CN103494999B - Pharmaceutical composition and pharmaceutical preparation, preparation method thereof and application thereof - Google Patents
Pharmaceutical composition and pharmaceutical preparation, preparation method thereof and application thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition which is characterized by comprising the following raw materials: a deer product, frankincense, myrrh, teasel root, dragon's blood, safflower, Chinese angelica, rhizoma drynariae, wolfberry, eucommia, hematoxylon, woodlouse, native copper, pseudo-ginseng, cucumber seed and nux vomica; and when 100 parts by weight of the deer product is taken as a reference, the pharmaceutical composition respectively comprises 100-200 parts by weight of the frankincense, the myrrh, the teasel root, the dragon's blood, the safflower, the Chinese angelica, the rhizoma drynariae, the wolfberry and the eucommia, 50-150 parts by weight of the hematoxylon, the woodlouse, the native copper and the pseudo-ginseng, 150-250 parts by weight of the cucumber seed, and 20-60 parts by weight of the nux vomica. The pharmaceutical composition and/or the pharmaceutical preparation is/are used when a fracture patient is routinely treated, and can effectively relieve swelling and pains, promote porosis and shorten the rehabilitation time of the fracture patient.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, the pharmaceutical preparation prepared by this pharmaceutical composition, the preparation method of pharmaceutical preparation, and described pharmaceutical composition, described pharmaceutical preparation and the application of pharmaceutical preparation prepared by described preparation method.
Background technology
Fracture is one of modal wound, and life and the life quality of the mankind in serious threat.After fracture, due to the particularity for the treatment of, often require that patient's hinders limb or traumatic part braking, this just makes patient have to long-term bed or make wound limbs be in apraxia state.At present reset, fixing and rehabilitation exercise are mainly to the treatment of fracture.
On the one hand, cause courses of infection because local is injured, swelling and ache very easily appears in fracture site; On the other hand, due to the compressing of fixture in fixation procedure, limbs also can be made to swell and ache and to increase the weight of gradually, also can cause acral as the positions such as finger, toe also occur significantly swelling and ache, green grass or young crops, the numbness etc. of becoming silted up situation, long compressing, it is downright bad that serious meeting causes limbs to be oppressed.And at present, mainly adopt lifting affected limb, make it as far as possible higher than heart plane, suitably give the methods such as ice compress, disappear to promote to swell and ache.
For normal adult, non-serious splintered fracture and dislocation and fracture, need fixing for a long time usually.But fixedly make suffering limb can not get for a long time effectively taking exercise for a long time, some useless syndromes can be produced, such as, suffering limb poor blood circulation causes fracture sclerotin can not get sufficient nutrition and make rehabilitation duration growth, amyotrophy, osteoporosis, ankylosis etc., brings great injury to patient and family.And after dismounting fixture, need the rehabilitation training of longer time to alleviate or to eliminate above-mentioned syndrome.
Summary of the invention
The object of the present invention is to provide one can effective reducing swelling and alleviating pain, promote callus formation and shorten the pharmaceutical composition of rehabilitation duration of fracture patient.
Another object of the present invention is also to provide a kind of pharmaceutical preparation containing said medicine combination, and the preparation method of this pharmaceutical preparation.
Another object of the present invention is also to provide a kind of aforementioned pharmaceutical compositions and pharmaceutical preparation and the pharmaceutical preparation that obtained by above-mentioned preparation method for reducing swelling and alleviating pain, the application promoted in the medicine of callus formation, treatment osteoporosis or treatment fracture.
To achieve these goals, first aspect, the invention provides a kind of pharmaceutical composition, wherein, this pharmaceutical composition contains following raw material: deer product, Olibanum, Myrrha, Radix Dipsaci, Sanguis Draxonis, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Lycii, charred Cortex Eucommiae, Lignum Sappan, Eupolyphaga Seu Steleophaga, Pyritum, Radix Notoginseng, Semen Cucumidis sativi and Semen Strychni; Wherein, with the deer product of 100 weight portions for benchmark, the content of Olibanum, Myrrha, Radix Dipsaci, Sanguis Draxonis, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Lycii and charred Cortex Eucommiae is 100-200 weight portion separately, the content of Lignum Sappan, Eupolyphaga Seu Steleophaga, Pyritum and Radix Notoginseng is 50-150 weight portion separately, the content of Semen Cucumidis sativi is 150-250 weight portion, and the content of Semen Strychni is 20-60 weight portion.
Preferably, described deer product is the deer product of Cervus nippon Temminck and/or the deer product of Cervus elaphus linnaeus.More preferably, described deer product is Ligamentum cervi and/or Os Cervi; Most preferably be Ligamentum cervi and Os Cervi.
