CN103491780A - Bactericide composition and bactericidal cleaning composition - Google Patents
Bactericide composition and bactericidal cleaning composition Download PDFInfo
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- CN103491780A CN103491780A CN201280020640.8A CN201280020640A CN103491780A CN 103491780 A CN103491780 A CN 103491780A CN 201280020640 A CN201280020640 A CN 201280020640A CN 103491780 A CN103491780 A CN 103491780A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
Abstract
The present invention provides a bactericide composition comprising a compound indicated in formula (I) and a triethanolamine (in the formula, R1 indicates a C1-C3 saturated straight-chain alkyl group, R2 indicates a C8-C12 saturated straight-chain alkyl group, X- indicates a halogen ion, and Y indicates a C8-C12 saturated straight-chain alkylene group.) The present invention also provides a bactericidal cleaning composition comprising the compound indicated by the formula (I), a nonionic surfactant, and a triethanolamine.
Description
Technical field
The present invention relates to bactericidal composition and desinfactant detergent composition, it is mainly used in sterilization or the sterilizing cleaning of (comprising its floor, wall, instrument and facility) such as bakery and confectionerys.The invention still further relates to sterilization method and the sterilizing cleaning method of using this composition.
Background technology
Place such as bakery and confectionery, the kitchen in dining room and the job shop in provisions shop processing food, from the viewpoint of health, need to carry out disinfection to floor, wall, instrument, facility etc.Various bactericide such as alcohol, chlorinated compound, peroxide, cationic surface active agent, amphoteric surfactant and biguanide compound are so far for sterilization.For example, as the DDAC of quaternary ammonium salt (cationic surface active agent) be safe and efficient bactericide as the hexamethylene of biguanide compound, and frequent the use.In addition, the place processing food, can cause that the dirt of microbial growth need to be washed off in operating process or afterwards.Desinfactant detergent with sterilization and cleaning effect is often used, and its permission carries out disinfection and cleans in a step.The desinfactant detergent composition of the desinfactant detergent composition of the combination that for example, has proposed so far to contain quaternary ammonium salt and nonionic surface active agent and/or amphoteric surfactant and the combination that contains biguanides bactericide and nonionic surface active agent.The desinfactant detergent composition that patent documentation 1 discloses the specific quaternary ammonium salt, amphoteric surfactant, nonionic surface active agent and the water that contain special ratios has high sterilization and cleaning effect and high stability.
Produced microorganism to the tolerance of quaternary ammonium salt or biguanides bactericide (below, also referred to as " drug-resistant microorganism ") in reusing these bactericide processes, and it causes that sterilization is insufficient.For example, described in non-patent literature 1, the bacterium that known pseudomonad (Pseudomonas) belongs to or Serratieae (Serratia) belongs to is the microorganism for DDAC or hexamethylene tolerance.Bactericide type for sterilization can periodically-varied, to prevent microorganism generation drug resistance.Yet the frequent change of bactericide causes operating efficiency low, cost increases, and therefore tends to avoid like this.Drug-resistant microorganism is processed such as clorox by the chlorination bactericide usually.Yet, tend to avoid using the chlorination bactericide, because they cause corrosion and damage on facilities and equipment, also cause that disadvantageous smell is residual.Tend to keep smooth property after using DDAC.Tend to keep viscosity after using hexamethylene.
From situation as above, required bactericidal composition is following composition, described composition to fungi such as mould with to general bacterium and drug-resistant microorganism is had to bactericidal effect, cause hardly the microorganisms drug resistance, even also like this when composition continues or uses continuously, and keep lower smooth property and lower viscosity after using composition.Also expectation has the desinfactant detergent composition of these characteristics and good washing performance (detergency).
reference listing
Patent documentation
[patent documentation 1] JP 4468010 B
Non-patent literature
[non-patent literature 1] Practical data collection regarding disinfection of microorganisms (being disclosed on August 11st, 2005, Science Forum Inc.).
summary of the invention
Technical problem
One of the object of the invention is to provide bactericidal composition, described bactericidal composition has bactericidal effect for fungi and general bacterium, also there is bactericidal effect for the microorganism to quaternary ammonium salt and/or the tolerance of biguanides bactericide, and cause hardly the tolerance of generation microorganism to composition.Another object of the present invention is that the desinfactant detergent composition is provided, and described desinfactant detergent composition has like the property class with described bactericidal composition characteristic and has good washing performance.
The solution of problem
The inventor has been found that the problems referred to above can be by following solution: the composition that contains following formula (I) compound and triethanolamine and the composition that contains following formula (I) compound, nonionic surface active agent and triethanolamine.
The invention provides the bactericidal composition that contains formula (I) compound and triethanolamine (below, also referred to as " bactericidal composition of the present invention "):
Wherein, R
1representative has the straight chain saturated alkyl of 1 to 3 carbon atom, R
2representative has the straight chain saturated alkyl of 8 to 12 carbon atoms, X
-represent halide ion, and
yrepresentative has the saturated straight chain alkylidene of 8 to 12 carbon atoms.
The present invention also provides the method for sterilizing objects, and it comprises above-mentioned bactericidal composition is contacted with article.
Further, the invention provides the desinfactant detergent composition that contains formula (I) compound, nonionic surface active agent and triethanolamine (below, also referred to as " desinfactant detergent composition of the present invention "):
Wherein, R
1representative has the straight chain saturated alkyl of 1 to 3 carbon atom, R
2representative has the straight chain saturated alkyl of 8 to 12 carbon atoms, X
-represent halide ion, and
yrepresentative has the saturated straight chain alkylidene of 8 to 12 carbon atoms.
The present invention also provides the method for sterilization and clean article, and it comprises above-mentioned desinfactant detergent composition is contacted with article.
Advantageous effects of the present invention
Bactericidal composition of the present invention has bactericidal effect for fungi such as mould and general bacterium, and also has excellent bactericidal effect for the drug-resistant microorganism to quaternary ammonium salt and/or the tolerance of biguanides bactericide.Even, when bactericidal composition continues or uses continuously one long-term period, said composition causes the tolerance of microorganisms to said composition itself hardly.In addition, keep lower smooth property and lower viscosity after using bactericidal composition of the present invention.The example of quaternary ammonium salt comprises DDAC and benzalkonium chloride.The example of biguanides bactericide comprises hexamethylene and CHG (chlorhexidine gluconate).
Desinfactant detergent composition of the present invention has bactericidal effect for fungi such as mould and general bacterium, and also has excellent bactericidal effect for the drug-resistant microorganism to quaternary ammonium salt and/or the tolerance of biguanides bactericide, and has good washing performance.Even, when the desinfactant detergent composition continues or uses continuously one long-term period, said composition causes the tolerance of microorganisms to said composition itself hardly.In addition, keep lower smooth property and lower viscosity after using desinfactant detergent composition of the present invention.
The description of embodiment
Bactericidal composition of the present invention and desinfactant detergent composition comprise formula (I) compound.In formula (I), R
1methyl, ethyl or propyl group, preferable methyl or ethyl, more preferably methyl.R
2the straight chain saturated alkyl that preferably there are 8 to 10 carbon atoms, more preferably decyl.X
-halide ion, preferred chlorion or bromide ion, more preferably chlorion.Y preferably has the saturated straight chain alkylidene of 10 to 12 carbon atoms, more preferably inferior decyl.
