CN103565902A - Slow release agent as well as preparation method and application thereof - Google Patents
Slow release agent as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN103565902A CN103565902A CN201310574687.5A CN201310574687A CN103565902A CN 103565902 A CN103565902 A CN 103565902A CN 201310574687 A CN201310574687 A CN 201310574687A CN 103565902 A CN103565902 A CN 103565902A
- Authority
- CN
- China
- Prior art keywords
- preparation
- slow releasing
- releasing agent
- surfactant
- release agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides a slow release agent and a preparation method thereof. The preparation method comprises the following steps: uniformly mixing savoury rhododendron oil, sodium alginate, a surfactant and distilled water to prepare an emulsion; adding the emulsion into a chloride water solution to obtain gelled small balls; drying the small balls to obtain small ball-shaped drugs; taking the small ball-shaped drugs as raw materials for preparing the savoury rhododendron oil-alginate embedded slow release agent. According to the preparation method, the drugs are prepared into the small ball-shaped drugs in a dripping manner, and the small ball-shaped drugs are packaged in different forms to obtain the slow release agent, so that the defects of the small ball-shaped drugs in morphologic aspects such as roundness, microcosmic bubbles and trailing do not influence the overall quality of the slow release agent and correspondingly the controllability of the product quality is improved; the prepared slow release agent is stable and controllable in chemical release speed, the fluctuation of blood concentration is avoided, the stimulus on a digestion system is avoided, and a used framework material is good in biocompatibility.
Description
[technical field]
The present invention relates to a kind of biological medicine technology field, relate in particular to a kind of slow releasing agent and its preparation method and application.
[background technology]
Rhododendron oil is the ethereal oil extracting from Hemerocallis citrina Baroni Cuculus polioephalus branch and leaf, and it has unique curative effect to chronic tracheitis, asthma etc., has heat-clearing and toxic substances removing, relieving cough and asthma, and spasmolytic circulation of qi promoting, the effect of stomach invigorating detumescence, and toxicity is little, few side effects.
The current preparation of Rhododendron mainly contains powder, tablet, pill, embedding medium, drop pill, emulsifying agent etc.The research of carrying out for Rhododendron oil formulation is at present mainly for drop pill, beta-schardinger dextrin-embedding preparation and emulsifying agent.And as the Rhododendron oil formulation for the treatment of the diseases such as chronic tracheitis, asthma, dropping pill formulation is the preparation of comparative maturity, You Yaoqihe research institution is also in the research of carrying out beta-schardinger dextrin-embedding preparation, but also exist at present carrying drug ratio not high, the problems such as Release Performance is undesirable, are also in conceptual phase.In actual production, the dosage form that adopts only has drop pill a kind of.
Technique and the method for producing at present Rhododendron oil drop pill are: the techniques such as 1 lixiviate through early stage, extraction extract rhododendron oil.2 mix even by rhododendron oil with edible oil and gelatin according to a certain percentage.3 splash into mixed solution in condensed fluid, form dropping pill formulation.Although the preparation technology of drop pill is from view of theory, method is simple, equipment investment is also few, but actual from producing, in preparation process, influence factor to product quality is more, particularly the dripping stage, the selection of formula, dripping temperature, dripping speed, condensing agent etc., even drip distance, water dropper bore, condensation column height etc. all has influence on the quality of drop pill.The production practices Zhong， manufacturing enterprise of preparing at Rhododendron oil drop pill is lower in drop pill preparation technology work-in-process qualification rate, is 30-50%, has a strong impact on production.4 drop pills are after patient takes, and after outside gel layer dissolves, medicine concentrate to discharge, patient's digestive system is stimulated larger, cause have the hiccups, feel sick, the discomfort such as vomiting.5 drop pill medicines easily cause the high blood drug level of patient after concentrating and discharging, and have certain toxicity.6 drop pills form peak, the paddy of blood drug level after taking in patient body, affect therapeutic effect.
These existing problems are all urgently to be resolved hurrily, and for this reason, relevant manufacturing enterprise has carried out the research work of beta-schardinger dextrin-investment novel form, but because carrying drug ratio is too low, drug release feature does not reach requirement etc., does not succeed.Meng Qing has just waited the volatile oil with beta-schardinger dextrin-embedding Cuculus polioephalus and Radix Angelicae Sinensis, and the carrying drug ratio of gained preparation is 54.64%; Hu Yongfang etc. are with beta-schardinger dextrin-embedding rhododendron oil, and carrying drug ratio is 57.12%.The research that above-mentioned research is novel form provides good approaches and methods, but carrying drug ratio is also not fully up to expectations.And play these methods, also only in laboratory, carry out at present, fail to obtain more ripe result.
