CN103503881A - Sterilization composition containing prothioconazole and famoxadone - Google Patents
Sterilization composition containing prothioconazole and famoxadone Download PDFInfo
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- CN103503881A CN103503881A CN201310417592.2A CN201310417592A CN103503881A CN 103503881 A CN103503881 A CN 103503881A CN 201310417592 A CN201310417592 A CN 201310417592A CN 103503881 A CN103503881 A CN 103503881A
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Abstract
The invention relates to sterilization composition containing prothioconazole and famoxadone. The sterilization composition comprises the following effective constituents: prothioconazole and famoxadone, wherein the mass ratio of prothioconazole to famoxadone is (1-50) to (50-1). A preparation comprises the following constituents: effective constituents-prothioconazole and famoxadone, and auxiliary constituents accepted and allowed for use in farm chemicals, wherein the mass percentage of the effective constituents is 1%-80%. The sterilization composition has dosage forms of missible oil, a suspending agent, wettable powder, water dispersible granules, an emulsion in water, a microemulsion, granules and a microcapsule, and is mainly used for preventing and treating powdery mildew, banded sclerotial blight, wilt diseases, leaf spot diseases, rust diseases, stalk break, net blotch, sheath blight, glume blight, downy mildew and late blight of wheat, barley, rapes, peanuts, paddy rice and bean crops.
Description
Technical field
The present invention relates to agriculture chemical compounding technical field, particularly relate to and a kind ofly contain prothioconazoles Yu the bactericidal composition of famoxadone.
Background technology
Prothioconazoles is a kind of New-type wide-spectrum triazolinthione series bactericidal agent of Beyer Co., Ltd's development, and prothioconazoles toxicity is low, and without teratogenesis, mutagenesis type, to embryo's avirulence, to human and environment safety.Prothioconazoles is mainly used in preventing and treating cereal crop as numerous diseases such as wheat, barley, rape, peanut, paddy rice and legume crops.Almost all wheat class diseases are had to good control efficiency, as the powdery mildew of Wheat and barley, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc.Can also prevent and treat the soil-borne disease of oily Lay and peanut, as stalk break, and main foliage disease, as gray mold, black spot, brown spot, balck shank, stalk break and rust etc.(its chemical structural formula is chemistry (the RS)-2-by name of prothioconazoles for 2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl-1-2-dihydro-3-1,2,4-triazole-3-thioketones
.
Famoxadone is new and effective, broad spectrum pesticide. suitable crop is as wheat, barley, pea, beet, rape, grape, potato, pawl class, capsicum, tomato etc.Be mainly used in preventing and treating important disease in Ascomycetes, Basidiomycetes, oomycetes subclass as powdery mildew, rust, glume blight, net blotch, downy mildew, late blight etc.There is lipophilicity, after spraying on crop leaf, easily adhere to, not by rain drop erosion special efficacy.Chemistry 3-anilino--5-methyl-5-(4-Phenoxyphenyl)-1 by name of famoxadone, 3-azoles quinoline-2,4-diketone, its chemical structural formula is
.
Using chemical agent is the most effectively means of controlling plant diseases.But long-term use single chemical bactericide continuously high dose, easily cause the problems such as residual, the environmental pollution of medicament and resistance to pesticide resistance fungi development.Reasonably chemical bactericide is composite or be mixed and have expansion fungicidal spectrum, improve control efficiency, extend the optimum period for applying fertilizer, reduce dosage, reduce poisoning, reduce residual, delay Antifungal resistance and the positive feature such as drug-fast generation and development, bactericide compounded is one of the effective method the most addressing the above problem.Exploitation new product bactericide price is constantly soaring, and by contrast, exploitation is efficient with research, low toxicity, low-residual composite be mixed there is small investment, the lead time is short and be subject to domestic and international attention, the numerous and confused dynamics that develops that strengthens.We filter out prothioconazoles Yu famoxadone carries out compositely on the basis of lab screening and field trial, have obvious synergistic effect.And about prothioconazoles Yu the composite bactericidal composition of famoxadone and application there is no at present people and reported.
