CN103589628B - Automatic sterilization, liquid preparation and sterile delivery system - Google Patents
Automatic sterilization, liquid preparation and sterile delivery system Download PDFInfo
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- CN103589628B CN103589628B CN201310568602.2A CN201310568602A CN103589628B CN 103589628 B CN103589628 B CN 103589628B CN 201310568602 A CN201310568602 A CN 201310568602A CN 103589628 B CN103589628 B CN 103589628B
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M39/00—Means for cleaning the apparatus or avoiding unwanted deposits of microorganisms
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Abstract
The invention discloses an automatic sterilization, liquid preparation and sterile delivery system. The system comprises a sterile liquid preparation and supply system and an online cleaning system, wherein the sterile liquid preparation and supply system comprises a liquid preparation unit, a distribution unit and a peristaltic pump; the distribution unit comprises a plurality of point-of-use pipe ports, each point-of-use pipe port comprises three pipe orifices which are connected in parallel, first pipe orifices are material outlets, second pipe orifices are communicated with a condensate water drain pipe through an n pneumatic diaphragm valve, and third pipe orifices are communicated with an online cleaning return pipe through an o pneumatic diaphragm valve and a b liquid delivery pump; and the online cleaning system comprises an injection water tank, an alkali tank, a heat exchanger and a c liquid delivery pump. The automatic sterilization, liquid preparation and sterile delivery system has the advantages that liquid (sterile materials) supply and sterile butt joint with downstream users are realized, and the materials are sent to all points of use in a completely closed and sterile state; and the sterile materials are transferred to a next process in a closed system under a sterile condition, the production technology is simplified, working processes are reduced, and the energy consumption and manpower are saved.
Description
Technical field
The present invention relates to mass-producing aseptic dosing in batches, delivery system, especially relate to autosterilization, dosing, aseptic delivery system.
Background technology
In bio-pharmaceuticals production system, in the preparation of the nutritive medium for cell or viral growth, delivery system, need to and join Agitation Tank, feed liquid pipeline, equipment carry out routine cleaning and sterilization, to guarantee that microorganism and the bacterial endotoxin of system meets production technique specified requirement.At present to Agitation Tank and join, cleaning and the sterilization of feed liquid pipeline, equipment be many by manually completing.The deficiency of its existence is sterilization, clean, sterilizing is not thorough, and in cleaning process, the dismounting of pipeline connection will bring artificially-contaminated risk; While labour intensity is large, inefficiency.
Summary of the invention
The object of the invention is to provide a kind of autosterilization, dosing, aseptic delivery system.
For achieving the above object, the present invention takes following technical proposals:
Autosterilization of the present invention, dosing, aseptic delivery system, comprise aseptic liquid-supplying system, the on-line cleaning system of joining; It is characterized in that: the described aseptic liquid-supplying system of joining comprises:
Dosing unit, dispensing unit, peristaltic pump; Described dosing unit comprises: Agitation Tank, and described Agitation Tank inner cavity top is provided with spray header, and described spray header import is communicated with on-line cleaning feed liquid pipeline respectively, by e pneumatic diaphragm valve, is communicated with pure vapour source by a pneumatic diaphragm valve; On Agitation Tank roof, offer gas inlet and water for injection entrance, described gas inlet is communicated with gas filter by b pneumatic diaphragm valve, described gas filter inlet mouth is communicated with pure vapour source by c pneumatic diaphragm valve, and be communicated with compressed air source by d pneumatic diaphragm valve, described water for injection entrance is communicated with injection water source by f pneumatic diaphragm valve; Agitation Tank discharge port is communicated with material conveying pipe by g pneumatic diaphragm valve, h pneumatic diaphragm valve, and is communicated with on-line cleaning back liquid pipeline by a liquid delivery pump; Described material conveying pipe is communicated with on-line cleaning feed liquid pipeline by i pneumatic diaphragm valve; Described