacology analysis:
Rhizoma Atractylodis: meridian distribution of property and flavor: pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Cure mainly: the transporting imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.
Rhizoma Alismatis: sweet in the mouth is light, cold in nature.Return kidney; Urinary bladder channel.There is effect for reducing blood fat.
The Radix Astragali: nature and flavor are sweet, tepor, return spleen, lung meridian is QI invigorating key medicine.
Fructus Corni: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse, interior-heat, quench one's thirst.
Gypsum Fibrosum: clearing away heat-fire, relieving restlessness is quenched the thirst, convergence granulation promoting.
Rhizoma Chuanxiong: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.
Radix Puerariae: property feeble QI, taste is micro-bitter.Deliver and bring down a fever, promoting the production of body fluid to quench thirst.Cure mainly: table disease fever without perspiration, rigidity pain on the head and nape, calentura is thirsty, quenches one's thirst, and macule is not saturating, diarrhea due to hypofunction of the spleen.Better to improving the symptom effects such as headache, dizziness, stiffness of the nape, tinnitus, numb limbs and tense tendons.
Cacumen Platycladi: < < Amplification on Materia Medica addendum > >: Cacumen Platycladi (Cacumen Biotae), the key medicine of nourishing YIN, how dry its property is, of a specified duration it, large strengthening the spleen soil, to grow its lung.
Radix Angelicae Sinensis: sweet in the mouth; Pungent; Bitter; Warm in nature.Enrich blood; Invigorate blood circulation.
Radix Salviae Miltiorrhizae: return through the popular feeling, Liver Channel.Function: promoting blood circulation to remove obstruction in the collateral, removing heat from blood detumescence, relieving restlessness clears away heart-fire.
Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and treatment disease, and the use link that this medicine is dropped into treatment disease provides science and objective foundation.Its test method and result of the test are as follows respectively:
1. the medicated diet that couple the present invention boils carries out animal acute toxicity test:
Medicine: the decoction being boiled by prescription of the present invention, saving backup ，You The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine in refrigerator provides.
Experimental animal: white mice, body weight is at 20-25g, and male and female select ，You Medical University Of Anhui to provide at random.
Method and result: get 50 of white mice, be divided into 5 groups, 10 every group, hungry about 15 hours, by every each 20ml, fill with medicine feed thing, in 24 hours, fill with respectively medicine feed thing 1,2,3,4,5 times, observe 5 days for the 1st, 2,3,4,5 groups, white mice is movable normal, and non-toxic reaction, without dead.Wherein white mice dosage is calculated by kg body weight dose, shows that oral liquid is without acute toxicity, clinical medicine dose safety.
2. the decoction that couple the present invention boils carries out long-term toxicity test for animals:
Experimental animal: rat, body weight, at 120-130g, all selects male white rat ，You Medical University Of Anhui to provide.
Method and result: get 50 of rat, be divided into 5 groups, every group 10, wherein the 1st, 2, 3, 4 groups as administration group, fill with respectively medicine feed thing 15ml for every group, 20ml, 30ml, 40ml, the 5th group of normal feeding as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the variation of tissues observed form, observe the effect of dosage, observe diet, movable variation, experimental results show that administration group and matched group are relatively without significant change, the visible kg body weight of pressing is calculated the equal non-toxic reaction of dosage doubly with respect to clinical 50-200, a kind of safe drugs.
3. in order to verify clinical efficacy, this prescription is tried out in First Attached Hospital, Anhui Medical Univ. and The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine respectively, and by choosing at random wherein 100 routine patients, fasting glucose is all more than 9.1 mM/ls, the course for the treatment of is the shortest 1 month, and the longest is 2 years.
Efficacy determination: adopt level Four standard;
Recovery from illness clinical improvements rate >=12%, effective clinical improvements rate >=56%, effective clinical improvement rate >=30%, invalid clinical improvements rate >=2%, concrete therapeutic outcome is referring to table 1.
