CN103491944A - 具有包含两种不同粘度增强剂的粘度增强体系的眼用组合物 - Google Patents

具有包含两种不同粘度增强剂的粘度增强体系的眼用组合物 Download PDF

Info

Publication number
CN103491944A
CN103491944A CN201280019679.8A CN201280019679A CN103491944A CN 103491944 A CN103491944 A CN 103491944A CN 201280019679 A CN201280019679 A CN 201280019679A CN 103491944 A CN103491944 A CN 103491944A
Authority
CN
China
Prior art keywords
viscosity
compositions
ophthalmic composition
composition
eye
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280019679.8A
Other languages
English (en)
Chinese (zh)
Inventor
M·A·乔罕
M·戈什
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Research LLC
Original Assignee
Alcon Manufacturing Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Manufacturing Ltd filed Critical Alcon Manufacturing Ltd
Publication of CN103491944A publication Critical patent/CN103491944A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280019679.8A 2011-04-22 2012-04-19 具有包含两种不同粘度增强剂的粘度增强体系的眼用组合物 Pending CN103491944A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161478084P 2011-04-22 2011-04-22
US61/478,084 2011-04-22
PCT/US2012/034187 WO2012145470A2 (en) 2011-04-22 2012-04-19 Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents

Publications (1)

Publication Number Publication Date
CN103491944A true CN103491944A (zh) 2014-01-01

Family

ID=46026952

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280019679.8A Pending CN103491944A (zh) 2011-04-22 2012-04-19 具有包含两种不同粘度增强剂的粘度增强体系的眼用组合物

Country Status (11)

Country Link
US (1) US20120270955A1 (https=)
EP (2) EP3045163A1 (https=)
JP (1) JP2014512387A (https=)
KR (1) KR20140022901A (https=)
CN (1) CN103491944A (https=)
AU (1) AU2012245454A1 (https=)
BR (1) BR112013026534A2 (https=)
CA (1) CA2833596A1 (https=)
MX (1) MX2013012308A (https=)
RU (1) RU2601115C2 (https=)
WO (1) WO2012145470A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113518646A (zh) * 2019-02-27 2021-10-19 参天制药株式会社 含有地夸磷索或其盐，乙烯基系高分子及纤维素系高分子的眼科用组合物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016013993A1 (en) * 2014-07-25 2016-01-28 Imuneks Farma Llac Sanayi Ve Ticaret A.Ş. Stable preservative free ophthalmic formulations of opioid antagonists
US20230093908A1 (en) * 2019-08-18 2023-03-30 IVIEW Therapeutics (Zhuhai) Co., Ltd. In-situ Gel Containing Cyclosporine Micelles as Sustained Ophthalmic Drug Delivery System
JP2023038930A (ja) * 2021-09-07 2023-03-17 学校法人近畿大学 眼表面薬物滞留化剤およびこれを含む点眼剤、並びに、これらの剤を用いた眼表面薬物滞留方法および眼科疾患治療方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1479631A (zh) * 2000-12-06 2004-03-03 ʿ 用于眼部药物递送的可逆胶凝系统
US20100249062A1 (en) * 2007-09-28 2010-09-30 Yasuko Matsumura Ophthalmic composition

