CN103479451A - Polyether-ether-ketone artificial spine intervertebral disc - Google Patents

Polyether-ether-ketone artificial spine intervertebral disc Download PDF

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Publication number
CN103479451A
CN103479451A CN201310467070.3A CN201310467070A CN103479451A CN 103479451 A CN103479451 A CN 103479451A CN 201310467070 A CN201310467070 A CN 201310467070A CN 103479451 A CN103479451 A CN 103479451A
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China
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end plate
lower end
spinal disc
upper end
upper
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CN201310467070.3A
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Chinese (zh)
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张忠祥
孙守贵
吴大卫
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北京贝思达生物技术有限公司
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Priority to CN201310467070.3A priority Critical patent/CN103479451A/en
Publication of CN103479451A publication Critical patent/CN103479451A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof

Abstract

A polyether-ether-ketone artificial spine intervertebral disc comprises an upper end plate, a lower end plate and a nucleus pulposus prosthesis arranged between the upper end plate and the lower end plate. The nucleus pulposus prosthesis is made of medical stainless steel or vitallium or biological ceramic and the upper end plate and the lower end plate are made of polyether-ether-ketone. The upper surface of the upper end plate and the lower surface of the lower end plate are respectively provided with a coarse surface and each coarse surface is formed according to the physical machining methods such as carving conducted by a carving machine and emery spraying. The upper end plate and the lower end plate are fixed to the spine in a fused mode, the nucleus pulposus prosthesis is placed between the upper end plate and the lower end plate and is also called a rotary center, three-dimensional rotary movement is achieved among the nucleus pulposus prosthesis, the upper end plate and the lower end plate, and therefore the function of motion of the normal spine intervertebral disc of a person can be provided. The upper end plate and the lower end plate which are made of the polyether-ether-ketone are good in biocompatibility and self-lubrication and quite resistant to abrasion. The nucleus pulposus prosthesis is good in mechanical performance and high in strength. The polyether-ether-ketone artificial spine intervertebral disc has the advantages of being simple in structure, good in biocompatibility, durable, and wide in adaptation disease range.

Description

一种聚醚醚酮人工脊柱椎间盘 Polyether ether ketone artificial spinal disc

技术领域 FIELD

[0001] 本发明属于骨科内固定器械技术领域,具体涉及一种适合于脊柱创伤及病变状态下的聚醚醚酮人工脊柱椎间盘。 [0001] The present invention belongs to the technical field fixation orthopedic devices, and more particularly to a suitable polyether ether ketone in an artificial spinal trauma and spinal disc disease state.

背景技术 Background technique

[0002]目前国内外脊柱人工椎间盘均以超高分子量聚乙烯(UHMWPE)与金属组合制成脊柱人工椎间盘。 [0002] Artificial spinal discs at home and abroad are ultrahigh molecular weight polyethylene (UHMWPE) is made of metal in combination with artificial spinal disc. 超高分子量聚乙烯(ultra high molecular weight polyethylene,UHMWPE)作为摩擦部位材料应用最广泛,UHMWPE磨损颗粒最重要的靶细胞就是巨噬细胞。 UHMWPE (ultra high molecular weight polyethylene, UHMWPE) material as a friction portion of the most widely used, UHMWPE wear particles is the most important target cells macrophages.

[0003] 金属、聚乙烯和聚甲基丙烯酸甲酯俗称有机玻璃(PMMA)颗粒均导致巨噬细胞浸润和大量炎性细胞因子的产生。 [0003] metal, polyethylene and polymethyl methacrylate, commonly known as plexiglass (PMMA) particles were lead to a large number of macrophage infiltration and inflammatory cytokines. 破骨细胞是从单核巨噬细胞系的破骨细胞前体细胞分化而来的多核细胞,是导致骨吸收最重要的细胞。 Osteoclasts are multinucleated cells derived from the mononuclear macrophage lineage osteoclast precursor cells, resulting in bone resorption is the most important cells. 磨损颗粒促使破骨细胞前体细胞向破骨细胞分化的过程很复杂,包括磨损颗粒的直接作用和与巨噬细胞引起假体周围细胞因子环境变化有关。 Wear particles to promote osteoclast precursor cells into osteoclasts process is complex, comprising a direct action of wear particles caused by macrophages and periprosthetic cytokine environmental change. 巨噬细胞被磨损颗粒不断刺激,产生大量促炎症介质和蛋白水解酶类。 Macrophages are wear particles continuously stimulated to produce a large number of proinflammatory mediators and proteolytic enzymes. 巨噬细胞集落刺激因子等,促进破骨细胞前体细胞向破骨细胞分化,最终导致骨溶解。 Macrophage colony stimulating factor, to promote osteoclast precursor cells into osteoclasts, resulting in osteolysis.