Second aspect, present invention also offers a kind of pharmaceutical preparation, and this pharmaceutical preparation contains active component and pharmaceutically acceptable adjuvant, and wherein, described active component is pharmaceutical composition as above.
Preferably, described pharmaceutical preparation is pill.Described adjuvant is Mel.
The third aspect, present invention also offers a kind of preparation method of pharmaceutical preparation, the method comprises, by pharmaceutical composition as above and adjuvant as above mixing also molding.
Fourth aspect, invention additionally provides a kind of pharmaceutical composition as above, power pharmaceutical preparation as above, and the application of the pharmaceutical preparation prepared by method as above in the medicine for reducing swelling and alleviating pain, promotion callus formation, treatment osteoporosis or treatment fracture.
While conventional therapy is carried out to fracture patient, use pharmaceutical composition provided by the invention and/or pharmaceutical preparation, can effectively reducing swelling and alleviating pain, promotion blood samples of patients circulate, and promote the formation of callus, thus shorten rehabilitation duration.
Other features and advantages of the present invention are described in detail in detailed description of the invention part subsequently.
Detailed description of the invention
Below the specific embodiment of the present invention is described in detail.Should be understood that, detailed description of the invention described herein, only for instruction and explanation of the present invention, is not limited to the present invention.
The invention provides a kind of pharmaceutical composition, wherein, this pharmaceutical composition contains following raw material: deer product, Olibanum, Myrrha, Radix Dipsaci, Sanguis Draxonis, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Lycii, charred Cortex Eucommiae, Lignum Sappan, Eupolyphaga Seu Steleophaga, Pyritum, Radix Notoginseng, Semen Cucumidis sativi and Semen Strychni; Wherein, with the deer product of 100 weight portions for benchmark, the content of Olibanum, Myrrha, Radix Dipsaci, Sanguis Draxonis, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Lycii and charred Cortex Eucommiae is 100-200 weight portion separately, the content of Lignum Sappan, Eupolyphaga Seu Steleophaga, Pyritum and Radix Notoginseng is 50-150 weight portion separately, the content of Semen Cucumidis sativi is 150-250 weight portion, and the content of Semen Strychni is 20-60 weight portion.
Preferably, with the deer product of 100 weight portions for benchmark, the content of Olibanum, Myrrha, Radix Dipsaci, Sanguis Draxonis, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Lycii and charred Cortex Eucommiae is 120-180 weight portion separately, the content of Lignum Sappan, Eupolyphaga Seu Steleophaga, Pyritum and Radix Notoginseng is 80-120 weight portion separately, the content of Semen Cucumidis sativi is 180-220 weight portion, and the content of Semen Strychni is 30-50 weight portion.
According to the present invention, having no particular limits the state of above-mentioned each raw material, such as, can be pulverulence, and also can be the liquid condition boiled after adding the water of equivalent according to aforementioned proportion, those skilled in the art can select according to practical situation.Preferably, described raw material is preferably pulverulence, and described powder is can by the siftage of 80-150 mesh sieve, and being more preferably can by the siftage of 100-120 mesh sieve.
Described deer product can be the product of various animal in deer family, is preferably the deer product of Cervus nippon Temminck (Cervus nipponTemminck) and/or the deer product of Cervus elaphus linnaeus (C.elaphus L.).In the present invention, the source of described deer product is had no particular limits, such as, commercially can buy the deer product that cooked for the present invention, also can be obtained, such as, by fresh deer product dry in the sun, oven dry or calcine by conventional concocting method.The method of described calcine is conventionally known to one of skill in the art, does not repeat them here.
Although the deer product containing aforementioned proportion in described pharmaceutical composition can realize object of the present invention, i.e. reducing swelling and alleviating pain, promote callus formation and shorten rehabilitation duration.But the present inventor finds, when described deer product is Ligamentum cervi and/or Os Cervi, when being preferably Ligamentum cervi and Os Cervi, above-mentioned effect is better.
When described deer product be Ligamentum cervi and Os Cervi time, the weight ratio of described Ligamentum cervi and Os Cervi is had no particular limits, as long as there are these two kinds of deer products namely can well realize object of the present invention simultaneously.Preferably, when the weight ratio of described Ligamentum cervi and Os Cervi is 1:0.5-1.5, the drug effect of described pharmaceutical composition can be further enhanced.
It should be noted that the deer product of described 100 weight portions refers to wherein a kind of content as a kind of during described deer product is Ligamentum cervi and Os Cervi herein; When during described deer product is Ligamentum cervi and Os Cervi two kinds, the deer product of described 100 weight portions refers to the total content of two kinds of deer products.
