CN103520263B - Anti-tumor medicinal composition and preparation method thereof - Google Patents
Anti-tumor medicinal composition and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
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- 230000000118 anti-neoplastic effect Effects 0.000 claims description 25
- 241000756943 Codonopsis Species 0.000 claims description 12
- 241000628997 Flos Species 0.000 claims description 12
- 239000009636 Huang Qi Substances 0.000 claims description 12
- 241001508722 Urtica fissa Species 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 10
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 9
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- 241000759271 Alangium Species 0.000 abstract 1
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- 241000110637 Cuscuta chinensis Species 0.000 abstract 1
- 241001071795 Gentiana Species 0.000 abstract 1
- 241001498082 Girardinia Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 244000267823 Hydrangea macrophylla Species 0.000 abstract 1
- 235000014486 Hydrangea macrophylla Nutrition 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
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Abstract
The invention discloses an anti-tumor medicinal composition, which comprises 20 to 30 weight parts of pilose asiabell root, 20 to 30 weight parts of astragalus, 20 to 30 weight parts of gentian, 5 to 15 weight parts of licorice, 5 to 15 weight parts of Chinese dodder seed, 5 to 15 weight parts of heterophyllous girardinia herb, 5 to 15 weight parts of hydrangea and 5 to 15 weight parts of Chinese alangium root. The invention also provides a preparation method of the anti-tumor medicinal composition. The anti-tumor medicinal composition has good curative effects and insignificant toxic and side effects, and is low in cost; the preparation method is simple, convenient and suitable for clinical application.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition and preparation method thereof, particularly a kind of antitumor medicine composition and preparation method thereof.
Background technology
Cancer is the general designation of a large class malignant tumor.The feature of cancerous cell be unrestrictedly, hypertrophy without end, the nutrient substance in patient body is consumed in a large number; Cancerous cell discharges multiple toxin, makes human body produce series of symptoms; Cancerous cell also can be transferred to whole body growth and breeding everywhere, cause human body to be become thin, unable, anemia, inappetence, heating and serious organ function impaired etc.Malignant tumor also can disorganize, organ 26S Proteasome Structure and Function, cause downright bad hemorrhage concurrent infection, patient is finally dead due to organ failure.
The essential therapeutic arsenals of current tumor is operation, chemotherapy, radiotherapy.Middle and advanced stage patient loses surgical engine meeting, though and operation can remove primary lesion, and breeding is educated in the regeneration fundamentally can not stopping cancerous cell, and post-surgical cancer very easily recurs; Though radiation and chemotherapy can kill cancerous cell, but make a large amount of normal tissue cells suffer damage simultaneously, toxic and side effects is obvious, and these toxic and side effects comprise that body is weak, inappetence, alopecia, suppression hemopoietic function, damage Liver and kidney ovarian function, bring out gastrointestinal reaction, bone marrow depression and liver, kidney, impairment of cardiac function etc.
Treatment by Chinese herbs cancer has successful experience and unique advantage, have anticancer press down swollen, improve body's immunity, reduce toxic and side effects of chemoradiotherapy, conditioner yin-yang, improve the outstanding role that band likes survival rate and life quality, especially to the rehabilitation after cancer operation, and the efficacy enhancing and toxicity reducing aspect of chemicotherapy has good effect.
Summary of the invention
Technical problem to be solved: in order to solve the defect that existing antitumor drug therapeutic effect is poor, toxic and side effects is large, the invention provides a kind of antineoplastic pharmaceutical compositions and preparation method thereof.
Technical scheme: in order to solve the problems of the technologies described above, the invention provides a kind of antineoplastic pharmaceutical compositions, comprise Radix Codonopsis 20-30 weight portion, Radix Astragali 20-30 weight portion, Radix Gentianae 20-30 weight portion, Radix Glycyrrhizae 5-15 weight portion, Semen Cuscutae 5-15 weight portion, Urtica fissa Pritz. 5-15 weight portion, Flos Hydrangeae Macrophyllae 5-15 weight portion, Radix Alangii 5-15 weight portion.
Pharmaceutical composition provided by the invention, preferred Radix Codonopsis 25 weight portion, the Radix Astragali 25 weight portion, Radix Gentianae 25 weight portion, Radix Glycyrrhizae 10 weight portion, Semen Cuscutae 10 weight portion, Urtica fissa Pritz. 10 weight portion, Flos Hydrangeae Macrophyllae 10 weight portion, Radix Alangii 10 weight portion.