[0004] 而UHMWPE的抗磨损能力较差,磨损不仅降低了假体的使用寿命,磨损颗粒易导致骨质溶解,发生无菌性松动,将导致二次手术的后果。 [0004] The UHMWPE wear resistance is poor, not only reduces the wear life of the prosthesis, wear particles easily lead to osteolysis, aseptic loosening, will lead to the consequences of secondary surgery.

发明内容 SUMMARY

[0005] 本发明就是为了解决上述现有技术中的问题,提供了一种聚醚醚酮人工脊柱椎间盘。 [0005] The present invention was made to solve the above problems of the prior art, a polyether ether ketone artificial spinal disc.

[0006] 为了达到上述目的,本发明采用如下技术方案: [0006] To achieve the above object, the present invention adopts the following technical solution:

本发明的聚醚醚酮人工脊柱椎间盘,包括上终板、下终板以及设置在上终板和下终板之间的髓核假体;髓核假体与上终板和下终板之间形成三维旋转移动,上终板和下终板由聚醚醚酮材料制成,上终板的上表面和下终板的下表面设有粗糙面。 Polyetheretherketone artificial spinal disc according to the present invention, includes an upper endplate, lower endplate and nucleus prosthesis disposed between the upper endplate and lower endplate; nucleus prosthesis with the upper endplate and lower endplate of a three-dimensional rotational movement between the upper end and the lower end plate is made of a plate material, polyether ether ketone, a lower surface and an upper surface of the lower endplate endplate is provided with a rough surface.

[0007] 所述的髓核假体的材质为医用不锈钢、钴铬钥或生物陶瓷。 [0007] The material of the nucleus prosthesis of medical stainless steel, cobalt chrome key or bioceramic.

[0008] 所述的髓核假体为球形的双极型髓核假体或半球形的单极型髓核假体。 [0008] The nucleus prosthesis spherical nucleus prosthesis bipolar or unipolar hemispherical nucleus prosthesis.

[0009] 所述的粗糙面采用雕刻加工、金钢砂喷制等物理加工方法制作而成。 [0009] The rough surface of a physical processing method using engraving, emery and the like made spray system.

[0010] 所述的上终板的上表面和下终板的下表面均形成有突起的棘。 [0010] The lower surface of the upper and lower endplates endplates are each formed with a ratchet projections.

[0011] 本发明具有的优点和积极效果是: [0011] The present invention has advantages and positive effects are:

本发明的的聚醚醚酮人工脊柱椎间盘,生物相容性好,机械性能好、自润滑性好,抗磨损能力强。 Polyether ether ketone of the present invention an artificial spinal disc, good biocompatibility, good mechanical properties, good self-lubricating, high wear resistance. 磨损颗粒不会导致骨质溶解,减少了脊柱人工椎间盘发生无菌性松动的几率,增加人工椎间盘假体的使用寿命,避免患者二次手术的后果。 Wear particles does not lead to osteolysis, reducing the chance of spinal artificial disc aseptic loosening, increase the service life of artificial disc prosthesis, patients avoid the consequences of secondary surgery. 髓核假体机械性能好,强度高。 Nucleus prosthesis good mechanical properties, high strength. 本发明具有结构简单,经久耐用,适应症范围广泛的特点。 The present invention has simple structure, is durable, a wide range of indications of features. 聚醚醚酮部件材料外表面设有粗糙面,利于部件与人体脊柱融合。 The outer surface of the PEEK material member is provided with a rough surface, and the body member facilitate spinal fusion.

