CN103520346A - Medicine composition for activating male sexual function - Google Patents
Medicine composition for activating male sexual function Download PDFInfo
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- CN103520346A CN103520346A CN201210232004.3A CN201210232004A CN103520346A CN 103520346 A CN103520346 A CN 103520346A CN 201210232004 A CN201210232004 A CN 201210232004A CN 103520346 A CN103520346 A CN 103520346A
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Abstract
The invention discloses a medicine composition for enhancing male sexual activity. The medicine composition comprises semen litchi, longan seeds, tangerine seeds and hawthorns. The medicine composition is suitable for men suffering from sexual desire disorders, low sexual desire, sexual aversion disorders or loss of libido, sexual hyperesthesia, erection problem, impotence, priapism, ejaculation disorder and premature ejaculation. In addition, the invention provides a preparation method of the medicine composition for enhancing male sexual activity. According to the preparation method, the medicine composition is prepared by heating the effective quantities of semen litchi, longan seeds, tangerine seeds and hawthorns in water or an alcohol-containing solvent.
Description
Technical field
The present invention relates to a kind of medical composition, relate in particular to a kind of for promoting the active medical composition of Male sexual.
Background technology
Male sexual disorder is divided into libido decline, Ejaculatory dysfunction (premature ejaculation or delay ejaculation) and modal erection disturbance substantially.Its origin cause of formation is psychological factor, physiologic factor and medicine factor.Psychological factor comprises by melancholia, oneself is lost the confidence and to the caused psychogenic sexual dysfunction of the anxiety of sexual behaviour; Physiologic factor comprises by the disease of cardiovascular, nerve, hormonal system or impaired the caused sexual dysfunction of cavernous body of penis; Medicine factor comprises for example takes the hypertensive medicine for the treatment of and/or the caused side effect of drugs of mental department.
On treatment erection disturbance, normal use there is height endurability, the phosphodiesterase inhibitor (PDE5inhibitors) of convenience, the advantage such as oral.The prescription drug of current three kinds of main phosphodiesterase inhibitors comprises: VIAGRA (Viagra, be sildenafil), the strong (Levitra of happy prestige, be vardenafil) and rhinoceros man of great strength (Cialis, tadalafil), to turn be mainly by loosening cavernous body of penis smooth muscle blood vessel dilating, then to reach the effect of erection to its effect machine.Yet, heart disease patient (angina pectoris, heart failure and have heart attack medical history) or once had the apoplexy of generation in nearly six months or sickle anemia patient is all not suitable for taking phosphodiesterase inhibitor, because phosphodiesterase inhibitor and the reciprocal action of some drugs generation may cause the life danger of sufferer.And phosphodiesterase inhibitor also can cause side effect such as comprising headache, dizziness, face's flushing, stomach discomfort, visual abnormality, nasal obstruction, myalgia, backache.
And the medicine for the treatment of early onset ejaculation (premature ejaculation) comprising: the dopamine antagonist that 1) acts on central nervous system (can suppress ejaculation such as neural tranquillizer and antipsychotic drug (good degree fixed (Hardol), Dogmatil, metoclopramide (Metoclopramide) etc.); 2) sympathetic inhibitor (for example Phenoxybenzamine (Phenoxybenzamine)) can postpone the ejaculation time, even not ejaculation; 3) serum augmentor (Serotonin) (for example fluoxetine (Fluoxetine), Sertraline (Sertraline)) can suppress ejaculation; 4) three ring resist melancholy agents (for example Clomipramine, Amitriptyline) can effectively suppress ejaculation, have the characteristic of anti-acetyl cholamine, anti-A type epinephrine and increase serum augmentor simultaneously; And 5) gamma amido butyric acid (GABA) promoter (anxiolytic drugs such as Ativan, Xanax) can be suppressed ejaculation slightly.
In Chinese medicine, there are many treatment sexual impotence or declare the ancient prescription of tonifying YANG, for example, such as usining animal organ, animal itself (a kind of Gekkonidae animal-Gecko), the three animal penes wine that soaks tens of kinds of medical materials or the Cordyceps such as Penis et testis cervi, Testis et penis callorhini, Cornu Cervi Pantotrichum as tonifying YANG medical material, may there is clinical efficacy, but more commonly utilize media or in the streets legend increase its effect, mystery flavour and sexual cue meaning.But these medical compositions seldom confirm sexual dysfunction tool improvement effect through animal.
