CN103495035B - Traditional Chinese medicine preparation for treating scabies as well as preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating scabies as well as preparation method thereof Download PDFInfo
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- CN103495035B CN103495035B CN201310464108.1A CN201310464108A CN103495035B CN 103495035 B CN103495035 B CN 103495035B CN 201310464108 A CN201310464108 A CN 201310464108A CN 103495035 B CN103495035 B CN 103495035B
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating scabies as well as a preparation method thereof. The raw materials of effective components of the traditional Chinese medicine preparation prepared include golden cypress, Boehmeria siamensis Craib, garden burnet, cactus, herb of Blin Conyza, kapok, common andrographis Herb, mung bean blister beetles, joint vetch, medical stone, catalpa leaves, xanthium sibiricum, senecio scandens, patience dock roots, edible tulip and mint. The traditional Chinese medicine preparation provided by the invention is prepared by adopting a modern advanced medical pharmaceutical technology. The selected medicinal raw materials are appropriately matched and meet the theories of traditional Chinese medicines and modern medicines, so that the preparation has the functions of clearing away heat and toxic materials, dispelling wind, eliminating dampness and swelling and promoting wound healing, has a remarkable curative effect on scabies symptoms such as papule, blister, pustule and pruritus, and has good preventing and treating effects to intercurrent eczema and infection. The preparation can improve the function of the human immune system and is remarkable in curative effect, safe, free from toxic and side effects and worth wide popularization and application.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of Chinese medicine preparation and preparation method for the treatment of scabies.
Background technology
Scabies is the dermatosis because sarcoptic mite skin infection causes.Sarcoptic mite parasitizes in skin, excavates in " tunnel " and produces mechanical stimulus, and secretions and Excreta cause allergic reaction, and cause the infected's skin acutely scratchy, night more so.
Scabies is many between finger, and be apt to occur in wrist and bend side, axil leading edge, umbilicus week and femoribus internus, during onset, skin is grain of rice large red pimple, vesicle, pustule and Cuniculus paca, has scratchiness.Scabies clinical manifestation is mainly xerosis cutis, incrustation, occurs the scaling speckle of hyperkeratotic erythema, also can occur erosion, pustule, stench, hair is withered to come off, the thickening change distortion of fingernail, lymph nodes of body as a whole enlargement, squama is thick, and state of an illness weight, infectiousness is extremely strong.Scabies site of pathological change be more common in skin wrinkle place and thin tender position (as under webs, wrist, the fossa cubitalis, axillary fossa, breast, umbilicus week, hypogastric region, the position such as inside external genitalia and stock), but adult's Head And Face and palm sole of the foot portion not easily get involved, and all can get involved in any position of infant, especially pudendum and oxter.
Scabies major transmission path is divided into directly contact and mediate contact.Direct contact comprise with patient with bed altogether by, shake hands, embraced ill child etc., the especially close contact of health, more easily infected; Mediate contact comprises the clothes, towel, footgear, bedding, bath towel etc. that contact and polluted by sarcoptic mite.Scabies spread speed is fast and infectiousness is very strong, and general sarcoptic mite leaves people's physical ability survival 2 ~ 3 days, therefore use patient clothes, bedding, footgear, medicated cap, pillow covering towel can by indirect infection, thus this disease often mutually infects in one family or dormitory.The crowd of the scabies that is easy to get comprises purchasing agent, canvasser, business personnel, driver etc., these people often travel widely. and staying everywhere, is secondly the suspect that in the student in dormitory, worker, employee etc. and prison, the criminal of serving a sentence or detention house are temporarily detained.
Existing scabies Therapeutic Method based on external-applied ointment, and is isolated patient, or takes calm antipruritic agent, antihistamine drug or 17-hydroxy-11-dehydrocorticosterone etc., because external used medicine is based on Western medicine, and interior containing hormone, the side effect for the treatment of scabies is large, easy recurrence, cures the symptoms, not the disease.