Summary of the invention
Based on above situation, the object of the invention is to provide a kind of new and effective pesticide sterilizing composite.Be mainly used in preventing and treating powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease, glume blight, downy mildew, the late blight of wheat, barley, rape, peanut, paddy rice and legume crop.
Technical scheme of the present invention realizes by following measures:
Contain prothioconazoles Yu a bactericidal composition for famoxadone, the active ingredient prothioconazoles of this bactericidal composition is Yu two yuan of famoxadones are composite, and all the other are auxiliary element.Active ingredient prothioconazoles in wherein said bactericidal composition is Yu the mass ratio of famoxadone is 1～50: 50～1, described bactericidal composition of the present invention is through toxicity test experimental verification, prothioconazoles is Yu the mass ratio of famoxadone is 1～20: 20～1 o'clock, and synergistic effect is better.
The formulations of pesticide that described bactericidal composition of the present invention can be prepared are missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion, granule, microcapsule formulations.Wherein active ingredient prothioconazoles is Yu the gross mass of famoxadone in preparation accounts for 1%～80% of the whole quality of the pharmaceutical preparations, while wherein accounting for 10%～60%, and toxicity and residually reach good balance, cost is also lower.
The specific embodiments of the formulations of pesticide that bactericidal composition of the present invention is mixed with is as follows:
Described bactericidal composition is cream preparation, and the mass fraction of component is: 1～50 part of prothioconazoles; 1～50 part of famoxadone; 10～30 parts of conventional emulsifiers; 20～50 parts of conventional solvents; 1～5 part of conventional synergist.The concrete production stage of this cream preparation is for first adding active ingredient prothioconazoles Yu famoxadone the oily liquids that becomes transparent and homogeneous after adding again emulsifier, synergist to stir after dissolving completely in solvent, filling, can be made into the cream preparation of the present composition.
Described bactericidal composition is suspending agent, and the mass fraction of component is: 1～50 part of prothioconazoles; 1～50 part of famoxadone; 5～20 parts of dispersants; 1～5 part of antifreezing agent; 0.1～2 part of thickener; 0.1～0.8 part of defoamer; 0～10 part of penetrating agent; 0.1～5 part of pH value conditioning agent; Water, surplus.The concrete production stage of this suspending agent is for first mixing other auxiliary agents, through high speed shear, mix, add active ingredient prothioconazoles Yu famoxadone, in ball crusher, abrading-ball is 2～3 hours, make a diameter all below 5mm, can be made into the suspending agent preparation of the present composition.
Described bactericidal composition is wetting powder, and the mass fraction of component is: 1～50 part of prothioconazoles; 1～50 part of famoxadone; 3～10 parts of dispersants; 1～5 part of wetting agent; Filler, surplus.The concrete production stage of this wetting powder is: by above-mentioned formula, active ingredient prothioconazoles is mixed Yu famoxadone and dispersant, wetting agent and filler, uniform stirring in stirred tank, after airslide disintegrating mill, mixing, can be made into the wetting powder of the present composition.
Described bactericidal composition is water dispersible granules, and the mass fraction of component is: 1～50 part of prothioconazoles; 1～50 part of famoxadone; 3～10 parts of dispersants; 1～10 part of wetting agent; 1～5 part of disintegrant; Filler, surplus.The concrete production stage of this water dispersible granules is: by above-mentioned formula, active ingredient prothioconazoles is mixed Yu famoxadone and dispersant, wetting agent, disintegrant and filler, with micro jet, pulverize, through mediating, then add and in fluidized bed prilling dryer, carry out granulation, dry, screening by sample analysis, can be made into the water dispersible granules of the present composition.
Described bactericidal composition is aqueous emulsion, and the mass fraction of component is: 1～50 part of prothioconazoles; 1～50 part of famoxadone; 3～30 parts of emulsifier; 5～15 parts of solvents; 2～15 parts of stabilizing agents; 1～5 part of antifreezing agent; 0.1～8 part of defoamer; 0.2～2 part of thickener; Water, surplus.The concrete production stage of this aqueous emulsion is: first by prothioconazoles Yu famoxadone, solvent and emulsifier, cosolvent are added together, make to be dissolved into uniform oil phase; By part water, antifreeze, other the insecticides adjuvant such as antimicrobial mixes into uniform water; When reactor high speed stirs, oil phase is added to water, slowly add water until reach phase inversion point, open clipper and carry out high speed shear, and add remaining water, shear about half an hour, form the aqueous emulsion of oil-in-water type, can be made into the aqueous emulsion of the present composition.
