CN103494824B - Kadcoccitones A在制备治疗或预防急性心衰药物中的应用 - Google Patents
Kadcoccitones A在制备治疗或预防急性心衰药物中的应用 Download PDFInfo
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- CN103494824B CN103494824B CN201310495829.9A CN201310495829A CN103494824B CN 103494824 B CN103494824 B CN 103494824B CN 201310495829 A CN201310495829 A CN 201310495829A CN 103494824 B CN103494824 B CN 103494824B
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- Prior art keywords
- heart failure
- acute heart
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- kadcoccitonesa
- kadcoccitones
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- 206010007556 Cardiac failure acute Diseases 0.000 title claims abstract description 18
- 239000003814 drug Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000002265 prevention Effects 0.000 title claims description 12
- 229930185251 kadcoccitone Natural products 0.000 title abstract description 3
- FVIZARNDLVOMSU-UHFFFAOYSA-N ginsenoside K Natural products C1CC(C2(CCC3C(C)(C)C(O)CCC3(C)C2CC2O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O FVIZARNDLVOMSU-UHFFFAOYSA-N 0.000 claims description 7
- 206010019280 Heart failures Diseases 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 3
- 230000000747 cardiac effect Effects 0.000 description 8
- 241000282472 Canis lupus familiaris Species 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 241000282465 Canis Species 0.000 description 3
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
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- 210000000709 aorta Anatomy 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
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- 230000002107 myocardial effect Effects 0.000 description 2
- 229960002275 pentobarbital sodium Drugs 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
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- 239000004375 Dextrin Substances 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000033240 Progressive symmetric erythrokeratodermia Diseases 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
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- 235000019425 dextrin Nutrition 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000007575 pulmonary infarction Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310495829.9A CN103494824B (zh) | 2013-10-21 | 2013-10-21 | Kadcoccitones A在制备治疗或预防急性心衰药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310495829.9A CN103494824B (zh) | 2013-10-21 | 2013-10-21 | Kadcoccitones A在制备治疗或预防急性心衰药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103494824A CN103494824A (zh) | 2014-01-08 |
CN103494824B true CN103494824B (zh) | 2016-02-10 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201310495829.9A Expired - Fee Related CN103494824B (zh) | 2013-10-21 | 2013-10-21 | Kadcoccitones A在制备治疗或预防急性心衰药物中的应用 |
Country Status (1)
Country | Link |
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CN (1) | CN103494824B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101965184A (zh) * | 2008-01-11 | 2011-02-02 | 里亚塔医药公司 | 合成三萜类化合物及用以治病之方法 |
-
2013
- 2013-10-21 CN CN201310495829.9A patent/CN103494824B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101965184A (zh) * | 2008-01-11 | 2011-02-02 | 里亚塔医药公司 | 合成三萜类化合物及用以治病之方法 |
Non-Patent Citations (1)
Title |
---|
Kadcoccitones A and B, Two New6/6/5/5-Fused Tetracyclic Triterpenoids;Cheng-Qin Liang,et al.,;《Organic Letters》;20121211;第14卷(第24期);第6362-6365页 * |
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CN103494824A (zh) | 2014-01-08 |
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C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Yingfu Inventor after: Chen Ying Inventor after: Su Dewang Inventor after: Cui Hongyu Inventor after: Wang He Inventor before: The inventor has waived the right to be mentioned |
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Effective date of registration: 20160108 Address after: Xiangyang District in Heilongjiang province Jiamusi City Xuefu street 154007 No. 184 3 Applicant after: Li Yingfu Address before: 211200, No. 1, industrial town, crystal Town, Lishui District, Jiangsu, Nanjing Applicant before: Sun Aihua |
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Effective date of registration: 20170407 Address after: 154000 Heilongjiang Province, Xiangyang District, Jiamusi, No. four Feng Road, No. 48 Patentee after: Jiamusi University Address before: Xiangyang District in Heilongjiang province Jiamusi City Xuefu street 154007 No. 184 3 Patentee before: Li Yingfu |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160210 Termination date: 20161021 |