CN103503866A

CN103503866A - Preparation method for Suke

Info

Publication number: CN103503866A
Application number: CN201210207569.6A
Authority: CN
Inventors: 不公告发明人
Original assignee: JIANGSU SINYI PHARMACEUTICAL CO Ltd
Current assignee: JIANGSU SINYI PHARMACEUTICAL CO Ltd
Priority date: 2012-06-23
Filing date: 2012-06-23
Publication date: 2014-01-15

Abstract

The invention discloses a preparation method for Suke which belongs to the field of disinfectant antiseptics for silkworms. The Suke is prepared from didecyldimethylammonium bromide, propylene glycol, a medicinal reinforcing agent and drinking water through inspection, dissolving, split charging and the like. The method has the following advantages: general equipment is used, the method is simple, product quality is good, poisonous and harmful gas and liquid are not discharged, and the produced Suke is an excellent disinfectant antiseptic for silkworms and can be used for disinfection of silkworm nurseries, rearing instruments, mulberry leaves and mulberry fields. An application method for the Suke is that the Suke diluted 200 to 300 times is sprayed for disinfection of the silkworm nurseries and the rearing instruments, and the Suke diluted 2000 to 3000 times is sprayed for disinfection of the mulberry leaves and the mulberry fields.

Description

The preparation method of a kind of speed gram

Technical field

The invention belongs to disinfectant field, relate in particular to the preparation method of a kind of speed gram.

Background technology

Speed gram is a kind of silkworm disinfection drug, and main component is first bromine ammonium in the last of the ten Heavenly stems, and outward appearance is colourless or micro-yellow liquid of vicidity, has foam to produce during jolting.The last of the ten Heavenly stems, first bromine ammonium was a kind of double-chain quaternary ammonium salt disinfectant, its mechanism of action is by the effects such as hydrophobic binding between electrostatic force, hydrogen bond force and surfactant molecule and protein molecule with cation, adsorb electronegative bacterial body, be gathered on cell wall, generating chamber's inhibition effect, causes bacterial growth suppressed and dead; Simultaneously its hydrophobic alkyl can also with the hydrophilic group effect of bacterium, change the permeability of film, then there is lysis, destroy cell structure, cause dissolving and the death of cell.Product of the present invention speed gram when solution state, can dissociate quaternary ammonium salt cationic, and phosphate electronegative in bacterium endochylema membrane phospholipid is combined, and low concentration is bacteriostasis, and high concentration plays bactericidal action; Bromide ion strengthens the hydrophily of molecule and lipophilicity simultaneously, and energy rapid permeability, to endochylema film fat layer and protein layer, changes the permeability of film, reaches bactericidal action.The impact that speed gram has is efficient, low toxicity, result of use are not subject to the variation of pH value, and easy to use, to rete malpighii, have the stronger effect of peeling off, stable chemical performance, dispersion and corrosion inhibition better, most bacteriums, fungi and algae are had to killing action, lipophilic virus is also had to certain effect.Residual strong drug action after speed gram use, to light and thermally stable, to metal, plastics, rubber and the equal non-corrosiveness of other materials, is mainly used in the sterilization in silkworm room, rearing instrument and mulberry leaf, mulberry field.The present invention is the preparation method of a kind of speed gram, and it is raw material that the method be take first bromine ammonium in the last of the ten Heavenly stems, propane diols, medicinal hardening agent, drinking water, by operations such as raw-material check, dissolving, packing, makes finished product; The advantage of the method is: use that common apparatus, technique are simple, good product quality, without toxic and harmful and fluid discharge, product is a kind of outstanding disinfection preservative, can be used for the sterilization in silkworm room, rearing instrument and mulberry leaf, mulberry field, using method is: silkworm room, disinfection of tools for silkworm rearing are sprayed with 200-300 times of liquid; Mulberry leaf, mulberry field sterilization are with 2000-3000 times of liquid spraying.

Summary of the invention

The problem that the present invention mainly solves is to provide a kind of method of producing fast gram in batches, the method be take first bromine ammonium in the last of the ten Heavenly stems, propane diols, medicinal hardening agent, drinking water and is produced speed gram as raw material, have advantages of use common apparatus, technique simple, without sewage toxic emission, product is a kind of silkworm high-effective disinfecting preservative, can be used for the sterilization in silkworm room, rearing instrument and mulberry leaf, mulberry field.The raw material proportioning that the present invention uses is: the last of the ten Heavenly stems first bromine ammonium 10%-12%, propane diols 7%-9%, medicinal hardening agent 1%, drinking water 80%.

The present invention can be achieved through the following technical solutions:

A production method for speed gram, its feature consists of following steps:

(1) water of formula ratio is sent into Agitation Tank, be heated to 40 ℃-45 ℃, while stirring the first bromine ammonium in the last of the ten Heavenly stems of formula ratio is added after Agitation Tank and continue to stir 0.5 hour to mixing.

