CN103488217A - Integrated micro-fluid control system - Google Patents
Integrated micro-fluid control system Download PDFInfo
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- CN103488217A CN103488217A CN201310475834.3A CN201310475834A CN103488217A CN 103488217 A CN103488217 A CN 103488217A CN 201310475834 A CN201310475834 A CN 201310475834A CN 103488217 A CN103488217 A CN 103488217A
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- fine setting
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- setting rotating
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Abstract
The invention relates to a control system for a micro-fluid control structure system and belongs to the field of micro-mechanical system designs. According to the control system, four bed plate supporting legs are arranged at the four corners of a control bed plate; the bed plate supporting legs are internally provided with horizontal debugging discs; the control bed plate is provided with a pair of guide rails; a clamping rod is erected on the guide rails; the clamping rod is hinged with a toggle clip plate; a horizontal liquid bubble device is arranged on the control bed plate; the control bed plate is divided into two layers of panels; a spherical liquid bag is arranged at each of the four corners of the middle position between the two layers of panels; the spherical liquid bags are communicated with a hydraulic chamber by hydraulic pipes; the hydraulic chamber is separated from a hydraulic cavity by a pair of clamping springs; the hydraulic chamber is internally provided with a piston; a screw rod is connected with one end of the piston and the piston is provided with a thread disc; hydraulic chamber scales are arranged on the outer wall of the hydraulic chamber. According to the control system for the micro-fluid control structure system, a micro-fluid chip is clamped on the control bed plate and the adaptation degree of a horizontal plane of the micro-fluid chip is adjusted from four directions of three dimensions so as to realize the control of a flowing direction and a flowing speed of micro-fluids.
Description
Technical field
The present invention relates to a kind of control system of microflow control structure system, belong to the micro mechanical system design field.
Background technology
The insider knows that it is a kind of microfluid phenomenon that electricity soaks, and it has started to be used as widely the driving mechanism of various fluids and electro-optic device; Electricity is wetting to be referred to by changing voltage between drop and insulated substrate, changes the wetting state of drop on substrate, changes contact angle, makes the phenomenon of drop generation deformation, displacement.The so-called wetting a kind of fluid that refers to solid surface is by process that one other fluid replaced.Liquid is sprawled at solid surface energy, and the solid-liquid contact face has the trend of expansion, and liquid is greater than its cohesion to the adhesion of solid surface, is exactly wetting.Liquid can not be sprawled at solid surface, and surface of contact has and is shrunk to spherical trend, is exactly nonwetting, and nonwetting to be exactly liquid be less than its cohesion to the adhesion of solid surface.The wettability effect on water resistant surface can change with voltage (therefore named electricity wetting), makes surface become more hydrophilic (moistening).Due to the more water suction that becomes now of the surface of original water resistant, oil reservoir has to change its form.It is the basis of electric wetted applications that this interface property is controlled.And the micro-fluidic chip technology is that the basic operation units such as the sample preparation of biological, chemistry, medical analysis process, reaction, separation, detection are integrated on the chip of a micro-meter scale, automatically complete the analysis overall process.Due to its great potential in fields such as biology, chemistry, medical science, developed into the brand-new research field of the subject crossing such as a biology, chemistry, medical science, fluid, electronics, material, machinery.The international recent development of micro-fluidic chip technical field is introduced in report, in conjunction with speaker's micro-fluidic chip research and development for many years achievement, introduces a set of complete and unique chip manufacturing process technology, and the microchip of multiple different application.
China Patent No.: 2009100286968 patent, it has set forth a kind of novel microflow control structure, this structure is utilized the wetting ultimate principle of electricity, spatial gradient by control medium thickness, form the spatial gradient of wetting state, thereby realized the control of microfluidic flow direction and flowing velocity.Its embodiment is to be provided with dielectric layer on the conductive substrates of structure, is provided with lyophobic layers on dielectric layer, and the both sides on lyophobic layers are provided with the both sides barrier, is provided with the top barrier on the barrier of both sides; Form mobile cavity by the space between lyophobic layers, both sides barrier, top barrier, microfluid is arranged in the cavity that flows; The thickness of dielectric layer successively decreases gradually along the flow direction of microfluid.When microfluid flows through cavity, microfluid by both sides barrier or top barrier as electrode application voltage.
