CN103505571A - Traditional Chinese medicine for treating femur head diseases and preparation method thereof - Google Patents
Traditional Chinese medicine for treating femur head diseases and preparation method thereof Download PDFInfo
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- CN103505571A CN103505571A CN201210208387.0A CN201210208387A CN103505571A CN 103505571 A CN103505571 A CN 103505571A CN 201210208387 A CN201210208387 A CN 201210208387A CN 103505571 A CN103505571 A CN 103505571A
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Abstract
The invention discloses a traditional Chinese medicine for treating femur head diseases. The traditional Chinese medicine comprises active components and auxiliary materials. The traditional Chinese medicine is characterized in that the active components comprise, by weight, 1400 to 1600 parts of Chinese angelica, 1400 to 1600 parts of pseudo-ginseng, 1400 to 1600 parts of lumbricus, 50 to 150 parts of pearl powder, 50 to 150 parts of Chinese magnoliavine fruit, 50 to 100 parts of borneol, 40 to 60 parts of saffron and 15 to 25 parts of total saponins of the stem and the leaf of ginseng. A preparation method for the traditional Chinese medicine comprises the following steps: pulverizing Chinese angelica, pseudo-ginseng, lumbricus, Chinese magnoliavine fruit and saffron into powder, adding pearl powder, borneol and total saponins of the stem and the leaf of ginseng and carrying out uniform mixing; and preparing a water bound pill or a granule so as to obtain the traditional Chinese medicine. The traditional Chinese medicine provided by the invention has effects on promoting blood circulation to remove blood stasis, clearing and activating the channels and collaterals, nourishing blood and engendering bones and is mainly applied to femur head necrosis and the like caused by malnutrition of muscles and bones.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine for the treatment of femoral head illness and preparation method thereof.
Background technology
Femur head necrosis is the generally acknowledged difficult disease of world's orthopaedics, and its serious harm human health, gently disables, severe one paralysis, disability and self care ability.The cause of disease that generally believes femur head necrosis is mainly: wound, hormone, excessive drinking or osteoporosis etc.Its symptom of mainly coming personally is pain and hip joint movable function obstacle.For this disease, mainly take conservative treatment early stage, late period is the artificial replacement's arts that adopt more.Though have the medicine of multiple treatment femur head necrosis to occur at present, exist in various degree the defects such as prescription is numerous and diverse, cost is high, the course for the treatment of is long, side effect is large, curative effect is undesirable.
Summary of the invention
The present invention cures the understanding of femoral head illness and medication experience based on China's Traditional Chinese Medicine theory and in conjunction with China's folk tradition bone, selected seven taste Chinese crude drugs, through scientific and reasonable compatibility, and by the theoretical prescription of traditional Chinese medical science pharmacology and be prepared into oral medicine by pharmaceutics principle, provide the medicine of the treatment femoral head illness that a kind of prescription is unique, cost is low, safe and reliable, evident in efficacy.
For achieving the above object, the technical solution used in the present invention is:
A kind of Chinese medicine for the treatment of femoral head illness, comprise active component and adjuvant, count by weight its active component and be: 1400～1600 parts of Radix Angelicae Sinensis, 1400～1600 parts of Radix Notoginseng, 1400～1600 parts of Pheretimas, 50～150 parts of Margarita powder, 50～150 parts of Fructus Schisandrae Chinensis, 50～100 parts of Borneolum Syntheticums, 40～60 parts of Stigma Crocis, 15～25 parts of stem and leaf of Radix Ginseng total saponins.
The Chinese medicine of described treatment femoral head illness, counts by weight its active component and is preferably: 1500 parts of Radix Angelicae Sinensis, 1500 parts of Radix Notoginseng, 1500 parts of Pheretimas, 100 parts of Margarita powder, 100 parts of Fructus Schisandrae Chinensis, 80 parts of Borneolum Syntheticums, 50 parts of Stigma Crocis, 20 parts of stem and leaf of Radix Ginseng total saponins.
The Chinese medicine of described treatment femoral head illness is made the conventional peroral dosage forms such as the watered pill or granule.