The resin that the bark that Olibanum (OLIBANUM) is olive subject plant Boswellia carterii (Boswellia carterii Birdw) and/or congener (as Bao Da Boswellia carterii Boswellia bhawdajiana Birdw. and wild Boswellia carterii Boswellia neglecta M.Moore) oozes out.
Olibanum is in long avette emulsus, similar round granule or be bonded into the irregular block differed in size, surperficial yellow-white, translucent, is had yellow-white powder; then color burn stored for a long time, matter is crisp, and heat is softened; the plane of disruption has hyaloid or wax sample gloss, the special fragrance of tool, mildly bitter flavor.Slightly see melting point mainly through being put by raw material in pot to fry with slow fire to surface, slightly in yellow, taking-up cools and obtains; Or fry when dissolving to surface, spray rice vinegar, continue to fry to outer bright light saturating, take out to cool and obtain.
Myrrha (MYRRHA) is the dry resin of olive subject plant Herba Violae tree (Commiphora myrrha Engl.) and/or congener (as breathed out Herba Violae tree Commiphora molmol Engl.).
Natural Myrrha is irregular particle agglomerate.Surface yellowish-brown or rufous, nearly translucent portion is brownish black, is had yellow dust.Matter heavily fortified point is crisp, and the plane of disruption is irregular. and matt: to have special fragrance, bitter in the mouth and micro-pungent.Gum opoponax is irregular bulk and granule, coheres the agglomerate becoming to differ in size more, and surperficial brown color is to sepia, opaque, and matter is solid or loose, has special fragrance, bitter in the mouth and have stickiness.Mainly through being stabbed by tree, resin is oozed out naturally by wound or crack mouth.Be just yellowish white liquid, fade to rufous lump in atmosphere, obtain after drying.
Radix Dipsaci (DIPSACIRADIX) is the dry root of Dipsacaceae plant Radix Dipsaci (Dipsacus asperoides C.Y.Cheng et T.M.Ai).
Radix Dipsaci is cylindrical, slightly flat, some microbends.Surface taupe or yellowish-brown, have vertical wrinkle and the rill of slightly distortion or obviously distortion, the hole skin sample spot of visible line and minority mark of fibrous root.Matter is soft, is long placed in rear hardening, frangibility, and section is uneven, and skin zone is blackish green or brown, outer rim brown or filbert, and woody part yellowish-brown, vessel cluster radially arranges.Feeble QI is fragrant, bitter in the mouth, micro-sweet then puckery.Mainly through raw material is cleaned silt, removing retained root head, runs through rear section and dries, sieve anti-dandruff obtaining.
The resin that Sanguis Draxonis (DRACONISSANGUIS) oozes out for babassu Sanguis Draxonis (Daemonorops dracoBl.) fruit.
Sanguis Draxonis is circle square or square brick shape in class slightly, and surface is dark red, glossy, with the Hydrargyri Oxydum Rubrum because of friction.Matter is hard and crisp, and the plane of disruption is red, and levigation is brick-red.Feeble QI, lightly seasoned.Insoluble in water, soften in the hot water.Processing method: take fruit, puts steaming and decocting in food steamer, and resin is oozed out; Or get fruit and mash, put in cloth bag, squeeze resin, then decoct into syrupy shape, cooled and solidified becomes block; Also trunk can be cut brokenly or bore with some apertures, resin be oozed out naturally, solidifies and form.
Flos Carthami (CARTHAMIFLOS) is the dried floral of feverfew Flos Carthami (Carthamus tinctorius L.).
Flos Carthami is the tubular flower not with ovary.Surface red is yellow or red.Matter is soft.Feeble QI is fragrant, mildly bitter flavor.Pluck when summer is spent orange red, dry in the shade, dry or dry and obtain.
Radix Angelicae Sinensis (ANGELICAESINENSISRADIX) is the dry root of umbelliferae angelica (Angelicasinensis (Oliv.) Diels).
Radix Angelicae Sinensis is slightly cylindrical, and supporting root is arranged at bottom.Surface yellowish-brown is to sepia, and tool indulges wrinkle and hole skin sample projection of growing crosswise.Root head (returning head) tool ring grain, upper end circle is blunt, or the several obviously outstanding rhizome trace of tool, has the residue of purple or yellowish green stem and sheath; Main root (returning body) surface irregularity; Supporting root (Radix Angelicae Sinensis) is upper coarse and lower fine, and many distortions have minority mark of fibrous root.Matter is pliable and tough, section yellow-white or fallow, and skin zone is thick, and have crack and the brown point-like secretory cavity of majority, woody part color is lighter, cambium ring yellowish-brown.There is strong fragrance, sweet in the mouth, pungent, micro-hardship.Chai Xing great, withered nothing oil or section are green and brown color person can not hyoscine.By raw material is removed impurity, clean, run through, shave, to dry or cold drying obtains.
