CN103518969A - Feed additive for controlling avian iluenza - Google Patents
Feed additive for controlling avian iluenza Download PDFInfo
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- CN103518969A CN103518969A CN201310482592.0A CN201310482592A CN103518969A CN 103518969 A CN103518969 A CN 103518969A CN 201310482592 A CN201310482592 A CN 201310482592A CN 103518969 A CN103518969 A CN 103518969A
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Abstract
The invention discloses a feed additive for controlling avian iluenza. The additive needed for preparing 100kg of feed is prepared from the following active ingredients by weight: 30-50g of common andrographis herb, 20-40g of isatis root, 20-40g of wild chrysanthemum, 20-40g of ash bark, 10-30g of puffball, 10-30g of mung beans, 10-30g of lithospermum erythrorhizon, 10-30g of rheum officinale, 10-30g of lobed kudzuvine root, 10-30g of cortex lycii, 10-30g of rhizoma atractylodis, 10-30g of fructus evodiae, 10-30g of the root of three-nerved spicebush, 10-20g of rice grain sprout, 5-10g of amantadine and 5-10g of sulfadiazine sodium. The feed additive is simple in proportioning, is convenient to use and has good control effects and few drug residues.
Description
technical field:
The present invention relates to chicken fowl field of feed, particularly a kind of feed addictive of preventing and treating avian influenza.
background technology:
The chicken Bird Flu ，Ben Bingyou A of orthomyxoviridae family type influenza virus causes take the acute bleeding sexually transmitted disease that expiratory dyspnea, egg drop reduction be principal character.The four seasons are easily sent out, but multiple with cold season.By alimentary canal and respiratory tract contact infection.The popular malicious type of China is mild at present.
The cause of disease of chicken Bird Flu is avian influenza virus, especially, with chicken and the easy infection of dove, can pass through alimentary canal, respiratory tract, skin and mucosal infections, very harmful.Symptom breaks out, can be without any symptom die by visitation of God, and most performance spirit is depressed, does not eat, and is reluctant activity, and feather is fluffy and disorderly, and head, wing are sagging, hyperthermia; Hen, dove are laid eggs and stop; Neck oedema, toe joint swelling; The inflammation of eye conjunctiva, oral mucosa blutpunkte, paralysis, blind.The death rate reaches 50-100%, course of disease 1-2 days.Cut open inspection and change mouth, glandular stomach, muscular stomach and duodenal hemorrhage, liver,kidney,spleen, lung have lark necrosis region, and there is lark exudate on air bag, peritonaeum and fallopian tubal surface, and spleen has gangrenosum acne lymph sample tubercle.During the morbidity of chicken Bird Flu, sick chicken hyperthermia, spiritual depressed, loose random, the diet minimizing of feather; It is hemorrhage that sick chicken performance has cough, expiratory dyspnea, a face oedema, hat wattle is blue, hind leg is opened up portion's scutellum; Whole body serous coat, mucous membrane and substantial viscera are seriously extensively hemorrhage.The laying hen colony of laying eggs sharply declines, and not etc., soft egg, thin skin egg, the egg that fades do not increase fall; Adularescent thickness or egg white sample secretion in fallopian tubal.
For avian influenza, once fall ill and spread, be difficult to for the moment control, conventionally need to cheat on a large scale and bury chicken fowl, raiser has been caused to great economic loss, therefore, anti-be greater than to control be only the correct attitude in the face of avian influenza.For example: anti-virus ability, the accompanying infection of control bacterium, protection reproductive system, the early treatment that strengthen chicken fowl reduce the degree of causing a disease.Strengthen feeding and management, stop importing into of this disease; With the popular strain in locality, prepare inactivated vaccine urgent immunity; Qingwen baidu powder spice, multidimensional drinking-water.Etc..In said method, qingwen baidu powder spice is that what to commonly use is also effectively, and still, current qingwen baidu powder chemical composition is more, has caused the problem of chicken fowl medicament residue, and as chicken finished product, equal index such as the medicament residue of egg etc. is higher.In view of this technical problem, need to occur that a kind of proportioning is simple, easy to use, prevention effect is good, a kind of feed addictive of preventing and treating avian influenza that medicament residue is little.
summary of the invention:
The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of proportioning simple, easy to use, prevention effect is good, a kind of feed addictive of preventing and treating avian influenza that medicament residue is little.