附图说明[0012] 图1是本发明的聚醚醚酮人工脊柱椎间盘的结构示意图; BRIEF DESCRIPTION [0012] FIG. 1 is a schematic view of the artificial spinal disc according to the present invention, the polyether ether ketone;

图2是本发明的双极型髓核假体的结构示意图; FIG 2 is a schematic view of a bipolar prosthetic nucleus of the present invention;

图3是本发明的单极型髓核假体的结构示意图。 3 is a schematic configuration of a monopole type prosthetic nucleus of the present invention.

[0013]附图中主要部件符号说明: [0013] BRIEF DESCRIPTION OF REFERENCE NUMERALS main components:

1.上终板 2.髓核假体 1. endplate nucleus prosthesis

3.下终板 4.粗糙面。 4. roughened surface of the lower end plate 3.

具体实施方式 Detailed ways

[0014] 下面结合附图和具体实施例对本发明的聚醚醚酮人工脊柱椎间盘做进一步说明。 [0014] The following drawings and specific embodiments of the PEEK artificial spinal disc according to the present invention is further described in conjunction. 下述各实施例仅用于说明本发明而并非对本发明的限制。 Embodiments of the present invention the following examples are only for illustration and not limitation of the invention.

[0015] 图1是本发明的聚醚醚酮人工脊柱椎间盘的结构示意图;图2是本发明的双极型髓核假体的结构示意图;图3是本发明的单极型髓核假体的结构示意图。 [0015] FIG. 1 is a schematic structural diagram of polyetheretherketone artificial spinal disc according to the present invention; FIG. 2 is a schematic view of a bipolar prosthetic nucleus of the present invention; FIG. 3 is a unipolar prosthetic nucleus of the present invention the schematic structure. 如图1至图3所示,本发明的聚醚醚酮人工脊柱椎间盘,包括上终板1、下终板3以及设置在上终板I和下终板3之间的髓核假体2。 1 to 3, polyetheretherketone artificial spinal disc according to the present invention, comprising an upper endplate, lower endplate, and 3 disposed on the endplate and the lower endplate I between the nucleus prosthesis 32 . 髓核假体2与上终板I和下终板3之间形成三维旋转移动。 Nucleus prosthesis 2 and the upper end and the lower end plate I are formed a three-dimensional rotational movement between the plate 3. 髓核假体2又称为旋转核心,采用医用不锈钢、钴铬钥或生物陶瓷材料制成。 2, also known as nucleus prosthesis rotary core, made of medical stainless steel, cobalt chrome key or bioceramic. 上终板I和下终板3由聚醚醚酮(peek)材料制成。 Upper and lower endplates endplates I 3 is made of polyether ether ketone (PEEK) material.

[0016] 上终板I的上表面和下终板3的下表面设有粗糙面4。 The lower surface of the upper [0016] surface of the upper endplate and lower endplate I 3 is provided with a roughened surface 4. 粗糙面4采用雕刻加工、金钢砂喷砂等物理加工方法制作而成。 4 roughened surface using engraving, emery physical processing method such as sandblasting made. 粗糙面4可与骨形成骨长上现象。 4 roughened surface may be formed on the phenomenon of the long bone and bone.