In known patent documentation, TaiWan, China patent announcement number discloses the local medical constituent of the hypersensitivity of a kind of prevention and treatment ejaculation ahead of time and/or sexual stimulus, the Radix Ginseng extract (without draft quintessence oil composition) of the purification that comprises Venenum Bufonis (Bufonis Venenum) extract of purification and contain saponin for No. I323174.This medical component reduces penis muscle contraction to be applied on male penis glans penis, reaches local anesthesia effect and extend the sexual behaviour time.Yet this medical component only has single effect, need before each sexual behaviour, use, and cannot have actual therapeutic effect to male sexual disorder.
Number No. I235062 announcement of TaiWan, China patent announcement is a kind of for prevention or the treatment of sexual dysfunction and vasoconstrictive drug regimen, and it comprises as the Herba Epimedii of active component and pharmaceutical carrier and excipient.Wherein, tested sufferer was taken this pharmaceutical composition after one month, evaluate questionnaire and add up, assess, yet the effect of this pharmaceutical composition may be over-evaluated or underestimate to this evaluation methodology to fill in voluntarily sexual function.
No. 201103554 announcement of TaiWan, China patent publication No. is a kind of in order to help the Fructus Arctii extract of the spongy body diastole effect of patients with erectile dysfunction.Yet this application case is only tested the tension variation of Fructus Arctii extract to the in vitro spongy body smooth muscle of rabbit, reality is tested mobiles, seems to be difficult to confirm that patients with erectile dysfunction is had to therapeutic efficiency.
TaiWan, China patent announcement number discloses for No. I298258 a kind of with Cordyceps (Cordyceps militaris) mycelium lifting fertility (increasing sperm quantity and quality).Yet it only confirms to increase sperm quantity and the motility of sperm of pig, its sexual function improving and sexual behaviour quality thereof that also cannot be associated in pig (or male) improves.
This case applicant is in view of deficiency of the prior art, through concentrated test and research, an and spirit of working with perseverance, visualize eventually this case, develop the novel medical composition that enlivens male's sexual, and the living animal sexual behaviour pattern of utilizing international approval confirms that medical composition of the present invention can effectively enliven, promotes and treat male's sexual, can overcome the deficiency of prior art.
Summary of the invention
Main purpose of the present invention is, a kind of medical composition is provided, can be to the active effect of male's sexual tool.For achieving the above object, the present invention is the medical composition that contains Semen Litchi, seed of Arillus Longan, Semen Citri Reticulatae, Fructus Crataegi for enlivening the medical composition of male's sexual.The weight portion of medical composition Chinese crude drug of the present invention is unrestricted, optimally for containing Semen Litchi 4 to 8 weight portions, seed of Arillus Longan 4 to 8 weight portions, Semen Citri Reticulatae 4 to 8 weight portions, Fructus Crataegi 2 to 4 weight portions.
Aforementioned medical composition is configured to pharmaceutically acceptable dosage form, includes but not limited to decoction, ball, cream, pellet, loose, dew, granule, capsule, lozenge, syrup, ointment, fluid extract, tincture.In addition, aforementioned medical composition also comprises additive, this additive comprise but be not limited to group that flavoring agent, toner, coloring agent and combination thereof form one of them, the suitable sense of mouth and visual experience while taking in order to improve this medical composition of gained.In addition, aforementioned medical composition also comprises the group being comprised of preservative agent, antiseptic, antibacterial, antifungal and combination thereof with reasonable volume, in order to improve the storage quality of described medical composition, or extends the pot-life of described medical composition.
Aforementioned medical composition is applicable to enliven defect or the obstacle of male's sexual, and aforementioned disadvantages or obstacle include but not limited to that dysaphrodisia, hyposexuality, property are detested or without libido, hypersexuality, erection problem, sexual impotence, priapism, defective ejaculation, premature ejaculation.
It is a kind of for promoting the preparation method of the active medical composition of Male sexual that the present invention also provides, comprise the Semen Litchi of effective dose, seed of Arillus Longan, Semen Citri Reticulatae and Fructus Crataegi with water or alcoholic solvent (as: rice wine, Sorghum vulgare Pers. etc.), use a kind of mode of heating to be prepared from, and aforementioned preferably mode of heating is with 100 ℃ of heating 60 minutes, carry out the preparation of medicinal liquid.
In some embodiments, the weight portion of aforementioned Chinese crude drug is unrestricted, is optimally Semen Litchi 4 to 8 weight portions, seed of Arillus Longan 4 to 8 weight portions, Semen Citri Reticulatae 4 to 8 weight portions, and Fructus Crataegi 2 to 4 weight portions.