To achieve these goals, the invention provides a kind of feed addictive of preventing and treating avian influenza, wherein, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 30-50g, Radix Isatidis 20-40g, mother chrysanthemum 20-40g, bark of ash 20-40g, Lasiosphaera fenzlii 10-30g, mung bean 10-30g, Asian puccoon 10-30g, rheum officinale 10-30g, root of kudzu vine 10-30g, root bark of Chinese wolf-berry 10-30g, rhizoma atractylodis 10-30g, evodia rutaecarpa 10-30g, root of three-nerved spicebush 10-30g, rice sprout 10-20g; Amantadine 5-10g, sulphoamidine pyridine sodium 5-10g.
Or, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 30-40g, Radix Isatidis 20-30g, mother chrysanthemum 20-30g, bark of ash 20-30g, Lasiosphaera fenzlii 10-20g, mung bean 10-20g, Asian puccoon 10-20g, rheum officinale 10-20g, root of kudzu vine 10-20g, root bark of Chinese wolf-berry 10-20g, rhizoma atractylodis 10-20g, evodia rutaecarpa 10-20g, root of three-nerved spicebush 10-20g, rice sprout 10-15g; Amantadine 5-8g, sulphoamidine pyridine sodium 5-8g.
Or, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 40-50g, Radix Isatidis 30-40g, mother chrysanthemum 30-40g, bark of ash 30-40g, Lasiosphaera fenzlii 20-30g, mung bean 20-30g, Asian puccoon 20-30g, rheum officinale 20-30g, root of kudzu vine 20-30g, root bark of Chinese wolf-berry 20-30g, rhizoma atractylodis 20-30g, evodia rutaecarpa 20-30g, root of three-nerved spicebush 20-30g, rice sprout 15-20g; Amantadine 8-10g, sulphoamidine pyridine sodium 8-10g.
Or, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 35-45g, Radix Isatidis 25-35g, mother chrysanthemum 25-35g, bark of ash 25-35g, Lasiosphaera fenzlii 15-25g, mung bean 15-25g, Asian puccoon 15-25g, rheum officinale 15-25g, root of kudzu vine 15-25g, root bark of Chinese wolf-berry 15-25g, rhizoma atractylodis 15-25g, evodia rutaecarpa 15-25g, root of three-nerved spicebush 15-25g, rice sprout 12-18g; Amantadine 6-9g, sulphoamidine pyridine sodium 6-9g.
Amantadine, tissue is cultivated and zoopery proves, and this medicine can prevent the not caused infection of influenza A virus of homophyletic effectively, with amantadine, chicken Bird Flu is prevented to find that this medicine has certain prevention effect.Amantadine can reduce infection probability, almost identical with the efficiency of influenza vaccines.With amantadine treatment, accelerate bring down a fever and alleviate acute infection symptom.But, use merely amantadine resultant effect limited, drug effect is not lasting.So need composite
Sulphoamidine pyridine sodium, this product is white crystalline powder; Odorless, mildly bitter flavor; Meet photochromic gradual change dark; Be long placed in humid air, i.e. absorbing carbon dioxide and separate out sulphadiazine slowly.This product is easily molten in water, slightly soluble in ethanol.This product is median acting sulfonamide class antimicrobial, to many Grain-positives and the equal tool antibacterial action of negative bacterium.Non-product enzyme staphylococcus aureus, micrococcus scarlatinae, streptococcus pneumonia, EHEC, Klebsiella, Salmonella, Shigella, NEISSERIA GONORRHOEAE, Neisseria meningitidis, haemophilus influenzae have antibacterial action, in vitro chlamydia trachomatis, star-shaped nocardia, plasmodium and Infection of Toxoplasma Gondii are also had to activity in addition.But, using merely sulphoamidine pyridine sodium, bactericidal effect is not obvious.So need composite.
Proportioning of the present invention is simple, easy to use, and prevention effect is good, and medicament residue is little, is specially:
Each traditional Chinese medicinal components is repeatedly purified and is added starch and obtain medicinal powder after flooding, by medicinal powder and amantadine, after stirring, amantadine obtains preventing and treating the feed addictive of avian influenza, to after the feed addictive of control avian influenza and feed stirring, carry out feeding, effect of the present invention use more separately amantadine or sulphoamidine pyridine sodium more remarkable, prevention effect is good.
the specific embodiment:
Configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 30-50g, Radix Isatidis 20-40g, mother chrysanthemum 20-40g, bark of ash 20-40g, Lasiosphaera fenzlii 10-30g, mung bean 10-30g, Asian puccoon 10-30g, rheum officinale 10-30g, root of kudzu vine 10-30g, root bark of Chinese wolf-berry 10-30g, rhizoma atractylodis 10-30g, evodia rutaecarpa 10-30g, root of three-nerved spicebush 10-30g, rice sprout 10-20g; Amantadine 5-10g, sulphoamidine pyridine sodium 5-10g.