[summary of the invention]
It is wayward that the technical problem to be solved in the present invention is to overcome the quality existing in prior art, and carrying drug ratio is not high, and the defect that Release Performance is undesirable provides a kind of preparation method of slow releasing agent.
For solving the problems of the technologies described above, the present invention adopts following technical proposals:
Rhododendron oil, sodium alginate, surfactant and distilled water are evenly mixed, be prepared into emulsion;
Monochloride aqueous solution is provided, and described aqueous chloride solution is at least one in calcium chloride solution or strontium chloride solution;
Described emulsion is added into the bead that obtains gelation in described aqueous chloride solution;
Described bead is carried out to dried, obtain coccoid medicine;
The described coccoid medicine of take prepares Rhododendron oil-alginate embedding slow releasing agent as raw material.
In embodiment provided by the invention, the described mass percent by Rhododendron oil, sodium alginate, surfactant and distilled water is than being (23-68.8%): (0.8-8%), (0.4-4%): (30-65%).
In embodiment provided by the invention, described surfactant is Polyethylene Glycol or cyclodextrin surfactant or spans surfactant or Tweens surfactant.
In embodiment provided by the invention, the concentration of described aqueous chloride solution is 0.2～6.5molL-1.
In embodiment provided by the invention, described dried is heat drying or lyophilization.
In addition, the present invention also provides a kind of slow releasing agent, and described slow releasing agent is come by the preparation method preparation by above-mentioned slow releasing agent.
In addition, the present invention also provides the application of a kind of slow releasing agent in tracheitis or asthma.
Adopt technique scheme, beneficial effect of the present invention is:
The preparation method of the slow releasing agent that the above embodiment of the present invention provides and slow releasing agent, evenly mix Rhododendron oil, sodium alginate, surfactant and distilled water, is prepared into emulsion; Described emulsion is added into the bead that obtains gelation in described aqueous chloride solution; Described bead is carried out to dried, obtain coccoid medicine; The described coccoid medicine of take prepares Rhododendron oil-alginate embedding slow releasing agent as raw material.Preparation method that the present invention adopts, first medicament dropping is made to pharmaceutical pellet, pharmaceutical pellet is carried out to multi-form encapsulation, and become final medicine, the defect of the pattern aspect such as the circularity of pharmaceutical pellet, microcosmic bubble, hangover like this, do not affect the total quality of medicine, just improved the degree of controllability of product quality accordingly yet; The slow releasing preparation that adopts said method to prepare, plays carrying drug ratio and is much higher than beta-schardinger dextrin-preparation; The slow releasing preparation that adopts said method to prepare, has good sustained release performance, make blood drug level uniform and stable, reduce drug toxicity, improve curative effect; While preparing by changing preparation, the mass percent of various materials, can carry out manual control in addition to drug release rate, and technique is simple, can be applicable to suitability for industrialized production.
[accompanying drawing explanation]
The flow chart of steps of the preparation method of the slow releasing agent that Fig. 1 provides for the embodiment of the present invention;
[specific embodiment]
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and the specific embodiments, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Refer to Fig. 1, steps flow chart Figure 100 of the preparation method of the slow releasing agent that Fig. 1 provides for the embodiment of the present invention, as can be seen from Fig. 1, the preparation method of slow releasing agent comprises the steps:
Step S110: Rhododendron oil, sodium alginate, surfactant and distilled water are evenly mixed, be prepared into emulsion;
Preferably, by the mass percent of Rhododendron oil, sodium alginate, surfactant and distilled water than being (23-68.8%): (0.8-8%), (0.4-4%): (30-65%).
Preferably, surfactant is Polyethylene Glycol or cyclodextrin surfactant or spans surfactant or Tweens surfactant.
The slow releasing preparation that the above embodiment of the present invention is prepared, adopted the alginate of good biocompatibility as embedded material, it has good biological health effect, in the drug release process of preparation after taking, framework material is also well digested and is absorbed, harmless.