The instantiation of formula (I) compound comprises 1, 10-bis-(3-decyl-glyoxal ethyline) decane dibromide, 1, 10-bis-(3-decyl-glyoxal ethyline) decane dichloride, 1, 12-bis-(3-decyl-glyoxal ethyline) dodecane dibromide, 1, 12-bis-(3-decyl-glyoxal ethyline) dodecane dichloride, 1, 10-bis-(3-octyl group-glyoxal ethyline) decane dibromide, 1, 10-bis-(3-octyl group-glyoxal ethyline) decane dichloride, 1, 12-bis-(3-octyl group-glyoxal ethyline) dodecane dibromide and 1, 12-bis-(3-octyl group-glyoxal ethyline) dodecane dichloride.Wherein, aspect the bactericidal effect to general bacterium, preferably 1,10-bis-(3-decyl-glyoxal ethyline) decane dibromide, 1,10-bis-(3-decyl-glyoxal ethyline) decane dichloride, 1,12-bis-(3-decyl-glyoxal ethyline) dodecane dibromide, 1,12-bis-(3-decyl-glyoxal ethyline) dodecane dichloride, 1,12-bis-(3-octyl group-glyoxal ethyline) dodecane dibromide and 1,12-bis-(3-octyl group-glyoxal ethyline) dodecane dichloride.Aspect the excellent compatibility with other sterilization components, more preferably 1,10-bis-(3-decyl-glyoxal ethyline) decane dibromide, 1,10-bis-(3-decyl-glyoxal ethyline) decane dichloride, 1,12-bis-(3-decyl-glyoxal ethyline) dodecane dichloride and 1,12-bis-(3-octyl group-glyoxal ethyline) dodecane dichloride, aspect bactericidal effect and the solvability in water to drug-resistant microorganism, further preferably 1,10-bis-(3-decyl-glyoxal ethyline) decane dichloride.
The amount of formula (I) compound in bactericidal composition of the present invention or desinfactant detergent composition is not particularly limited.When bactericidal composition of the present invention or desinfactant detergent composition are aqueous solution form, the amount of said composition Chinese style (I) compound is 0.001 to 50 % by weight preferably, more preferably 0.005 to 30 % by weight, even more preferably 0.015 to 10 % by weight, and 3 to 10 % by weight particularly preferably.When the amount of formula (I) compound is less than 0.001 % by weight, for the inhibition of the growth of the drug-resistant microorganism to the tolerance of quaternary ammonium salt and/or biguanides bactericide, tend to descend.When the amount of formula (I) compound during more than 50 % by weight, composition is difficult to operation because viscosity rise tends to become.
Desinfactant detergent composition of the present invention comprises nonionic surface active agent.The example of nonionic surface active agent comprises cocoanut fatty acid diethanolamide, lauric acid diethyl amide, polyoxyalkylene alkyl, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, sucrose fatty ester and polyoxyethylene-oxypropylene block polymer.In these compounds, cocoanut fatty acid diethanolamide and polyoxyalkylene alkyl are preferred.The HLB value of the nonionic surface active agent contained in desinfactant detergent composition of the present invention preferably 4 to 15, more preferably 9 to 14.Two or more nonionic surface active agent can be used in combination.
The amount of nonionic surface active agent in desinfactant detergent composition of the present invention, with respect to 1 weight portion formula (I) compound, be preferably 0.1 to 20 weight portion, more preferably 1 to 10 weight portion, more preferably 2 to 5 weight portions.When the amount of nonionic surface active agent is less than 0.1 weight portion, washing performance tends to reduce.When the amount of nonionic surface active agent, during more than 20 weight portion, in aqueous solution form, may be separated and white casse, and composition tends to be difficult to wash.
Aspect washing performance and storage stability, in desinfactant detergent composition of the present invention, preferred compositions is used cocoanut fatty acid diethanolamide and polyoxyalkylene alkyl as nonionic surface active agent.When being used in combination these compounds, with respect to the cocoanut fatty acid diethanolamide of 1 weight portion, polyoxyalkylene alkyl is 0.05 to 1.0 weight portion preferably, and more preferably 0.1 to 0.3 weight portion.
The amount of the triethanolamine in bactericidal composition of the present invention or desinfactant detergent composition is not particularly limited.With respect to formula (I) compound of 1 weight portion, the amount of triethanolamine is 0.0025 to 24.5 weight portion preferably, more preferably 0.005 to 5 weight portion, further preferred 0.01 to 1.5 weight portion.When the amount of triethanolamine is less than 0.0025 weight portion, following problem (i) to (iv) may occur: (i) bactericidal effect deficiency, (ii) when bactericidal composition or desinfactant detergent composition are aqueous solution form, at the cryogenic conditions stability inferior, reduce, (iii) when mixing in composition by following extra sterilization composition and/or additive, produce white casse in the aqueous solution, and (iv) be not enough to prevent metal erosion.When the amount of triethanolamine, during more than 24.5 weight portion, the pH of the bactericidal composition of aqueous solution form or desinfactant detergent composition can excessively rise, and composition tends to the metal high corrosion.
The bactericidal composition of the present invention of aqueous solution form and the pH of desinfactant detergent composition are not particularly limited.The pH of composition preferably 7 to 12, and more preferably 7.5 to 11, further preferably 7.7 to 9.5, and particularly preferably 8 to 9.4.
In bactericidal composition of the present invention or desinfactant detergent composition, triethanolamine is when the amount of formula (I) compound of 1 weight portion is in the scope of 0.0025 to 24.5 weight portion, and the pH of the composition of aqueous solution form is in 7 to 12 scope.If necessary, can use alkaline reagent to adjust the pH of said composition.Bactericidal composition of the present invention and desinfactant detergent composition can contain alkaline reagent, and described alkaline reagent can not cause and change such as precipitation and white casse in said composition.The example of alkaline reagent comprises sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, potash, sodium bicarbonate, saleratus, concentrated crystal soda, sodium metasilicate, sodium sesquisilicate, sodium metasilicate, sodium orthophosphate, sodium pyrophosphate, sodium phosphate trimer, Magcophos and calgon.In these alkaline reagents, aspect the stability of the composition stored with aqueous solution form, preferred sodium hydroxide and potassium hydroxide.Two or more these alkaline reagents can be used in combination.
Formula (I) compound, nonionic surface active agent and being used in combination of triethanolamine make, with use independent formula (I) Compound Phase ratio, the bactericidal effect that desinfactant detergent composition performance of the present invention strengthens, particularly for the bactericidal effect of drug-resistant microorganism, and make, with using independent nonionic surface active agent, compare, said composition is brought into play excellent washing performance.In desinfactant detergent composition of the present invention, about bactericidal effect and washing performance, bring into play the synergy of three kinds of compositions (being formula (I) compound, nonionic surface active agent and triethanolamine).