Described bactericidal composition is microemulsion, and the mass fraction of component is: 1～50 part of prothioconazoles; 1～50 part of famoxadone; 10～30 parts of emulsifier, 1～8 part of antifreezing agent, 0.5～10 part of stabilizing agent, 20～50 parts of conventional solvent cosolvents.Prothioconazoles, Yu famoxadone dissolves completely with cosolvent, then is added to other compositions such as emulsifier, antifreezing agent stabilizing agent, evenly mix, finally add water, after fully stirring, can be made into microemulsion.
Described bactericidal composition is granule, and the mass fraction of component is: 1～50 part of prothioconazoles; 1～50 part of famoxadone; 1～10 part of wetting dispersing agent; 0.1～5 part of thickener; 0.1～5 part of defoamer; Castor oil, surplus is supplied.Each components such as active ingredient prothioconazoles Yu famoxadone, dispersant, stabilizing agent, defoamer and solvent are mixed in the ratio of formula, put into after the grinding of sand milling still, send in mixer for well-distribution and mix and get product.
Described bactericidal composition is microcapsule formulations, and the mass fraction of component is: 1～50 part of prothioconazoles; 1～50 part of famoxadone; 5～20 parts, urea; 5～20 parts, formaldehyde; 5～20 parts of emulsifying dispersants; 1～5 part of antifreezing agent; 0.1～2 part of thickener; 0.1～0.8 part of defoamer; Water, surplus.In being housed, the there-necked flask of agitating device adds urea and formaldehyde (amount of substance ratio is about l:1.5～2.0), left and right, pH value to 8～9 with sodium hydroxide solution regulator solution, then be warming up to 70～80 ℃, reaction obtains stable urea resin prepolymer.Get a certain amount of prothioconazoles Yu famoxadone is dissolved in cyclohexane, and add emulsifying dispersant in solution, follow vigorous stirring, the O/W type stable emulsion that to be made into the aqueous solution of take containing emulsifying dispersant be water.Above-mentioned urea resin prepolymer is added in emulsion, regulate pH value, polymerization reaction take place under acid catalysis condition, is wrapped oil phase substance, forms microcapsule granule.Slowly heat up, solidify, temperature is controlled at 40～50 ℃, hardening time 1h.Selection adds appropriate auxiliary agent, the microcapsule suspending agent that gets final product stablely.
Wherein above-described emulsifier is selected from calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, any or more than one any mixtures than forming in polyoxyethylene aliphatic alcohol ether.
Described solvent is dimethylbenzene or biodiesel, toluene, diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine-based vegetable oil code name is ND-45, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), one or more in water equal solvent are arbitrarily than the mixture forming.
It is LG-3, GY-D1252, GY-D1256, SNWGF-01 that described dispersant is selected from polycarboxylate code name, lignosulfonates code name is 201107,21108, alkylphenol polyoxyethylene methyl ether condensate sulfate, alkylsulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, polyoxyethylene carboxylate, aliphatic amine polyoxyethylene ether, one or more in fatty acid glyceride APEO.
Described wetting agent is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, and Nekal BX, moistening bleeding agent F, alkylbenzenesulfonate polyoxyethylene triphen is phosphenylic acid salt dimly, spaonin powder, silkworm excrement, one or more in soapberry powder.
Described disintegrant is selected from bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, one or more in sodium bicarbonate.
Described thickener is selected from xanthans, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose, Magnesiumaluminumsilicate, in polyvinyl alcohol one or more.
Described stabilizing agent is selected from sodium citrate, a kind of in resorcinol.
Described antifreezing agent is selected from ethylene glycol, propane diols, one or more in glycerine.
Described defoamer is selected from silicone oil, silicone compound, C
10-20saturated fat acid compounds, C
8-10one or more of fatty alcohol.
