CN103479628B - Lycojaponicumin A在制备抗疱疹病毒的药物中的应用 - Google Patents
Lycojaponicumin A在制备抗疱疹病毒的药物中的应用 Download PDFInfo
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- CN103479628B CN103479628B CN201310436248.8A CN201310436248A CN103479628B CN 103479628 B CN103479628 B CN 103479628B CN 201310436248 A CN201310436248 A CN 201310436248A CN 103479628 B CN103479628 B CN 103479628B
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- Prior art keywords
- hsv
- lycojaponicumin
- herpesvirus
- virus
- herpes
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- 239000003814 drug Substances 0.000 title claims abstract description 15
- 230000003602 anti-herpes Effects 0.000 title claims abstract description 5
- WGVQKABRYXBLGW-WUZBVLBZSA-N (1R,2S,5S,7S,10S,13S)-7-hydroxy-7-methyl-17-oxa-14-azapentacyclo[12.2.1.02,10.02,13.05,10]heptadecane-3,9-dione Chemical compound O=C([C@@]12CC3)C[C@@](C)(O)C[C@H]1CC(=O)[C@@]12[C@H]3N2CC[C@H]1O2 WGVQKABRYXBLGW-WUZBVLBZSA-N 0.000 title claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 12
- 241000700588 Human alphaherpesvirus 1 Species 0.000 abstract description 15
- 241000700605 Viruses Species 0.000 abstract description 11
- 208000029433 Herpesviridae infectious disease Diseases 0.000 abstract description 8
- 241000701074 Human alphaherpesvirus 2 Species 0.000 abstract description 6
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 238000002474 experimental method Methods 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 238000011161 development Methods 0.000 abstract description 2
- 229930185194 lycojaponicumin Natural products 0.000 abstract 4
- 238000002360 preparation method Methods 0.000 description 7
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000523 sample Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241001529453 unidentified herpesvirus Species 0.000 description 4
- 241000700584 Simplexvirus Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 231100000645 Reed–Muench method Toxicity 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 241000197194 Bulla Species 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 206010056254 Intrauterine infection Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
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Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310436248.8A CN103479628B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备抗疱疹病毒的药物中的应用 |
Applications Claiming Priority (1)
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CN201310436248.8A CN103479628B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备抗疱疹病毒的药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103479628A CN103479628A (zh) | 2014-01-01 |
CN103479628B true CN103479628B (zh) | 2015-12-09 |
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CN201310436248.8A Expired - Fee Related CN103479628B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备抗疱疹病毒的药物中的应用 |
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CN (1) | CN103479628B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
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2013
- 2013-09-23 CN CN201310436248.8A patent/CN103479628B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Inventor after: Zhang Hongli Inventor before: Jiang Chunping Inventor before: Wang Hui |
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TA01 | Transfer of patent application right |
Effective date of registration: 20151104 Address after: 325011, building 1112, building A, 209 Wenchang Road, hi tech Zone, Longwan District, Zhejiang, Wenzhou Applicant after: Wenzhou Chengqiao Technology Co.,Ltd. Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing guangkangxie Biomedical Technology Co.,Ltd. |
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Effective date of registration: 20181213 Address after: 409000 Baijiahe Road, Zhengyang Industrial Park, Qianjiang District, Chongqing Patentee after: CHONGQING QIANJIANG APENG TECHNOLOGY ENTERPRISE INCUBATOR CO.,LTD. Address before: 325011 room 1112, building A, 209 Wenchang Road, hi tech Zone, Longwan District, Wenzhou, Zhejiang. Patentee before: Wenzhou Chengqiao Technology Co.,Ltd. |
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TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151209 Termination date: 20210923 |