The slow releasing agent that the above embodiment of the present invention is prepared, has added the surfactant of good biocompatibility, has improved the water solublity of rhododendron oil, contributes to improve drug effect.
Step S120: monochloride aqueous solution is provided, and aqueous chloride solution is at least one in calcium chloride solution or strontium chloride solution;
Preferably, the concentration of aqueous chloride solution is 0.2～6.5molL-1.
Step S130: described emulsion is added into the bead that obtains gelation in aqueous chloride solution;
Particularly, resulting emulsion in step S130 is evenly slowly added drop-wise to the aqueous chloride solution in step S120, makes the bead of gelation.
Step S140: described bead is carried out to dried, obtain coccoid medicine;
Preferably, adopt direct drying, or lyophilization processes described bead, obtain coccoid medicine.
Step S150: the described coccoid medicine of take prepares Rhododendron oil-alginate embedding slow releasing agent as raw material.
Particularly, take coccoid medicine as raw material prepares Rhododendron oil-alginate embedding slow releasing agent, can adopt following method to obtain:
Using coccoid medicine directly as Rhododendron oil-alginate embedding sustained-release granular formulation; Coccoid medicine is filled into and in capsule, makes Rhododendron oil-alginate embedding slow releasing capsule; Take coccoid medicine as raw material, adopt existing common processes to be prepared into Rhododendron oil-alginate embedding slow releasing pill; Take coccoid medicine as raw material, adopt existing common processes to be prepared into Rhododendron oil-alginate embedding slow release tablet.
In addition, the present invention also provides slow releasing agent and the application in tracheitis or asthma thereof prepared by a kind of preparation method that adopts above-mentioned slow releasing agent.
Slow releasing agent provided by the invention, have in vivo evenly, stable, the drug release feature that continues, controllably discharge medicine, at the uniform velocity release, crest and the trough of blood drug level have been avoided, make blood drug level maintain a metastable numerical value, the toxicity of having avoided high blood drug level to cause, avoided the stimulation to patient, the mode of this continual and steady administration is simultaneously more conducive to improve curative effect, particularly Rhododendron oil is as the medicine for the treatment of asthma and bronchopathy, and continual and steady administration is particularly important to improving curative effect; In addition, this slow releasing agent after being taken by patient, medicine in stomach and intestinal portion with relative speed stably, discharge constantly, when discharging, constantly digested and assimilated, avoid the gastral stimulation to patient, avoided patient to have the hiccups, feel sick, vomit, improved the wish of patient's drug administration.
The preparation method of the slow releasing agent that the above embodiment of the present invention provides and slow releasing agent, evenly mix Rhododendron oil, sodium alginate, surfactant and distilled water, is prepared into emulsion; Described emulsion is added into the bead that obtains gelation in described aqueous chloride solution; Described bead is carried out to dried, obtain coccoid medicine; The described coccoid medicine of take prepares Rhododendron oil-alginate embedding slow releasing agent as raw material.Preparation method that the present invention adopts, first medicament dropping is made to pharmaceutical pellet, pharmaceutical pellet is carried out to multi-form encapsulation, and become final medicine, the defect of the pattern aspect such as the circularity of pharmaceutical pellet, microcosmic bubble, hangover like this, do not affect the total quality of medicine, just improved the degree of controllability of product quality accordingly yet; In addition, the slow releasing preparation that adopts said method to prepare, plays carrying drug ratio and is much higher than beta-schardinger dextrin-preparation; The slow releasing preparation that adopts said method to prepare, has good sustained release performance, make blood drug level uniform and stable, reduce drug toxicity, improve curative effect; While preparing by changing preparation, the mass percent of various materials, can carry out manual control in addition to drug release rate, and technique is simple, can be applicable to suitability for industrialized production.