Another object of the present invention is to provide a kind of preparation method of Chinese medicine of described treatment femoral head illness, its preparation method is: get Radix Angelicae Sinensis, Radix Notoginseng, Pheretima, Fructus Schisandrae Chinensis, Stigma Croci powder and become fine powder, add Margarita powder, Borneolum Syntheticum, stem and leaf of Radix Ginseng total saponins, mix homogeneously, controlling the water circulation ball or granulation agent, obtain.
Prescription of the present invention is unique, each component drug synergism, complement each other, compatibility is reasonable, has blood circulation promoting and blood stasis dispelling, dredge the meridian passage, an effect of the bone growth promoting that nourishes blood, and is mainly used in obstruction of collaterals by blood stasis, muscles and bones mistake is supported the diseases such as caused femur head necrosis.This product is by the theoretical prescription of traditional Chinese medical science pharmacology and be prepared into oral medicine by pharmaceutics principle, and its prescription compatibility is rigorous, and drug effect is remarkable, selects YAOJING thin, and medical material is easy to get, and has no side effect.The present invention adopts modern crafts high efficiency extraction preparation, production process environmental friendliness, and product stability is guaranteed.
The specific embodiment
Below in conjunction with embodiment, to further instruction of the present invention, in embodiment, be parts by weight, but the present invention is not limited thereto.
Application Example one
Embodiment 1
Get Radix Angelicae Sinensis 1500g, Radix Notoginseng 1500g, Pheretima 1500g, Fructus Schisandrae Chinensis 100g, Stigma Croci 50g powder becomes fine powder, adds Margarita powder 100g, Borneolum Syntheticum 80g, stem and leaf of Radix Ginseng total saponins 20g, mix homogeneously, controlling the water circulation ball or granulation agent, obtain.
Embodiment 2
Get Radix Angelicae Sinensis 1400g, Radix Notoginseng 1500g, Pheretima 1600g, Fructus Schisandrae Chinensis 80g, Stigma Croci 50g powder becomes fine powder, adds Margarita powder 100g, Borneolum Syntheticum 100g, stem and leaf of Radix Ginseng total saponins 20g, mix homogeneously, controlling the water circulation ball or granulation agent, obtain.
Embodiment 3
Get Radix Angelicae Sinensis 1600g, Radix Notoginseng 1400g, Pheretima 1500g, Fructus Schisandrae Chinensis 100g, Stigma Croci 55g powder becomes fine powder, adds Margarita powder 110g, Borneolum Syntheticum 60g, stem and leaf of Radix Ginseng total saponins 15g, mix homogeneously, controlling the water circulation ball or granulation agent, obtain.
Embodiment 4
Get Radix Angelicae Sinensis 1500g, Radix Notoginseng 1400g, Pheretima 1600g, Fructus Schisandrae Chinensis 100g, Stigma Croci 45g powder becomes fine powder, adds Margarita powder 90g, Borneolum Syntheticum 90g, stem and leaf of Radix Ginseng total saponins 25g, mix homogeneously, controlling the water circulation ball or granulation agent, obtain.
Embodiment 5
Get Radix Angelicae Sinensis 1500g, Radix Notoginseng 1600g, Pheretima 1400g, Fructus Schisandrae Chinensis 120g, Stigma Croci 40g powder becomes fine powder, adds Margarita powder 80g, Borneolum Syntheticum 90g, stem and leaf of Radix Ginseng total saponins 20g, mix homogeneously, controlling the water circulation ball or granulation agent, obtain.
Application Example two: finished product is differentiated
Embodiment 6
Get 5 grams of this product and put micro-Microscopic observation, muscle fiber is colourless, faint yellow or light green color, and wavy is crooked or slightly tight straight, and fall apart from or be straight being staggered sometimes, the colourless or light green of irregular block sheet, translucent, glossy.Sometimes visible fine and closely woven wavy grain or stratification lines, add dilute hydrochloric acid and produce rapidly bubble.Mycelia is elongated, colourless, not branch or branch, and intensive intersection is agglomerating or fragment into joint.
Embodiment 7
Get 5 grams of this product, the grinding 40ml that adds diethyl ether, supersound process 15 minutes, filter, filtrate is waved to 1ml, as need testing solution, separately get Radix Angelicae Sinensis control medicinal material 0.2g, 10ml adds diethyl ether, be made in the same way of control medicinal material solution, according to thin layer chromatography (2000 editions appendix VIB of Chinese Pharmacopoeia), test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, normal butane-the ethyl acetate (9: 1) of take is developing solvent, launch, take out, dry, put under uviol lamp (365nm) and inspect, in test sample chromatograph, with control medicinal material chromatograph relevant position on the fluorescence speckle of aobvious same color.