Rhizoma Drynariae (DRYNARIAERHIZOMA) is the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi (Drynariafortune (Kunze) J.Sm.).
This product is flat strip, bends more, has branch.Surface close by dark-brown to the ramentum of burgundy, soft as hair, through the fire person of burning in sepia or crineous, both sides and upper surface equal tool projection or recessed circular leaf scar, minority have petiole residual base and fibrous root residual.Body is light, and matter is crisp, frangibility, section rufous, and vascular bundle is yellow point-like, arrangement ring formation.Feeble QI is lightly seasoned, micro-puckery.The whole year all can excavate, removing silt, dry, or burns remove floss (scale) again and obtain.
Fructus Lycii (LYCIIFRUCTUS) is the dry mature fruit of plant of Solanaceae lycium barbarum (Lycium barbarum, LB.).
Fructus Lycii is class spindle or ellipse.Surface redness or kermesinus, there is the stylar scar of kick shape on top, the carpopodium trace of base portion adularescent.Peel is pliable and tough, shrinkage; Sarcocarp meat, soft and moist.Kind of subclass kidney shape is flat and stick up, the light yellow or brown color in surface.Feeble QI, taste is sweet.Summer, autumn two gather when season, fruit took on a red color, hot-air seasoning, and removing carpopodium obtains, or dries in the air to rhicnosis, dries, and removing carpopodium obtains.
The bark that charred Cortex Eucommiae (Cortex Eucommiae former plant Cortex Eucommiae Eucommia ulmoides Oliv.) is the Eucommiaceae plant Cortex Eucommiae.
Charred Cortex Eucommiae is smooth en plaque or roll film shape.Outer surface taupe brown, coarse, there are irregular lobe groove stricture of vagina and rhomboid transverse fissure hole skin, sometimes visible light gray lichens speckle.Inner surface is smooth, mulberry.The crisp frangibility of matter, section has silvery white filament to be connected, fine and closely woven, slightly retractility.Feeble QI, taste is slightly bitter, and that chews has gummy residue.Processing method: 1, remove rough bark, clean, run through, dice or strand, dry; 2, get Cortex Eucommiae block, put in pot and fry with high heat to black and fracture of wire, but palpus sustainability, spray with saline, take out, prevent resume combustion, dry and get final product; Or get Cortex Eucommiae block, first mix thoroughly with saline and exhaust in rearmounted pot, fry with high heat to black and fracture of wire sustainability, with water spray fire extinguishing star, taking-up is dried.
Lignum Sappan (SAPPANLIGNUM) is the dry duramen of leguminous plant Lignum Sappan (Caesalpinia sappan L.).
Lignum Sappan is elongated cylindrical or to cuing open semi-cylindrical.Surface yellowish red color to brownish red, tool cutter sheeter lines. common longitudinal crack.Matter is hard.Section somewhat gloss, annual ring is obvious, the marrow of the visible burgundy had, matter pine, band bright star.Feeble QI, taste is micro-puckery.More than autumn, remove white sapwood, drying obtains.
The female worm dry body that Eupolyphaga Seu Steleophaga (EUPOLYPHAGA STELEOPHAGA) is Corydiidae insecticide eupolyphoge sinensis (Eupolyphaga sinesis Walker) or Ji eupolyphoge sinensis (Steleophaga plancyi (Boleny)).
Eupolyphaga Seu Steleophaga is flattened egg-shape.Front end is narrower, and rear end is wider, back puce, and tool gloss is aptery.Pronotary is more flourishing, covers head; Abdomen backboard 9 saves, and arranges in imbricate.Outside of belly rufous, head is less, has filiform antenna 1 right, often comes off, and chest has foot 3 right, tool fine, soft fur and thorn.Abdominal part has horizontal link.Matter is crisp, frangible.Gas is smelt as of rotten fish, and taste is micro-salty.Ji eupolyphoge sinensis.Back is dark brown, usually at edge with khaki speckle and black point.After seizure, put and scald dead in boiling water, dry or dry and obtain.
Pyritum (PYRITUM) is sulfide-based mineral yellow iron mine race pyrite.
Pyritum shape mostly is cube, and aggregation is compact massive.Surface is bright faint yellow, has metallic luster; Some yellowish-brown or sepia, without metallic luster.Tool striped, the green black of streak or brownish red.Body weight, matter is hard or slightly crisp, easily smashes, and section yellow-white, has metallic luster; Or section sepia, visible silvery white bright star.Main containing ferrous disulfide (FeS
2).After excavating, except roguing stone obtains.