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 100 | 12 | 56 | 30 | 2 | 98 |
The invention has the beneficial effects as follows: the present invention meets Chinese medical discrimination theory on Chinese crude drug selection and compatibility, and compound method is simple, after compatibility, make water decoction, remarkable to diabetes patient's therapeutic effect, and have no side effect, reached complementary object in drug matching.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
Take by weight each crude drug: 40 parts of Rhizoma Atractylodis, 40 parts of Rhizoma Alismatis, 60 parts of the Radixs Astragali, 20 parts of Fructus Corni, 30 parts of Gypsum Fibrosum, 30 parts of Rhizoma Chuanxiongs, 30 parts of Radix Puerariaes, 30 parts of Cacumen Platycladis, 10 parts of Radix Angelicae Sinensis, 20 parts of Radix Salviae Miltiorrhizaes.
Above-mentioned each taste material medicine is mixed to be placed in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.Instruction: decoction, get a pair and take herb liquid, each oral 150 milliliters, one day twice, sub-service sooner or later, 7 days was a course for the treatment of.
Embodiment 2
By following parts by weight, take each crude drug: 35 parts of Rhizoma Atractylodis, 35 parts of Rhizoma Alismatis, 55 parts of the Radixs Astragali, 15 parts of Fructus Corni, 25 parts of Gypsum Fibrosum, 35 parts of Rhizoma Chuanxiongs, 35 parts of Radix Puerariaes, 35 parts of Cacumen Platycladis, 15 parts of Radix Angelicae Sinensis, 25 parts of Radix Salviae Miltiorrhizaes.
Above-mentioned each taste material medicine is mixed to be placed on and in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction, in decoction, add after the conventional adjuvant of preparation or carrier, preparations shaping, obtains pill.Within 1st, take twice, each ball, sub-service sooner or later, 7 days is a course for the treatment of.
Embodiment 3
By following parts by weight, take each crude drug: 45 parts of Rhizoma Atractylodis, 45 parts of Rhizoma Alismatis, 65 parts of the Radixs Astragali, 25 parts of Fructus Corni, 35 parts of Gypsum Fibrosum, 25 parts of Rhizoma Chuanxiongs, 25 parts of Radix Puerariaes, 25 parts of Cacumen Platycladis, 5 parts of Radix Angelicae Sinensis, 15 parts of Radix Salviae Miltiorrhizaes.
Above-mentioned each taste material medicine is mixed to be placed in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction; Instruction: decoction, get a pair and take herb liquid, each oral 120 milliliters, one day twice, sub-service sooner or later, 7 days was a course for the treatment of.
Embodiment 4
By following parts by weight, take each crude drug: 32 parts of Rhizoma Atractylodis, Rhizoma Alismatis 28 32 parts of Fen, Herba Polygoni Avicularis, 8 parts of Radix Aconiti Lateralis Preparatas, 62 parts of Radix Astragali, 18 parts of Fructus Corni, 12 parts of Ramulus Cinnamomi, 32 parts of Herba Plantaginiss, 8 parts of Radix Salviae Miltiorrhizaes, 12 parts, Folium Nelumbinis.
Above-mentioned each taste material medicine is mixed to be placed in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction; Instruction: decoction, get a pair and take herb liquid, each oral 150 milliliters, one day twice, sub-service sooner or later, 7 days was a course for the treatment of.
Model case
Case 1
Turn round and look at so-and-so, female, 50 years old.Regular thirsty polydipsia, faint, day by day become thin, the appearance headache phenomenon of indirect, did not note at ordinary times, by tcm diagnosis, was YIN fluid deficiency, scorching inclined to one side Sheng, belongs to diabetes category, and through twice inspection, fasting glucose is 9.5 mM/ls and 9.8 mM/ls, takes the pill that the present invention makes, each 1, twice on the one, sooner or later sub-service, 7 days is a course for the treatment of, takes altogether two courses for the treatment of.Rear further consultation, symptom alleviates, and through patient symptom, alleviates, and spirit is better; After continue to have taken 4 courses for the treatment of and consolidated, blood glucose is always all very steady so far, not recurrence.