The core of its patent is by control medium thickness, makes liquid be subject to gravity and stream from high to lower; Thereby the speed that therefore thickness of medium has directly affected miniflow has affected wetting state.But this invents its dielectric thickness changing value is constant, so its speed of controlling miniflow is a definite value; And, for a microfluidic control chip, the liquid of its test is that viscosity is all different, therefore the medium of this fixedly gradient is too stiff, and application is wideless, the too small drawback of the scope of application.And a fatal drawback is more arranged is that it must guarantee that its clamping plane is surface level when using micro flow chip, not so the medium of its gradient does not reach the purpose of controlling flowing velocity and direction.
Summary of the invention
Control by mounting medium the spatial gradient that forms wetting state in order to overcome at present, thereby realize the shortcoming and defect of the control of microfluidic flow direction and flowing velocity, the object of the present invention is to provide a kind of microfluidic control chip three-dimensional space position to control, thereby indirectly realized the purpose that dielectric thickness is variable.
The technical scheme that the present invention solves its technical matters employing is: integrated microfluidic control system, its structure mainly comprises: control platen, the platen spike, level debugging dish, spheroid liquid capsule, horizontal vacuole device, guide rail, supporting rod, buckle board, wind, micro flow chip, hydraulic tube, the hydraulic pressure thorax, hydraulic cavities, piston, the screw thread dish, screw rod, liquid thorax scale, upper left fine setting rotating disk, lower-left fine setting rotating disk, upper right fine setting rotating disk, bottom right fine setting rotating disk, jump ring, four jiaos of places of described control platen are provided with four platen spikes, be provided with level debugging dish in the platen spike, control platen and be provided with pair of guide rails, added the standing of guide rail has a supporting rod, is hinged with buckle board on supporting rod, control platen one place and be provided with horizontal vacuole device,
Described control platen divides two-layer panel, at four jiaos of places in two-layer centre position, respectively is provided with spheroid liquid capsule; Spheroid liquid capsule connects by hydraulic tube and hydraulic pressure thorax; Hydraulic pressure thorax and hydraulic cavities separate by a pair of jump ring; Be provided with piston in the hydraulic pressure thorax, piston one end is connected with screw rod, and screw rod is provided with the screw thread dish; The outer wall of hydraulic pressure thorax is provided with liquid thorax scale;
Rotating disk, lower-left fine setting rotating disk, upper right fine setting rotating disk, four fine setting rotating disks of bottom right fine setting rotating disk are finely tuned in the upper left that is provided with that described four spheroid liquid capsules are corresponding with it; Four fine setting rotating disks are hinged by an end of screw rod respectively; Four fine setting rotating disks are provided with knob, pointer, scale.
Above-mentioned hydraulic tube is rigid pipe.
Above-mentioned its every flight pitch of screw thread dish be 17 ~ 22 the circle/centimetre.
The spacing of above-mentioned its two-layer panel of control platen is 0.8cm ~ 2cm.
Above-mentioned supporting rod one end also is hinged with wind.
The beneficial effect that the present invention has is: in controlling on platen, then its four direction three-dimensional is adjusted to the adaptability height of its surface level by the clamping micro flow chip, thereby realized the control of microfluidic flow direction and flowing velocity; Surface level is adjusted precision and has been reached 7 percent ~ 15 precision of every centimetre, and this kind of precision reached controls requirement capillaceous; Whether by controlling the horizontal debugging control of platen early stage, having got rid of surface level position in outer bound pair test process affects accurately; Realization of debugging by the fine setting rotating disk with knob, pointer, scale the surface level obliquity visual.
The accompanying drawing explanation
Fig. 1 is the whole formation of the integrated microfluidic control system of the present invention schematic diagram.
The structural representation that Fig. 2 is a micro flow chip of the integrated microfluidic control system clamping of the present invention.
The core component structural representation that Fig. 3 is the integrated microfluidic control system surface level height of the present invention fine adjustment.
In figure, 1-controls platen, 2-platen spike, 3-level debugging dish, 4-spheroid liquid capsule, the horizontal vacuole device of 5-, 6-guide rail, 7-supporting rod, 8-buckle board, the 9-wind, 10-micro flow chip, 11-hydraulic tube, 12-hydraulic pressure thorax, the 13-hydraulic cavities, 14-piston, 15-screw thread dish, 16-screw rod, 17-liquid thorax scale, 18-upper left fine setting rotating disk, 19-lower-left fine setting rotating disk, 20-upper right fine setting rotating disk, 21-bottom right fine setting rotating disk, 22-jump ring.
Embodiment
Below in conjunction with accompanying drawing, 1-3 makes a detailed explanation the specific embodiment of the present invention.
