CN103506342A - Clean-in-place unit of pharmaceutical equipment - Google Patents
Clean-in-place unit of pharmaceutical equipment Download PDFInfo
- Publication number
- CN103506342A CN103506342A CN201310483618.3A CN201310483618A CN103506342A CN 103506342 A CN103506342 A CN 103506342A CN 201310483618 A CN201310483618 A CN 201310483618A CN 103506342 A CN103506342 A CN 103506342A
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- CN
- China
- Prior art keywords
- tank body
- heat exchanger
- pharmaceutical equipment
- place
- cleaning unit
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B2203/00—Details of cleaning machines or methods involving the use or presence of liquid or steam
- B08B2203/007—Heating the liquid
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention discloses a clean-in-place unit of pharmaceutical equipment. The clean-in-place unit of the pharmaceutical equipment comprises a tank body, a heat exchanger and a unit control cabinet, wherein the heat exchanger is a sterile double-tube-plate heat exchanger, the upper end of the tank body and the lower end of the tank body are both connected with the heat exchanger through pipelines, pneumatic diaphragm valves are arranged on the pipelines between the tank body and the heat exchanger respectively, a washing pump and a reflux pump are arranged on the pipeline between the lower end of the tank body and the heat exchanger, an electric control valve is arranged on a steam pipeline which is connected with the heat exchanger, two acid-base tanks are arranged below the tank body, the two acid-base tanks are connected to the tank body through metering pumps, and all valves are connected with the unit control cabinet. The clean-in-place unit of the pharmaceutical equipment has the advantages that working efficiency is high, the sterile double-tube-plate heat exchanger is not prone to leakage, cross contamination of bidirectional media is avoided, and production quality of drugs is guaranteed.
Description
Technical field
The present invention relates to a kind of cleaning unit, specifically a kind of pharmaceutical equipment for pharmaceutical industry cleaning unit in place.
Background technology
In existing cleaning unit, mainly adopted traditional heat exchangers as firing equipment, this kind equipment fineness and complete emptyingly cannot meet the good job specification of new edition GMP() requirement, in order effectively to address the above problem, those skilled in the art,, by further investigation, gradually adopt aseptic double tube plate heat exchanger to replace traditional heat exchangers at present.Yet Problems In Heat Exchangers has solved, for control, the FDA(Food and Drug Administration cleaned) the also not well solution of technological difficulties such as requirements, space size.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical equipment cleaning unit in place, this cleans, and unit volume is little, operating efficiency is high, aseptic double tube plate heat exchanger is difficult for leaking, and has solved the problem that cross pollution affects drug quality.
The present invention solves the technical scheme that its technical problem takes: a kind of pharmaceutical equipment cleaning unit in place, comprise tank body, heat exchanger and machine set control cabinet, described heat exchanger is aseptic double tube plate heat exchanger, the two ends up and down of described tank body are connected with heat exchanger respectively by pipeline, on pipeline between tank body and heat exchanger, be respectively arranged with pneumatic diaphragm valve, pipeline between tank body lower end and heat exchanger is provided with scavenging pump and reflux pump, on the steam pipework being connected, is provided with electric control valve with heat exchanger; The below of tank body is provided with two soda acid tanks, and two soda acid tanks are connected to tank body by measuring pump respectively; Each valve is all connected with machine set control cabinet.
Described tank body is pharmacy Special cleaning tank, and tank inner surface fineness is less than 0.41 micron, and tank body outer surface is provided with heat-insulation layer.
The thickness of described heat-insulation layer is 50 millimeters.
Described tank body adopts stainless steel material to make, and the corner of tank interior all forms round-corner transition, and the junction of tank body is and is welded.
Described pneumatic diaphragm valve comprises valve and lower valve, and upper valve and lower valve are arranged on a distributor upper end.
Described pipeline is without blind pipe design, entirely emptying.
Described machine set control cabinet is provided with man-machine interface, and the display screen of man-machine interface is touch-screen.
Described heat exchanger adopts 316L stainless steel to make.
Compared with prior art, the present invention has following outstanding beneficial effect:
1, cleaning fluid can reach the effect of moment intensification by aseptic double tube plate heat exchanger, has improved operating efficiency.
2, aseptic double tube plate heat exchanger adopts 316L stainless steel to make, meet the current requirements of FDA and GMP, corrosion resistance is strong, adopt unified material, there is unified thermal coefficient of expansion, when variations in temperature, can not produce local stress, difficult leakage, can there is not cross pollution in bi-directional medium, for the quality of production of medicine provides guarantee.
3, volume is little, takes up room little, easy to use.
Accompanying drawing explanation
Fig. 1 is front view of the present invention (pipeline is not shown);
Fig. 2 is the left view (soda acid tank, pneumatic diaphragm valve, distributor and part pipeline are not shown) of Fig. 1.