Living animal sexual behaviour pattern used in the present invention comprises: ride (mount), insert (intromission) and ejaculation (Ejaculation).Be described as follows:
1, ride: male Mus lies prone and rides with it female Mus, be equal to the performance of assessment mankind libido, erection, occur the process (corresponding indication: dysaphrodisia, hyposexuality, property detest, without libido) of libido;
2, insert: male Mus penis enters female Mus vagina, be equal to assessment mankind erection hardness sufficient, without early onset ejaculation (corresponding indication: erection problem, sexual impotence, priapism, premature ejaculation); And
3, ejaculation: leave female Mus after male Mus ejaculation, be equal to and assess human sexuality's persistency and antisecosis ability (the corresponding indication: defective ejaculation) after ejaculation.And the assessment of ejaculation is also represented to have comprised the behavior that rides and insert.
Detailed technology of the present invention and better enforcement aspect, will be described in following content, for field tool under the present invention, conventionally know that the knowledgeable understands feature of the present invention according to this.
Accompanying drawing explanation
The frequency that rides that Figure 1A is depicted as the public FVB mice of using different pharmaceutical compares block diagram.
The insertion frequency that Figure 1B is depicted as the public FVB mice of using different pharmaceutical compares block diagram.
The ejaculation frequency that Fig. 1 C is depicted as the public FVB mice of using different pharmaceutical compares block diagram.
Fig. 1 D is depicted as the ejaculation time comparison block diagram of the public FVB mice of using different pharmaceutical.
Fig. 1 E is depicted as the sexual behaviour scoring of the public FVB mice of using different pharmaceutical and compares block diagram.
Ride frequency, insertion frequency and ejaculation frequency that Fig. 1 F is depicted as the public FVB mice of using different pharmaceutical comprehensively compare block diagram.
Fig. 2 A is depicted as the riding frequency, insert frequency and ejaculation frequency scattergram of public FVB mice of using saline solution.
Fig. 2 B is depicted as the riding frequency, insert frequency and ejaculation frequency scattergram of public FVB mice of using VIAGRA.
Fig. 2 C is depicted as the riding frequency, insert frequency and ejaculation frequency scattergram of public FVB mice of the pharmaceutical composition of the present invention of using embodiment 1.
Fig. 2 D is depicted as the riding frequency, insert frequency and ejaculation frequency scattergram of public FVB mice of the pharmaceutical composition of using embodiment 2.
Fig. 2 E is depicted as the riding frequency, insert frequency and ejaculation frequency scattergram of public FVB mice of the pharmaceutical composition of using embodiment 3.
The specific embodiment
For the effect of understanding better technical characterictic of the present invention and reaching, below tie accompanying drawing preferred embodiment of the present invention is elaborated.
[embodiment 1]
Embodiment 1 is medical composition of the present invention, it take Semen Litchi (3g), seed of Arillus Longan (3g), Semen Citri Reticulatae (3g) and Fructus Crataegi (1.5g) is medical material, through cutting into slices and adding after 1800 milliliters, water, with 100 ℃ of heating, within 60 minutes, carry out the preparation of medicinal liquid, until medicinal liquid is concentrated into 30% amount that is about original volume.The solvent (as: rice wine, Sorghum vulgare Pers. etc.) that water also can contain ethanol replaces.
[embodiment 2]
Embodiment 2 is experimental group medical composition, it take the Radix Rehmanniae (3g), Radix Angelicae Sinensis (3g), Rhizoma Chuanxiong (3g) and Radix Paeoniae Rubra (3g) is medical material, through cutting into slices and adding after 1800 milliliters, water, with 100 ℃ of heating, within 60 minutes, carry out the preparation of medicinal liquid, until medicinal liquid is concentrated into 30% amount that is about original volume.
[embodiment 3]
Embodiment 3 is another experimental group medical composition, and it take Gecko powder (10g) is medical material, adds 100 milliliters of hot water of 90 ° of C, soaks elimination impurity after 60 minutes and completes preparation.
Carrying out experiment made on the living Mus when test, every experimental mouse gavages the medical composition of 2 embodiment 1,2 or 3, each 0.2 milliliter every day.
The animal experiment acquisition that the present invention carries out " committee (Institutional Animal Care and Use Committee(IACUC) is looked after and used to laboratory animal) " agree to and carry out according to its standard.
First, laboratory animal adopts 5 week age without the FVB mice of sex experience, male and female half and half.Then, the environment of the female Mus sub-cage rearing of male Mus is bright in 22 ° of C constant temperature, 12 hours, 12 hours dark cycle, gives sufficient feedstuff and drinking-water.