Described filler is selected from kaolin, diatomite, bentonite, attapulgite, white carbon, starch, one or more in precipitated calcium carbonate.
The present invention be take prothioconazoles Yu the composite bactericide that famoxadone is active ingredient has obvious synergistic effect, delay the drug-fast generation in key, and reduced one-tenth and produced cost and use cost, the powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease, glume blight, downy mildew, the late blight that are mainly used in preventing and treating wheat, barley, rape, peanut, paddy rice and legume crop.
Embodiment
For making technical scheme of the present invention, object and advantage are clearer, and the present invention describes with following specific embodiment, but the present invention is not limited to these examples.The mode that effect experiment of the present invention adopts indoor biometrics and field trial to combine, if no special instructions, the ratio of below mentioning is all ratio of quality and the number of copies.
Embodiment: prothioconazoles proportioning co-toxicity experiments different from famoxadone.
1.1 reagent agent
The former medicine of 96% famoxadone, the former medicine of 95% prothioconazoles, above-mentioned former medicine provides by research and development department of extra large rel medicine company limited company.
1.2 test targets
Separation and purification gained on the wheat powdery mildew incidence of leaf that wheat powdery mildew germ ，Cong takes back Fengyang County, cultivates and preserves in 4 ℃ of refrigerators on PDA inclined-plane.
For examination medium
:
PDA medium
:potato 200g, glucose 20g, agar 20g, water 1000ml.
AEA medium
:dusty yeast 5g/L, glycerine 20mL/L, MgSO
40.25g/L, NaNO
36g/L, KCl 0.5g/L, KH
2pO
41.5g/L, agar powder 20g/L, deionized water 1L.
1.3 test method
1.3.1 medicament preparation
First use the former medicine of acetone solution, according to the result of preliminary experiment, two appropriate former medicines are made into several different proportionings, then it is stand-by with acetone, each processing to be diluted to respectively to several concentration gradients.
Susceptible wheat cultivation, in pot for growing seedlings, is placed in to greenhouse and cultivates, and plant grows to three to four leaf after dates, gathers the blade of identical leaf age, for cultivation and the mensuration of wheat powdery mildew.
1.3.2 the cultivation of wheat powdery mildew and the preparation of spore suspension
Wheat powdery mildew adopts plants method to cultivate under 20 ℃, the condition of 12h alternation of light and darkness, and every 30 d turn culture 1 time.During inoculation, with the conidium on sterile water wash-out incidence of leaf, being mixed with spore concentration is l * 10
6the suspension of individual/mL.
1.3.3 strains tested sensitivity testing
Adopt leaf dish moisturizing method to carry out toxicity test.First the blade of collection is prepared into the leaf dish that diameter is 1.5cm, mix at random, be placed in respectively the series concentration liquid configuring and soak lh, 50 leaf dishes of each concentration, test is with the blank that is treated to of adding medicine not, after immersion finishes, leaf faces up and puts on the wetting blotting paper of identical liquor strength, liquid on leaf dish is blotted, the spore suspension l0L preparing is inoculated in to leaf dish central authorities, and room temperature is placed after 5 min, is placed under 20 ℃, the condition of 1 2h alternation of light and darkness and cultivates, after 10d, measure the onset area on leaf dish, calculate EC
50.
On the basis of preliminary experiment, in order to upper method, respectively single dose prothioconazoles and famoxadone are carried out to toxicity test, the two EC
50value is respectively 6.6184 ㎎/l and 8.1932 ㎎/l.
The percentage that accounts for leaf disc area according to lesion area is divided sick level
0 grade: anosis;
1 grade: sorus area accounts for below 5% of whole leaf area;
3 grades: sorus area accounts for below the 6%-10% of whole leaf area;
5 grades: sorus area accounts for below the 11%-20% of whole leaf area;
7 grades: sorus area accounts for below the 21%-50% of whole leaf area;
9 grades: sorus area accounts for the more than 50% of whole leaf area;
1.3.4 mixture toxicity test and interpretation of result
By single dose toxicity test method, according to mixed ratio, carry out the toxicity test of mixture.
If contrast lethality<5%, does not proofread and correct, contrast lethality, between 5%-20%, is proofreaied and correct by formula 2, contrast lethality>20%, test need be reformed.