Chinese medicine, as China's traditional medicine, is therefrom developed a kind of Drug therapy scabies, is had good development prospect.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of scabies, Chinese medicine preparation of the present invention adopts modern advanced medical pharmaceutical technology to make, selected medical material compatibility is suitable, meet the traditional Chinese medical science and modern medicine theory, there is effect of heat-clearing and toxic substances removing, loose wind dehumidifying, detumescence sore, for scabies symptoms such as pimple, vesicle, pustule and prurituss, there is significant curative effect, also good Prevention and Curation effect is had for concurrent eczema and infection, human immune system's function can be improved, and therapeutic effect is remarkable, safe without toxic side effect, should be widely promoted application.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for scabies, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Treat a preparation method for the Chinese medicine preparation of scabies, comprise following processing step:
(1) get Cortex Phellodendri, eight stupefied fiber crops, Radix Sanguisorbae, Herba Andrographis, Herba Aeschynonenes Indicae, Herba Senecionis Scandentis, Radix Rumicis Patientiae and Pseudobulbus Cremastrae Seu Pleiones to clean, dry, put into container, add the distilled water of 8-12 times amount, soak after 4-5 hour, boil 3-4 hour, extract; Again add 6-8 times amount distilled water, boil 2-3 hour, extract; Finally, add 4-6 times amount distilled water, heated and boiled 1-2 hour, extract; Merge three extracting solution, filter, filtrate is concentrated under 80 DEG C of conditions and is dried to dry extract, for subsequent use;
(2) Radix et Caulis Opuntiae Dillenii is mashed extracting juice, stay juice for subsequent use;
(3) get Herba Swertiae davidi, Folium catalpae ovatae, Herba Xanthii and Herba Menthae to clean, dry, mash, add the distilled water of 3 times amount, stir, filter, it is for subsequent use to get filtrate;
(4) get Lytta caragana Pallas to clean, be placed in slow fire in pot and be fried to crisp, be placed in mortar, grind into powder, cross 120 order fine powders, for subsequent use;
(5) get silk cotton and Maifanitum is placed in mortar, grind into powder, cross 200 order fine powders, for subsequent use;
(6) get the dry extract obtained by above-mentioned steps (1)-(5), juice, filtrate and fine powder mixing, utilize modern advanced pharmacy science and technology, make capsule, be the Chinese medicine preparation of described treatment scabies.
The property of medicine of the present invention's Chinese medicine used is as follows:
Cortex Phellodendri: bitter in the mouth, cold in nature, enter kidney, urinary bladder channel.Heat clearing and damp drying; Eliminating fire and detoxication.Cure mainly hygropyretic dysentery, have loose bowels, jaundice, nocturnal emission, stranguria with turbid discharge, leukorrhagia, hectic fever due to YIN-deficiency consumptive fever, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, skin sore, skin eczema." medicineization justice " carries: " pathogenic fire reducing can capit ad calcem, and the thorough marrow of the skin that falls invariably thoughtfully, specially rushes down the fire of kidney and bladder." modern medicine study confirms, Cortex Phellodendri is containing the main component such as berberine, obacunone, and have the effect of antibacterial, convergence, antiinflammatory, to symptoms such as various skin noxious dampness, skin infection, effect is good.
Eight stupefied fiber crops: lightly seasoned, property is put down.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Cure mainly acute appendicitis, amenorrhea is suffered from abdominal pain, and has loose bowels, rheumatalgia, urticaria, skin pruritus, eczema, variola.
Radix Sanguisorbae: bitter in the mouth, acid, cold in nature, nontoxic, enter liver, lung, kidney, large intestine channel.Cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Cure mainly haematemesis, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, sore, carbuncle and painful swelling, eczema, pudendal pruritus." not Lu " carries: " malignant boil, disappear wine, and except quenching one's thirst, mending and hindering absolutely, in puerperal, plug, can make incised wound cream, and main internal hemorrhage due to trauma is more than, insufficiency of blood for only pus and blood, all flaccidity." modern medicine study confirmation, Radix Sanguisorbae contains a large amount of tannin, has stronger convergence, and energy vasoconstrictive, reduces the permeability of blood vessel, reduces inflammatory exudation, also has obvious bactericidal action simultaneously, can resist charrin's disease.
Radix et Caulis Opuntiae Dillenii: bitter in the mouth, cool in nature, enter the heart, lung, stomach three warp.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, benefiting stomach and stopping pain, antitussive.For taste-blindness rate, acute dysentery, cough; Mumps is controlled in external, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald." Luchuan book on Chinese herbal medicine " carries: " eliminating inflammation and expelling toxin, evacuation of pus granulation promoting.Cure mainly carbuncle sore furuncle and phyma, cough.”