Or, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 30-40g, Radix Isatidis 20-30g, mother chrysanthemum 20-30g, bark of ash 20-30g, Lasiosphaera fenzlii 10-20g, mung bean 10-20g, Asian puccoon 10-20g, rheum officinale 10-20g, root of kudzu vine 10-20g, root bark of Chinese wolf-berry 10-20g, rhizoma atractylodis 10-20g, evodia rutaecarpa 10-20g, root of three-nerved spicebush 10-20g, rice sprout 10-15g; Amantadine 5-8g, sulphoamidine pyridine sodium 5-8g.
Or, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 40-50g, Radix Isatidis 30-40g, mother chrysanthemum 30-40g, bark of ash 30-40g, Lasiosphaera fenzlii 20-30g, mung bean 20-30g, Asian puccoon 20-30g, rheum officinale 20-30g, root of kudzu vine 20-30g, root bark of Chinese wolf-berry 20-30g, rhizoma atractylodis 20-30g, evodia rutaecarpa 20-30g, root of three-nerved spicebush 20-30g, rice sprout 15-20g; Amantadine 8-10g, sulphoamidine pyridine sodium 8-10g.
Or, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 35-45g, Radix Isatidis 25-35g, mother chrysanthemum 25-35g, bark of ash 25-35g, Lasiosphaera fenzlii 15-25g, mung bean 15-25g, Asian puccoon 15-25g, rheum officinale 15-25g, root of kudzu vine 15-25g, root bark of Chinese wolf-berry 15-25g, rhizoma atractylodis 15-25g, evodia rutaecarpa 15-25g, root of three-nerved spicebush 15-25g, rice sprout 12-18g; Amantadine 6-9g, sulphoamidine pyridine sodium 6-9g.
Object lesson is as follows:
Example 1, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 50g, Radix Isatidis 40g, mother chrysanthemum 40g, bark of ash 40g, Lasiosphaera fenzlii 30g, mung bean 30g, Asian puccoon 30g, rheum officinale 30g, rheum officinale 30g, root of kudzu vine 30g, root bark of Chinese wolf-berry 30g, rhizoma atractylodis 30g, evodia rutaecarpa 30g, root of three-nerved spicebush 30g, rice sprout 20g; Amantadine 10g, sulphoamidine pyridine sodium 10g.
By Herba Andrographitis, Radix Isatidis, mother chrysanthemum, the bark of ash, Lasiosphaera fenzlii, mung bean, Asian puccoon, rheum officinale, the root of kudzu vine, the root bark of Chinese wolf-berry, rhizoma atractylodis, evodia rutaecarpa, the root of three-nerved spicebush, rice sprout is cleaned, after flooding operation, add starch, dry to obtain medicinal powder, (, decoct, extract decoction liquor one time, then boiling, then extract secondary decoction liquor; Boiling again, then extract decoction liquor three times, this decoction liquor of three times is poured on together, concentrated, add starch, after oven dry medicinal powder) after the medicinal powder that obtains adds amantadine, sulphoamidine pyridine sodium to stir, stir with 100 kilograms of feeds again, carry out feeding.
Example 2, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 30g, Radix Isatidis 20g, mother chrysanthemum 20g, bark of ash 20g, Lasiosphaera fenzlii 10g, mung bean 10g, Asian puccoon 10g, rheum officinale 10g, root of kudzu vine 10g, root bark of Chinese wolf-berry 10g, rhizoma atractylodis 10g, evodia rutaecarpa 10g, root of three-nerved spicebush 10g, rice sprout 10g; Amantadine 5g, sulphoamidine pyridine sodium 5g.
By Herba Andrographitis, Radix Isatidis, mother chrysanthemum, the bark of ash, Lasiosphaera fenzlii, mung bean, Asian puccoon, rheum officinale, the root of kudzu vine, the root bark of Chinese wolf-berry, rhizoma atractylodis, evodia rutaecarpa, the root of three-nerved spicebush, rice sprout is cleaned, after flooding operation, add starch, dry to obtain medicinal powder, (, decoct, extract decoction liquor one time, then boiling, then extract secondary decoction liquor; Boiling again, then extract decoction liquor three times, this decoction liquor of three times is poured on together, concentrated, add starch, after oven dry medicinal powder) after the medicinal powder that obtains adds amantadine, sulphoamidine pyridine sodium to stir, stir with 100 kilograms of feeds again, carry out feeding.