The logarithm value of drug concentration (mg/L) of take is independent variable x, and the probability value of corrected mortality of take is dependent variable y, sets up respectively virulence regression equation formula, adopts DPS software to calculate the LC of single dose and each proportioning mixture
50according to the abundant method of Sun Yun, calculate co-toxicity coefficient (CTC).Co-toxicity coefficient CTC, computing formula is as follows: (take prothioconazoles as standard medicament, its toxicity index is 100):
The LC of the toxicity index of famoxadone (TI)=prothioconazoles
50the LC of/famoxadone
50* 100
The LC of true toxicity index (ATI)=prothioconazoles of M
50the LC of/M
50* 100
TI * P famoxadone of TI * P prothioconazoles+famoxadones of theoretical toxicity index (TTI)=prothioconazoles of M
TTI * 100 of the ATI/M of the co-toxicity coefficient of M (CTC)=M
In formula:
M is prothioconazoles from the mixture of the different proportionings of famoxadone
P prothioconazoles is prothioconazoles shared ratio in mixture
P famoxadone Wei famoxadone shared ratio in mixture.
2.1 toxicity test results
Table 1 famoxadone and the prothioconazoles toxicity test to wheat powdery mildew
As can be seen from the table, the result of the test of different proportion proportioning shows, in active ingredient ratio, dilute respectively and all show stronger synergistic effect, wherein take prothioconazoles Yu famoxadone as 1:20～20:1 time the good suggestion of synergistic effect suitable proportion 1:10～10:1 left and right mixture preparation is carried out to further field control effectiveness test, to evaluate its field practical application effect.
3, field trial control wheat powdery mildew, the experimental result of cucumber downy mildew
3.1 field trial control wheat powdery mildews
3.1.1 test method
Test site, in great Tong Qiao village, capital town, Fengyang County, is wheat for studying thing, and kind is short morning 781, broadcasts sowing, and growing way is better, and test is established every mu and established contrast totally 10 processing.Every processing repeats 4 times, and random district group is arranged, 30 square metres of community areas.
3.1.2 control time and number of times
Before dispenser, after the 1st medicine, after 7 days and the 2nd dispenser, 7 days, 14Tian，Mei community adopt 5 samplings of diagonal, every some investigation 20 strains, 2 leaves are got in the Qian Meizhuzi upper end of blooming, after blooming, sword-like leave 2 leaves are got in every strain, by leaf classification investigation occurring degree, calculate disease and refer to and control efficiency.
Grade scale is as follows:
0 grade: anosis;
1 grade: lesion area accounts for below 5% of one-piece blade area;
3 grades: lesion area accounts for the 6%-15% of one-piece blade area;
5 grades: lesion area accounts for the 16%-25% of one-piece blade area;
7 grades: lesion area accounts for the 26%-50% of one-piece blade area;
9 grades: lesion area accounts for the more than 50% of one-piece blade area.
3.1.3 drug effect computational methods
The total number of sheets * 100 of sick leaf rate (%)=sick number of sheets/investigate
Disease index=∑ (the sick number of sheets * relative level numerical value at different levels)/(investigating the total number of sheets * 9) * 100
Disease index after the front disease index * treatment region medicine of control efficiency (%)=〔1-(blank district medicine)/(the front disease index of disease index * treatment region medicine after blank district medicine)) * 100.
3.1.4 poisoning investigation method
After dispenser, whether 14d range estimation medicament has poisoning to crop continuously.
3.1.5 result of the test and analysis
Each processes the effect of control wheat powdery mildew.
Table 2
As shown in Table 2 Bing sulphur Jun Zuo famoxadone with 1:3 ratio composite bactericide for wheat powdery mildew control successful higher than prothioconazoles Yu famoxadone single dose, bactericidal effect increases progressively with the increase of dosage.According to field range estimation, within the scope of test dose, plant growth is normal, and the poisoning phenomenon to wheat does not all appear in each treatment agent, illustrates that it is safe to wheat.Advise that the bactericide different from the mechanism of action mixes use to delay the drug-fast generation of germ.