Embodiment: integrated microfluidic control system, its structure mainly comprises: control platen 1, platen spike 2, level debugging dish 3, spheroid liquid capsule 4, horizontal vacuole device 5, guide rail 6, supporting rod 7, buckle board 8, wind 9, micro flow chip 10, hydraulic tube 11, hydraulic pressure thorax 12, hydraulic cavities 13, piston 14, screw thread dish 15, screw rod 16, liquid thorax scale 17, upper left fine setting rotating disk 18, lower-left fine setting rotating disk 19, upper right fine setting rotating disk 20, bottom right fine setting rotating disk 21, jump ring 22, 1 four jiaos of places of described control platen are provided with four platen spikes 2, be provided with level debugging dish 3 in platen spike 2, control platen 1 and be provided with pair of guide rails 6, added the standing of guide rail 6 has a supporting rod 7, is hinged with buckle board 8 on supporting rod 7, control platen 1 one places and be provided with horizontal vacuole device 5,
1 minute two-layer panel of described control platen, respectively be provided with spheroid liquid capsule 4 at four jiaos of places in two-layer centre position; Spheroid liquid capsule 4 connects by hydraulic tube 11 and hydraulic pressure thorax 12; Hydraulic pressure thorax 12 separates by a pair of jump ring 22 with hydraulic cavities 13; Be provided with piston 14 in hydraulic pressure thorax 12, piston 14 1 ends are connected with screw rod 16, and screw rod 16 is provided with screw thread dish 15; The outer wall of hydraulic pressure thorax 12 is provided with liquid thorax scale 17;
Rotating disk 18, lower-left fine setting rotating disk 19, upper right fine setting rotating disk 20,21 4 fine setting rotating disks of bottom right fine setting rotating disk are finely tuned in the upper left that is provided with that described four spheroid liquid capsules 4 are corresponding with it; Four fine setting rotating disks are hinged by an end of screw rod 16 respectively; Four fine setting rotating disks are provided with knob, pointer, scale.
Described hydraulic tube 11 is rigid pipe.
Described screw thread dish 15 its every flight pitch be 17 ~ 22 circles/centimetre.
The spacing of described control platen 1 its two-layer panel is 0.8cm ~ 2cm.
Described supporting rod 7 one ends also are hinged with wind 9.
When the present invention operates, at first will control platen 1 and carry out leveling by the level debugging dish 3 on platen spike 2, make control platen 1 after leveling in the surface level position, whether can observation post obtain from the interior vacuole of horizontal vacuole device 5 middle position in the surface level position.Put after platen 1 is controlled in leveling into a micro flow chip 10 that needs experiment, tests again and clamped by buckle board 8, in clamping process, the size adaptation of its micro flow chip 10 can be rolled its supporting rod 7 to realize in the rear tune contracting of guide rail 6 space by being shaken wind 9; The micro flow chip be held 10 after adjusting space size adaptation is fixed in to be controlled on platen 1; Now according to the upper left of being regulated of micro flow chip 10 its chip capillary canalicular flow directions, finely tune rotating disk 18, lower-left fine setting rotating disk 19, upper right fine setting rotating disk 20,21 4 fine setting rotating disks of bottom right fine setting rotating disk.After adjustment process, start to carry out electrochemistry experiment etc.Hydraulic tube 11 in the present invention is rigidity, its objective is the stability that guarantees to guarantee its control platen 1 surface level in each fine setting rotating disk adjustment process.
Core of the present invention is: carry out high-precision micro flow chip 10 three dimensions under the prerequisite that platen 1 is surface level the adjustment of artificial property is carried out in its 4 planimetric positions guarantee controlling, make the surface level obliquity after adjustment meet the flow direction of experiment control microfluid and the requirement of flowing velocity.
Therefore under the prerequisite of the core point that does not deviate from this heating, all make prima facie change all within this patent protection domain.