Further set forth by the following examples the present invention, these embodiment are only presented for purposes of illustration, do not limit the scope of the invention.Except dated actual conditions, the test method in embodiment is all carried out according to normal condition.
embodiment 1:
By Rhododendron oil, sodium alginate, Polyethylene Glycol and appropriate water in mass ratio for 68.8%:0.8%:0.4%:30% mix homogeneously makes even emulsion; The calcium chloride solution that is added into concentration and is 0.2molL-1 in above-mentioned emulsion obtains the bead of gelation; The bead of above-mentioned gelation is stirred gently, then standing, formed bead is taken out, with distilled water wash, obtain moisture coccoid medicine and the direct drying of aqueous drug bead is obtained to dried pellet shape medicine; Using coccoid medicine directly as Rhododendron oil-alginate embedding sustained-release granular formulation.
embodiment 2:
By Rhododendron oil, sodium alginate, cyclodextrin and appropriate water in mass ratio for 45%:4%:2%:45% mix homogeneously makes even emulsion; The strontium chloride solution that is added into concentration and is 3molL-1 in above-mentioned emulsion obtains the bead of gelation; The bead of above-mentioned gelation is stirred gently, then standing, formed bead is taken out, with distilled water wash, obtain moisture coccoid medicine and the direct drying of aqueous drug bead is obtained to dried pellet shape medicine; Coccoid medicine is filled into and in capsule, makes Rhododendron oil-alginate embedding slow releasing capsule.
embodiment 3:
By Rhododendron oil, sodium alginate, cyclodextrin and appropriate water in mass ratio for 23%:8%:4%:65% mix homogeneously makes even emulsion; In above-mentioned emulsion, be added into the bead that calcium chloride solution that concentration is 6.5molL-1 and strontium chloride solution mixed solution obtain gelation; The bead of above-mentioned gelation is stirred gently, then standing, formed bead is taken out, with distilled water wash, obtain moisture coccoid medicine and the direct drying of aqueous drug bead is obtained to dried pellet shape medicine; Take coccoid medicine as raw material, adopt existing common processes to be prepared into Rhododendron oil-alginate embedding slow releasing pill.
The above, it is only preferred embodiment of the present invention, not the present invention is done to any pro forma restriction, although the present invention discloses as above with preferred embodiment, yet not in order to limit the present invention, any those skilled in the art, do not departing within the scope of technical solution of the present invention, when can utilizing the technology contents of above-mentioned announcement to make a little change or being modified to the equivalent embodiment of equivalent variations, in every case be not depart from technical solution of the present invention content, any simple modification of above embodiment being done according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (7)
1. a preparation method for slow releasing agent, is characterized in that, comprises the steps:
Rhododendron oil, sodium alginate, surfactant and distilled water are evenly mixed, be prepared into emulsion;
Monochloride aqueous solution is provided, and described aqueous chloride solution is at least one in calcium chloride solution or strontium chloride solution;
Described emulsion is added into the bead that obtains gelation in described aqueous chloride solution;
Described bead is carried out to dried, obtain coccoid medicine;
The described coccoid medicine of take prepares Rhododendron oil-alginate embedding slow releasing agent as raw material.
2. the preparation method of slow releasing agent according to claim 1, it is characterized in that, the described mass percent by Rhododendron oil, sodium alginate, surfactant and distilled water is than being (23-68.8%): (0.8-8%), (0.4-4%): (30-65%).
3. the preparation method of slow releasing agent according to claim 1 and 2, is characterized in that, described surfactant is Polyethylene Glycol or cyclodextrin surfactant or spans surfactant or Tweens surfactant.
4. the preparation method of slow releasing agent according to claim 1, is characterized in that, the concentration of described aqueous chloride solution is 0.2～6.5molL-1.
5. the preparation method of slow releasing agent according to claim 1, is characterized in that, described dried is heat drying or lyophilization.
6. a slow releasing agent, is characterized in that, comprises slow releasing agent prepared by the preparation method of the slow releasing agent described in claim 1 to 5 any one.