(2) be cooled to normal temperature, the propane diols of formula ratio is added to Agitation Tank, stir after 0.2 hour, the medicinal hardening agent that adds formula ratio, stir after 0.3 hour again, mixture is sent into Bipitch liquid dosing filling machine and carry out cannedly, filling is to get product after 500 milliliters/bottle or 1000 milliliters/bottle.

(3) using method of fast gram is: silkworm room, disinfection of tools for silkworm rearing are sprayed with 200-300 times of liquid; Mulberry leaf, mulberry field sterilization are with 2000-3000 times of liquid spraying.

The described first bromine ammonium solution temperature in the last of the ten Heavenly stems of step (1) is 43 ℃.

The invention has the beneficial effects as follows: the production method that a kind of speed gram is provided, the advantage of this production method is: use common apparatus, technique simple, without sewage toxic emission, product is a kind of silkworm disinfection preservative, is mainly used in the sterilization for silkworm room, rearing instrument, mulberry leaf, mulberry field sterilization.

Embodiment

Embodiment 1

By accounting for total amount, being that 80% water is sent into Agitation Tank, being heated to 40 ℃-45 ℃, is to continue to stir 0.5 hour to mixing after 10% first bromine ammonium in the last of the ten Heavenly stems adds Agitation Tank by accounting for total amount while stirring; Being cooled to normal temperature, is that 9% propane diols adds Agitation Tank by accounting for total amount, stirs after 0.2 hour, add that to account for total amount be 1% medicinal hardening agent, stir after 0.3 hour again, mixture is sent into Bipitch liquid dosing filling machine and carry out cannedly, filling is to get product after 500 milliliters/bottle or 1000 milliliters/bottle; The using method of fast gram is: silkworm room, disinfection of tools for silkworm rearing are sprayed with 200-300 times of liquid; Mulberry leaf, mulberry field sterilization are with 2000-3000 times of liquid spraying.

Embodiment 2

By accounting for total amount, being that 80% water is sent into Agitation Tank, being heated to 40 ℃-45 ℃, is to continue to stir 0.5 hour to mixing after 11% first bromine ammonium in the last of the ten Heavenly stems adds Agitation Tank by accounting for total amount while stirring; Being cooled to normal temperature, is that 8% propane diols adds Agitation Tank by accounting for total amount, stirs after 0.2 hour, add that to account for total amount be 1% medicinal hardening agent, stir after 0.3 hour again, mixture is sent into Bipitch liquid dosing filling machine and carry out cannedly, filling is to get product after 500 milliliters/bottle or 1000 milliliters/bottle; The using method of fast gram is: silkworm room, disinfection of tools for silkworm rearing are sprayed with 200-300 times of liquid; Mulberry leaf, mulberry field sterilization are with 2000-3000 times of liquid spraying.

Embodiment 3

By accounting for total amount, being that 80% water is sent into Agitation Tank, being heated to 40 ℃-45 ℃, is to continue to stir 0.5 hour to mixing after 12% first bromine ammonium in the last of the ten Heavenly stems adds Agitation Tank by accounting for total amount while stirring; Being cooled to normal temperature, is that 7% propane diols adds Agitation Tank by accounting for total amount, stirs after 0.2 hour, add that to account for total amount be 1% medicinal hardening agent, stir after 0.3 hour again, mixture is sent into Bipitch liquid dosing filling machine and carry out cannedly, filling is to get product after 500 milliliters/bottle or 1000 milliliters/bottle; The using method of fast gram is: silkworm room, disinfection of tools for silkworm rearing are sprayed with 200-300 times of liquid; Mulberry leaf, mulberry field sterilization are with 2000-3000 times of liquid spraying.

Claims

1. a preparation method for speed gram, its composition of raw materials counts by weight percentage: comprise first bromine ammonium 10%-12% in the last of the ten Heavenly stems, propane diols 7%-9%, medicinal hardening agent 1%, drinking water 80%; It is characterized in that: step (1) is sent the water of formula ratio into Agitation Tank, be heated to 40 ℃-45 ℃, while stirring the first bromine ammonium in the last of the ten Heavenly stems of formula ratio is added after Agitation Tank and continue to stir 0.5 hour to mixing; Step (2) is cooled to normal temperature, the propane diols of formula ratio is added to Agitation Tank, stir after 0.2 hour, the medicinal hardening agent that adds formula ratio, stir again after 0.3 hour, mixture is sent into Bipitch liquid dosing filling machine and carry out cannedly, filling is to get product after 500 milliliters/bottle or 1000 milliliters/bottle.

2. the preparation method of a kind of speed according to claim 1 gram, its step (1) feature is: described first bromine ammonium solution temperature in the last of the ten Heavenly stems is 43 ℃.

3. the preparation method of a kind of speed according to claim 1 gram, the using method of speed gram is: for silkworm room, disinfection of tools for silkworm rearing, with 200-300 times of liquid, spray; For mulberry leaf, mulberry field sterilization, with 2000-3000 times of liquid, spray.