Present invention also offers a kind of preparation method of antineoplastic pharmaceutical compositions, comprise the following steps:
(1) Radix Codonopsis 10-15 weight portion, Radix Astragali 10-15 weight portion, Radix Gentianae 10-15 weight portion, Radix Glycyrrhizae 10-15 weight portion, Semen Cuscutae 10-15 weight portion, Urtica fissa Pritz. 10-15 weight portion, Flos Hydrangeae Macrophyllae 10-15 weight portion, Radix Alangii 10-15 weight portion are mixed to get mixed material, add the ethanol water reflux, extract, 2-4 hour of 5-30 times of quality;
(2) elimination medicinal residues, leave standstill 12 to 24 hours, and filter, filtrate is concentrated into the clear paste that relative density is 1.12 to 1.16;
(3) clear paste adds 5-10 times of water gaging, leaves standstill 12 to 24 hours, and filter, filtrate is concentrated into dry, obtains said composition.
Wherein, in step (1), described ethanol water volume ratio is 7:3.
Wherein, in step (1), reflux temperature is 75-85 DEG C.
The quality of described ethanol water is 10-20 times of mixed material.
Beneficial effect: antineoplastic pharmaceutical compositions therapeutic effect provided by the invention is good, toxic and side effects is little, cheap, preparation method is easy, is suitable for clinical practice.
Detailed description of the invention
According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only for illustration of the present invention, and should can not limit the present invention described in detail in claims yet.
Embodiment 1 antineoplastic pharmaceutical compositions 1.
Prescription: Radix Codonopsis 250g, Radix Astragali 250g, Radix Gentianae 250g, Radix Glycyrrhizae 100g, Semen Cuscutae 100g, Urtica fissa Pritz. 100g, Flos Hydrangeae Macrophyllae 100g, Radix Alangii 100g.
Preparation method: Radix Codonopsis 250g, Radix Astragali 250g, Radix Gentianae 250g, Radix Glycyrrhizae 100g, Semen Cuscutae 100g, Urtica fissa Pritz. 100g, Flos Hydrangeae Macrophyllae 100g, Radix Alangii 100g, obtain mixed material, adds 12.5kg ethanol water reflux, extract, 3 hours;
Elimination medicinal residues, leave standstill 12 to 24 hours, and filter, filtrate is concentrated into the clear paste that relative density is 1.12 to 1.16, obtains 400ml clear paste;
Clear paste adds 3200ml water, leaves standstill 12 to 24 hours, and filter, filtrate is concentrated into dry, obtains said composition.
Embodiment 2 antineoplastic pharmaceutical compositions 2.
Prescription: Radix Codonopsis 200g, Radix Astragali 200g, Radix Gentianae 300g, Radix Glycyrrhizae 50g, Semen Cuscutae 50g, Urtica fissa Pritz. 150g, Flos Hydrangeae Macrophyllae 150g, Radix Alangii 150g.
Preparation method: Radix Codonopsis 200g, Radix Astragali 200g, Radix Gentianae 300g, Radix Glycyrrhizae 50g, Semen Cuscutae 50g, Urtica fissa Pritz. 150g, Flos Hydrangeae Macrophyllae 150g, Radix Alangii 150g are mixed, obtains mixed material, add 6.25kg ethanol water reflux, extract, 2 hours;
Elimination medicinal residues, leave standstill 12 to 24 hours, and filter, filtrate is concentrated into the clear paste that relative density is 1.12 to 1.16, obtains 120ml clear paste;
Clear paste adds 600ml water, leaves standstill 12 to 24 hours, and filter, filtrate is concentrated into dry, obtains said composition.
Embodiment 3 antineoplastic pharmaceutical compositions 3.
Prescription: Radix Codonopsis 300g, Radix Astragali 300g, Radix Gentianae 300g, Radix Glycyrrhizae 150g, Semen Cuscutae 150g, Urtica fissa Pritz. 150g, Flos Hydrangeae Macrophyllae 150g, Radix Alangii 150g.
Preparation method: by Radix Codonopsis 300g, Radix Astragali 300g, Radix Gentianae 300g, Radix Glycyrrhizae 150g, Semen Cuscutae 150g, Urtica fissa Pritz. 150g, Flos Hydrangeae Macrophyllae 150g, Radix Alangii 150g, obtain mixed material, adds 25kg ethanol water reflux, extract, 4 hours;
Elimination medicinal residues, leave standstill 12 to 24 hours, and filter, filtrate is concentrated into the clear paste that relative density is 1.12 to 1.16, obtains 500ml clear paste;
Clear paste adds 5000ml water, leaves standstill 12 to 24 hours, and filter, filtrate is concentrated into dry, obtains said composition.
Embodiment 4 antitumor evaluating drug effect.
1. laboratory animal and modeling
Regular grade ICR mice 70, male and female half and half, body weight 18-22g; Be divided into 7 groups at random after weighing, often organize 10; Be respectively: blank group, the high, medium and low dosage group of positive controls, antineoplastic pharmaceutical compositions of the present invention 1, antineoplastic pharmaceutical compositions 2 groups, antineoplastic pharmaceutical compositions 3 groups.