Embodiment 8
Get this product 9g and add water 4ml, shake up, add water saturated n-butyl alcohol 20ml, sealing, jolting 10 minutes, places 2 hours, centrifugal, get supernatant, add the water 20ml that n-butyl alcohol is saturated and shake up, placement makes layering, (centrifugal if desired), gets n-butanol layer, evaporate to dryness, residue adds methanol 1ml to be made to dissolve, as need testing solution.Separately get ginsenoside R and arasaponin R1 reference substance, add methanol and make the solution that converges that every 1ml respectively contains 0.5mg, product solution, according to thin layer chromatography (2000 editions appendix VIB of Chinese Pharmacopoeia) experiment, draws each 5 μ l of above-mentioned two kinds of solution in contrast, put respectively on same silica gel g thin-layer plate, the upper solution of normal butane-ethyl acetate-water (4: 1: 5) of take is developing solvent, launches, and takes out, dry, spray is with ethanol solution of sulfuric acid (1 → 10).With 106 ℃ of bakings approximately 10 minutes.In test sample chromatograph, with control medicinal material chromatograph relevant position on the fluorescence speckle of aobvious same color.
Application Example three: clinical application effect
One, usage and consumption:
Oral, a 5g-10g, 3 times on the one 3 months is a course for the treatment of.1 hour ante cibum warm water delivery service.Anemia of pregnant woman is cautious use of.Avoid and use hormone medicine.Period in a medicine is avoided tobacco and wine.
Two, criterion of therapeutical effect:
With reference to X-P in the 108th page " femur head necrosis therapeutic evaluation " in " integrative therapy femur head necrosis " (Guo Yongchang, Deng like that publishing house of democracy Bian， Henan Medical Univ. publishes) book, judge definition and criterion of therapeutical effect.
1) outstanding: pain disappears, and joint motion is normal, and X-P is determined with the image of reparation.
2) good: pain obviously alleviates or substantially disappears, hip joint is movable obviously to be improved, and takes care of oneself, and abandons to turn walking ，X-P judging section sclerotin and have reparation phenomenon.
3) can: pain relief, funtion part is recovered, life still can be taken care of oneself, X-P judges that sclerotin repairs phenomenon to some extent.
4) poor: pain does not subtract, walk lamely obviously, the difficulty of squatting down, life inconvenience, X-P judges that bone destruction is serious.
With medicine of the present invention, treated case and reached 100 many cases, determined curative effect, that wherein cures (outstanding, good) completely accounts for 60%, basic healing (can) account for 29%, total effective rate reaches 91%.Following selection portion is divided the curative effect of healing case history with explanation medicine of the present invention.
Three, model case:
Example 1
Zhao X, man, 47 years old, once used hormones because treating non-specific encephalitis in one's early years.After right hip joint wounds in 2000, occur right lower extremity, the right hip arthralgia, in JIUYUE, 2002 X-radiodiagnosis x has femoral head crackle, and that the outer place of femoral head has is cracked, subside, and walking limping pain increases the weight of by sky, can't take care of oneself, and is diagnosed as right lateral thigh head necrosis early stage.Successively arrive the ground such as Xi'an, Beijing, Shanghai, through too much family's hospitalize is all ineffective, the state of an illness is day by day serious.Rise in May, 2005, takes medicine of the present invention after 4 months, and the atrophy sick lower limb that walking is walked lamely as bavin recovers normal, and freely, radiodiagnosis femoral head is cracked, the disappearance of subsiding in walking, and bone trabecula is arranged fine and close, cures completely.Visit not recurrence so far.X-P is judged to be outstanding.
Example 2
Open XX, man, 55 years old, because of wound and hormone, caused that left side femoral head is cracked, subside, interior 1/4th places distortion in June, 2009.There is serious hindrance in suffering limb, leans on crutches.Take medicine of the present invention after 1 course for the treatment of, in JIUYUE, 2009, substantially cure, throw away crutches; After taking again 2 courses for the treatment of, cure completely, activity freely.X-P is judged to be outstanding.