Herba Swertiae davidi: bitter in the mouth, cool in nature, return lung meridian.Heat-clearing and toxic substances removing, dampness removing.Cure mainly jaundice due to damp-heat, cough due to lung-heat, laryngopharynx swelling and pain, toothache, dysentery, urinary tract infection, suppurative osteomyelitis, conjunctivitis, adnexitis, pelvic inflammatory disease, herpes zoster, scabies sore." Chinese herbal medicine is commonly used in Sichuan " carries: " clearing away lung-heat, parasite killing.For jaundice due to damp-heat, larynx is red and swollen, malignant boil scabies.”
Silk cotton: acrid in the mouth, sweet, property is put down, and enters stomach, large intestine channel.Clearing away heat-damp and promoting diuresis, promoting blood circulation and detumescence.Cure mainly chronic gastritis, gastric ulcer, have loose bowels, dysentery, waist foot is unsuccessful, and lower limb knee joint pain, skin ulcer are swollen, traumatic injury etc.Modern medicine study confirms, silk cotton has clearing away heat and cooling blood, removes stagnant removing food stagnancy, regulates human immunity and anticancer function.
Herba Andrographis: bitter in the mouth, cold in nature, GUIXIN, lung, large intestine, urinary bladder channel.Removing heat from blood dampness, heat-clearing and toxic substances removing, anti-inflammation detumescence, pain relieving.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can treat furuncle toxic swelling, trauma infection contamination etc.
Lytta caragana Pallas: acrid in the mouth, slightly warm in nature is poisonous.Diuresis, blood stasis dispelling, removing toxic substances.For dysuria, amenorrhea, lyssodexis; Scabies skin infection is controlled in external, tuberculous lymphadenitis." detailed outline " carries: " disappear scrofula for main hernia, Li little Shui.Lower expectorant knot.Control deafness, corneal nebula ， Rabid-dog dog wound poison.The same Mylabris of complementary work.”
Herba Aeschynonenes Indicae: sweet in the mouth, hardship, cold in nature, nontoxic, attach to the lung and stomach meridians.Heat clearing away, removes wind, dampness removing, detumescence, removing toxic substances.Control anemopyretic cold, jaundice, dysentery, gastritis, abdominal distention, gonorrhea, carbuncle, dermatitis, eczema.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " heat clearing away disappears stagnant.Control flatulence, dyspepsia, ache induced by gastritis, anemopyretic cold, eczema, dermatitis.”
Maifanitum: sweet in the mouth, warm in nature, nontoxic, return liver, stomach, kidney channel.Detoxicating and resolving stagnation of pathogens, removing the necrotic tissue and promoting granulation, except cold damp eliminating, the liver benefiting stomach invigorating, blood circulation promoting and blood stasis dispelling, diuresis fossil, life lengthening.Cure mainly carbuncle carbuncle on the back, acne, eczema, beriberi, miliaria, finger is chapped, chloasma, toothache, oral ulcer, rheumatic arthralgia, lumbago and backache, chronic hepatitis, gastritis, dysentery, diabetes, neurasthenia, wound is red and swollen, hypertension, senile sclerosis of blood vessels, tumor, lithangiuria.
Folium catalpae ovatae: bitter in the mouth, cold in nature, GUIXIN, lung meridian.Heat-clearing and toxic substances removing, killing parasites for relieving itching.Cure mainly fever of children, furuncle, scabies." four tones of standard Chinese pronunciation book on Chinese herbal medicine " carries: " wash children's's high fever, all skin ulcer scabies, skin pruritus.”
Herba Xanthii: bitter in the mouth, pungent, cold in nature, poisonous, returns lung meridian.Removing toxic substances parasite killing, loose wind dehumidifying, understand things pain-stopping.Cure mainly flu, wind syndrome of head, dizzy, nasal sinusitis, conjunctival congestion, corneal nebula, pathogenic wind-warm arthralgia pain, contracture numbness, wind leprosy, furuncle, scabies, skin pruritus, hemorrhoid, dysentery, arthralgia chiefly caused by damp pathogen contracture.
Herba Senecionis Scandentis: cold in nature, bitter in the mouth, returns lung, liver, large intestine channel.Heat-clearing and toxic substances removing, improving eyesight is antipruritic.For anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema, furuncle." Bencao Tujing " carries: " boil with Radix Glycyrrhizae and do drink-service, improving eyesight of bringing down a fever.Flower, leaf: control eye effective.”