When zoopery starts, public FVB mice is divided into 5 groups, 6 every group, wherein, one group is control group, fills with food saline solution; One group is positive control group, fills with food VIAGRA (10mg/kg body weight, i.e. 10g/g body weight); And other three groups be experimental group, fill with respectively the medical composition of the above-mentioned three kinds of embodiment 1,2 of food and 3.Therefore, public FVB mice every day early, fill with food saline solution, VIAGRA, embodiment 1,2 or 3 medical compositions according to body weight (10ml/kg body weight, i.e. 10L/g body weight) evening, continues 2 weeks.
And aspect female FVB mice, in sexual behaviour observation experiment, carry out giving for first 36 hours every female FVB mice 50 μ g estradiol benzoates (estradiol benzoate) and before 4 hours, gave 500 μ g progesterone (progesterone) luring into and oestrusing.
In dark place, at random a male FVB mice and a female FVB mice are placed in to independent and clean mouse cage, with the male Mus in night-vision camera shooting mouse cage and the sexual behaviour of female Mus, reach 4 hours.With the shooting film of 3rd hour, carry out riding, inserting of sexual behaviour process and ejaculation behavior.
Statistical analysis
The experiment analysis results of every group represents with meansigma methods ± standard deviation (mean ± SD).With Student ' s t-test, analyze normal distribution and the diversity situation of experimental data.With Mann-Whitney U test, analyze abnormal distribution and the dependency situation of experimental data.P value < 0.05 of statistical result has been considered as statistical meaning.
Experimental result
According to aforementioned defined ride, insert and the statistical data of ejaculation behavior and the sexual function scoring carried out as shown in Table 1.
The statistical data of the sexual function scoring of table one, public FVB mice
Note: sexual behaviour mark=A * 1+B * 2+C * 3+D
According to the block diagram of the every standards of grading made of table one respectively as shown in Figure 1A to Fig. 1 F.In Figure 1A, the mice of using the pharmaceutical composition of the present invention of embodiment 1 shows and is only second to the mice of using VIAGRA.In Figure 1B, the mice of using VIAGRA shows the highest insertion frequency, and the mice of using the pharmaceutical composition of the present invention of embodiment 1 takes second place.In Fig. 1 C, use the mice of pharmaceutical composition of the present invention of embodiment 1 and other mices of 4 groups and compare and present higher ejaculation frequency (for using 3.5 times of mice of VIAGRA).In Fig. 1 D, use the mice of pharmaceutical composition of the present invention of embodiment 1 and other mices of 4 groups and present the higher ejaculation time (for using 17.0 times of mice of VIAGRA).In Fig. 1 E, according to the sexual behaviour mark calculating formula of table one, use the mice of pharmaceutical composition of the present invention of embodiment 1 and other mices of 4 groups and compare and there is the highest sexual behaviour mark (for using 8.1 times of mice of VIAGRA).Because assessment and the judgement of mice ejaculation behavior comprised the behavior that rides and insert, the experimental result of combined statement one and Figure 1A to Fig. 1 E is known, the mice of using the pharmaceutical composition of the present invention of embodiment 1 has sequentially completed the sexual behaviour that rides, inserts and ejaculate, and far above clinical medicine VIAGRA.Therefore, pharmaceutical composition of the present invention can substitute the VIAGRA as clinical medicine, and become, effective enhancement Male sexual enlivens and medicine or the prescription for the treatment of male sexual disorder.
Fig. 1 F is for merging the result of Figure 1A to Fig. 1 C, represent to use embodiment 1 pharmaceutical composition of the present invention mice from ride the globality time of the act of ejaculate compared with other mices of 4 groups for height, also represent that pharmaceutical composition of the present invention can be used for treating prospermia of males.
In addition, the mice of analysis different experiments group rides frequency, inserts frequency and ejaculation frequency scattergram.In Fig. 2 A, there is not insertion behavior in the mice of using saline solution, and globality is enlivened the time in the 3rd hour only about approximately 15 minutes.In Fig. 2 B, use the property time of enlivening of the mice of VIAGRA and comparatively disperse, and the sexual behaviour of part only ride and insert, and without completing ejaculation, representing the libido that VIAGRA may stimulate public FVB mice but cannot allow it complete ejaculation behavior.In Fig. 2 C, the mice of using the medical composition of the present invention of embodiment 1 shows ejaculation behavior fully and for a long time, and expression can enliven male sexual function.In Fig. 2 D, show and use embodiment 2 medical compositions that comprise the Radix Rehmanniae, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Radix Paeoniae Rubra and cannot effectively enliven male sexual function.In Fig. 2 E, show that using embodiment 3 medical compositions that comprise Gecko powder only can cause the libido of public FVB mice in short time.