peristaltic pump import is communicated with on-line cleaning feed liquid pipeline, by k pneumatic diaphragm valve, is communicated with Agitation Tank inner chamber top by j pneumatic diaphragm valve; Agitation Tank sidewall is provided with cooling water outlet and sampling valve, and described cooling water outlet is communicated with CWR road by p pneumatic diaphragm valve, and is communicated with industrial steam source by x pneumatic diaphragm valve; Agitation Tank inner cavity top is communicated with condensed water elimination pipeline by respiratory organ, q pneumatic diaphragm valve; Agitation Tank intracavity bottom is communicated with condensed water elimination pipeline, by s pneumatic diaphragm valve, is communicated with cooling water inlet pipe road by r pneumatic diaphragm valve; Agitation Tank discharge port is communicated with condensed water elimination pipeline by g pneumatic diaphragm valve, t pneumatic diaphragm valve, and is communicated with the gas inlet of Agitation Tank roof by g pneumatic diaphragm valve, u pneumatic diaphragm valve, b pneumatic diaphragm valve; Described sampling valve is communicated with Agitation Tank discharge port by v pneumatic diaphragm valve, w pneumatic diaphragm valve, g pneumatic diaphragm valve;
Described dispensing unit comprises a plurality of use point pipe joints, described each use some pipe joint all the m pneumatic diaphragm valve by be separately communicated with material conveying pipe; Described each use point pipe joint is three mouths of pipe in parallel, first mouth of pipe is material outlet, second mouth of pipe is communicated with condensed water elimination pipeline by n pneumatic diaphragm valve, and the 3rd mouth of pipe is communicated with on-line cleaning back liquid pipeline by o pneumatic diaphragm valve and b liquid delivery pump.
Described on-line cleaning system comprises:
Injection water pot, alkali tank, interchanger, c liquid delivery pump; Described injection water pot, alkali tank inner cavity top are respectively equipped with spray header, and described two spray headers are communicated with injection water source by A pneumatic diaphragm valve, B pneumatic diaphragm valve respectively; The tube side import of described interchanger is communicated with industrial steam source by A pneumatic angle pedestal valve, and its tube side outlet is communicated with condensed water discharge tube by B pneumatic angle pedestal valve, trap; The shell side outlet of interchanger is communicated with alkali tank, and its shell side import is communicated with described liquid delivery pump outlet by C pneumatic diaphragm valve; The outlet of c liquid delivery pump is communicated with on-line cleaning back liquid pipeline, by E pneumatic diaphragm valve, is communicated with on-line cleaning feed liquid pipeline by D pneumatic diaphragm valve; The import of c liquid delivery pump is communicated with, by F pneumatic diaphragm valve, is communicated with the intracavity bottom of alkali tank with injection water pot intracavity bottom by A manual diaphragm valve; Described line cleans back liquid pipeline and is communicated with, by H pneumatic diaphragm valve, is communicated with the spray header of alkali tank inner chamber with the spray header of injection water pot inner chamber by G pneumatic diaphragm valve, and is communicated with blow-off line by I pneumatic diaphragm valve; On the on-line cleaning back liquid pipeline between G pneumatic diaphragm valve, H pneumatic diaphragm valve, be provided with B manual diaphragm valve; Injection water pot intracavity bottom is communicated with blow-off line, by K pneumatic diaphragm valve, is communicated with condensed water discharge tube by J pneumatic diaphragm valve; The import of described c liquid delivery pump is communicated with blow-off line by L pneumatic diaphragm valve; Injection water pot inner chamber top is communicated with pure vapour source by M pneumatic diaphragm valve, C manual diaphragm valve.
The invention has the advantages that the supply that realizes liquid (sterile material) docks with the aseptic of downstream user, under closed sterile soft state completely, sending to each and using point.Sterile material by transfer to next process under aseptic condition, has been simplified production technique in closed system, has reduced work operation, makes sterilizing, liquid dosage, the liquid of water for injection supply a step and completes.Energy consumption and manpower have greatly been saved.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Fig. 2 is aseptic structure for amplifying schematic diagram of joining liquid-supplying system described in Fig. 1.