Radix Notoginseng is the dry root welding technology of panax araliaceae plant (Panax notoginseng (Burk.) F.H.Chen).
Main root is that class is conical or cylindrical.Surface taupe or lark, have interrupted vertical wrinkle and supporting root trace.There is stem trace on top, has strumae around.Body weight, matter is solid, section celadon, yellow green or canescence, and woody part is micro-radially to be arranged.Feeble QI, bitter in the mouth Hui Tian.Rib is cylindrical or conical.Clip is irregular shrinkage bulk or strip, and there are several obvious stem trace and ring grain in surface, section center celadon or white, edge bottle green or Lycoperdon polymorphum Vitt.Autumn excavates before the flowers are in blossom, cleans, and separately main root, a root and rhizome, dry.
Semen Cucumidis sativi is the seed of cucurbitaceous plant Fructus Cucumidis sativi (Cucumis satiuus L.).To gather in summer, autumn mellow fruit, cut open, take out seed, clean, dry and obtain.
The dry mature seed of Semen Strychni (STRYCHNISEMEN) loganiaceae plant Semen Strychni (Strychnos nuxvomica L.).
Semen Strychni is button shape circular plate type, and normal one side protuberance, one side is slightly recessed.Surface is close by greyish brown or celadon thin,tough silk shape fine hair, asks to surrounding and arranges radially, have a sample gloss certainly.Edge slightly swells, thicker, the bossed hole of bead, the bossed round point shape hilum of bottom center.Matter is hard, the visible yellowish white endosperm of parallel section, cutin shape, and cotyledon is heart-shaped.Feeble QI, taste is extremely bitter.
In the present invention, the source of above-mentioned various raw material is had no particular limits, such as, can commercially buy the product cooked, also can be obtained by conventional concocting method, such as can by raw material being carried out drying and grinding and obtain.Dry method for drying or naturally drying, can be preferably nature and dries.The method of grinding can be the Ginding process of field of Chinese medicines routine, and the condition of grinding preferably enables described raw material by the powder of 80-150 object sieve aperture, preferably can pass through 100-120 object sieve aperture.
Pharmaceutical composition of the present invention can by obtaining described various raw material mixing.As long as the condition of mixing makes various raw material according to ratio mix homogeneously of the present invention.
It should be noted that herein, above-mentioned various raw material can be obtained according to carrying out being ground to preferred particle size range in the present invention again after content range mixing of the present invention in the present invention, also the various raw materials being ground to particle size range of the present invention in advance can be mixed to get according to proportioning of the present invention.
Pharmaceutical composition provided by the invention, can suppress infection and the growth of affected part pathogenic bacteria on the one hand, thus can play the effect of reducing swelling and alleviating pain.On the other hand, described pharmaceutical composition can blood circulation promoting, thus contributes to the absorption of hydrops, can also bring more nutrition for affected part; Bone resorption and callus formation can also be promoted into simultaneously, thus promote the growth of osteocyte, make sclerotin calcification, be conducive to bone diseases such as treatment osteoporosis or fracture etc.
Second aspect, present invention also offers a kind of pharmaceutical preparation, and this pharmaceutical preparation contains active component and pharmaceutically acceptable adjuvant, and wherein, described active component is pharmaceutical composition as above.
According to the present invention, described active component and pharmaceutically acceptable adjuvant can be prepared into any type of pharmaceutical preparation.Such as, can be unguentum, capsule or pill.Described pharmaceutically acceptable adjuvant specifically can be selected according to the dosage form of prepared pharmaceutical preparation, and the foundation of described selection is conventionally known to one of skill in the art, does not repeat them here.
The present inventor finds, when being pill by described pharmaceutical preparation, taken by oral, curative effect is better.With the gross weight of pharmaceutical preparation for benchmark, the content of described active component can be 30-60 % by weight, and be preferably 40-50 % by weight, the content of described adjuvant is 40-70 % by weight, is preferably 50-60 % by weight.
Described pill is preferably honeyed pill, and described adjuvant is preferably Mel, and in a more preferred case, described adjuvant is preferably Mel, and described Mel can be commercially available various Mel.
Based on this, present invention also offers a kind of preparation method of pill, the method comprises, and is mixed by drug regimen provided by the invention and molding with adjuvant as above.
Pharmaceutical composition of the present invention can by obtaining described various raw material mixing.With the gross weight of obtained pill for benchmark, the consumption of described active component can be 30-60 % by weight, and be preferably 40-50 % by weight, the consumption of described adjuvant is 40-70 % by weight, is preferably 50-60 % by weight.