Example 3, configures 100 kilograms of additives that feed is required, according to unit of weight, configures following active component:
Herba Andrographitis 35g, Radix Isatidis 25g, mother chrysanthemum 25g, bark of ash 25g, Lasiosphaera fenzlii 15g, mung bean 15g, Asian puccoon 15g, rheum officinale 15g, root of kudzu vine 15g, root bark of Chinese wolf-berry 15g, rhizoma atractylodis 15g, evodia rutaecarpa 15g, root of three-nerved spicebush 15g, rice sprout 12g; Amantadine 6g, sulphoamidine pyridine sodium 6g.
By Herba Andrographitis, Radix Isatidis, mother chrysanthemum, the bark of ash, Lasiosphaera fenzlii, mung bean, Asian puccoon, rheum officinale, the root of kudzu vine, the root bark of Chinese wolf-berry, rhizoma atractylodis, evodia rutaecarpa, the root of three-nerved spicebush, rice sprout is cleaned, after flooding operation, add starch, dry to obtain medicinal powder, (, decoct, extract decoction liquor one time, then boiling, then extract secondary decoction liquor; Boiling again, then extract decoction liquor three times, this decoction liquor of three times is poured on together, concentrated, add starch, after oven dry medicinal powder) after the medicinal powder that obtains adds amantadine, sulphoamidine pyridine sodium to stir, stir with 100 kilograms of feeds again, carry out feeding.
Example 4, configures 100 kilograms of additives that feed is required, according to unit of weight, configures following active component:
Herba Andrographitis 45g, Radix Isatidis 35g, mother chrysanthemum 35g, bark of ash 35g, Lasiosphaera fenzlii 25g, mung bean 25g, Asian puccoon 25g, rheum officinale 25g, root of kudzu vine 25g, root bark of Chinese wolf-berry 25g, rhizoma atractylodis 25g, evodia rutaecarpa 25g, root of three-nerved spicebush 25g, rice sprout 18g; Amantadine 9g, sulphoamidine pyridine sodium 9g.
By Herba Andrographitis, Radix Isatidis, mother chrysanthemum, the bark of ash, Lasiosphaera fenzlii, mung bean, Asian puccoon, rheum officinale, the root of kudzu vine, the root bark of Chinese wolf-berry, rhizoma atractylodis, evodia rutaecarpa, the root of three-nerved spicebush, rice sprout is cleaned, after flooding operation, add starch, dry to obtain medicinal powder, (, decoct, extract decoction liquor one time, then boiling, then extract secondary decoction liquor; Boiling again, then extract decoction liquor three times, this decoction liquor of three times is poured on together, concentrated, add starch, after oven dry medicinal powder) after the medicinal powder that obtains adds amantadine, sulphoamidine pyridine sodium to stir, stir with 100 kilograms of feeds again, carry out feeding.
Data comparison:
By be mixed 20 chicken fowl of 100 kilograms of feed feedings 15 days of amantadine 5-10g, with influenza virus, infect 3 days (putting into one of disease chicken), observed result, as A group,
By be mixed 20 chicken fowl of 100 kilograms of feed feedings 15 days of sulphoamidine pyridine sodium 5-10g, with influenza virus, infect 3 days (putting into one of disease chicken), observed result, as B group,
By the medicinal powder in example 1-4 (preferably using the medicinal powder in example 1), (by Herba Andrographitis, Radix Isatidis, mother chrysanthemum, the bark of ash, Lasiosphaera fenzlii, mung bean, Asian puccoon, rheum officinale, the root of kudzu vine, the root bark of Chinese wolf-berry, rhizoma atractylodis, evodia rutaecarpa, the root of three-nerved spicebush, rice sprout is cleaned, after flooding operation, add starch, dry to obtain medicinal powder), be mixed 20 chicken fowl of 100 kilograms of feed feedings 15 days of this medicinal powder, with influenza virus, infect 3 days (putting into one of disease chicken), observed result, as C group.
Simple feed, 20 chicken fowl of feeding 15 days, the observed result used.With influenza virus, infect 3 days (putting into one of disease chicken), as D group.