Extra sterilization component can mix in bactericidal composition of the present invention or desinfactant detergent composition.The example that can mix the extra sterilization composition in bactericidal composition of the present invention or desinfactant detergent composition comprises that quaternary ammonium salt is such as DDAC and benzalkonium chloride; The biguanides bactericide is such as hexamethylene and CHG; With the organic iodine bactericide such as iodine glycine complex.In these extra sterilization compositions, aspect the bactericidal effect for producing the brood cell bacterium, preferred biguanides bactericide, and hexamethylene particularly preferably.The extra sterilization composition can be used separately, or two or more in these extra sterilization compositions can be used in combination.
When the extra sterilization composition mixes in bactericidal composition of the present invention or desinfactant detergent composition, formula (I) compound with respect to 1 weight portion, preferred 0.5 to 40 weight portion of the amount of extra sterilization component in said composition, more preferably 0.7 to 10 weight portion, and further preferred 1 to 5 weight portion.When the amount of extra sterilization composition is less than 0.5 weight portion, the bactericidal effect of extra sterilization composition tends to insufficient performance.When the amount of extra sterilization composition during more than 40 weight portion, in the storage process of the composition of aqueous solution form, tend to produce white casse.
As required, additive can further mix in bactericidal composition of the present invention or desinfactant detergent composition.The example that can mix the additive of said composition comprises ethanol, colouring agent, spices and cleaning additive.With respect to the composition of aqueous solution form, in bactericidal composition of the present invention or desinfactant detergent composition, the amount of these additives is generally 5 % by weight or still less.
Bactericidal composition of the present invention and desinfactant detergent composition can solid form such as tablet and powder, with semi-solid form such as paste and gel or provide with aqueous solution form.When bactericidal composition of the present invention or desinfactant detergent composition provide with solid or semi-solid form, said composition is dissolved in the water, and the aqueous solution obtained can be applied to article to be sterilized or to be sterilized and clean article.When bactericidal composition of the present invention or desinfactant detergent composition provide with aqueous solution form, the aqueous solution itself or its dilute solution can be applied to article to be sterilized or to be sterilized and clean article.
The method for preparing bactericidal composition of the present invention or desinfactant detergent composition is not particularly limited.For example, the bactericidal composition of solid form and desinfactant detergent composition can mix and obtain by the simple required composition (if need to together with excipient) that mixes.The mixture of required composition can further stand common medicine process for preparation such as granulation and compressing tablet to obtain composition.The bactericidal composition of semi-solid form and desinfactant detergent composition can for example obtain by mixing required composition and water and adhesive and gelling agent.The bactericidal composition of aqueous solution form and desinfactant detergent composition can be for example by required composition being dissolved in equably in water or by obtaining as the solid of above-mentioned preparation or semi-solid combination are dissolved in water.
When adjusting the pH of bactericidal composition of the present invention or desinfactant detergent composition, the step of carrying out the pH adjustment is not particularly limited.Usually, alkaline reagent can be added in the bactericidal composition or desinfactant detergent composition of aqueous solution form of preparation.The amount that the bactericidal composition of aqueous solution form or desinfactant detergent composition can be adjusted to the alkaline reagent of required pH scope pre-determines, and then, the alkaline reagent of this amount can be dissolved in water equably with together with composition in bactericidal composition or desinfactant detergent composition.The alkaline reagent that the pH of composition can be adjusted to the scheduled volume of required scope can be mixed in the bactericidal composition or desinfactant detergent composition of solid or semi-solid form.
The example of the bactericidal composition of the present invention provided with solid or semi-solid form comprises:
(a) composition of the triethanolamine of the formula that contains 1 to 99 % by weight (I) compound and 0.0001 to 5 % by weight;
(b) composition of the triethanolamine of the formula that contains 3 to 50 % by weight (I) compound and 0.005 to 3 % by weight; With
(c) composition of the triethanolamine of the formula that contains 5 to 15 % by weight (I) compound and 0.001 to 1 % by weight.
The example of the bactericidal composition of the present invention that comprises the extra sterilization composition comprises:
(d) composition of the triethanolamine of the formula that contains 1 to 98 % by weight (I) compound, 0.0001 to 5 % by weight and the biguanides bactericide of 1 to 98 % by weight;
(e) composition of the triethanolamine of the formula that contains 3 to 50 % by weight (I) compound, 0.005 to 3 % by weight and the biguanides bactericide of 3 to 50 % by weight; With
(f) composition of the triethanolamine of the formula that contains 5 to 15 % by weight (I) compound, 0.001 to 1 % by weight and the biguanides bactericide of 5 to 15 % by weight.
The example of the bactericidal composition of the present invention provided with aqueous solution form comprises:
(g) composition of the aqueous solution of formula (I) compound that conduct contains 0.001 to 50 % by weight and the triethanolamine of 0.075 to 50 % by weight;
(h) composition of the aqueous solution of formula (I) compound that conduct contains 1 to 20 % by weight and the triethanolamine of 0.09 to 10 % by weight; With
(i) composition of the aqueous solution of formula (I) compound that conduct contains 3 to 10 % by weight and the triethanolamine of 0.1 to 6 % by weight.
In these compositions, preferred composition (h), particularly preferably composition (i).
The example of the bactericidal composition of the present invention of the aqueous solution form that comprises the extra sterilization composition comprises:
(j) composition of the aqueous solution of the biguanides bactericide of formula (I) compound that conduct contains 0.001 to 50 % by weight, the triethanolamine of 0.075 to 99 % by weight and 0.0005 to 30 % by weight;
(j) composition of the aqueous solution of the biguanides bactericide of formula (I) compound that conduct contains 1 to 20 % by weight, the triethanolamine of 0.09 to 98 % by weight and 1 to 20 % by weight; With
(l) composition of the aqueous solution of the biguanides bactericide of formula (I) compound that conduct contains 3 to 10 % by weight, the triethanolamine of 1 to 93 % by weight and 3 to 16 % by weight.
In these compositions, preferred composition (k), more preferably composition (l).The composition (m) of the aqueous solution of the hexamethylene of formula (I) compound that particularly preferably conduct contains 3 to 10 % by weight, the triethanolamine of 1 to 93 % by weight and 3 to 16 % by weight.
The bactericidal composition of the present invention of aqueous solution form, if necessary, also can be used by the form that water further is added into to the dilute solution obtained in composition.Even, when composition is used with the dilute solution form, the amount of this dilute solution Chinese style (I) compound is preferably 0.001 to 50 % by weight.For example, bactericidal composition of the present invention can following form be used:
(n) aqueous solution of the triethanolamine of the formula that contains 0.001 to 0.25 % by weight (I) compound and 0.0004 to 0.25 % by weight;
(o) aqueous solution of the triethanolamine of the formula that contains 0.005 to 0.1 % by weight (I) compound and 0.0005 to 0.0015 % by weight; With
(p) aqueous solution of the triethanolamine of the formula that contains 0.015 to 0.045 % by weight (I) compound and 0.0006 to 0.001 % by weight.
In these forms, preferred aqueous solutions (o), the particularly preferably aqueous solution (p).