Described adjuvant is preferably Mel.The temperature of described mixing can be 100-130 DEG C, and be preferably 105-110 DEG C, the time of mixing can be 10-60 minute.
The method of described molding can adopt the conventional forming method for the preparation of pill, such as, the medicine block be mixed to form can be put into pellet processing machine and become ball.The small honey pill of 0.37 gram is preferably made with doctor's pellet processing machine.
Present invention also offers a kind of pharmaceutical composition as above, pharmaceutical preparation as above, and the application of the pharmaceutical preparation prepared by method as above in the medicine for reducing swelling and alleviating pain, promotion callus formation, treatment osteoporosis or treatment fracture.
The pharmaceutical composition formed by the raw material of content described above, pharmaceutical preparation as above, and the pill that as described above prepared by method can play reducing swelling and alleviating pain, promote the effect of callus formation, especially to osteoporosis and fracture, there is good curative effect, can effectively carry callus formation, reducing swelling and alleviating pain, effect of reunion of fractured tendons and bones.Can blood circulation promoting when using as above pharmaceutical composition of the present invention or pharmaceutical preparation, osteoblast is enlivened, impels the formation of sclerotin calcification and callus, be conducive to the healing of fracturing.
In addition, the traditional Chinese medical science to union of fracture theory is: treatment fracture is elder generation with blood circulation promoting and blood stasis dispelling, and blood is not lived in then becoming silted up and do not gone, and becomes silted up and does not go then bone not connect.While replacement and fixation, necessary blood circulation promoting and blood stasis dispelling, reunion of fractured tendons and bones, takes a tonic or nourishing food to build up one's health cloudy blood etc.And pharmaceutical composition provided by the invention and pharmaceutical preparation can play the effect of good blood circulation promoting and blood stasis dispelling, thus fracture patient can be enable to fully recover fast.
In more detail the present invention is described below by embodiment.
The processing method of raw material used in following examples is as follows.
The Ligamentum cervi of the Cervus nippon Temminck of health and Os Cervi dried at 110 DEG C respectively, grind afterwards and use 120 object screen clothes to screen, siftage is respectively Cervus nippon Temminck Ligamentum cervi as raw material and Os Cervi.
The Ligamentum cervi of the Cervus elaphus linnaeus of health and Os Cervi dried at 110 DEG C respectively, grind afterwards and use 120 object screen clothes to screen, siftage is Cervus elaphus linnaeus Ligamentum cervi as raw material and Os Cervi.
Grind after respectively Olibanum, Myrrha, Radix Dipsaci, Sanguis Draxonis, Flos Carthami, Radix Angelicae Sinensis, charred Cortex Eucommiae, Rhizoma Drynariae, Fructus Lycii, Radix Notoginseng, Eupolyphaga Seu Steleophaga, Pyritum, Semen Strychni, Semen Cucumidis sativi and Lignum Sappan being dried and use 120 object screen cloth screenings, and selecting the siftage of each raw material for the preparation of pharmaceutical composition of the present invention.
Table 1
| Embodiment | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Pharmaceutical composition is numbered | A1 | A2 | A3 | A4 | A5 |
| Deer product | 100 | 100 | 100 | 100 | 100 |
| Olibanum | 150 | 120 | 180 | 100 | 200 |
| Myrrha | 150 | 180 | 120 | 200 | 102 |
| Radix Dipsaci | 120 | 150 | 180 | 200 | 100 |
| Sanguis Draxonis | 180 | 160 | 120 | 98 | 204 |
| Flos Carthami | 140 | 120 | 180 | 200 | 100 |
| Radix Angelicae Sinensis | 155 | 180 | 120 | 200 | 98 |
| Rhizoma Drynariae | 120 | 165 | 180 | 105 | 201 |
| Fructus Lycii | 180 | 150 | 120 | 200 | 100 |
| Charred Cortex Eucommiae | 115 | 145 | 185 | 100 | 200 |
| Lignum Sappan | 100 | 80 | 120 | 48 | 148 |
| Eupolyphaga Seu Steleophaga | 115 | 75 | 121 | 150 | 50 |
| Pyritum | 120 | 80 | 100 | 55 | 155 |
| Radix Notoginseng | 80 | 100 | 120 | 50 | 150 |
| Semen Cucumidis sativi | 200 | 180 | 220 | 250 | 150 |
| Semen Strychni | 40 | 30 | 50 | 20 | 60 |
In above embodiment:
Deer product described in embodiment 1 and 5 is Ligamentum cervi and the Os Cervi of Cervus nippon Temminck, and amount ratio is 1:1;
Deer product described in embodiment 2 is Ligamentum cervi and the Os Cervi of Cervus elaphus linnaeus, and amount ratio is 1:0.5;
Deer product described in embodiment 3 is the Ligamentum cervi of Cervus elaphus linnaeus and the Os Cervi of Cervus nippon Temminck, and amount ratio is 1:1.5;
Embodiment 4 is the Ligamentum cervi of Cervus nippon Temminck and the Os Cervi of Cervus elaphus linnaeus, and amount ratio is 1:1.