Select the S180 sarcoma tumor of well-grown 7-10 days, be inoculated in right side of mice armpit subcutaneous, about 4.5-5 × 10
6cell/only.
2. Experimental agents
Positive control drug: 5-FU: draw 5-FU injection 0.5ml(12.5mg), add in 9ml normal saline, be made into the solution of 1.25mg/ml.
Antineoplastic pharmaceutical compositions 1: the antineoplastic pharmaceutical compositions prepared by embodiment 1.
Antineoplastic pharmaceutical compositions 2: the antineoplastic pharmaceutical compositions prepared by embodiment 2.
Antineoplastic pharmaceutical compositions 3: the antineoplastic pharmaceutical compositions prepared by embodiment 3.
3. experiment and result
After tumor inoculation 24h, except blank group, all the other group mices give corresponding medicine.
During administration, every day measures body weight, within the 8th day, puts to death mice, claims tumor weight, calculate each group of average tumor weight, by following formulae discovery tumor control rate.
Antineoplastic pharmaceutical compositions of the present invention is little on the impact of S180 sarcoma Mouse Weight, but has obvious inhibitory action to S180 sarcoma, and the results are shown in Table 1, comparing with blank group has significant differences P<0.01.
Table 1 antineoplastic pharmaceutical compositions of the present invention is on the impact of S180 implanted solid tumor growth
P<0.01。
Claims (6)
1. antineoplastic pharmaceutical compositions, is characterized in that: be made up of Radix Codonopsis 20-30 weight portion, Radix Astragali 20-30 weight portion, Radix Gentianae 20-30 weight portion, Radix Glycyrrhizae 5-15 weight portion, Semen Cuscutae 5-15 weight portion, Urtica fissa Pritz. 5-15 weight portion, Flos Hydrangeae Macrophyllae 5-15 weight portion, Radix Alangii 5-15 weight portion.
2. a kind of antineoplastic pharmaceutical compositions according to claim 1, is characterized in that: be made up of Radix Codonopsis 25 weight portion, the Radix Astragali 25 weight portion, Radix Gentianae 25 weight portion, Radix Glycyrrhizae 10 weight portion, Semen Cuscutae 10 weight portion, Urtica fissa Pritz. 10 weight portion, Flos Hydrangeae Macrophyllae 10 weight portion, Radix Alangii 10 weight portion.
3. the preparation method of antineoplastic pharmaceutical compositions according to claim 1, is characterized in that: comprise the following steps:
(1) Radix Codonopsis 20-30 weight portion, Radix Astragali 20-30 weight portion, Radix Gentianae 20-30 weight portion, Radix Glycyrrhizae 5-15 weight portion, Semen Cuscutae 5-15 weight portion, Urtica fissa Pritz. 5-15 weight portion, Flos Hydrangeae Macrophyllae 5-15 weight portion, Radix Alangii 5-15 weight portion are mixed to get mixed material, add the ethanol water reflux, extract, 2-4 hour of 5-20 times of quality;
(2) elimination medicinal residues, leave standstill 12 to 24 hours, and filter, filtrate is concentrated into the clear paste that relative density is 1.12 to 1.16;
(3) clear paste adds 5-10 times of water gaging, leaves standstill 12 to 24 hours, and filter, filtrate is concentrated into dry, obtains said composition.
4. the preparation method of a kind of antineoplastic pharmaceutical compositions according to claim 3, is characterized in that: the quality of described ethanol water is 10-15 times of mixed material.
5. the preparation method of a kind of antineoplastic pharmaceutical compositions according to claim 3, is characterized in that: in step (1), and described ethanol water volume ratio is 7:3.
6. the preparation method of a kind of antineoplastic pharmaceutical compositions according to claim 3, is characterized in that: in step (1), and reflux temperature is 75-85 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310492341.0A CN103520263B (en) | 2013-10-18 | 2013-10-18 | Anti-tumor medicinal composition and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310492341.0A CN103520263B (en) | 2013-10-18 | 2013-10-18 | Anti-tumor medicinal composition and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103520263A CN103520263A (en) | 2014-01-22 |
| CN103520263B true CN103520263B (en) | 2015-06-03 |
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| CN201310492341.0A Active CN103520263B (en) | 2013-10-18 | 2013-10-18 | Anti-tumor medicinal composition and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101502636A (en) * | 2009-03-05 | 2009-08-12 | 张晋玮 | Pure medicinal formulation for treating cancer and preparation method thereof |
-
2013
- 2013-10-18 CN CN201310492341.0A patent/CN103520263B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101502636A (en) * | 2009-03-05 | 2009-08-12 | 张晋玮 | Pure medicinal formulation for treating cancer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《中医治则指导下抗肿瘤中药的临床分类》;龙泳伶等;《中国中医药现代远程教育》;20110630;第9卷(第12期);88-89 * |
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