When bactericidal composition of the present invention comprises the extra sterilization composition, composition can for example be used with following form:
(q) aqueous solution of the triethanolamine of the formula that contains 0.001 to 0.25 % by weight (I) compound, 0.0004 to 0.5 % by weight and the biguanides bactericide of 0.0005 to 0.15 % by weight;
(r) aqueous solution of the triethanolamine of the formula that contains 0.005 to 0.1 % by weight (I) compound, 0.0005 to 0.45 % by weight and the biguanides bactericide of 0.005 to 0.1 % by weight; With
(s) aqueous solution of the triethanolamine of the formula that contains 0.015 to 0.045 % by weight (I) compound, 0.005 to 0.4 % by weight and the biguanides bactericide of 0.02 to 0.08 % by weight.
In these forms, preferred aqueous solutions (r), the more preferably aqueous solution (s).The aqueous solution (t) that particularly preferably contains the hexamethylene of the triethanolamine of formula (I) compound, 0.005 to 0.4 % by weight of 0.015 to 0.045 % by weight and 0.02 to 0.08 % by weight.
The example of the desinfactant detergent composition of the present invention provided with solid or semi-solid form comprises:
(A) composition of the nonionic surface active agent of the formula that contains 1 to 98 % by weight (I) compound, 1 to 98 % by weight and the triethanolamine of 0.0001 to 5 % by weight;
(B) composition of the nonionic surface active agent of the formula that contains 3 to 50 % by weight (I) compound, 10 to 90 % by weight and the triethanolamine of 0.0005 to 3 % by weight; With
(C) composition of the nonionic surface active agent of the formula that contains 5 to 15 % by weight (I) compound, 20 to 80 % by weight and the triethanolamine of 0.001 to 1 % by weight.
The example of the desinfactant detergent composition of the present invention that comprises the extra sterilization composition comprises:
(D) composition of the biguanides bactericide of the nonionic surface active agent of the formula that contains 1 to 97 % by weight (I) compound, 1 to 97 % by weight, the triethanolamine of 0.0001 to 5 % by weight and 1 to 97 % by weight;
(E) composition of the biguanides bactericide of the nonionic surface active agent of the formula that contains 3 to 50 % by weight (I) compound, 10 to 90 % by weight, the triethanolamine of 0.0005 to 3 % by weight and 3 to 50 % by weight; With
(F) composition of the biguanides bactericide of the nonionic surface active agent of the formula that contains 5 to 15 % by weight (I) compound, 20 to 80 % by weight, the triethanolamine of 0.001 to 1 % by weight and 5 to 15 % by weight.
The example of the desinfactant detergent composition of the present invention provided with aqueous solution form comprises:
(G) composition of the aqueous solution of the triethanolamine of formula (I) compound that conduct contains 0.001 to 50 % by weight, the nonionic surface active agent of 0.0001 to 60 % by weight and 0.075 to 50 % by weight;
(H) composition of the aqueous solution of the triethanolamine of formula (I) compound that conduct contains 1 to 20 % by weight, the nonionic surface active agent of 1 to 45 % by weight and 0.09 to 10 % by weight;
(J) composition of the aqueous solution of the triethanolamine of formula (I) compound that conduct contains 3 to 10 % by weight, the nonionic surface active agent of 6 to 25 % by weight and 0.1 to 6 % by weight;
(K) composition of the aqueous solution of the polyoxyalkylene alkyl of formula (I) compound that conduct contains 1 to 20 % by weight, the cocoanut fatty acid diethanolamide of 0.952 to 22.5 % by weight, 0.048 to 22.5 % by weight and the triethanolamine of 0.09 to 10 % by weight; With
(L) composition of the aqueous solution of the polyoxyalkylene alkyl of formula (I) compound that conduct contains 3 to 10 % by weight, the cocoanut fatty acid diethanolamide of 5.45 to 19.23 % by weight, 0.55 to 5.77 % by weight and the triethanolamine of 0.1 to 6 % by weight.
In these compositions, preferred composition (K), particularly preferably composition (L).
The example of the desinfactant detergent composition of the present invention of the aqueous solution form that comprises the extra sterilization composition comprises:
(M) composition of the aqueous solution of the triethanolamine of formula (I) compound that conduct contains 0.001 to 50 % by weight, the nonionic surface active agent of 0.0001 to 60 % by weight, 0.075 to 99 % by weight and the biguanides bactericide of 0.0005 to 30 % by weight;
(N) composition of the aqueous solution of the triethanolamine of formula (I) compound that conduct contains 1 to 20 % by weight, the nonionic surface active agent of 1 to 45 % by weight, 0.09 to 97 % by weight and the biguanides bactericide of 1 to 15 % by weight;
(O) composition of the aqueous solution of the triethanolamine of formula (I) compound that conduct contains 3 to 10 % by weight, the nonionic surface active agent of 6 to 25 % by weight, 1 to 89 % by weight and the biguanides bactericide of 2 to 5 % by weight;
(P) composition of the aqueous solution of the hexamethylene of the polyoxyalkylene alkyl of formula (I) compound that conduct contains 0.001 to 50 % by weight, the cocoanut fatty acid diethanolamide of 0.0001 to 30 % by weight, 0 to 30 % by weight, the triethanolamine of 0.075 to 99 % by weight and 0.0005 to 30 % by weight;
(Q) composition of the aqueous solution of the hexamethylene of the polyoxyalkylene alkyl of formula (I) compound that conduct contains 1 to 20 % by weight, the cocoanut fatty acid diethanolamide of 0.952 to 22.5 % by weight, 0.048 to 22.5 % by weight, the triethanolamine of 0.09 to 97 % by weight and 1 to 15 % by weight; With
(R) composition of the aqueous solution of the hexamethylene of the polyoxyalkylene alkyl of formula (I) compound that conduct contains 3 to 10 % by weight, the cocoanut fatty acid diethanolamide of 5.45 to 19.23 % by weight, 0.55 to 5.77 % by weight, the triethanolamine of 1 to 89 % by weight and 2 to 5 % by weight.
In these compositions, preferred composition (P), more preferably composition (Q), particularly preferably composition (R).
The desinfactant detergent composition of the present invention of aqueous solution form, if necessary, also can be used by the form that water further is added into to the dilute solution obtained in composition.Even, when composition is used with the dilute solution form, the amount of this dilute solution Chinese style (I) compound is preferably 0.001 to 50 % by weight.For example, desinfactant detergent composition of the present invention can following form be used:
(S) aqueous solution of the nonionic surface active agent of the formula that contains 0.001 to 0.25 % by weight (I) compound, 0.0000005 to 0.3 % by weight and the triethanolamine of 0.0004 to 0.25 % by weight;
(T) aqueous solution of the nonionic surface active agent of the formula that contains 0.005 to 0.1 % by weight (I) compound, 0.005 to 0.225 % by weight and the triethanolamine of 0.0005 to 0.0015 % by weight;
(U) aqueous solution of the nonionic surface active agent of the formula that contains 0.015 to 0.045 % by weight (I) compound, 0.03 to 0.125 % by weight and the triethanolamine of 0.0006 to 0.001 % by weight;
(V) aqueous solution of the triethanolamine of the cocoanut fatty acid diethanolamide of the formula that contains 0.005 to 0.1 % by weight (I) compound, 0.00476 to 0.1125 % by weight, the polyoxyalkylene alkyl of 0.00024 to 0.1125 % by weight and 0.0005 to 0.0015 % by weight; With
(W) aqueous solution of the triethanolamine of the cocoanut fatty acid diethanolamide of the formula that contains 0.015 to 0.045 % by weight (I) compound, 0.02725 to 0.09615 % by weight, the polyoxyalkylene alkyl of 0.00275 to 0.02885 % by weight and 0.0006 to 0.001 % by weight.