Example 3
Soup X, female, 51 years old, because other diseases cause that with hormone fl head is downright bad, other hospitalizes 3 years, femoral head became flat at that time, distortion, gap increases, and thigh atrophy walking is walked lamely, hurt like hell, and defecation inconvenience, can't take care of oneself.Take medicine of the present invention restore funcitons gradually after 1 course for the treatment of, pain alleviates greatly, defecation normal, after take again 1 course for the treatment of, it is normal that all functions are recovered.X-P is judged to be outstanding.
Example 4
Lee XX, man, 45 years old, hormone and wound caused right femur head necrosis, first by many hospitalizes, did not feel any better.Take 2 courses for the treatment of of medicine of the present invention (6 months), radiodiagnosis bone trabecula is high-visible, articular surface smooth and continuous, and gap normal, activity is freely.X-P is judged to be well.
Example 5
History X, man, 65 years old, within 2008, because hormone causes that fl head aseptic ischemic is downright bad, elder generation was by many hospitalizes, not only invalid, is on the rise on the contrary.The femoral head crown subsides, and has sequestrum, and bone density increases, but transmittance is uneven, and walking disorder is walked lamely, and stool is inconvenient.Take 2 courses for the treatment of of medicine of the present invention, substantially cure.The new osteogenesis of radiodiagnosis, sequestrum is absorbed gradually, and bone density is even, and articular surface is smooth and continuous comparatively.X-P is judged to be well.
Claims (4)
1. a Chinese medicine for the treatment of femoral head illness, comprise active component and adjuvant, it is characterized in that counting by weight its active component and be: 1400～1600 parts of Radix Angelicae Sinensis, 1400～1600 parts of Radix Notoginseng, 1400～1600 parts of Pheretimas, 50～150 parts of Margarita powder, 50～150 parts of Fructus Schisandrae Chinensis, 50～100 parts of Borneolum Syntheticums, 40～60 parts of Stigma Crocis, 15～25 parts of stem and leaf of Radix Ginseng total saponins.
2. the Chinese medicine for the treatment of femoral head illness according to claim 1, is characterized in that counting by weight its active component and is: 1500 parts of Radix Angelicae Sinensis, 1500 parts of Radix Notoginseng, 1500 parts of Pheretimas, 100 parts of Margarita powder, 100 parts of Fructus Schisandrae Chinensis, 80 parts of Borneolum Syntheticums, 50 parts of Stigma Crocis, 20 parts of stem and leaf of Radix Ginseng total saponins.
3. the Chinese medicine for the treatment of femoral head illness according to claim 1 and 2, is characterized in that: the Chinese medicine of described treatment femoral head illness is made the watered pill or granule.
4. a preparation method for the treatment of as claimed in claim 1 the Chinese medicine of femoral head illness, it is characterized in that comprising the steps: to get Radix Angelicae Sinensis, Radix Notoginseng, Pheretima, Fructus Schisandrae Chinensis, Stigma Croci powder and become fine powder, add Margarita powder, Borneolum Syntheticum, stem and leaf of Radix Ginseng total saponins, mix homogeneously, controlling the water circulation ball or granulation agent, obtain.
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| CN201210208387.0A CN103505571B (en) | 2012-06-21 | 2012-06-21 | A kind ofly treat Chinese medicine of femoral head illness and preparation method thereof |
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| CN201210208387.0A CN103505571B (en) | 2012-06-21 | 2012-06-21 | A kind ofly treat Chinese medicine of femoral head illness and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737732A (en) * | 2023-01-06 | 2023-03-07 | 北京朕荣国际生物科技有限公司 | Medicine composition for treating compact osteitis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1531938A (en) * | 2003-03-19 | 2004-09-29 | 王璐林 | Chinese medicinal preparation for treating femoral head necrosis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1531938A (en) * | 2003-03-19 | 2004-09-29 | 王璐林 | Chinese medicinal preparation for treating femoral head necrosis |
Non-Patent Citations (1)
| Title |
|---|
| 吴晶晶: "人参皂苷对小鼠骨髓MSC体外增殖及成骨分化的影响", 《中国优秀硕士学位论文全文数据库（医药卫生科技辑）》, 15 October 2010 (2010-10-15) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737732A (en) * | 2023-01-06 | 2023-03-07 | 北京朕荣国际生物科技有限公司 | Medicine composition for treating compact osteitis |
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