Example 1-4 of the present invention, respectively 20 chicken fowl of feeding are 15 days, with influenza virus, infect 3 days (putting into one of disease chicken), then carry out effect comparison with tetra-groups of above-mentioned A, B, C, D, as following table:
By upper table, can find out, proportioning of the present invention is simple, easy to use, prevention effect is good, and medicament residue is little, each traditional Chinese medicinal components is repeatedly purified and is added starch and obtain medicinal powder after flooding, by medicinal powder and amantadine, after stirring, amantadine obtains preventing and treating the feed addictive of avian influenza, will after the feed addictive of control avian influenza and feed stirring, carry out feeding, effect of the present invention use more separately amantadine or sulphoamidine pyridine sodium more remarkable, prevention effect is good.Drug residue of the present invention is 80% of A group, 85% of B group, 97% of C group.
Claims (4)
1. a feed addictive of preventing and treating avian influenza, is characterized in that, configures 100 kilograms of additives that feed is required, according to unit of weight, configures following active component:
Herba Andrographitis 30-50g, Radix Isatidis 20-40g, mother chrysanthemum 20-40g, bark of ash 20-40g, Lasiosphaera fenzlii 10-30g, mung bean 10-30g, Asian puccoon 10-30g, rheum officinale 10-30g, root of kudzu vine 10-30g, root bark of Chinese wolf-berry 10-30g, rhizoma atractylodis 10-30g, evodia rutaecarpa 10-30g, root of three-nerved spicebush 10-30g, rice sprout 10-20g; Amantadine 5-10g, sulphoamidine pyridine sodium 5-10g.
2. prevent and treat according to claim 1 the feed addictive of avian influenza, it is characterized in that, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 30-40g, Radix Isatidis 20-30g, mother chrysanthemum 20-30g, bark of ash 20-30g, Lasiosphaera fenzlii 10-20g, mung bean 10-20g, Asian puccoon 10-20g, rheum officinale 10-20g, root of kudzu vine 10-20g, root bark of Chinese wolf-berry 10-20g, rhizoma atractylodis 10-20g, evodia rutaecarpa 10-20g, root of three-nerved spicebush 10-20g, rice sprout 10-15g; Amantadine 5-8g, sulphoamidine pyridine sodium 5-8g.
3. prevent and treat according to claim 1 the feed addictive of avian influenza, it is characterized in that, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 40-50g, Radix Isatidis 30-40g, mother chrysanthemum 30-40g, bark of ash 30-40g, Lasiosphaera fenzlii 20-30g, mung bean 20-30g, Asian puccoon 20-30g, rheum officinale 20-30g, root of kudzu vine 20-30g, root bark of Chinese wolf-berry 20-30g, rhizoma atractylodis 20-30g, evodia rutaecarpa 20-30g, root of three-nerved spicebush 20-30g, rice sprout 15-20g; Amantadine 8-10g, sulphoamidine pyridine sodium 8-10g.
4. prevent and treat according to claim 1 the feed addictive of avian influenza, it is characterized in that, configure 100 kilograms of additives that feed is required, according to unit of weight, configure following active component:
Herba Andrographitis 35-45g, Radix Isatidis 25-35g, mother chrysanthemum 25-35g, bark of ash 25-35g, Lasiosphaera fenzlii 15-25g, mung bean 15-25g, Asian puccoon 15-25g, rheum officinale 15-25g, root of kudzu vine 15-25g, root bark of Chinese wolf-berry 15-25g, rhizoma atractylodis 15-25g, evodia rutaecarpa 15-25g, root of three-nerved spicebush 15-25g, rice sprout 12-18g; Amantadine 6-9g, sulphoamidine pyridine sodium 6-9g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310482592.0A CN103518969A (en) | 2013-10-16 | 2013-10-16 | Feed additive for controlling avian iluenza |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138656A (en) * | 2015-04-08 | 2016-11-23 | 罗彩莲 | A kind of medicine treating avian influenza |
| CN106359886A (en) * | 2016-09-18 | 2017-02-01 | 贝嘉美（天津）生物技术研发有限公司 | Minor element feed additive |
-
2013
- 2013-10-16 CN CN201310482592.0A patent/CN103518969A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138656A (en) * | 2015-04-08 | 2016-11-23 | 罗彩莲 | A kind of medicine treating avian influenza |
| CN106359886A (en) * | 2016-09-18 | 2017-02-01 | 贝嘉美（天津）生物技术研发有限公司 | Minor element feed additive |
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Application publication date: 20140122 |