In these forms, preferred aqueous solutions (V), the particularly preferably aqueous solution (W).
When desinfactant detergent composition of the present invention comprises the extra sterilization composition, composition can for example be used with following form:
(X) aqueous solution of the biguanides bactericide of the nonionic surface active agent of the formula that contains 0.001 to 0.25 % by weight (I) compound, 0.0000005 to 0.3 % by weight, the triethanolamine of 0.0004 to 0.49 % by weight and 0.0005 to 0.15 % by weight;
(Y) aqueous solution of the biguanides bactericide of the nonionic surface active agent of the formula that contains 0.005 to 0.1 % by weight (I) compound, 0.005 to 0.225 % by weight, the triethanolamine of 0.0005 to 0.465 % by weight and 0.005 to 0.1 % by weight;
(Z) aqueous solution of the biguanides bactericide of the nonionic surface active agent of the formula that contains 0.015 to 0.045 % by weight (I) compound, 0.03 to 0.125 % by weight, the triethanolamine of 0.005 to 0.445 % by weight and 0.01 to 0.025 % by weight;
(AA) aqueous solution of the triethanolamine of the cocoanut fatty acid diethanolamide of the formula that contains 0.001 to 0.25 % by weight (I) compound, 0.0000005 to 0.3 % by weight, the polyoxyalkylene alkyl of 0 to 0.3 % by weight, 0.0004 to 0.49 % by weight and the hexamethylene of 0.0005 to 0.15 % by weight;
(AB) aqueous solution of the triethanolamine of the cocoanut fatty acid diethanolamide of the formula that contains 0.005 to 0.1 % by weight (I) compound, 0.00476 to 0.1125 % by weight, the polyoxyalkylene alkyl of 0.00024 to 0.1125 % by weight, 0.0005 to 0.465 % by weight and the hexamethylene of 0.005 to 0.1 % by weight; With
(AC) aqueous solution of the triethanolamine of the cocoanut fatty acid diethanolamide of the formula that contains 0.015 to 0.045 % by weight (I) compound, 0.02725 to 0.09615 % by weight, the polyoxyalkylene alkyl of 0.00275 to 0.02885 % by weight, 0.005 to 0.445 % by weight and the hexamethylene of 0.01 to 0.025 % by weight.
In these forms, preferred aqueous solutions (AA), the more preferably aqueous solution (AB), the particularly preferably aqueous solution (AC).
In order to use bactericidal composition of the present invention or desinfactant detergent composition to carry out disinfection or sterilizing cleaning to article, the composition of aqueous solution form can be contacted with these article.Contact method is not particularly limited.Bactericidal composition of the present invention or desinfactant detergent composition can be contacted with article by common method such as sprinkling, spraying, submergence and wiping.Further, can use brush, sponge etc. with bactericidal composition or desinfactant detergent composition, dirt to be removed from article to be sterilized or to be sterilized and clean article.
Bactericidal composition of the present invention or desinfactant detergent composition and article to be sterilized or time of contacting with to be sterilized with clean article are not particularly limited during this time, and can suitably determine according to the concentration of active component.For example, when will with the above-mentioned aqueous solution (n) or (S) bactericidal composition of form or desinfactant detergent composition when room temperature contacts with article, by contacting 30 seconds to 10 minutes, preferably within 1 to 5 minute, can obtaining sufficient bactericidal effect or sterilizing cleaning effect.
For the preparation of the bactericidal composition of the present invention of semi-solid form or aqueous solution form or the water of desinfactant detergent composition, can be the water of any purifying, such as ion exchange water and distilled water, running water and natural water is such as low water and underflow water, and chlorine or metal ion content lower aspect preferred pure water.
Bactericidal composition of the present invention and desinfactant detergent composition can be used for the floor in bakery and confectionery, hospital, stock barn, hotel, dining room, school and shop and sterilization or the sterilizing cleaning of wall.Said composition also can be used for sterilization or the sterilizing cleaning such as the device for food production and/or processing and the instrument that uses in for example bakery and confectionery for the article of food associated uses.Device for food production and/or processing can comprise various agitators, blender, homogenizer and automatic gas cutting machine.Instrument can comprise chopping board, kitchen knife, tableware, containers for food use and wiping dish cloth.
Bactericidal composition of the present invention and desinfactant detergent composition have bactericidal effect for fungi such as mould with for general bacterium, and, for the microorganism to quaternary ammonium salt and/or the tolerance of biguanides bactericide, for example the microorganism of DDAC (DDAC) and/or hexamethylene (PHMB) tolerance is also brought into play to bactericidal activity.Therefore, bactericidal composition of the present invention and desinfactant detergent composition can be used as being applied to bactericidal composition and the desinfactant detergent composition of article especially, described article inside or the top existence microorganism to quaternary ammonium salt and/or the tolerance of biguanides bactericide.
In the time of even during bactericidal composition of the present invention and desinfactant detergent composition are used a rapid lapse of time, with the situation of wherein using quaternary ammonium salt and/or biguanides bactericide, compare, said composition causes the drug resistance of microorganisms to composition hardly.Therefore, bactericidal composition of the present invention and desinfactant detergent composition also can be used as being applied to bactericidal composition and the desinfactant detergent composition of article, described article inner or top may be owing to using these reagent to produce the microorganism to quaternary ammonium salt and/or the tolerance of biguanides bactericide.
Example to the microorganism of quaternary ammonium salt and/or biguanides bactericide tolerance comprises the microorganism of pseudomonas and the microorganism of Serratia, such as clayey Serratieae (Serratia marcescens) and liquefied Serratia (Serratia liquefaciens).
Bactericidal composition of the present invention and desinfactant detergent composition are suitable as continuously or continue the composition of use.Particularly, even when bactericidal composition of the present invention and desinfactant detergent composition through a rapid lapse of time continuously or while continuing to use, said composition causes the tolerance of microorganisms to said composition hardly.More specifically, bactericidal composition of the present invention and desinfactant detergent composition are characterised in that, when by the said composition repeated application during in identical items, with wherein with the same manner, quaternary ammonium salt and/or biguanides bactericide repeated application are compared in the situation of article, produce to the microorganism of said composition tolerance still less.As used in this article, statement " repeated application is in identical items " refers to when microbe species to be sterilized restriction, and same combination repeatedly (for example 2 times, 3 times, 4 times, 5 times, 6 times, 7 times, 8 times or more times) is applied to identical items or is applied to the same microorganism kind." use continuously " refer to same combination for example in the following manner (composition A, composition A, composition A ...) double or more times use." continue use " refers to that same combination is not double or more times uses, but different components is used at certain intervals and continues the application of same combination to identical items.For example, when composition in the following manner (composition A, composition B, composition C, composition A, composition D ...) while using, composition A is used continuously, but continue to use.
Embodiment
The present invention further describes below by the mode of embodiment.For following each test, microbial growth is observed in symbol "+" representative in table, and microbial growth is not observed in symbol "-" representative.