In figure: 1 soda acid tank, 2 measuring pumps, 3 tank bodies, 4 heat exchangers, 5 pneumatic diaphragm valves, 6 distributors, 7 man-machine interfaces, 8 machine set control cabinets.
The specific embodiment
Below in conjunction with Figure of description and specific embodiment, the invention will be further described:
As shown in Figure 1 and Figure 2, a kind of pharmaceutical equipment cleaning unit in place, comprise tank body 3, heat exchanger 4 and machine set control cabinet 8, described heat exchanger 4 is aseptic double tube plate heat exchanger, the two ends up and down of described tank body 3 are connected with heat exchanger 4 respectively by pipeline, on pipeline between tank body 3 and heat exchanger 4, be respectively arranged with pneumatic diaphragm valve 5, the pipeline between tank body 3 lower ends and heat exchanger 4 is provided with scavenging pump and reflux pump, on the steam pipework being connected, is provided with electric control valve with heat exchanger 4; The below of tank body 3 is provided with 1, two soda acid tank 1 of two soda acid tanks and by measuring pump 2, is connected to tank body 3 respectively; Each valve is all connected with machine set control cabinet 8.
Described tank body 3 is pharmacy Special cleaning tank, and tank body 3 inner surface fineness are less than 0.41 micron, and tank body 3 outer surfaces are provided with heat-insulation layer.
The thickness of described heat-insulation layer is 50 millimeters.
Described tank body 3 adopts stainless steel material to make, and the corner of tank body 3 inside all forms round-corner transition, and the junction of tank body 3 is and is welded.
Described pneumatic diaphragm valve 5 comprises valve and lower valve, and upper valve and lower valve are arranged on distributor 6 upper ends.
Described pipeline is without blind pipe design, entirely emptying.Pipeline meets 3D designing requirement.
Described machine set control cabinet 8 is provided with man-machine interface 7, and the display screen of man-machine interface 7 is touch-screen.
Described heat exchanger 4 adopts 316L stainless steel to make, and corrosion resistance is strong, adopts unified material, there is unified thermal coefficient of expansion, when variations in temperature, can not produce local stress, difficult leakage, can there is not cross pollution in bi-directional medium, for the quality of production of medicine provides guarantee.
In pharmaceutical equipment of the present invention cleaning unit in place, the equipment contacting with material all adopts 316L stainless steel to make, and unit can be realized function of on-line cleaning and SIP disinfect in situ system self disinfection function.
Described pneumatic diaphragm valve 5 executive systems are carried operation, circulation, pressure control, shunting, and the unlatching of each valve is controlled automatically by machine set control cabinet 8, and pipeline and valve all can carry out independent cleaning by situ cleaning system, have reduced to greatest extent cleaning dead angle.
Two soda acid tanks 1 contain respectively acid solution, alkali lye, by measuring pump 2, are connected to tank body 3, complete the configuration of cleaning fluid in tank body 3.Distributor 6 Shang Ge road pneumatic diaphragm valves 5 are transported to cleaning fluid pipeline and the equipment that need to clean.Operator controls by man-machine interface 7 and 8 pairs of whole cleaning processes of machine set control cabinet.
Cleaning when pharmaceutical equipment of the present invention cleaning unit in place is used has following several scheme:
During routine operation, first constant volume, then rinses in advance by purified water, then uses cleaning fluid wash cycles, then with water for injection, carries out fine purifiation, then with clean compressed air, purges, and finally uses pure steam sterilizing.
When self cleans, first by purified water, rinse in advance, then constant volume, then uses cleaning fluid wash cycles, then with water for injection, carries out fine purifiation, then with clean compressed air, purges, and finally uses pure steam sterilizing.
In the process to cleaning fluid heating, adjust acid base concentration simultaneously, save effective time, different cleaning operating modes, adopts different cleaning temperatures and acid base concentration.
The above, principles more of the present invention just explain through diagrams, this description is not that in concrete structure and the scope of application described shown in the present invention will being confined to, therefore the corresponding modify being likely utilized every and equivalent, all belong to the scope of the claims that the present invention applies for.
Except technical characterictic described in description, all the other technical characterictics are those skilled in the art's known technology.
Claims (8)
1. a pharmaceutical equipment cleaning unit in place, comprise tank body, heat exchanger and machine set control cabinet, it is characterized in that, described heat exchanger is aseptic double tube plate heat exchanger, the two ends up and down of described tank body are connected with heat exchanger respectively by pipeline, on pipeline between tank body and heat exchanger, be respectively arranged with pneumatic diaphragm valve, the pipeline between tank body lower end and heat exchanger is provided with scavenging pump and reflux pump, on the steam pipework being connected, is provided with electric control valve with heat exchanger; The below of tank body is provided with two soda acid tanks, and two soda acid tanks are connected to tank body by measuring pump respectively; Each valve is all connected with machine set control cabinet.