Claims (5)
1. integrated microfluidic control system, its structure mainly comprises: control platen (1), platen spike (2), level debugging dish (3), spheroid liquid capsule (4), horizontal vacuole device (5), guide rail (6), supporting rod (7), buckle board (8), wind (9), micro flow chip (10), hydraulic tube (11), hydraulic pressure thorax (12), hydraulic cavities (13), piston (14), screw thread dish (15), screw rod (16), liquid thorax scale (17), upper left fine setting rotating disk (18), lower-left fine setting rotating disk (19), upper right fine setting rotating disk (20), bottom right fine setting rotating disk (21), jump ring (22), it is characterized in that: control platen (1) Si Jiaochu and be provided with four platen spikes (2), be provided with level debugging dish (3) in platen spike (2), control platen (1) and be provided with pair of guide rails (6), added the standing of guide rail (6) has a supporting rod (7), is hinged with buckle board (8) on supporting rod (7), control platen (1) one place and be provided with horizontal vacuole device (5),
Described control platen (1) minute two-layer panel, respectively be provided with spheroid liquid capsule (4) at four jiaos of places in two-layer centre position; Spheroid liquid capsule (4) connects by hydraulic tube (11) and hydraulic pressure thorax (12); Hydraulic pressure thorax (12) separates by a pair of jump ring (22) with hydraulic cavities (13); Be provided with piston (14) in hydraulic pressure thorax (12), piston (14) one ends are connected with screw rod (16), and screw rod (16) is provided with screw thread dish (15); The outer wall of hydraulic pressure thorax (12) is provided with liquid thorax scale (17);
Rotating disk (18), lower-left fine setting rotating disk (19), upper right fine setting rotating disk (20), (21) four fine setting rotating disks of bottom right fine setting rotating disk are finely tuned in the upper left that is provided with that described four spheroid liquid capsules (4) are corresponding with it; Four fine setting rotating disks are hinged by an end of screw rod (16) respectively; Four fine setting rotating disks are provided with knob, pointer, scale.
2. integrated microfluidic control system according to claim 1, is characterized in that described hydraulic tube (11) is rigid pipe.
3. integrated microfluidic control system according to claim 1, it is characterized in that its every flight pitch of described screw thread dish (15) be 17 ~ 22 circles/centimetre.
4. integrated microfluidic control system according to claim 1, is characterized in that the spacing of its two-layer panel of described control platen (1) is 0.8cm ~ 2cm.
5. integrated microfluidic control system according to claim 1, is characterized in that described supporting rod (7) one ends also are hinged with wind (9).
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| CN201310475834.3A CN103488217A (en) | 2013-10-14 | 2013-10-14 | Integrated micro-fluid control system |
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| CN201310475834.3A CN103488217A (en) | 2013-10-14 | 2013-10-14 | Integrated micro-fluid control system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106525724A (en) * | 2016-10-26 | 2017-03-22 | 杭州霆科生物科技有限公司 | Centrifugal fully integrated detection system of methanal and pH value |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101497017A (en) * | 2009-01-05 | 2009-08-05 | 东南大学 | Microflow control structure |
| CN101497006A (en) * | 2009-01-15 | 2009-08-05 | 宁波大学 | Digital microfluid micro-mixer and mixing method |
| WO2010077322A1 (en) * | 2008-12-31 | 2010-07-08 | Microchip Biotechnologies, Inc. | Instrument with microfluidic chip |
| CN102056838A (en) * | 2008-04-11 | 2011-05-11 | 弗卢丁公司 | Multilevel microfluidic systems and methods |
| CN203520202U (en) * | 2013-10-14 | 2014-04-02 | 徐云鹏 | Integrated microfluid control system |
-
2013
- 2013-10-14 CN CN201310475834.3A patent/CN103488217A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102056838A (en) * | 2008-04-11 | 2011-05-11 | 弗卢丁公司 | Multilevel microfluidic systems and methods |
| WO2010077322A1 (en) * | 2008-12-31 | 2010-07-08 | Microchip Biotechnologies, Inc. | Instrument with microfluidic chip |
| CN101497017A (en) * | 2009-01-05 | 2009-08-05 | 东南大学 | Microflow control structure |
| CN101497006A (en) * | 2009-01-15 | 2009-08-05 | 宁波大学 | Digital microfluid micro-mixer and mixing method |
| CN203520202U (en) * | 2013-10-14 | 2014-04-02 | 徐云鹏 | Integrated microfluid control system |
Non-Patent Citations (4)
| Title |
|---|
| 孙立国等: "微流控装置制备聚合物微珠的研究", 《黑龙江大学工程学报》, vol. 2, no. 2, 25 May 2011 (2011-05-25), pages 39 - 43 * |
| 孟庆宜: "微流控芯片凝血检测装置的设计", 《分析仪器》, no. 1, 28 January 2010 (2010-01-28), pages 31 - 33 * |
| 赵亮等: "集成微流控芯片", 《科学通报》, vol. 56, no. 23, 15 August 2011 (2011-08-15), pages 1855 - 1870 * |
| 陈陶等: "一种基于微流控技术的光开关阵列设计与研制", 《光电子 激光》, vol. 21, no. 11, 15 November 2010 (2010-11-15), pages 1605 - 1608 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106525724A (en) * | 2016-10-26 | 2017-03-22 | 杭州霆科生物科技有限公司 | Centrifugal fully integrated detection system of methanal and pH value |
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Application publication date: 20140101 |