Comprehensive Figure 1A to Fig. 1 F figure and Fig. 2 A to Fig. 2 E, the medical composition that comprises Semen Litchi, seed of Arillus Longan, Semen Citri Reticulatae and Fructus Crataegi can effectively enliven male's sexual, applicable to dysaphrodisia, hyposexuality, property, detests or without Male sexual physiological decease or obstacles such as libido, hypersexuality, erection problem, sexual impotence, priapism, defective ejaculation, premature ejaculation.Its performance is equal to or is better than prescription drug-VIAGRA, and the Gecko powder medical composition of also declaring to have Yang-strengthening effect is more effective.
The above embodiment is only for illustrating technological thought of the present invention and feature; its objective is and make those skilled in the art can understand content of the present invention and implement according to this; but should not limit scope of patent protection of the present invention with this; one of ordinary skill in the art are not within departing from the spirit and scope of the present invention; above-described embodiment carries out equivalent variations and improvement relatively, all should belong to the technical scope that the present invention protects.
Claims (9)
1. for promoting the active medical composition of Male sexual, it is characterized in that, comprise a Semen Litchi, a seed of Arillus Longan, a Semen Citri Reticulatae and a Fructus Crataegi.
2. medical composition according to claim 1, is characterized in that, this Fructus Litchi is that 4 to 8 weight portions, this seed of Arillus Longan are that 4 to 8 weight portions, this Semen Citri Reticulatae are that 4 to 8 weight portions, this Fructus Crataegi are 2 to 4 weight portions.
3. medical composition according to claim 1, is characterized in that, this medical composition is suitable for using that dysaphrodisia, hyposexuality, property are detested or without libido, hypersexuality, erection problem, sexual impotence, priapism, defective ejaculation or premature ejaculation.
4. medical composition according to claim 1, it is characterized in that, this medical composition is configured to a pharmaceutically acceptable dosage form, the group that this pharmaceutically acceptable dosage form selects free decoction, ball, cream, pellet, loose, dew, granule, capsule, lozenge, syrup, ointment, fluid extract and tincture to form.
5. medical composition according to claim 1, is characterized in that, this medical composition also comprises an additive, and this additive is selected from the group that a flavoring agent, a toner, a coloring agent and combination thereof form.
6. medical composition according to claim 1, is characterized in that, this medical composition also comprises the group being comprised of a preservative agent, an antiseptic, an antibacterial, an antifungal and combination thereof with reasonable volume.
7. for promoting a preparation method for the active medical composition of Male sexual, it is characterized in that, comprise a Semen Litchi of effective dose, a seed of Arillus Longan, a Semen Citri Reticulatae and a Fructus Crataegi with water or containing the solvent of ethanol, and use a mode of heating to be prepared from.
8. preparation method according to claim 7, is characterized in that, this mode of heating is 100 ℃ of heating 60 minutes.
9. preparation method according to claim 7, is characterized in that, this Semen Litchi is 4 to 8 weight portions, and this seed of Arillus Longan is 4 to 8 weight portions, and this Semen Citri Reticulatae is 4 to 8 weight portions, and this Fructus Crataegi is 2 to 4 weight portions.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210232004.3A CN103520346B (en) | 2012-07-05 | 2012-07-05 | Enliven the medical composition of male's sexual |
| TW101125402A TWI461207B (en) | 2012-07-05 | 2012-07-13 | Pharmaceutical compositions to the improved sexual behavior of male |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210232004.3A CN103520346B (en) | 2012-07-05 | 2012-07-05 | Enliven the medical composition of male's sexual |
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| Publication Number | Publication Date |
|---|---|
| CN103520346A true CN103520346A (en) | 2014-01-22 |
| CN103520346B CN103520346B (en) | 2015-11-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210232004.3A Active CN103520346B (en) | 2012-07-05 | 2012-07-05 | Enliven the medical composition of male's sexual |
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| TW (1) | TWI461207B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049475A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese traditional medicine for treating barrenness caused by no sperm |
-
2012
- 2012-07-05 CN CN201210232004.3A patent/CN103520346B/en active Active
- 2012-07-13 TW TW101125402A patent/TWI461207B/en active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049475A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese traditional medicine for treating barrenness caused by no sperm |
Non-Patent Citations (2)
| Title |
|---|
| 汪志铮: "水果皮核可作畜禽饲料", 《福建农药》 * |
| 陶婷婷等: "单味中药治疗弱精子症的研究现状", 《浙江中医药大学学报》 * |
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| Publication number | Publication date |
|---|---|
| TW201402141A (en) | 2014-01-16 |
| TWI461207B (en) | 2014-11-21 |
| CN103520346B (en) | 2015-11-18 |
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