2. a kind of pharmaceutical equipment according to claim 1 cleaning unit in place, is characterized in that, described tank body is pharmacy Special cleaning tank, and tank inner surface fineness is less than 0.41 micron, and tank body outer surface is provided with heat-insulation layer.
3. a kind of pharmaceutical equipment according to claim 2 cleaning unit in place, is characterized in that, the thickness of described heat-insulation layer is 50 millimeters.
4. a kind of pharmaceutical equipment according to claim 3 cleaning unit in place, is characterized in that, described tank body adopts stainless steel material to make, and the corner of tank interior all forms round-corner transition, and the junction of tank body is and is welded.
5. a kind of pharmaceutical equipment according to claim 4 cleaning unit in place, is characterized in that, described pneumatic diaphragm valve comprises valve and lower valve, and upper valve and lower valve are arranged on a distributor upper end.
6. a kind of pharmaceutical equipment according to claim 5 cleaning unit in place, is characterized in that, described pipeline is without blind pipe design, entirely emptying.
7. according to the cleaning unit in place of a kind of pharmaceutical equipment described in claim 1 or 6, it is characterized in that, described machine set control cabinet is provided with man-machine interface, and the display screen of man-machine interface is touch-screen.
8. according to the cleaning unit in place of a kind of pharmaceutical equipment described in claim 1 or 6, it is characterized in that, described heat exchanger adopts 316L stainless steel to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310483618.3A CN103506342A (en) | 2013-10-16 | 2013-10-16 | Clean-in-place unit of pharmaceutical equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310483618.3A CN103506342A (en) | 2013-10-16 | 2013-10-16 | Clean-in-place unit of pharmaceutical equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103506342A true CN103506342A (en) | 2014-01-15 |
Family
ID=49890072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310483618.3A Pending CN103506342A (en) | 2013-10-16 | 2013-10-16 | Clean-in-place unit of pharmaceutical equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103506342A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050183744A1 (en) * | 2004-02-23 | 2005-08-25 | Staub Richard K. | Methods for treating CIP equipment and equipment for treating CIP equipment |
| US20080210262A1 (en) * | 2004-04-16 | 2008-09-04 | Normand Lauzon | Cleaning Method and Apparatus |
| CN201261022Y (en) * | 2008-09-11 | 2009-06-24 | 上海远跃轻工机械有限公司 | Intelligent type on-line cleaning system |
| CN201558836U (en) * | 2009-12-28 | 2010-08-25 | 中国船舶重工集团公司第七�三研究所 | CIP (Cleaning In Place) automatic cleaning device |
| CN201768703U (en) * | 2010-07-26 | 2011-03-23 | 济南西斯普换热系统有限公司 | Instant-heating CIP cleaning machine set |
| CN102338572A (en) * | 2010-07-26 | 2012-02-01 | 济南西斯普换热系统有限公司 | Sterile dual-tubeplate shell-and-tube heat exchanger |
| CN202143889U (en) * | 2011-07-01 | 2012-02-15 | 绿雪生物工程(深圳)有限公司 | In-situ cleaning system |
| CN203508471U (en) * | 2013-10-16 | 2014-04-02 | 济南西斯普换热系统有限公司 | In-place cleaning unit of pharmaceutical equipment |
-
2013
- 2013-10-16 CN CN201310483618.3A patent/CN103506342A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050183744A1 (en) * | 2004-02-23 | 2005-08-25 | Staub Richard K. | Methods for treating CIP equipment and equipment for treating CIP equipment |
| US20080210262A1 (en) * | 2004-04-16 | 2008-09-04 | Normand Lauzon | Cleaning Method and Apparatus |
| CN201261022Y (en) * | 2008-09-11 | 2009-06-24 | 上海远跃轻工机械有限公司 | Intelligent type on-line cleaning system |
| CN201558836U (en) * | 2009-12-28 | 2010-08-25 | 中国船舶重工集团公司第七�三研究所 | CIP (Cleaning In Place) automatic cleaning device |
| CN201768703U (en) * | 2010-07-26 | 2011-03-23 | 济南西斯普换热系统有限公司 | Instant-heating CIP cleaning machine set |
| CN102338572A (en) * | 2010-07-26 | 2012-02-01 | 济南西斯普换热系统有限公司 | Sterile dual-tubeplate shell-and-tube heat exchanger |
| CN202143889U (en) * | 2011-07-01 | 2012-02-15 | 绿雪生物工程(深圳)有限公司 | In-situ cleaning system |
| CN203508471U (en) * | 2013-10-16 | 2014-04-02 | 济南西斯普换热系统有限公司 | In-place cleaning unit of pharmaceutical equipment |
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| PB01 | Publication | ||
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Application publication date: 20140115 |