Fig. 3 is the structure for amplifying schematic diagram of the unit of dosing described in Fig. 2.
Fig. 4 is the structure for amplifying schematic diagram of unit of providing and delivering described in Fig. 2.
Fig. 5 is the structure for amplifying schematic diagram of the system of on-line cleaning described in Fig. 1.
Embodiment
As Figure 1-5, autosterilization of the present invention, dosing, aseptic delivery system, comprise aseptic liquid-supplying system 45, on-line cleaning system 46, industrial steam source 44, compressed air source 13, pure vapour source 8, injection water source 15, CWR road 25, condensed water discharge tube 47, the blow-off line 48 of joining; The described aseptic liquid-supplying system of joining comprises dosing unit 1, dispensing unit 2, peristaltic pump 3.
As shown in Figure 1, 2, 3, described dosing Unit 1 comprises: Agitation Tank 4, described Agitation Tank 4 inner cavity tops are provided with spray header, and described spray header import is communicated with on-line cleaning feed liquid pipeline 6 respectively, by e pneumatic diaphragm valve 7, is communicated with pure vapour source 8 by a pneumatic diaphragm valve 5; On Agitation Tank 4 roofs, offer gas inlet and water for injection entrance, described gas inlet is communicated with gas filter 10 by b pneumatic diaphragm valve 9, described gas filter 10 inlet mouths are communicated with pure vapour source 8 by c pneumatic diaphragm valve 11, and be communicated with compressed air source 13 by d pneumatic diaphragm valve 12, described water for injection entrance is communicated with injection water source 15 by f pneumatic diaphragm valve 14; Agitation Tank 4 discharge ports are communicated with material conveying pipe 18 by g pneumatic diaphragm valve 16, h pneumatic diaphragm valve 17, and are communicated with on-line cleaning back liquid pipeline 20 by a liquid delivery pump 19; Described material conveying pipe 18 is communicated with on-line cleaning feed liquid pipeline 6 by i pneumatic diaphragm valve 21; Described peristaltic pump 3 imports are communicated with on-line cleaning feed liquid pipeline 6, by K pneumatic diaphragm valve 67, are communicated with Agitation Tank 4 inner chamber tops by J pneumatic diaphragm valve 66.
Described Agitation Tank 4 sidewalls are provided with cooling water outlet and sampling valve, and described cooling water outlet is communicated with CWR road 25 by p pneumatic diaphragm valve 24, and are communicated with industrial steam source 44 by x pneumatic diaphragm valve 43; Agitation Tank 4 inner cavity tops are communicated with condensed water elimination pipeline 28 by respiratory organ 26, q pneumatic diaphragm valve 27; Agitation Tank 4 intracavity bottoms are communicated with condensed water elimination pipeline 28, by s pneumatic diaphragm valve 30, are communicated with cooling water inlet pipe road 31 by r pneumatic diaphragm valve 29; Agitation Tank 4 discharge ports are communicated with condensed water elimination pipeline 28, and are communicated with the gas inlet of Agitation Tank 4 roofs by g pneumatic diaphragm valve 16, u pneumatic diaphragm valve 33, b pneumatic diaphragm valve 9 by g pneumatic diaphragm valve 16, t pneumatic diaphragm valve 32; Described sampling valve is communicated with Agitation Tank 4 discharge ports by v pneumatic diaphragm valve 34, w pneumatic diaphragm valve 35, g pneumatic diaphragm valve 16.