Embodiment 1-5
Embodiment 1-5 is for the preparation of the Chinese medicine composition that the invention provides thing.
According to the consumption (all with parts by weight) shown in table 1, each raw material is mixed, respectively obtained compositions A1-A5.
Embodiment 6-7
Embodiment 6-7 is for the preparation of pharmaceutical composition provided by the invention.
According to the method pharmaceutical compositions of embodiment 1, unlike, the deer product in embodiment 6 is all the Ligamentum cervi of Cervus nippon Temminck, and the deer product in embodiment 7 is all the Os Cervi of Cervus nippon Temminck.Obtained compositions A6 and A7 respectively.
Comparative example 1
This comparative example is for the preparation of pharmaceutical composition provided by the invention.
According to the method pharmaceutical compositions of embodiment 1, unlike, not containing deer product in described pharmaceutical composition.Obtained compositions C1.
Embodiment 8-14
Embodiment 8-14 is for the preparation of pill provided by the invention.
Mel is heated to 110 DEG C, the Chinese medicine composition A1-A7 then prepared by embodiment 1-7 respectively joins in Mel, endures 20 minutes at 110 DEG C.Then join in pellet processing machine after Temperature fall to 25 DEG C and make ball, the weight of every ball is 0.37 gram, obtains pill B1-B7.
Wherein, described Mel is Mel;
With the gross weight of described pill for benchmark, in embodiment 8,13 and 14, the content of A1, A6 and A7 is 45 % by weight, and the content of Mel is 55 % by weight;
In embodiment 9, the content of A2 is 40 % by weight, and the content of Mel is 60 % by weight;
In embodiment 10, the content of A3 is 50 % by weight, and the content of Mel is 50 % by weight.
In embodiment 11, with the gross weight of described pill for benchmark, the content of A4 is 30 % by weight, and the content of Mel is 70 % by weight.
In embodiment 12, with the gross weight of described pill for benchmark, the content of A5 is 60 % by weight, and the content of Mel is 40 % by weight.
Comparative example 2
Comparative example 2 is for the preparation of the pill of reference.
Pill is prepared according to the method for embodiment 8, unlike, the pharmaceutical composition used is C1, obtains pill D1.
Test case 1-7
Test case 1-10 is for illustration of the drug effect that the invention provides pharmaceutical composition and pharmaceutical preparation.
Select 140 men and women patients with fracture of tibia and fibula in various degree, the age of patient, between 30-70 year, is divided into 10 groups at random, often organizes 20 people.First adopt conventional method reset to fracture patient and fix, make patient's Ipsilateral of lying on one's side be the curved placement of semiflexion, trouble lower limb both sides sandbag chokes.Often organize the pill that patient distinguishes the embodiment 8-14 of oral 12 balls separately sooner or later.Take 1 month all continuously.Every day checks once, records the natural law that each group membership swells and ache when all disappearing respectively, all can movable in bed time natural law, held by both hands turn natural law when practising natural law when walking and recovery from illness lowerly, the results are shown in Table 2.
Contrast test example 1
According to the method for test case 1-7, fracture of tibia and fibula patient is treated, unlike, the pill D1 in application comparative example 2.Every day checks once, records the natural law that each group membership swells and ache when all disappearing respectively, all can movable in bed time natural law, held by both hands turn natural law when practising natural law when walking and recovery from illness lowerly, the results are shown in Table 2.
Contrast test example 2
According to the method for test case 1-7, fracture of tibia and fibula patient is treated, unlike, do not take pill provided by the invention.Every day checks once, records the natural law that each group membership swells and ache when all disappearing respectively, all can movable in bed time natural law, held by both hands turn natural law when practising natural law when walking and recovery from illness lowerly, the results are shown in Table 2.
Table 2
As can be seen from the test result of table 2, pharmaceutical composition provided by the invention and pharmaceutical preparation can make patient swell and ache to disappear faster, and effectively can improve the cure rate of fracture patient, reduce the misery of patient.According to clinical observation, the basis of conventional therapy use pharmaceutical composition provided by the invention and pharmaceutical preparation make healing time treat its normal healing time shorten time of 1/3rd or half than simple recuperation.