Radix Rumicis Patientiae: bitter in the mouth, acid, cold in nature.Cooling blood for hemostasis, heat-clearing and toxic substances removing, parasite killing.For dysfunctional uterine hemorrhage, spit blood, spitting of blood, epistaxis, gingival hemorrhage, tail, duodenal hemorrhage, have blood in stool, purpura, constipation, edema; Scabies is controlled in external, furuncle, seborrheic dermatitis." the sweet peaceful blue or green Chinese herbal medicine choosing in Shan " carries: " heat-clearing and toxic substances removing, antiinflammatory detumescent, hemostasis.Control metrorrhagia, gastric hemorrhage, thrombocytopenia, dysentery, chronic hepatitis, carbuncle furuncle ".
Pseudobulbus Cremastrae Seu Pleiones: acrid in the mouth, cold in nature, slightly poisonous, return liver, stomach warp.Heat-clearing and toxic substances removing.For furuncle swelling toxin, sore throat swells and ache, red and swollen heat pain.
Herba Menthae: acrid in the mouth, cool in nature, enter lung, Liver Channel.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.Cure mainly affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest." a thousand pieces of gold dietetic therapy " carries: " dynamic diabetes." modern medicine study confirms, Herba Menthae can the emotion of nervous indignation gently, spirit can be improved, make body and mind vigorously pleased, help fall asleep, have certain assosting effect to central nervous system.
The present invention compared with prior art, has following beneficial effect:
Chinese medicine preparation of the present invention adopts modern advanced medical pharmaceutical technology to make, selected medical material compatibility is suitable, meet the traditional Chinese medical science and modern medicine theory, there is effect of heat-clearing and toxic substances removing, loose wind dehumidifying, detumescence sore, for scabies symptoms such as pimple, vesicle, pustule and prurituss, there is significant curative effect, also have good Prevention and Curation effect to concurrent eczema and infection, human immune system's function can be improved, and therapeutic effect is remarkable, safe without toxic side effect, should be widely promoted application.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The preparation method of Chinese medicine preparation of the present invention, comprises following processing step:
(1) get Cortex Phellodendri, eight stupefied fiber crops, Radix Sanguisorbae, Herba Andrographis, Herba Aeschynonenes Indicae, Herba Senecionis Scandentis, Radix Rumicis Patientiae and Pseudobulbus Cremastrae Seu Pleiones to clean, dry, put into container, add the distilled water of 8-12 times amount, soak after 4-5 hour, boil 3-4 hour, extract; Again add 6-8 times amount distilled water, boil 2-3 hour, extract; Finally, add 4-6 times amount distilled water, heated and boiled 1-2 hour, extract; Merge three extracting solution, filter, filtrate is concentrated under 80 DEG C of conditions and is dried to dry extract, for subsequent use;
(2) Radix et Caulis Opuntiae Dillenii is mashed extracting juice, stay juice for subsequent use;
(3) get Herba Swertiae davidi, Folium catalpae ovatae, Herba Xanthii and Herba Menthae to clean, dry, mash, add the distilled water of 3 times amount, stir, filter, it is for subsequent use to get filtrate;
(4) get Lytta caragana Pallas to clean, be placed in slow fire in pot and be fried to crisp, be placed in mortar, grind into powder, cross 120 order fine powders, for subsequent use;
(5) get silk cotton and Maifanitum is placed in mortar, grind into powder, cross 200 order fine powders, for subsequent use;
(6) get the dry extract obtained by above-mentioned steps (1)-(5), juice, filtrate and fine powder mixing, utilize modern advanced pharmacy science and technology, make capsule, be the Chinese medicine preparation of described treatment scabies.
Usage and dosage: oral, every day three times, each 3, within five days, be a course for the treatment of, four to six courses for the treatment of can cure, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The present embodiment Chinese medicine preparation preparation method processing step and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The present embodiment Chinese medicine preparation preparation method processing step and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The present embodiment Chinese medicine preparation preparation method processing step and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of scabies, select scabies patient 600 routine clinical observation, patient is divided into two groups at random, treatment group 300 example, wherein man 150 example, women 150 example, age 2-60 year, 31.5 years old mean age, course of disease 1-36 month, average 12.3 months; Matched group 300 example, wherein male 155 example, women 145 example, age 3-62 year, 32.2 years old mean age, course of disease 1-35 month, average 12 months.Two groups of conditions of patients qualifications and record of service are basically identical, without significant difference, have comparability, keep on a diet all on request for two groups.