3.2 field trial control cucumber downy mildews
3.2.1 test method
Test site, in the Pingdu herbary of Shandong, is cucumber for examination vegetables, and growing way is better, and test is established every mu and established contrast totally 10 processing.Every processing repeats 4 times, and random district group is arranged, 14 square metres of community areas.
3.2.2 control time and number of times
Before dispenser, after the 1st medicine, after 7 days and the 2nd dispenser, 7 days, 14Tian，Mei community adopt 5 samplings of diagonal, every some investigation 2 strains, and totally 10 strains, investigation complete stool blade, by leaf classification investigation occurring degree, calculates disease and refers to and control efficiency.
Grade scale is as follows:
0 grade: anosis;
1 grade: lesion area accounts for below 5% of one-piece blade area;
3 grades: lesion area accounts for the 6%-15% of one-piece blade area;
5 grades: lesion area accounts for the 16%-25% of one-piece blade area;
7 grades: lesion area accounts for the 26%-50% of one-piece blade area;
9 grades: lesion area accounts for the more than 50% of one-piece blade area.
3.2.3 drug effect computational methods
The total number of sheets * 100 of sick leaf rate (%)=sick number of sheets/investigate
Disease index=∑ (the sick number of sheets * relative level numerical value at different levels)/(investigating the total number of sheets * 9) * 100
Disease index after the front disease index * treatment region medicine of control efficiency (%)=〔1-(blank district medicine)/(the front disease index of disease index * treatment region medicine after blank district medicine)) * 100.
3.2.4 poisoning investigation method
After dispenser, whether 14d range estimation medicament has poisoning to crop continuously.
3.2.5 result of the test and analysis
Each processes the effect of control cucumber downy mildew.(table 3)
The Mixed Pharmacy of different proportion, tests by different consumptions as can be seen from Table 3, and Bing sulphur Jun Zuo famoxadone is all better than contrasting medicament and bactericidal effect with its right control of 1:3 ratio composite bactericide and increases progressively with the increase of dosage.According to field range estimation, within the scope of test dose, plant growth is normal, and the poisoning phenomenon to cucumber does not all appear in each treatment agent, illustrates that it is safe to cucumber.Advise that the bactericide different from the mechanism of action mixes use to delay the drug-fast generation of germ.
In sum, the present invention contains prothioconazoles Yu the bactericidal composition of famoxadone has good control efficiency to wheat powdery mildew, cucumber downy mildew, and it is to target crop safety.Complex preparation has not only improved preventive effect, and has expanded fungicidal spectrum, widens the scope of application, reduces costs, and multiple diseases is played to the double effect of controlling of a medicine, alleviates manpower and materials, improves productivity effect.So the invention of this complex preparation is of great significance social tool with popularization.
Claims (4)
1. a bactericidal composition that contains prothioconazoles and famoxadone, it is characterized in that: the active ingredient of this bactericidal composition is that prothioconazoles is Yu famoxadone binary built, all the other are auxiliary element, and wherein active ingredient prothioconazoles is Yu the mass ratio of famoxadone is 1～50: 50～1.
2. bactericidal composition according to claim 1, is characterized in that: prothioconazoles is Yu the gross weight of famoxadone in preparation accounts for 1%～80% of the whole quality of the pharmaceutical preparations.
3. bactericidal composition according to claim 2, is characterized in that: prothioconazoles is Yu the gross weight of famoxadone in preparation accounts for 5%～60% of the whole quality of the pharmaceutical preparations.
4. according to the bactericidal composition described in claim 1 or 2 or 3, it is characterized in that: the formulation of this bactericidal composition is missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion, granule, microcapsule formulations
.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103965183A (en) * | 2014-03-17 | 2014-08-06 | 上海应用技术学院 | Fluorine-containingoxazolidinonecompound as well as preparation method and application thereof |
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| CN103965183A (en) * | 2014-03-17 | 2014-08-06 | 上海应用技术学院 | Fluorine-containingoxazolidinonecompound as well as preparation method and application thereof |
| CN103965183B (en) * | 2014-03-17 | 2017-05-03 | 上海应用技术学院 | Fluorine-containingoxazolidinonecompound as well as preparation method and application thereof |
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Application publication date: 20140115 |