Test example 1
By following sample microorganism (i) to (viii) is diluted to 10 with normal saline solution
6the PHMB aqueous solution that the concentration of the liquid of the concentration of cfu/ml and each 0.03 ml of obtaining (for sample microorganism (iii) and (viii) be 0.1ml) and each 3 ml (for sample microorganism (iii) and (viii) be 10 ml) is 1.25-320 ppm.Then the mixture obtained is placed 5 minutes at 25 ℃.After sensibilization time warp, again stirred.A platinum loop of each mixture is taken out, be inoculated in 10 ml BHI liquid nutrient mediums (being 10 ml SCDLP medium for sample microorganism (viii)).Medium is hatched 48 hours (hatching 120 hours for sample microorganism (ii)) at 30 ℃.The BHI liquid nutrient medium of microbe inoculation (being nonvaccinated SCDLP medium for sample microorganism (viii)) is not as reference substance, by visual examination, the turbidity of medium and reference substance is compared, to determine the bactericidal effect of PHMB for each sample microorganism.The results are shown in table 1.
PHMB: hexamethylene
BHI: brain heart extract
SCDLP: containing the soybean of lecithin and polysorbate80-casein digestive fluid medium
Sample microorganism (i): Pseudomonas aeruginosa (Pseudomonas aeruginosa) NBRC13736
Sample microorganism (ii): aspergillus niger (Aspergillus niger) ATCC16404
Sample microorganism (iii): bacillus cereus (Bacillus cereus) NBRC15305
Sample microorganism (iv): clayey Serratieae (bacterium 1 separated from bakery and confectionery)
Sample microorganism (v): liquefied Serratia (bacterium 2 separated from bakery and confectionery)
Sample microorganism (vi): clayey Serratieae (bacterium 3 separated from bakery and confectionery)
Sample microorganism (vii): clayey Serratieae (bacterium 4 separated from bakery and confectionery)
Sample microorganism (viii): bacillus subtilis (Bacillus subtilis) IFO13719.
Test example 2
Measure the bactericidal effect of DDAC to each sample microorganism in the mode identical with test example 1, except sample microorganism (i) to (vii) and the DDAC tested in test example 1 is used as bactericide.The results are shown in table 2.
DDAC: DDAC.
Test example 3
Formula (I) compound [1,10-bis-(3-decyl-glyoxal ethyline) decane dichloride] that preparation contains following demonstration amount and the aqueous solution of PHMB, prepare the cosmetic variation that checks solution in latter 3 hours.The results are shown in table 3.
[table 3]
Embodiment 1 to 6 and comparative example 1 to 13
bactericidal activity test 1 (mould)
Will be by with normal saline solution, the spore suspension of following sample microorganism being diluted to 10
6the concentration of cfu/ml and each 0.03 ml liquid of obtaining mixes with each 3 ml aqueous solution (wherein making said composition concentration by the bactericidal composition with listing in sterile water dilution table 4 separately is that 0.1 to 0.3 % by weight obtains).Then the mixture obtained is placed 5 minutes at 25 ℃.After sensibilization time warp, again stirred.A platinum loop of each mixture is taken out, be inoculated in 10 ml BHI liquid nutrient mediums.Medium is hatched 120 hours at 30 ℃.The BHI liquid nutrient medium of microbe inoculation, as reference substance, does not compare the turbidity of medium and reference substance by visual examination, to determine the bactericidal effect of bactericidal composition.
Sample microorganism (ii): aspergillus niger ATCC16404.
The results are shown in table 5.Bactericidal composition of the present invention is compared with the composition of comparative example, for mould, brings into play excellent bactericidal activity.
bactericidal activity test 2 (producing the brood cell bacterium)
Will be by with normal saline solution, the spore suspension of following sample microorganism being diluted to 10
6the concentration of cfu/ml and each 0.1 ml liquid of obtaining mixes with each 10 ml aqueous solution (wherein making said composition concentration by the bactericidal composition with listing in sterile water dilution table 4 separately is that 0.1 to 0.3 % by weight obtains).Then the mixture obtained is placed 5 minutes at 25 ℃.After sensibilization time warp, again stirred.A platinum loop of each mixture is taken out, be inoculated in 10 ml BHI liquid nutrient mediums.Medium is hatched 48 hours at 30 ℃.The BHI liquid nutrient medium of microbe inoculation, as reference substance, does not compare the turbidity of medium and reference substance by visual examination, to determine the bactericidal effect of bactericidal composition to microorganism.
Sample microorganism (iii): bacillus cereus NBRC15305.
The results are shown in table 6.Bactericidal composition of the present invention is compared with the composition of comparative example, for producing the brood cell bacterium, brings into play excellent bactericidal activity.
bactericidal activity test 3 (drug-resistant microorganisms)
The following sample microorganism that will separate from bakery and confectionery is cultivated 24 hours 30 ℃ in the BHI liquid nutrient medium.Will be by with normal saline solution, the microorganism of cultivation being diluted to 10
6the concentration of cfu/ml and each 0.03 ml liquid of obtaining and each 3 ml aqueous solution (wherein separately in the bactericidal composition by dilution embodiment 1-6 and table 7 bactericidal composition of demonstration to make said composition concentration be that 0.025 to 0.1 % by weight obtains) mix.Then the mixture obtained is placed 5 minutes at 25 ℃.After sensibilization time warp, again stirred.A platinum loop of each mixture is taken out, be inoculated in 10 ml BHI liquid nutrient mediums.Medium is hatched 48 hours at 30 ℃.The BHI liquid nutrient medium of microbe inoculation, as reference substance, does not compare the turbidity of medium and reference substance by visual examination, to determine the bactericidal effect of bactericidal composition to microorganism.
Sample microorganism (iv): clayey Serratieae (bacterium 1 separated from bakery and confectionery).
The results are shown in table 8.Bactericidal composition of the present invention is compared with the composition of comparative example, for drug-resistant microorganism, brings into play excellent bactericidal activity.
bactericidal activity test 4 (drug-resistant microorganisms)
The following sample microorganism that will separate from bakery and confectionery is cultivated 24 hours 30 ℃ in the BHI liquid nutrient medium.Will be by with normal saline solution, the microorganism of cultivation being diluted to 10
6the concentration of cfu/ml and each 0.03 ml liquid of obtaining and each 3 ml aqueous solution (wherein separately in the bactericidal composition by dilution embodiment 1-6 and table 7 bactericidal composition of demonstration to make said composition concentration be that 0.08 to 1.33 % by weight obtains) mix.Then the mixture obtained is placed 1 minute at 25 ℃.After sensibilization time warp, again stirred.A platinum loop of each mixture is taken out, be inoculated in 10 ml BHI liquid nutrient mediums.Medium is hatched 120 hours at 30 ℃.The BHI liquid nutrient medium of microbe inoculation, as reference substance, does not compare the turbidity of medium and reference substance by visual examination, to determine the bactericidal effect of bactericidal composition to microorganism.
Sample microorganism (v): liquefied Serratia (bacterium 2 separated from bakery and confectionery).