2, treatment group patient takes Chinese medicine preparation of the present invention, oral, every day three times, each 3, within five days, is a course for the treatment of, and taking four to six courses for the treatment of continuously can cure, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding; Matched group takes chlorphenamine treatment, and by specification is taken.
3, Outcome measure:
(1) cure: the clinical symptom disappearance such as pimple, vesicle, pustule and scratchiness, scabies is fully recovered.
(2) take a turn for the better: above-mentioned symptom is alleviated to some extent.
(3) invalid: symptom is unchanged.
4, therapeutic outcome:
Treatment group: cure 212 examples, take a turn for the better 70 examples, and invalid 18 examples, total effective rate is 94%.
Matched group: cure 99 examples, take a turn for the better 118 examples, and without turning 83 examples, total effective rate is 72.3%.
Above result display, the total effective rate for the treatment of group is apparently higher than matched group.
Model case is illustrated:
1, Lee, man, 56 years old, peasant, people from Qingdao, whole body many places suffered from scabies, and after taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, scabies disappears, and continues to take 2 courses for the treatment of, and recovery from illness is without recurrence.
2, Tan, female, 45 years old, secondary school teachers, people from Handan, Hebei, suffered from the pale red tuberosity thing of Semen Glycines size, is diagnosed as scabies tuberosity, with violent pruritus at groin place.Take 4 courses for the treatment of of Chinese medicine preparation of the present invention, scabies is fully recovered.
3, beam, female, 24 years old, Building Materials Factory workman, people from Datong.Around wrist curved surface, mammary areola, umbilicus, there is chestnut grain pimple pustule at the place such as thigh both sides, and clinical diagnosis is pus alveolitoid scabies.Recommend through doctor, take 5 courses for the treatment of of Chinese medicine preparation of the present invention, scabies is fully recovered, and has no recurrence.
4, high mountain, man, 8 years old, pupil, people from Hengshui, Hebei.There is the light and shallow tunnel of color in Head And Face, indistinctly as wire, substrate mild inflammation and pinkiness, occur together vesicle, and easily get a glimpse of worm point through horny layer, in small white spots shape projection, with violent pruritus, has a strong impact on nighttime sleep, and clinical diagnosis is scabies.Take 3 courses for the treatment of of Chinese medicine preparation of the present invention, recovery from illness has no recurrence.
Claims (5)
1. treat a Chinese medicine preparation for scabies, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
2. a kind of Chinese medicine preparation for the treatment of scabies according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
3. a kind of Chinese medicine preparation for the treatment of scabies according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
4. a kind of Chinese medicine preparation for the treatment of scabies according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
5. as described in any one of claim 1-4, treat a preparation method for the Chinese medicine preparation of scabies, it is characterized in that: comprise following processing step:
(1) get Cortex Phellodendri, eight stupefied fiber crops, Radix Sanguisorbae, Herba Andrographis, Herba Aeschynonenes Indicae, Herba Senecionis Scandentis, Radix Rumicis Patientiae and Pseudobulbus Cremastrae Seu Pleiones to clean, dry, put into container, add the distilled water of 8-12 times amount, soak after 4-5 hour, boil 3-4 hour, extract; Again add 6-8 times amount distilled water, boil 2-3 hour, extract; Finally, add 4-6 times amount distilled water, heated and boiled 1-2 hour, extract; Merge three extracting solution, filter, filtrate is concentrated under 80 DEG C of conditions and is dried to dry extract, for subsequent use;
(2) Radix et Caulis Opuntiae Dillenii is mashed extracting juice, stay juice for subsequent use;
(3) get Herba Swertiae davidi, Folium catalpae ovatae, Herba Xanthii and Herba Menthae to clean, dry, mash, add the distilled water of 3 times amount, stir, filter, it is for subsequent use to get filtrate;
(4) get Lytta caragana Pallas to clean, be placed in slow fire in pot and be fried to crisp, be placed in mortar, grind into powder, cross 120 order fine powders, for subsequent use;
(5) get silk cotton and Maifanitum is placed in mortar, grind into powder, cross 200 order fine powders, for subsequent use;
(6) get the dry extract obtained by above-mentioned steps (1)-(5), juice, filtrate and fine powder mixing, make capsule, be the Chinese medicine preparation of described treatment scabies.
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| 疥疮500例临床分析;郑玉兰等;《陕西中医学院学报》;19890228;第12卷(第2期);第31页右栏第13-15行 * |
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