Case 2
Grasp so-and-so people from Anqing of ，Nv ，40Sui， Anhui Province, while being in, always feel faint, frequent micturition, skin is comparatively dry and with headache.On inspection, three empty stomach whole blood blood glucose, all more than 9.2 mM/ls, are diagnosed as diabetes.Take the decoction that the present invention makes, each oral 150 milliliters, one day course for the treatment of of the first two three times, morning, noon and afternoon sub-service; Take two courses for the treatment of of further consultation afterwards, symptom alleviates to some extent; Take half a year continuously afterwards, faint, frequent micturition, the symptoms such as xerosis cutis disappear substantially, and the mental status is better, and also no headache phenomenon, and blood glucose is always steady so far.
Case 3
Open up certain people from Taihe County of ，Nan ，54Sui， Anhui Province, when before diagnosis, on an empty stomach whole blood blood glucose surpasses 10.2 mM/ls (200 milligrams/deciliter), insulin secretion is few, is polydipsia, polyphagia, polyuria and the classical symptom such as lose weight.Take continuously afterwards 3 courses for the treatment of of decoction that the present invention makes, symptom is clearly better.After take continuously again 2 courses for the treatment of of decoction of the present invention, through measuring blood, be tending towards normally, and blood glucose does not rise so far.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (7)
1. a Chinese medicine preparation for the treatment of diabetes, is characterized in that: the medicament of being made by the crude drug of following weight portion,
Rhizoma Atractylodis 35-45 part, Rhizoma Alismatis 35-45 part, Radix Astragali 55-65 part, Fructus Corni 15-25 part, Gypsum Fibrosum 25-35 part, Rhizoma Chuanxiong 25-35 part, Radix Puerariae 25-35 part, Cacumen Platycladi 25-35 part, Radix Angelicae Sinensis 5-15 part, Radix Salviae Miltiorrhizae 15-25 part.
2. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1, is characterized in that: the medicament of being made by the crude drug of following weight portion,
40 parts of Rhizoma Atractylodis, 40 parts of Rhizoma Alismatis, 60 parts of the Radixs Astragali, 20 parts of Fructus Corni, 30 parts of Gypsum Fibrosum, 30 parts of Rhizoma Chuanxiongs, 30 parts of Radix Puerariaes, 30 parts of Cacumen Platycladis, 10 parts of Radix Angelicae Sinensis, 20 parts of Radix Salviae Miltiorrhizaes.
3. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1 and 2, is characterized in that: described medicament is any suitable preparation clinically.
4. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 3, is characterized in that: described preparation is oral formulations.
5. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 4, is characterized in that: described oral formulations is decoction or capsule or pill or tablet.
6. prepare a kind of method for the treatment of the Chinese medicine preparation of diabetes described in claim 1 or 2 any one, it is characterized in that: comprise the following steps,
A. by described weight portion, take each taste crude drug;
B. above-mentioned each taste material medicine is mixed to be placed on and in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction, can in decoction, add after the conventional adjuvant of preparation or carrier, preparations shaping, obtains pill, capsule or tablet.
7. according to the Chinese medicine preparation described in claim 1 or 2 any one, treating the purposes of whole blood blood glucose in more than 9.1 mM/ls diabetes medicament on an empty stomach.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260772A (en) * | 2016-06-03 | 2017-10-20 | 王家强 | A kind of Chinese medicine for treating diabetes |
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| CN102274447A (en) * | 2011-08-27 | 2011-12-14 | 赵国辉 | Medicinal composition for treating diabetes |
| CN102743540A (en) * | 2012-06-14 | 2012-10-24 | 黄培光 | Combined blood sugar-reduction formula |
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| CN107260772A (en) * | 2016-06-03 | 2017-10-20 | 王家强 | A kind of Chinese medicine for treating diabetes |
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