7. a slow releasing agent according to claim 6 application in tracheitis or asthma.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310574687.5A CN103565902B (en) | 2013-11-13 | 2013-11-13 | Slow releasing agent and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310574687.5A CN103565902B (en) | 2013-11-13 | 2013-11-13 | Slow releasing agent and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103565902A true CN103565902A (en) | 2014-02-12 |
| CN103565902B CN103565902B (en) | 2016-01-20 |
Family
ID=50039183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310574687.5A Expired - Fee Related CN103565902B (en) | 2013-11-13 | 2013-11-13 | Slow releasing agent and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103565902B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593504A (en) * | 2004-07-15 | 2005-03-16 | 天津大学 | Microencapsulation method of Chinese traditional medicine |
| CN1872028A (en) * | 2006-04-28 | 2006-12-06 | 深圳市人民医院 | Immune magnetic Nano microsphere, preparation method, and application |
| CN101401975A (en) * | 2008-11-07 | 2009-04-08 | 中国人民解放军第三军医大学第三附属医院 | Tissue engineering bone carrying sustained-release antimicrobial peptide and preparation method thereof |
| CN101947212A (en) * | 2010-09-08 | 2011-01-19 | 华侨大学 | Micro-embedded medicament carrier and preparation method thereof |
| CN101972038A (en) * | 2010-10-28 | 2011-02-16 | 上海理工大学 | Slowly-released filter stick essence microcapsule and preparation method thereof |
-
2013
- 2013-11-13 CN CN201310574687.5A patent/CN103565902B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593504A (en) * | 2004-07-15 | 2005-03-16 | 天津大学 | Microencapsulation method of Chinese traditional medicine |
| CN1872028A (en) * | 2006-04-28 | 2006-12-06 | 深圳市人民医院 | Immune magnetic Nano microsphere, preparation method, and application |
| CN101401975A (en) * | 2008-11-07 | 2009-04-08 | 中国人民解放军第三军医大学第三附属医院 | Tissue engineering bone carrying sustained-release antimicrobial peptide and preparation method thereof |
| CN101947212A (en) * | 2010-09-08 | 2011-01-19 | 华侨大学 | Micro-embedded medicament carrier and preparation method thereof |
| CN101972038A (en) * | 2010-10-28 | 2011-02-16 | 上海理工大学 | Slowly-released filter stick essence microcapsule and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 樊英等: "黄芪多糖海藻酸钠微胶囊的制备及释放性能研究", 《饲料研究》 * |
| 胡永芳等: "正交实验研制烈香杜鹃油-β-环糊精包合物", 《中成药》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103565902B (en) | 2016-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106389344A (en) | Calcium carbonate particles and preparation method thereof | |
| CN1775274A (en) | Cough-relieving sputum-resolving medicinal composition and preparing method | |
| CN110917233B (en) | Preparation method of lithospermum oil | |
| CN103565902B (en) | Slow releasing agent and its preparation method and application | |
| CN1958010A (en) | Composition preparation of Chinese traditional medicine, and preparation method | |
| CN105496982B (en) | A kind of chitosan tablet and preparation method thereof | |
| CN100345534C (en) | Yinzhi huang capsule, its preparation method and use | |
| CN106176622A (en) | A kind of isorhynchophylline slow releasing preparation treating hypertension and preparation method thereof | |
| CN107233542B (en) | Application of longhurendan in preparing medicine for preventing and/or treating hepatic fibrosis | |
| CN100375616C (en) | Bone strengthening dripping pills with Premena fulva craib as raw material and method for preparing the same | |
| CN101057868A (en) | Traditional Chinese medicine preparation for treating osteoporosis diseases and its preparation method and quality controlling method | |
| CN109908075A (en) | A kind of Berberine hydrochloride is slow-releasing gel used and preparation method thereof | |
| CN101036681A (en) | Analgesic aconitum flavum | |
| CN103656606A (en) | Polypeptide colon-targeted drug delivery preparation and preparation method thereof | |
| CN105708796A (en) | Sustained release preparation containing trazodone hydrochloride oral solution and preparation method of sustained release preparation | |
| CN105395574A (en) | Medicinal and edible compound squalene and fish oil soft capsule for preventing and treating cardiovascular and cerebtovascular disease | |
| CN1850231A (en) | Longxuejie granules and its preparing technology | |
| CN105125588B (en) | The method for reducing hiruto freeze-dried powder fishy smell using yeast fermentation | |
| CN112641752A (en) | Soft capsule, preparation method thereof and application thereof in treating constipation | |
| CN104906119A (en) | Naoluotong capsule and preparation method therefor | |
| CN1686166A (en) | Medicinal composition for treating blood vessel kind disease, its preparation process and its use | |
| CN1872234A (en) | Composition of medication for inducing diuresis to alleviate edema, preparing and controlling quality method, usage | |
| CN1528380A (en) | Medicine for preventing and treating chronic exhaustion syndrome and preparing method thereof | |
| CN1872044A (en) | Medication for treating coronary heart disease | |
| CN1695629A (en) | Oral preparation of quick releasing Breviscapini and producing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160120 Termination date: 20211113 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |