CN103520601A - Chinese medicinal preparation for treating diabetic retinopathy - Google Patents

Abstract

The invention discloses a Chinese medicinal preparation for treating diabetic retinopathy. The diabetic retinopathy belongs to blurred vision, sudden blind, vitreousopacity and the like in medicines. The key to diagnosis and treatment is mentioned that if three types of diabetes are occurred for a long time, essence and blood are deficient, or the eyes cannot see, or the hands are feet are disabled. At present, the Chinese medicine doctors coherently think that the disease is the deteriorated case caused by the symptoms of long-term morbidity, deficiency of yin and body fluid and less nourishment of the eyes. According to the Chinese medicinal preparation, the Chinese medicines including asiatic bilberry, cortex acanthopanacis, radix polygonati officinalis, the root bark of white mulberry, semen Cuscutae, raspberry, Chinese flowering crabapple, hairy triumfetta, ceratostigma root, rhizoma sparganii, whorledleaf solomonseal rhizome, wolfberry fruit and liquorice, are decocted with water to prepare decoction. The clinical test shows that the total effective rate is up to 1.43 percent, the curative effect is good, and poor reaction in the treatment group is avoided.

Description

A kind of Chinese medicine preparation for the treatment of diabetic retinopathy

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of diabetic retinopathy.

Background technology

Diabetic retinopathy (DR) is the severe ocular complication of diabetes, is the one of the main reasons of blinding.Laser photocoagulation can effectively preventing DR development, be the important means for the treatment of at present DR, but have certain side effect and limitation.I find through clinical observation for many years, utilize Diabetes Mellitus Treated With Traditional Chinese Medicine retinopathy not only to have good curative effect, and side effect am little.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of diabetic retinopathy.Diabetes belong to " diabetes " category in the traditional Chinese medical science, and diabetic renal papillary necrosis belongs to the categories such as the traditional Chinese medical science " blurring of vission ", " sudden blindness ", " cloud and mist moves fine "." key to Diagnosis and Treatment " mentions " three types of diabetes for a long time it, essence and blood loses, or order is without finding, or brothers attach undue importance to one thing to the neglect of the other ".At present ，Zhong medical circles more as one man think that primary disease is due to the deteriorated case of onset diabetes with the passing of time, due to Yin and fluid deficiency, malnutrition of eyes.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment diabetic retinopathy is made by the Chinese medicine of following weight portion: Fructus Vaccinii Bracteati 9-15 part, Cortex Acanthopancis 7-9 part, Rhizoma Polygonati Odorati 6-12 part, Cortex Mori 8-16 part, Semen Cuscutae 15-20 part, Fructus Rubi 7-11 part, Herba Begoniae Yunnanensis 6-10 part, Radix Seu Folium Triumfettae Pilosae 7-12 part, Radix ceratostigmatis willemottiani 4-7 part, Rhizoma Sparganii 10-14 part, Rhizoma Polygonati Verticillati 11-13 part, Fructus Lycii 10-14 part, Radix Glycyrrhizae 4-6 part.

Preferred: 13 parts of Fructus Vaccinii Bracteati, 8 parts of Cortex Acanthopanciss, 9 parts of Rhizoma Polygonati Odorati, 12 parts of Cortex Mori, 18 parts of Semen Cuscutae, 9 parts of Fructus Rubies, 8 parts of Herba Begoniae Yunnanensis, 9.5 parts of Radix Seu Folium Triumfettae Pilosae, 5.5 parts of Radix ceratostigmatis willemottianis, 12 parts of Rhizoma Sparganii, 12 parts of Rhizoma Polygonati Verticillatis, 12 parts of Fructus Lycii, 5 parts, Radix Glycyrrhizae.

Preparation method: make decoction by traditional preparation method decocting.

In side: Fructus Vaccinii Bracteati, Cortex Acanthopancis: supplementing the kidney to control the nocturnal, strong muscle improving eyesight, blood circulation and promoting silt, enhancing immunity; Rhizoma Polygonati Odorati: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst; Cortex Mori: tonify deficiency QI invigorating, blood sugar lowering; Semen Cuscutae: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity; Fructus Rubi: the liver and the kidney tonifying, improving eyesight; Herba Begoniae Yunnanensis, Radix Seu Folium Triumfettae Pilosae: promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling; Radix ceratostigmatis willemottiani: promoting blood circulation and stopping pain, blood stasis dispersing and fresh blood promoting; Rhizoma Sparganii: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving; Rhizoma Polygonati Verticillati, Fructus Lycii: suppressing the hyperactive liver to relieve the wind syndrome, yin nourishing improving eyesight, liver-nourishing kidney-boosting, resisting fatigue, radioprotective; Radix Glycyrrhizae: in QI invigorating benefit, coordinating the actions of various ingredients in a prescription.

Clinical data

1. all diabetic retinopathy (DR) patients of physical data are outpatient service and the inpatient during my institute in March, 2010-2012 year January, and totally 46 example is 68,39 of male 25 examples, 29 of female's 21 examples, oldest is 77 years old, and minimum is 44 years old, average out to 61.5 years old.Suffering from diabetes (DM) course of disease the longest is 30 years, and the shortest is 5 years, and average course of disease is 12.5 years.Be divided into two groups: matched group is 33 of totally 23 examples, 17 of male 13 examples, 16 of female's 10 examples, the mean age is 60.42 years old.Wherein simple type 15 example is 19,14 of proliferous type 8 examples.Average course of disease is 12.3.Treatment group is 35 of totally 23 examples, 16 of male 11 examples, and 19 of female's 12 examples, the mean age is 61.50 years old.Wherein simple type 14 example is 18,17 of proliferous type 9 examples.Average course of disease is 13.1.

2. diagnostic criteria is diagnosed as diabetes (DM) through internal medicine, and retinopathy carries out typing by stages by the 3rd the ophthalmology meeting specified standard in the whole nation.Syndrome Differentiation of Traditional Chinese Medicine changes and meets the deficiency of both QI and YIN blood stasis type of holding concurrently according to clinical manifestation and optical fundus.Physical data no difference of science of statistics, has comparability.

3. two groups of patients of Therapeutic Method all give laser photocoagulation treatment, specific as follows: with the abundant mydriasis of Mydrin-P to 7-8mm; 0.5% tetracaine topical anesthesia, adopts American I RI S part L-532nm Laser machine and 0cu l a r laser cornea mirror to carry out laser photocoagulation.Treatment group patient takes Chinese medicine preparation of the present invention simultaneously, prescription: (Fructus Vaccinii Bracteati 13g, Cortex Acanthopancis 8g, Rhizoma Polygonati Odorati 9g, Cortex Mori 12g, Semen Cuscutae 18g, Fructus Rubi 9g, Herba Begoniae Yunnanensis 8g, Radix Seu Folium Triumfettae Pilosae 9.5g, Radix ceratostigmatis willemottiani 5.5g, Rhizoma Sparganii 12g, Rhizoma Polygonati Verticillati 12g, Fructus Lycii 12g, Radix Glycyrrhizae 5g), order potion, divide three decoction being taken warmly, serve on 1-4 month.

3. criterion of therapeutical effect is formulated with reference to State Administration of Traditional Chinese Medicine " disease of tcm Standardization of diagnosis and curative effect " drafted.Effective: retinal hemorrhage point, hard exudate and cotton-wool patches obviously reduce, angiomatous change is without increasing, more than vision improves 4 row; Effective: retinal hemorrhage point, hard exudate and cotton-wool patches obviously reduce, and angiomatous change does not increase, more than vision improves 2 row; Invalid: retinal hemorrhage point, hard exudate and cotton-wool patches are without changing or increasing, and hemangioma changes and increases, vision is without progressive or decline.

4. two groups of patients of therapeutic outcome all treated after 1 course for the treatment of, and treatment group total effective rate 91.43% is better than 78.79% of matched group, and difference has statistical significance (P < 0.05), and concrete Comparison of therapeutic data are in Table 1.

Table 1 liang group Comparison of therapeutic

6. untoward reaction: the routine patient for the treatment of group 33 does not find untoward reaction, matched group is in therapeutic process, and 1 generation net is de-, 3 complicated with acute angle closure glaucoma.All the other cases are not found untoward reaction.

The specific embodiment

Embodiment mono-: Fructus Vaccinii Bracteati 13g, Cortex Acanthopancis 8g, Rhizoma Polygonati Odorati 9g, Cortex Mori 12g, Semen Cuscutae 18g, Fructus Rubi 9g, Herba Begoniae Yunnanensis 8g, Radix Seu Folium Triumfettae Pilosae 9.5g, Radix ceratostigmatis willemottiani 5.5g, Rhizoma Sparganii 12g, Rhizoma Polygonati Verticillati 12g, Fructus Lycii 12g, Radix Glycyrrhizae 5g, make decoction by traditional preparation method decocting.

Embodiment bis-: Fructus Vaccinii Bracteati 15g, Cortex Acanthopancis 9g, Rhizoma Polygonati Odorati 12g, Cortex Mori 8g, Semen Cuscutae 20g, Fructus Rubi 11g, Herba Begoniae Yunnanensis 10g, Radix Seu Folium Triumfettae Pilosae 12g, Radix ceratostigmatis willemottiani 4g, Rhizoma Sparganii 14g, Rhizoma Polygonati Verticillati 13g, Fructus Lycii 10g, Radix Glycyrrhizae 6g, make decoction by traditional preparation method decocting.

Embodiment tri-: Fructus Vaccinii Bracteati 9g, Cortex Acanthopancis 7g, Rhizoma Polygonati Odorati 6g, Cortex Mori 16g, Semen Cuscutae 15g, Fructus Rubi 7g, Herba Begoniae Yunnanensis 6g, Radix Seu Folium Triumfettae Pilosae 7g, Radix ceratostigmatis willemottiani 7g, Rhizoma Sparganii 10g, Rhizoma Polygonati Verticillati 11g, Fructus Lycii 14g, Radix Glycyrrhizae 4g, make decoction by traditional preparation method decocting.

Claims (2)

1. treat a Chinese medicine preparation for diabetic retinopathy, it is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: Fructus Vaccinii Bracteati 9-15 part, Cortex Acanthopancis 7-9 part, Rhizoma Polygonati Odorati 6-12 part, Cortex Mori 8-16 part, Semen Cuscutae 15-20 part, Fructus Rubi 7-11 part, Herba Begoniae Yunnanensis 6-10 part, Radix Seu Folium Triumfettae Pilosae 7-12 part, Radix ceratostigmatis willemottiani 4-7 part, Rhizoma Sparganii 10-14 part, Rhizoma Polygonati Verticillati 11-13 part, Fructus Lycii 10-14 part, Radix Glycyrrhizae 4-6 part.

2. a kind of Chinese medicine preparation for the treatment of diabetic retinopathy according to claim 1, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: 13 parts of Fructus Vaccinii Bracteati, 8 parts of Cortex Acanthopanciss, 9 parts of Rhizoma Polygonati Odorati, 12 parts of Cortex Mori, 18 parts of Semen Cuscutae, 9 parts of Fructus Rubies, 8 parts of Herba Begoniae Yunnanensis, 9.5 parts of Radix Seu Folium Triumfettae Pilosae, 5.5 parts of Radix ceratostigmatis willemottianis, 12 parts of Rhizoma Sparganii, 12 parts of Rhizoma Polygonati Verticillatis, 12 parts of Fructus Lycii, 5 parts, Radix Glycyrrhizae.