The results are shown in table 9.Bactericidal composition of the present invention is compared with the composition of comparative example, for drug-resistant microorganism, brings into play excellent bactericidal activity.
drug resistance generation inhibition test
According to the standard method (liquid nutrient medium micro-dilution method) of Japanization iatreusiology meeting (Japanese Society of Chemotherapy), continuous measurement minimal inhibitory concentration (MIC).The composition of embodiment 1 and comparative example 13 is diluted to obtain with sterile water the drug solution that composition concentration is 0.007 to 1.792 % by weight, and will be adjusted to concentration is 2 times of high Nutrient broths of prescribed concentration (Eiken Chemical Co., Ltd. manufacture, the common liq medium ' Eiken'E-MC35) to be added into wherein with this drug solution equivalent.The mixture obtained is stirred, and then the amount with 150 μ l/ holes is dispensed in microtiter plate (96 hole).Next, the following sample microorganism of each that will separate from bakery and confectionery is cultivated 20 hours 30 ℃ in the NB medium, and the culture obtained is diluted to 10 with normal saline solution
7the concentration of cfu/ml.Then by the culture of dilution, the amount with 7.5 μ l/ holes is seeded in the microtiter plate that contains the medium prepared as mentioned above.This plate is hatched 48 hours in the constant temperature oven of 30 ℃, by visual examination, check microbial growth, measure MIC.Further, from the hole that there is maximum drug concentration between the hole of checking growth therein, collect culture, with normal saline solution, be diluted to 10
7the concentration of cfu/ml.Use the culture of dilution, again measure in the same manner as described above MIC.Altogether measure MIC 8 times by repeating said procedure, and the variation of checking MIC.
Sample microorganism (vi): clayey Serratieae (bacterium 3 separated from bakery and confectionery)
Sample microorganism (vii): clayey Serratieae (bacterium 4 separated from bakery and confectionery).
The results are shown in table 10 and 11.About the composition of embodiment 1, MIC is low, even the 8th, takes turns also so, and it is 0.056 % by weight (for sample microorganism (vi)) and 0.028 % by weight (for sample microorganism (vii)).Verified that formula (I) compound [1,10-bis-(3-decyl-glyoxal ethyline) decane dichloride] compares with the situation of wherein using DDAC, caused hardly the generation drug-resistant microorganism.
[table 10]
The propagation of clayey Serratieae (bacterium 3 separated from bakery and confectionery)
[table 11]
The propagation of clayey Serratieae (bacterium 4 separated from bakery and confectionery)
metal corrosion test
By embodiment 1 and 5 and each 60 ml 0.3% aqueous solution of the composition of comparative example 12 and 13 be dispensed in the vial with the 70ml volume of lid.The test film (it is long that it is measured as 50 mm, and 30 mm are wide and 1 mm is thick) be made of copper is immersed in the aqueous solution, and stores 1 month in constant temperature oven under 25 ℃.By visual examination check store after the outward appearance of test film, with according to following standard corrosivity.The copper sheet that uses the alternative said composition aqueous solution of running water to store under the same conditions is as control sample.
Grade:
" zero (circle) ": than still less corrosion of contrast
" △ (triangle) ": be equal to contrast
" * (fork) ": than the more corrosion of contrast.
Result is as shown in Table 12.Keep and process the outward appearance that front sheet is equal to the sheet of embodiment 1 compositions-treated, it shows compares significantly less corrosion with control sample.About the sheet by embodiment 5 compositions-treated, observe a little and fade, but observe, do not get rusty or variable color.With the whole variable color of the sheet of comparative example 12 compositions-treated, it shows compares the more corrosion of generation with control sample.About the sheet by comparative example 13 compositions-treated, it fades significantly, and its outward appearance and control sample are equal to.
[table 12]
Embodiment 7 to 14 and comparative example 14 to 22
bactericidal activity test 5 (producing the brood cell bacterium)
Will be by with normal saline solution, the spore suspension of following sample microorganism being diluted to 10
6the concentration of cfu/ml and each 0.1 ml liquid of obtaining mixes with each 10 ml aqueous solution (wherein making said composition concentration by the desinfactant detergent composition of listing in dilution table 13 separately is that 0.1 to 0.3 % by weight obtains).Then the mixture obtained is placed 5 minutes at 25 ℃.After sensibilization time warp, again stirred.A platinum loop of each mixture is taken out, be inoculated in 10 ml SCDLP (soybean-casein digest) medium.Medium is hatched 48 hours at 30 ℃.The SCDLP medium of microbe inoculation, as reference substance, does not compare the turbidity of medium and reference substance by visual examination, to determine the bactericidal effect of desinfactant detergent composition to microorganism.
Sample microorganism (viii): bacillus subtilis IFO13719.
The results are shown in table 14.Desinfactant detergent composition of the present invention is compared with the composition of comparative example, for producing the brood cell bacterium, brings into play excellent bactericidal activity.
bactericidal activity test 6 (drug-resistant microorganisms)
The following sample microorganism that will separate from bakery and confectionery is cultivated 24 hours 30 ℃ in BHI (brain heart extract) medium.Will be by with normal saline solution, the microorganism of cultivation being diluted to 10
6the concentration of cfu/ml and each 0.03 ml liquid of obtaining mixes with each 3 ml aqueous solution (wherein making said composition concentration by the desinfactant detergent composition of demonstration in dilution table 13 separately is that 0.0125 to 0.1 % by weight obtains).Then the mixture obtained is placed 1 minute at 25 ℃.After sensibilization time warp, again stirred.A platinum loop of each mixture is taken out, be inoculated in 10 ml BHI medium.Medium is hatched 48 hours at 30 ℃.The BHI medium of microbe inoculation, as reference substance, does not compare the turbidity of medium and reference substance by visual examination, to determine the bactericidal effect of desinfactant detergent composition to microorganism.
Sample microorganism (iv): clayey Serratieae (bacterium 1 separated from bakery and confectionery).
The results are shown in table 15.Desinfactant detergent composition of the present invention is compared with the composition of comparative example, for drug-resistant microorganism, brings into play excellent bactericidal activity.
the washing performance test
According to Leanut method (JIS-K3362), use embodiment 7,8,11 and 12 and table 16 in the desinfactant detergent composition that shows carry out under the following conditions the washing performance test: temperature is 30 ℃, washs 3 minutes, rinses 1 minute.The intensity basis that dirt is removed is by being assessed based on the washing washing force that the following formula of the weight of sheet glass calculates before and afterwards
Result is as shown in Table 17.Desinfactant detergent composition of the present invention is compared with the composition of comparative example, brings into play higher washing performance.
Industrial applicability
Bactericidal composition of the present invention and desinfactant detergent composition can be used for the floor in bakery and confectionery, hospital, stock barn, hotel, dining room, school and shop and sterilization or the sterilizing cleaning of wall.Said composition also can be used for sterilization or the sterilizing cleaning such as the device for food production and/or processing and the instrument that uses in for example bakery and confectionery for the article of food associated uses.
In addition, bactericidal composition of the present invention and desinfactant detergent composition can be used as being applied to bactericidal composition and the desinfactant detergent composition of article especially, and described article inside or top existence maybe may produce the microorganism to quaternary ammonium salt and/or the tolerance of biguanides bactericide.