As shown in Fig. 1,4, described dispensing unit 2 comprises a plurality of use point pipe joints, described each use some pipe joint all the m pneumatic diaphragm valve 36 by be separately communicated with material conveying pipe 18; Described each use point pipe joint is three mouths of pipe in parallel, first mouth of pipe 37 is material outlet, second mouth of pipe 38 is communicated with condensed water elimination pipeline 28 by n pneumatic diaphragm valve 40, and the 3rd mouth of pipe 39 is communicated with on-line cleaning back liquid pipeline 20 by o pneumatic diaphragm valve 41 and c liquid delivery pump 52.
As shown in Figure 1,5, described on-line cleaning system 46 comprises:
Injection water pot 49, alkali tank 50, interchanger 51, c liquid delivery pump 52; Described injection water pot 49, alkali tank 50 inner cavity tops are respectively equipped with spray header, and described two spray headers are communicated with injection water source 15 by A pneumatic diaphragm valve 53, B pneumatic diaphragm valve 54 respectively; The tube side import of described interchanger 51 is communicated with industrial steam source 44 by A pneumatic angle pedestal valve 55, and its tube side outlet is communicated with condensed water discharge tube 47 by B pneumatic angle pedestal valve 56, trap; The shell side outlet of interchanger 51 is communicated with alkali tank 50, and its shell side import is communicated with described c liquid delivery pump 52 outlets by C pneumatic diaphragm valve 57; The outlet of c liquid delivery pump 52 is communicated with on-line cleaning back liquid pipeline 20, by E pneumatic diaphragm valve 59, is communicated with on-line cleaning feed liquid pipeline 6 by D pneumatic diaphragm valve 58; The import of c liquid delivery pump 52 is communicated with, by F pneumatic diaphragm valve 61, is communicated with the intracavity bottom of alkali tank 50 with injection water pot 49 intracavity bottoms by A manual diaphragm valve 60; Described on-line cleaning back liquid pipeline 20 is communicated with, by H pneumatic diaphragm valve 63, is communicated with the spray header of alkali tank 50 inner chambers with the spray header of injection water pot 49 inner chambers by G pneumatic diaphragm valve 62, and is communicated with blow-off line 48 by I pneumatic diaphragm valve 64; On the on-line cleaning back liquid pipeline 20 between G pneumatic diaphragm valve 62, H pneumatic diaphragm valve 63, be provided with B manual diaphragm valve 65.Injection water pot 49 intracavity bottoms are communicated with blow-off line 48, by K pneumatic diaphragm valve 67, are communicated with condensed water discharge tube 47 by J pneumatic diaphragm valve 66; The import of described c liquid delivery pump 52 is communicated with blow-off line 48 by L pneumatic diaphragm valve 68.Injection water pot 49 inner chamber tops are communicated with pure vapour source 8 by M pneumatic diaphragm valve 69, C manual diaphragm valve 70.
Principle of work of the present invention is summarized as follows:
One, the principle of work of dosing unit:
1, the sterilization of dosing unit, clean: to open a pneumatic diaphragm valve 5, make Agitation Tank 4 open and be communicated with on-line cleaning feed liquid pipeline 6 by peristaltic pump 3 import j pneumatic diaphragm valves 22, open m pneumatic diaphragm valve 36, o pneumatic diaphragm valve 41, n pneumatic diaphragm valve 40, the unit 2 that makes to provide and deliver is communicated with on-line cleaning back liquid pipeline 20, opening peristaltic pump 3 carries out disinfection, cleaning, but reach sterilization, during cleaning effect, close a pneumatic diaphragm valve 5, j pneumatic diaphragm valve 22, Agitation Tank 4 and on-line cleaning feed liquid pipeline 6 are disconnected, close m pneumatic diaphragm valve 36, o pneumatic diaphragm valve 41, n pneumatic diaphragm valve 40, unit 2 and 20 disconnections of on-line cleaning back liquid pipeline make to provide and deliver, complete sterilization, cleaning.
2, the sterilizing of tank body: during inner chamber sterilizing, open c pneumatic diaphragm valve 11, b pneumatic diaphragm valve 9, Agitation Tank 4 is communicated with pure steam 8 by gas filter 10, during sterilizing, pure steam enters Agitation Tank 4, Agitation Tank 4 inner chambers are carried out to 121 ℃, sterilizing in 60 minutes, during sterilizing, open sampling valve v pneumatic diaphragm valve 34, , w pneumatic diaphragm valve 35, g pneumatic diaphragm valve 16, sampling line is communicated with Agitation Tank 4 discharge ports, reach sterilizing object, prevent that thief hole from becoming dead angle, when sterilizing, open r pneumatic diaphragm valve 29, Agitation Tank 4 is communicated with condensed water elimination pipeline 28, reach the effect of discharge water of condensation, make sterilizing reach requirement, after finishing, sterilizing closes c pneumatic diaphragm valve 11, Agitation Tank 4 is disconnected by gas filter 10 and pure steam 8, close sample valve v pneumatic diaphragm valve 34 simultaneously,, w pneumatic diaphragm valve 35, g pneumatic diaphragm valve 16, sampling line and Agitation Tank 4 discharge ports are disconnected, finally close r pneumatic diaphragm valve 29, Agitation Tank 4 and condensed water elimination pipeline 28 are disconnected, complete inner chamber sterilizing, during exocoel sterilizing (sterilization of liquids), open x pneumatic diaphragm valve 43, Agitation Tank 4 exocoels are communicated with industrial steam source 44, by thermal exchange, inner chamber liquid is carried out to sterilizing in 116 ℃, 40 minutes, during sterilizing, open q pneumatic diaphragm valve 27, Agitation Tank 4 exocoels are connected with condensed water elimination pipeline 28, reach the effect of sterilizing.After sterilizing finishes, close x pneumatic diaphragm valve 43, Agitation Tank 4 exocoels and industrial steam source 44 are disconnected, close q pneumatic diaphragm valve 27 simultaneously, Agitation Tank 4 exocoels and condensed water elimination pipeline 28 are disconnected, complete exocoel sterilizing.
3, the liquid dosage of dosing unit: the location of water for injection, open f pneumatic diaphragm valve 14, make Agitation Tank 4 and water for injection pipeline communication, make water for injection inject Agitation Tank 4, according to the usage quantity of producing carry out water for injection quantitatively, after the amount of water for injection reaches quantitatively, that closes nutrient solution adds f pneumatic diaphragm valve 14, Agitation Tank 4 and injection water source 15 are disconnected, complete the quantitative of water for injection; The injection of liquid, open K pneumatic diaphragm valve 67, input duct is communicated with Agitation Tank 4, according to liquid formulations, utilize peristaltic pump 3 that all substratum are squeezed in Agitation Tank 4, after finishing, close K pneumatic diaphragm valve 67, input duct and Agitation Tank 4 are disconnected, complete the injection of liquid, finish to cultivate all working of unit.
Two, the principle of work of dispensing unit:
1, cleaning of dispensing unit, sterilization, open A pneumatic diaphragm valve 53, Agitation Tank 4 is communicated with on-line cleaning feed liquid pipeline 6, open m pneumatic diaphragm valve 36, o pneumatic diaphragm valve 41, n pneumatic diaphragm valve 40, the unit 2 that makes to provide and deliver is communicated with on-line cleaning back liquid pipeline 20, opening peristaltic pump 3 carries out disinfection, cleaning, but reach sterilization, during cleaning effect, close A pneumatic diaphragm valve 53, Agitation Tank 4 and on-line cleaning feed liquid pipeline 6 are disconnected, close m pneumatic diaphragm valve 36, o pneumatic diaphragm valve 41, n pneumatic diaphragm valve 40, unit 2 and 20 disconnections of on-line cleaning back liquid pipeline make to provide and deliver, complete sterilization, cleaning.
2, the conveying of liquid, opens g pneumatic diaphragm valve 16, h pneumatic diaphragm valve 17, Agitation Tank 4 is communicated with material conveying pipe 18, and by peristaltic pump 3, the liquid in Agitation Tank 4 is transported to and is respectively used a little; Each m pneumatic diaphragm valve 36 that uses point to open as required is separately connected the first mouth of pipe 37(material outlet) for production and application, after finishing, production closes g pneumatic diaphragm valve 16, h pneumatic diaphragm valve 17, Agitation Tank 4 and material conveying pipe 18 are disconnected, close simultaneously and use the m pneumatic diaphragm valve 36 of point to complete liquid conveying.
3, the principle of work of peristaltic pump:
When peristaltic pump 3 starts, give sterilization, clean, liquid is carried that power is provided.
Three, the principle of work of on-line cleaning system:
1, injection water pot 49 sterilizings: open M pneumatic diaphragm valve 69, K pneumatic diaphragm valve 67, J pneumatic diaphragm valve 66, and open pure steam that C manual diaphragm valve 70 makes pure vapour source 8 and enter injection water pot 49 and carry out sterilizing in 121 ℃, 60 minutes, after sterilizing, close all valves, sterilizing finishes.Then carry out the deposit of water for injection, open the water for injection that A pneumatic diaphragm valve 53 makes injection water source 15 and enter injection water pot 49, according to usage quantity, carry out water for injection, after reaching setting consumption, close B pneumatic diaphragm valve 54, finally carry out the cleaning of tank body and distribution system, that is: open E pneumatic diaphragm valve 59, I pneumatic diaphragm valve 64, start c liquid delivery pump 52, make to inject the interior water for injection of water pot 49 and through on-line cleaning feed liquid pipeline 6, enter Agitation Tank 4 and distribution system rinses by c liquid delivery pump 52, and enter blow-off line 48 through on-line cleaning back liquid pipeline 20, after reaching standard, specific conductivity stops cleaning.
2, the preparation of alkali tank 50 alkali lye: it is quantitative to carry out the first, as requested alkali lye, open the water for injection that B pneumatic diaphragm valve 54 makes injection water source 15 and enter alkali tank 50, according to usage quantity, carry out water for injection, after reaching setting water consumption, close B pneumatic diaphragm valve 54, add the alkali consumption of setting to mix, complete the preparation of alkali lye.The second, the heating of alkali lye: the temperature requirement while using according to alkali lye is used front heating to alkali lye, open C pneumatic diaphragm valve 57, F pneumatic diaphragm valve 61, and start c liquid delivery pump 52, make alkali lye pass through in alkali tank 50, to circulate after interchanger 51 heating, while reaching the temperature while using, close C pneumatic diaphragm valve 57, F pneumatic diaphragm valve 61, and close c liquid delivery pump 52, complete liquid heat.Three, sterilization: open F pneumatic diaphragm valve 61, E pneumatic diaphragm valve 59, H pneumatic diaphragm valve 63, and start c liquid delivery pump 52, the Agitation Tank 4 and the distribution system that make the alkali lye in alkali tank 50 through on-line cleaning feed liquid pipeline 6, enter subsequent processing by c liquid delivery pump 52 carry out disinfection, and enter alkali tank 50 through on-line cleaning back liquid pipeline 20, reach after disinfecting time, close pneumatic diaphragm valve 61, the pneumatic pneumavalve 59 of E, the pneumatic pneumavalve 63 of H of opening of F, and close c liquid delivery pump 52, complete sterilization.Four, the discharge of alkali lye: open F pneumatic diaphragm valve 61, L pneumatic diaphragm valve 68 is discharged to the liquid in alkali tank 50 in blow-off line 48.
3, interchanger 51: the liquid passing through is heated, open A pneumatic angle pedestal valve 55, B pneumatic angle pedestal valve 56, making outside industrial steam source 44 enter 51 pairs of liquid that pass through of interchanger heats, while reaching production and application, temperature stops heating, close A pneumatic angle pedestal valve 55, B pneumatic angle pedestal valve 56, complete liquid heat.
4, the effect of c liquid delivery pump 52: utilize c liquid delivery pump 52 to produce power, the liquid of 50 li of injection water pots 49, alkali tank is transported to and needs to go in the equipment of clean, sterilization and system.
Claims (1)
1. autosterilization, dosing, an aseptic delivery system, comprise aseptic liquid-supplying system, the on-line cleaning system of joining; It is characterized in that: the described aseptic liquid-supplying system of joining comprises:
Dosing unit, dispensing unit, peristaltic pump; Described dosing unit comprises: Agitation Tank, and described Agitation Tank inner cavity top is provided with spray header, and described spray header import is communicated with on-line cleaning feed liquid pipeline, by e pneumatic diaphragm valve, is communicated with pure vapour source by a pneumatic diaphragm valve; On Agitation Tank roof, offer gas inlet and water for injection entrance, described gas inlet is communicated with gas filter by b pneumatic diaphragm valve, described gas filter inlet mouth is communicated with pure vapour source by c pneumatic diaphragm valve, and be communicated with compressed air source by d pneumatic diaphragm valve, described water for injection entrance is communicated with injection water source by f pneumatic diaphragm valve; Agitation Tank discharge port is communicated with material conveying pipe by g pneumatic diaphragm valve, h pneumatic diaphragm valve, and is communicated with on-line cleaning back liquid pipeline by a liquid delivery pump; Described material conveying pipe is communicated with on-line cleaning feed liquid pipeline by i pneumatic diaphragm valve; Described peristaltic pump import is communicated with on-line cleaning feed liquid pipeline, by k pneumatic diaphragm valve, is communicated with Agitation Tank inner chamber top by j pneumatic diaphragm valve; Agitation Tank sidewall is provided with cooling water outlet and sampling valve, and described cooling water outlet is communicated with CWR road by p pneumatic diaphragm valve, and is communicated with industrial steam source by x pneumatic diaphragm valve; Agitation Tank inner cavity top is communicated with condensed water elimination pipeline by respiratory organ, q pneumatic diaphragm valve; Agitation Tank intracavity bottom is communicated with condensed water elimination pipeline, by s pneumatic diaphragm valve, is communicated with cooling water inlet pipe road by r pneumatic diaphragm valve; Agitation Tank discharge port is communicated with condensed water elimination pipeline by g pneumatic diaphragm valve, t pneumatic diaphragm valve, and is communicated with the gas inlet of Agitation Tank roof by g pneumatic diaphragm valve, u pneumatic diaphragm valve, b pneumatic diaphragm valve; Described sampling valve is communicated with Agitation Tank discharge port by v pneumatic diaphragm valve, w pneumatic diaphragm valve, g pneumatic diaphragm valve;
Described dispensing unit comprises a plurality of use point pipe joints, described each use some pipe joint all the m pneumatic diaphragm valve by be separately communicated with material conveying pipe; Described each use point pipe joint is three mouths of pipe in parallel, first mouth of pipe is material outlet, second mouth of pipe is communicated with condensed water elimination pipeline by n pneumatic diaphragm valve, and the 3rd mouth of pipe is communicated with on-line cleaning back liquid pipeline by o pneumatic diaphragm valve and b liquid delivery pump;
Described on-line cleaning system comprises:
Injection water pot, alkali tank, interchanger, c liquid delivery pump; Described injection water pot, alkali tank inner cavity top are respectively equipped with spray header, and described two spray headers are communicated with injection water source by A pneumatic diaphragm valve, B pneumatic diaphragm valve respectively; The tube side import of described interchanger is communicated with industrial steam source by A pneumatic angle pedestal valve, and its tube side outlet is communicated with condensed water discharge tube by B pneumatic angle pedestal valve, trap; The shell side outlet of interchanger is communicated with alkali tank, and its shell side import is communicated with described c liquid delivery pump outlet by C pneumatic diaphragm valve; The outlet of c liquid delivery pump is communicated with on-line cleaning back liquid pipeline, by E pneumatic diaphragm valve, is communicated with on-line cleaning feed liquid pipeline by D pneumatic diaphragm valve; The import of c liquid delivery pump is communicated with, by F pneumatic diaphragm valve, is communicated with the intracavity bottom of alkali tank with injection water pot intracavity bottom by A manual diaphragm valve; Described line cleans back liquid pipeline and is communicated with, by H pneumatic diaphragm valve, is communicated with the spray header of alkali tank inner chamber with the spray header of injection water pot inner chamber by G pneumatic diaphragm valve, and is communicated with blow-off line by I pneumatic diaphragm valve; On the on-line cleaning back liquid pipeline between G pneumatic diaphragm valve, H pneumatic diaphragm valve, be provided with B manual diaphragm valve; Injection water pot intracavity bottom is communicated with blow-off line, by K pneumatic diaphragm valve, is communicated with condensed water discharge tube by J pneumatic diaphragm valve; The import of described c liquid delivery pump is communicated with blow-off line by L pneumatic diaphragm valve; Injection water pot inner chamber top is communicated with pure vapour source by M pneumatic diaphragm valve, C manual diaphragm valve.
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| CN201310568602.2A CN103589628B (en) | 2013-11-15 | 2013-11-15 | Automatic sterilization, liquid preparation and sterile delivery system |
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| CN201310568602.2A CN103589628B (en) | 2013-11-15 | 2013-11-15 | Automatic sterilization, liquid preparation and sterile delivery system |
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| CN104229709B (en) * | 2014-09-03 | 2016-08-31 | 江苏新美星包装机械股份有限公司 | Sterile liquid switching induction system |
| CN106139258B (en) * | 2015-04-08 | 2019-03-26 | 上海昊海生物科技股份有限公司 | A kind of method that pipeline prepares sterile Medical sodium hyaluronate gel |
| CN105193713B (en) * | 2015-10-16 | 2018-05-25 | 四川科伦药业股份有限公司 | Injection preparation system |
| CN106726576B (en) * | 2016-12-27 | 2023-01-31 | 上海创洁科技有限公司 | Suspension preparation and conveying system |
| CN107347473A (en) * | 2017-07-04 | 2017-11-17 | 岭南园林股份有限公司 | A kind of trees drip solution production system and its production technology |
| CN109364279A (en) * | 2018-09-06 | 2019-02-22 | 丽珠集团利民制药厂 | It is a kind of can online CIP/SIP thimerosal filtration sterilization and cleaning system |
| CN109481674A (en) * | 2018-11-14 | 2019-03-19 | 大连亚维药业有限公司 | A kind of production method of the sterile cream drug of biology |
| CN109439547A (en) * | 2018-11-22 | 2019-03-08 | 英诺维尔智能科技（苏州）有限公司 | A kind of full-automatic sterile method for implanting of large capacity reagent |
| CN114288886A (en) * | 2021-11-18 | 2022-04-08 | 浙江优全护理用品科技股份有限公司 | Liquid preparation system |
| CN117380620A (en) * | 2023-11-09 | 2024-01-12 | 诺泽流体科技(上海)有限公司 | On-line cleaning control method for high-toxicity and high-activity drug residues in jet mill |
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| US20100285555A1 (en) * | 2009-05-07 | 2010-11-11 | Defense Life Sciences, Llc | Distributed biofuel manufacturing system (dbms) |
| CN101691247B (en) * | 2009-10-09 | 2011-05-11 | 浙江卫信生物药业有限公司 | Pathogenic microorganism waste liquor treatment system |
| CN101974409B (en) * | 2010-11-27 | 2013-05-01 | 福州大北农生物技术有限公司 | Bacterial culture fermentation tank device and fermentation technology thereof |
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