[0017] 上终板I和下终板3与脊柱融合固定,髓核假体2与上终板1、下终板3之间形成三维旋转移动。 The [0017] I and a lower end plate 3 and the end plate fixed to spinal fusion, prosthetic nucleus and the upper end plate 2 1, three-dimensional rotational movement between the end plate 3. 髓核假体2可以是球形的双极型髓核假体或半球形的单极型髓核假体。 Nucleus prosthesis 2 can be spherical nucleus prosthesis bipolar or unipolar hemispherical nucleus prosthesis. 单极型髓核假体为一端与上终板(或下终板)固定,另一端与下终板(或上终板)形成三维旋转移动。 Unipolar nucleus prosthesis endplate of the upper end (or lower end plate) is fixed, the other end of the lower end plate (end plate or on) three-dimensional rotational movement. 双极型髓核假体为两端分别与上终板和下终板形成三维旋转移动,具有两个活动点,单极型髓核假体与上终板、下终板组合使用其稳定性较强,双极型髓核假体与上终板、下终板组合使用其灵活性较强,均为人体提供正常脊柱椎间盘的活动功能。 Bipolar prosthetic nucleus as both ends and the upper endplate and lower endplate forming a three-dimensional rotating movement, having two movable points, unipolar nucleus prosthesis and the upper endplate, lower endplate in combination of stability strong nucleus bipolar prosthesis and the endplate, lower endplate strong combination of flexibility, both human activities provide normal spinal disc function.

[0018] 本发明的上终板I和下终板3的表面也可以不设置涂层或粗糙面,同样可以实现脊柱椎间盘的功能。 [0018] the present invention on the endplate and the lower endplate I surface 3 may not be provided with a coating or roughened surface, the same function can be achieved spinal disc.

[0019] 上终板I的上表面和下终板3的下表面均形成有突起的棘,棘的作用是刺入人体脊柱中提高其植入稳定性。 The lower surface of the upper [0019] surface of the upper endplate and lower endplate I 3 are formed with a projection of the ratchet, the ratchet effect is inserted into the body spine implant to improve its stability.

[0020] 本发明采用聚醚醚酮制成上终板和下终板。 [0020] The present invention uses polyether ether ketone formed on the end plate and the lower endplate. 聚醚醚酮(peek)具有良好的生物相容性和稳定的化学特性,各国学者们对PEEK的生物相容性进行了研究,通过体外细胞培养、动物体内植入等方法对材料的细胞毒性、细胞增殖率、致突变性、黏附性、细胞生物学功能等指标进行了测定,一系列研究证明PEEK具有良好的生物相容性和稳定的化学特性。 Polyether ether ketone (PEEK) has good biocompatibility and stable chemical properties, scholars biocompatible PEEK States were studied, the cytotoxicity of the material by in vitro cell culture, animal implantation or the like , cell proliferation rate, mutagenicity, adhesion, cell biological function were measured, a series of studies have shown that PEEK having good biocompatibility and stable chemical properties. PEEK材料的体积磨损率约为UHMWPE的1/2。 Volume wear rate of UHMWPE PEEK material is about 1/2.

[0021 ] PEEK是韧性和刚性兼备并取得平衡的塑料,机械特性佳,聚醚醚酮PEEK生物相容性好,自润滑性好,抗磨损能力强,磨损颗粒不会导致骨质溶解。 [0021] PEEK is between toughness and rigidity balance, and plastics, good mechanical properties, good biocompatibility PEEK polyetheretherketone, self-lubricating, high wear resistance, the wear particles do not lead to osteolysis. 聚醚醚酮PEEK制成上、下终板消除了因金属材料接触人体骨骼造成人体金属过敏的现象,解决了人体对金属的排异问题,使其植入人群范围扩大。 Polyether ether ketone, PEEK, the lower end plate is eliminated due to the phenomenon of metal materials contact with human body caused by metal allergy bone solve the problem of rejection of the metal body, so as to expand the implant range of people. 尤为重要的是PEEK无毒、质轻、耐腐蚀,是与人体骨骼最接近的材料,因此可采用PEEK代替金属制造人体骨骼。 PEEK is particularly important that the non-toxic, light weight, corrosion resistance, is the closest human bone material, the PEEK may be used instead of metal for producing the human skeleton. 聚醚醚酮PEEK可在134°C下经受3000次循环高压灭菌,这一特性能满足灭菌要求,用它可制造需高温蒸汽消毒的各种医疗器械。 Polyetheretherketone PEEK may be subjected at 134 ° C 3000 autoclave cycles, this feature can be sterilized to meet the requirements, it can be manufactured with high temperature steam sterilization required various medical instruments. 耐辐照性耐高辐照的能力很强,超过了通用树脂中耐辐照性最好的聚苯乙烯。 Radiation resistance capability of very high resistance to radiation, than the best general-purpose polystyrene resin, radiation resistance. 可以作成Y辐照剂量达IlOOMrad时仍能保持良好的绝缘能力的高性能,所以可做辐射灭菌产品。 It can be made still maintain good insulation capability of high performance when Y radiation doses up to IlOOMrad, so do radiation sterilization products. 因此聚醚醚酮材料制作成上终板和下终板,此产品抗磨损能力强,生物相容性好,植入范围广泛,灭菌方式较多,使用时灭菌便利。 Thus PEEK material into an upper and a lower end plate endplate Related strong wear resistance, good biocompatibility and a wide range of implants, many of sterilization, sterilization using convenience.