Claims (29)
1. bactericidal composition, it contains formula (I) compound and triethanolamine:
[Chemical formula 1]
Wherein, R
1representative has the straight chain saturated alkyl of 1 to 3 carbon atom, R
2representative has the straight chain saturated alkyl of 8 to 12 carbon atoms, X
-represent halide ion, and
yrepresentative has the saturated straight chain alkylidene of 8 to 12 carbon atoms.
2. according to the bactericidal composition of claim 1, wherein said formula (I) compound is to be selected from one or more following compounds: 1,10-bis-(3-decyl-glyoxal ethyline) decane dichloride, 1,10-bis-(3-decyl-glyoxal ethyline) decane dibromide, 1,12-bis-(3-decyl-glyoxal ethyline) dodecane dichloride and 1,12-bis-(3-octyl group-glyoxal ethyline) dodecane dichloride.
3. according to the bactericidal composition of claim 1 or 2, wherein said formula (I) compound is 1,10-bis-(3-decyl-glyoxal ethyline) decane dichloride.
4. according to the bactericidal composition of any one in claim 1-3, its formula that contains 0.001 to 50 % by weight (I) compound.
5. according to the bactericidal composition of any one in claim 1-4, the triethanolamine that its formula with respect to 1 weight portion (I) compound contains 0.0025 to 24.5 weight portion.
6. according to the bactericidal composition of any one in claim 1-5, it further contains the biguanides bactericide.
7. according to the bactericidal composition of claim 6, the biguanides bactericide that its formula with respect to 1 weight portion (I) compound contains 0.5 to 40 weight portion.
8. according to the bactericidal composition of claim 6 or 7, wherein said biguanides bactericide is hexamethylene.
9. according to the bactericidal composition of any one in claim 1-8, it is aqueous solution form.
10. according to the bactericidal composition of claim 9, the pH of wherein said composition is 7 to 12.
11., according to the bactericidal composition of claim 9 or 10, the alkaline reagent that the pH of wherein said composition is selected from sodium hydroxide and potassium hydroxide with one or more is adjusted.
12., according to the bactericidal composition of any one in claim 1-11, it is for the sterilization of article, described article inside or top existence maybe may produce the microorganism to quaternary ammonium salt and/or the tolerance of biguanides bactericide.
13., for the method for sterilizing objects, it comprises the bactericidal composition according to any one in claim 1-12 is contacted with described article.
14. the desinfactant detergent composition, it contains formula (I) compound, nonionic surface active agent and triethanolamine:
[Chemical formula 2]
Wherein, R
1representative has the straight chain saturated alkyl of 1 to 3 carbon atom, R
2representative has the straight chain saturated alkyl of 8 to 12 carbon atoms, X
-represent halide ion, and
yrepresentative has the saturated straight chain alkylidene of 8 to 12 carbon atoms.
15. the desinfactant detergent composition according to claim 14, wherein said formula (I) compound is to be selected from one or more following compounds: 1,10-bis-(3-decyl-glyoxal ethyline) decane dichloride, 1,10-bis-(3-decyl-glyoxal ethyline) decane dibromide, 1,12-bis-(3-decyl-glyoxal ethyline) dodecane dichloride and 1,12-bis-(3-octyl group-glyoxal ethyline) dodecane dichloride.
16., according to the desinfactant detergent composition of claims 14 or 15, wherein said formula (I) compound is 1,10-bis-(3-decyl-glyoxal ethyline) decane dichloride.
17. according to claim 14 to the desinfactant detergent composition of any one in 16, its formula that contains 0.001 to 50 % by weight (I) compound.
18. according to the desinfactant detergent composition of any one in claim 14-17, the nonionic surface active agent that its formula with respect to 1 weight portion (I) compound contains 0.1 to 20 weight portion.
19., according to the desinfactant detergent composition of any one in claim 14-18, wherein said nonionic surface active agent is one or more compounds that are selected from cocoanut fatty acid diethanolamide and polyoxyalkylene alkyl.
20. according to the desinfactant detergent composition of claim 19, the polyoxyalkylene alkyl that its cocoanut fatty acid diethanolamide with respect to 1 weight portion contains 0.05 to 1.0 weight portion.
21. according to the desinfactant detergent composition of any one in claim 14-20, the triethanolamine that its formula with respect to 1 weight portion (I) compound contains 0.0025 to 24.5 weight portion.
22., according to the desinfactant detergent composition of any one in claim 14-21, it further contains the biguanides bactericide.
23. according to the desinfactant detergent composition of claim 22, the biguanides bactericide that its formula with respect to 1 weight portion (I) compound contains 0.5 to 40 weight portion.
24., according to the desinfactant detergent composition of claim 22 or 23, wherein said biguanides bactericide is hexamethylene.
25., according to the desinfactant detergent composition of any one in claim 14-24, it is aqueous solution form.
26., according to the desinfactant detergent composition of claim 25, the pH of wherein said composition is 7 to 12.
27., according to the desinfactant detergent composition of claim 25 or 26, the alkaline reagent that the pH of wherein said composition is selected from sodium hydroxide and potassium hydroxide with one or more is adjusted.
28. according to the desinfactant detergent composition of any one in claim 14-27, its sterilization for article and clean, described article inside or top existence maybe may produce the microorganism to quaternary ammonium salt and/or the tolerance of biguanides bactericide.
29., for sterilization and the method for clean article, it comprises the desinfactant detergent composition according to any one in claim 14-28 is contacted with described article.
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| JP2011101726A JP5784964B2 (en) | 2011-04-28 | 2011-04-28 | Disinfectant composition and disinfecting method |
| JP2011-101727 | 2011-04-28 | ||
| JP2011-101726 | 2011-04-28 | ||
| JP2011101727A JP5784965B2 (en) | 2011-04-28 | 2011-04-28 | Disinfectant cleaning composition and disinfectant cleaning method |
| PCT/JP2012/061797 WO2012148004A1 (en) | 2011-04-28 | 2012-04-27 | Bactericide composition and bactericidal cleaning composition |
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| BE790089A (en) * | 1971-10-14 | 1973-04-13 | Ici Ltd | DERIVATIVES OF IMIDAZOLE |
| GB9515720D0 (en) * | 1995-08-01 | 1995-10-04 | Zeneca Ltd | Bacterial coating compositions |
| DK1671541T3 (en) * | 2000-09-20 | 2016-07-25 | Lonza Ag | DISINFECTANT |
-
2012
- 2012-04-27 WO PCT/JP2012/061797 patent/WO2012148004A1/en active Application Filing
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008972A1 (en) * | 1992-10-20 | 1994-04-28 | Zeneca Limited | Oligomeric heterocyclic salts and their use as antimicrobial agents in swimming pools and spas |
| JPH11323384A (en) * | 1998-05-13 | 1999-11-26 | Nof Corp | High-concentration liquid detergent composition |
| JP2002348593A (en) * | 2001-05-28 | 2002-12-04 | Kao Corp | Liquid detergent composition |
| JP2006328170A (en) * | 2005-05-25 | 2006-12-07 | Kao Corp | Liquid detergent composition for clothes |
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|---|---|
| WO2012148004A1 (en) | 2012-11-01 |
| TW201249341A (en) | 2012-12-16 |
| CN103491780B (en) | 2015-07-08 |
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