This shows, pharmaceutical composition provided by the invention and pharmaceutical preparation and the pharmaceutical composition prepared by preparation method provided by the invention have reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, promotion bone resorption and osteoplastic effect, thus can shorten the rehabilitation duration of fracture patient.
More than describe the preferred embodiment of the present invention in detail; but the present invention is not limited to the detail in above-mentioned embodiment, within the scope of technical conceive of the present invention; can carry out multiple simple variant to technical scheme of the present invention, these simple variant all belong to protection scope of the present invention.
It should be noted that in addition, each the concrete technical characteristic described in above-mentioned detailed description of the invention, in reconcilable situation, can be combined by any suitable mode.In order to avoid unnecessary repetition, the present invention illustrates no longer separately to various possible compound mode.
In addition, also can carry out combination in any between various different embodiment of the present invention, as long as it is without prejudice to thought of the present invention, it should be considered as content disclosed in this invention equally.
Claims (10)
1. a pharmaceutical composition, it is characterized in that, this pharmaceutical composition is prepared from by following raw material: deer product, Olibanum, Myrrha, Radix Dipsaci, Sanguis Draxonis, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Lycii, charred Cortex Eucommiae, Lignum Sappan, Eupolyphaga Seu Steleophaga, Pyritum, Radix Notoginseng, Semen Cucumidis sativi and Semen Strychni; Wherein, with the deer product of 100 weight portions for benchmark, the content of Olibanum, Myrrha, Radix Dipsaci, Sanguis Draxonis, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Lycii and charred Cortex Eucommiae is 100-200 weight portion separately, the content of Lignum Sappan, Eupolyphaga Seu Steleophaga, Pyritum and Radix Notoginseng is 50-150 weight portion separately, the content of Semen Cucumidis sativi is 150-250 weight portion, the content of Semen Strychni is 20-60 weight portion, and wherein, described deer product is Ligamentum cervi and/or Os Cervi.
2. pharmaceutical composition according to claim 1, wherein, described deer product is the deer product of Cervus nippon Temminck and/or the deer product of Cervus elaphus linnaeus.
3. pharmaceutical composition according to claim 1 and 2, wherein, described deer product is Ligamentum cervi and Os Cervi; The weight ratio of described Ligamentum cervi and Os Cervi is 1:0.5-1.5.
4. pharmaceutical composition according to claim 1 and 2, wherein, described pharmaceutical composition is can by the powder of the sieve aperture of 80-150 mesh sieve.
5. a pharmaceutical preparation, this pharmaceutical preparation contains active component and pharmaceutically acceptable adjuvant, it is characterized in that, described active component is the pharmaceutical composition described in any one in claim 1-4.
6. pharmaceutical preparation according to claim 5, wherein, described pharmaceutical preparation is pill, and with the gross weight of described pill for benchmark, the content of described active component is 30-60 % by weight, and the content of described adjuvant is 40-70 % by weight.
7. pharmaceutical preparation according to claim 6, wherein, with the gross weight of described pill for benchmark, the content of described active component is 40-50 % by weight, and the content of described adjuvant is 50-60 % by weight.
8. according to the pharmaceutical preparation in claim 5-7 described in any one, wherein, described adjuvant is Mel.
9. a preparation method for pill, the method comprises, by the pharmaceutically acceptable adjuvant mixing also molding in the pharmaceutical composition in claim 1-4 described in any one and claim 6-8 described in any one.
10. the pharmaceutical composition in claim 1-4 described in any one, pharmaceutical preparation in claim 5-8 described in any one, and the application of the pharmaceutical preparation prepared by method according to claim 9 in the medicine for the preparation of reducing swelling and alleviating pain, promotion callus formation, treatment osteoporosis or treatment fracture.
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| CN105168537A (en) * | 2015-09-14 | 2015-12-23 | 中国科学院新疆理化技术研究所 | Compound medicine for treating bone fracture and preparation method of compound medicine |
| CN106177783A (en) * | 2016-08-23 | 2016-12-07 | 北海桔泉金花茶有限公司 | A kind of golden camellia wine being added with Rhizoma Drynariae and preparation method thereof |
| CN106215102A (en) * | 2016-08-23 | 2016-12-14 | 北海桔泉金花茶有限公司 | A kind of golden camellia wine being added with Pyritum and preparation method thereof |
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| CN1218729C (en) * | 2003-02-21 | 2005-09-14 | 付宝 | Xuerongguyugao ointment for healing fracture and its prepn |
| CN101019975A (en) * | 2007-03-14 | 2007-08-22 | 吴方忠 | Fracture treating Chinese medicine composition and its prepn |
| CN102091234B (en) * | 2011-01-25 | 2012-02-08 | 王根保 | Traditional Chinese medicine composition for treating bone fracture diseases |
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