[0022] 髓核假体采用医用不锈钢、钴铬钥或生物陶瓷等材料制成。 [0022] The prosthetic nucleus made of medical stainless steel, cobalt chrome key or the like bioceramic material. 医用不锈钢强度高,具有较强的机械性能,抗腐蚀性能优异,生物相容性相对较差,但成本低廉,适合较贫困地区使用。 Medical stainless steel of high strength, with strong mechanical properties, excellent corrosion resistance, biocompatibility relatively poor, but low cost, suitable for the poorer regions.

[0023] Co-Cr-Mo合金主要用于制造关节替换假体连接件的主干,承受重载荷,如膝关节和髋关节等。 [0023] Co-Cr-Mo alloys are mainly used for manufacturing a joint replacement prosthesis stem connecting member, to withstand heavy loads, such as the knee and hip joints. 这种合金有很强的抗蚀性,Co-Cr-Mo合金(钴铬钥合金)具有很高的疲劳强度和极限抗拉强度,植入很长时间后,也很少会发生断裂。 This alloy has a strong corrosion resistance, Co-Cr-Mo alloys (cobalt-chromium alloy key) having a high fatigue strength and ultimate tensile strength, after implantation for a long time, rarely be fractured.

[0024] 生物陶瓷不仅具有不锈钢塑料所具有的特性,而且具有亲水性、能与细胞等生物组织表现出良好的亲和性。 [0024] Biological ceramic having not only a stainless steel with the characteristics of plastic, and having a hydrophilic, can exhibit a good affinity with the cells and other biological tissues. 生物陶瓷除用于测量、诊断治疗等外,主要是用作生物硬组织的代用材料,可用于骨科、整形外科、牙科、口腔外科、心血管外科、眼外科、耳鼻喉科及普通外科等方面。 Except for the bioceramic measurement, diagnosis and treatment endures, is used primarily as a biological hard tissue substitute material can be used in orthopedics, orthopedic, dentistry, oral surgery, cardiovascular surgery, eye surgery, and general surgery, ENT . 生物硬组织代用材料有体骨、动物骨,后来发展到采用不锈钢和塑料,由于这些生物材料在生物体中使用,不锈钢存在溶析、腐蚀和疲劳问题,塑料存在稳定性差和强度低的问题。 Biological hard tissue with a bone substitute material, animal bones, was developed to stainless steel and plastic, since the use of these materials in the biological organism, the presence of stainless steel elution, corrosion and fatigue problems, there is a difference of stability problems and low strength plastic. 因此生物陶瓷具有广阔的发展前景,目前世界各国相继发展了生物陶瓷材料。 Therefore, biological ceramics have broad prospects for development, is currently the world have developed a bio-ceramic materials. 生物惰性陶瓷主要是指化学性能稳定,生物相溶性好的陶瓷材料。 Bioinert ceramics mainly refers to chemical stability, good biocompatibility ceramic material. 这类陶瓷材料的结构都比较稳定,分子中的键力较强,而且都具有较高的机械强度。 Such structural ceramic materials are relatively stable, strong force bonds in a molecule, and having a high mechanical strength. 耐磨性以及化学稳定性。 Abrasion resistance, and chemical stability.