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4027020A (en) 1974-10-29 1977-05-31 Millmaster Onyx Corporation Randomly terminated capped polymers
US3931319A (en) 1974-10-29 1976-01-06 Millmaster Onyx Corporation Capped polymers
US4525346A (en) 1981-09-28 1985-06-25 Alcon Laboratories, Inc. Aqueous antimicrobial ophthalmic solutions
US4407791A (en) 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
US4836986A (en) 1984-09-28 1989-06-06 Bausch & Lomb Incorporated Disinfecting and preserving systems and methods of use
US5037647A (en) 1988-09-15 1991-08-06 Alcon Laboratories, Inc. Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride
US5145643A (en) 1990-01-05 1992-09-08 Allergan, Inc. Nonoxidative ophthalmic compositions and methods for preserving and using same
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
US5300287A (en) 1992-11-04 1994-04-05 Alcon Laboratories, Inc. Polymeric antimicrobials and their use in pharmaceutical compositions
US5540930A (en) * 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
WO1997028827A1 (fr) * 1996-02-07 1997-08-14 Rohto Pharmaceutical Co., Ltd. Composition ophtalmique possedant une viscosite adaptee
DK0999825T3 (da) 1997-07-29 2004-02-09 Alcon Lab Inc Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater
WO2005042026A1 (ja) * 2003-10-31 2005-05-12 Wakamoto Pharmaceutical Co., Ltd. 可逆性熱ゲル化水性組成物
CN101073556A (zh) * 2007-06-25 2007-11-21 苏州瑞桥医药科技有限公司 一种散瞳眼用制剂及其制备方法
RU2600863C2 (ru) * 2007-12-10 2016-10-27 Сентисс Фарма Прайвит Лимитед Офтальмическая композиция, включающая фенилэфрин
ES2638771T3 (es) 2008-03-17 2017-10-24 Novartis Ag Composiciones farmacéuticas acuosas que contienen complejos de borato-poliol
TWI489997B (zh) 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1479631A (zh) * 2000-12-06 2004-03-03 ʿ 用于眼部药物递送的可逆胶凝系统
US20100249062A1 (en) * 2007-09-28 2010-09-30 Yasuko Matsumura Ophthalmic composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113518646A (zh) * 2019-02-27 2021-10-19 参天制药株式会社 含有地夸磷索或其盐，乙烯基系高分子及纤维素系高分子的眼科用组合物
CN113518646B (zh) * 2019-02-27 2023-12-12 参天制药株式会社 含有地夸磷索或其盐，乙烯基系高分子及纤维素系高分子的眼科用组合物

Also Published As

Publication number Publication date
WO2012145470A2 (en) 2012-10-26
CA2833596A1 (en) 2012-10-26
RU2013152026A (ru) 2015-05-27
KR20140022901A (ko) 2014-02-25
BR112013026534A2 (pt) 2016-12-27
EP2699229A2 (en) 2014-02-26
RU2601115C2 (ru) 2016-10-27
MX2013012308A (es) 2014-01-31
WO2012145470A3 (en) 2013-04-25
EP3045163A1 (en) 2016-07-20
JP2014512387A (ja) 2014-05-22
US20120270955A1 (en) 2012-10-25
AU2012245454A1 (en) 2013-10-17

Similar Documents

Publication Publication Date Title
CN102958509B (zh) 用于不含防腐剂的非粘性前列腺素类溶液的聚合物给药系统
CN102802604B (zh) 含有硼酸盐-多元醇复合物的水性药物组合物
TWI746662B (zh) 眼科用製品及黏度降低抑制方法
JP2004514731A (ja) 眼薬送達のための可逆的ゲル化システム
TWI629057B (zh) 眼科用組成物
CN103747786A (zh) 比马前列素和溴莫尼定的固定剂量组合
JP2011021002A (ja) 眼科用組成物
CN103491944A (zh) 具有包含两种不同粘度增强剂的粘度增强体系的眼用组合物
KR20130100273A (ko) 점안용 수성 조성물
AU2012245538B2 (en) Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents
TW202519198A (zh) 治療糖尿病黃斑水腫的方法
JP2017501184A (ja) 低減された眼圧で術後の炎症を治療するための方法
JP6589099B2 (ja) 濃縮水性アザライド製剤
US20170128481A9 (en) Ocular treatment with reduced intraocular pressure
WO2019123266A1 (en) Ophthalmic composition having a prostaglandin and a beta-blocker
CN103140215A (zh) 具有提高的溶解度特征的药物组合物
HK1178446B (en) Polymeric delivery system for a nonviscous prostaglandin-based solution without preservatives
HK1201464B (en) Polymeric delivery system for a nonviscous prostaglandin-based solution without preservatives

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20140101

RJ01 Rejection of invention patent application after publication