[0025] 聚醚醚酮(peek)部件与椎体相接触的表面采用粗糙面, 此表面能刺激此部位快速长骨且无副作用,可给不同患者均带来良好福音。 [0025] surface of the vertebral body contact member and the polyether ether ketone (PEEK) using roughened surface, this surface can stimulate this part of the long bones quickly and no side effects, can be brought to different patients were good news.

Claims (9)

1.一种聚醚醚酮人工脊柱椎间盘,包括上终板(I)、下终板(3)以及设置在上终板(I)和下终板(3)之间的髓核假体(2);髓核假体(2)与上终板(I)和下终板(3)之间形成三维旋转移动,其特征在于:上终板(I)和下终板(3)由聚醚醚酮材料制成,上终板(I)的上表面和下终板(3)的下表面设有粗糙面(4)。 An artificial spinal disc polyether ether ketone, includes an upper endplate (I), the lower end plate (3) disposed on the endplate (I) and a lower end plate between the nucleus prosthesis (3) ( 2); nucleus prosthesis (2) and the upper end plate (I) and lower endplates rotational movement between a three-dimensional (3), characterized in that: the end plate (I) upper and lower end plate (3) from poly material made ether ether ketone, and the lower surface of the upper endplate (I) of the endplate (3) is provided with a rough surface of the lower surface (4).
2.根据权利要求1所述的聚醚醚酮人工脊柱椎间盘,其特征在于:髓核假体(2)的材质为医用不锈钢。 2. polyetheretherketone according to claim 1 artificial spinal disc, comprising: a prosthetic nucleus material (2) for medical stainless steel.
3.根据权利要求1所述的聚醚醚酮人工脊柱椎间盘,其特征在于:髓核假体(2)的材质为钴铬钥。 The polyetheretherketone said artificial spinal disc of claim 1, wherein: the prosthetic nucleus material (2) is a cobalt chrome key.
4.根据权利要求1所述的聚醚醚酮人工脊柱椎间盘,其特征在于:髓核假体(2)的材质为生物陶瓷。 The polyetheretherketone said artificial spinal disc of claim 1, wherein: the prosthetic nucleus material (2) is a bioceramic.
5.根据权利要求1至权利要求4中的任意一项所述的聚醚醚酮人工脊柱椎间盘,其特征在于:髓核假体(2)为球形的双极型髓核假体。 According to any of claims 1 to 4 claims polyetheretherketone artificial spinal disc, comprising: a prosthetic nucleus (2) is a bipolar spherical nucleus prosthesis.
6.根据权利要求1至权利要求4中的任意一项所述的聚醚醚酮人工脊柱椎间盘,其特征在于:髓核假体(2)为半球形的单极型髓核假体。 4 according to any of claims 1 to claim polyetheretherketone artificial spinal disc, wherein: the prosthetic nucleus (2) is a unipolar nucleus prosthesis hemispherical.
7.根据权利要求1所述的聚醚醚酮人工脊柱椎间盘,其特征在于:粗糙面(4)采用雕刻加工的物理加工方法制作而成。 The polyether ether ketone artificial spinal disc according to claim 1, wherein: the roughened surface (4) by physical processing method of engraving made.
8.根据权利要求1所述的聚醚醚酮人工脊柱椎间盘,其特征在于:粗糙面(4)采用金钢砂喷制的物理加工方法制作而成。 8. The polyether ether ketone of the artificial spinal disc of claim 1, wherein: the roughened surface (4) physical processing method using emery made of spray system.
9.根据权利要求1所述的聚醚醚酮人工脊柱椎间盘,其特征在于:上终板(I)的上表面和下终板(3)的下表面均形成有突起的棘。 9. The polyether ether ketone of the artificial spinal disc of claim 1, wherein: an upper surface and a lower end plate (I) of the endplate (3) are formed in the lower surface of the spine with a projection.
CN201310467070.3A 2013-10-10 2013-10-10 Polyether-ether-ketone artificial spine intervertebral disc CN103479451A (en)

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