CN105105875B - A kind of biomimetic prosthetic hip joint with interior growth function - Google Patents

A kind of biomimetic prosthetic hip joint with interior growth function Download PDF

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CN105105875B
CN105105875B CN201510470685.0A CN201510470685A CN105105875B CN 105105875 B CN105105875 B CN 105105875B CN 201510470685 A CN201510470685 A CN 201510470685A CN 105105875 B CN105105875 B CN 105105875B
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porous support
layer
hip joint
prosthetic hip
bioactivity
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CN105105875A (en
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王玲
康建峰
庞小强
李涤尘
靳忠民
刘亚雄
贺健康
连芩
王满毅
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Xian Jiaotong University
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Abstract

The invention discloses a kind of biomimetic prosthetic hip joint with interior growth function, the joint is made up of artificial cartilage layer, interfacial adhesion layer and porous support, and artificial cartilage and porous support are spheroid shape surface;Articular surface cornerite is 60 120 °, and when cornerite is 80 120 °, 36 equally distributed convex columns are circumferentially devised in prosthese inner surface;The porous coating of bioactivity is prepared in femoral stem outer surface, and coating material is changed in gradient outward by inner;The loose structure that porous support is designed as having gradient according to finite element optimization result, aperture are 300 800 μm;Porosity is 20 85%;The present invention can preserve bone amount to greatest extent and maintain the biomechanical characterization of femur, with good mechanical property and tribological property, by inducing or promoting Oesteoblast growth to ensure prothesis implant body and the effective interface bond strength of natural bone, stability and service life after Using prosthesis are improved.

Description

A kind of biomimetic prosthetic hip joint with interior growth function
Technical field
The joint prosthesis technical field impaired the invention belongs to repair joint bone cartilage, and in particular to one kind has interior growth The biomimetic prosthetic hip joint of function.
Background technology
Because the reasons such as Osteoarthritis, aseptic necrosis of femoral head, bone tumour cause hip lesion, and with generation The continuous aggravation of boundary's aging population, osteoporosis cause fracture increasingly to highlight, and annual millions of patient need to receive pass Repairing and treating is saved, has a strong impact on the quality of life of patient.
The main sign of arthritis disease is articular cartilage lesion, and its therapeutic modality mainly gives according to cartilage lesion degree Selection.Initial stage can use cartilage transplantation reparation, such as:Marrow stimulation, Cartilage transplantation, allogeneic cartilage are transplanted, are autologous Chondrocyte cell transplantation, artificial material repair cartilage defect etc., and every kind of method has itself indication and limitation, mainly has: Material source is limited, implant survival rate and immune response etc., and belongs to small range reparation mostly.Later stage uses joint replacement It has been highly developed technology to be treated.At present, hip prosthesis implant common used material have metal-high crosslinked polyethylene, Ceramics-high crosslinked polyethylene, ceramic to ceramic etc., but still exist stress shielding, prosthetic loosening, potential metal ion harm, The technical barrier such as ceramic fragmentation and abnormal sound is urgently to be resolved hurrily.Clinical effectiveness statistics shows to select the patient of joint replacement just to tend to year Lightization, and revision rate is higher after Using prosthesis certain time limit, influences prosthese service life.Therefore, for mitigation patient pain simultaneously Recover function of joint, improve the reliability in prosthese service phase and increase the service life the always objective of prosthetic designs and pursuit Target.
Gu human articular cartilage is a kind of stream/two-phase viscoplasticity, layered porous medium material, and artificial joint prosthesis is mostly Individual layer hard material, in institutional framework, material properties, biomethanics with also existing compared with natural joint in terms of tribological property Larger difference, the role of " function reproduction " is more play, as the extension in cycle of being on active service will appear from the problem of various.Pin The deficiency remained to current hip joint disease treatment method, with the fast development of advanced manufacturing technology and biomaterial, base In to the institutional framework of natural joint and the understanding of material property, using bionic design concept and tissue engineering technique reparation Lesion joint turns into current research focus.Ding Chunming etc. is invented《A kind of organizational project joint two-phase support and its preparation side Method and application》(application number:201310202139.X), biology reconstruction is carried out for the existing joint prosthesis of organizational project joint replacement to carry Supplied a kind of possibility, but fix in support, load-carrying properties etc. go back Shortcomings.Therefore, the present invention proposes one kind and had The biomimetic prosthetic hip prosthesis design of interior growth function, it is intended to which lesion cartilage is substituted by artificial cartilage or tissue engineering bone/cartilage To keep original good characteristic, induce or promote Gegenbaur's cell to be grown in the porous support for be loaded with growth factor, ensure false Reliability and stability after body implantation.
The content of the invention
In order to overcome the above-mentioned problems of the prior art, it is an object of the invention to provide one kind to have interior growth function Biomimetic prosthetic hip joint, the articular prosthesis has good biomechanical property and tribological property, while being capable of maximum limit The preservation bone amount of degree and the biomechanical characterization for maintaining femur, and by inducing or promoting Oesteoblast growth to ensure Using prosthesis Thing and the enough interface bond strengths of natural bone, improve the stability and service life after Using prosthesis, meet many patients Physiology and functional requirement.
In order to achieve the above object, technical scheme:
A kind of biomimetic prosthetic hip joint with interior growth function, including the porous support layer that upper surface is spheroid shape curved surface 3, in the femoral stem 5 of the lower surface central integral chemical conversion type of porous support layer 3, in addition to artificial cartilage layer 1, pass through interfacial adhesion layer 2 are connected porous support layer 3 with artificial cartilage layer 1;The upper surface of porous support layer 3 is with human body both sides late-segmental collapse Line is that frontal axis is major axis, and vertical axis is short axle, and a length of 40-60mm of major axis, artificial cartilage layer 1 and porous support layer 3 have Identical flattening of ellipsoid is 0-10%, and the thickness of artificial cartilage layer 1 is 0.5-2.5mm;The artificial cartilage layer 1 and porous support The sphere wrap angle of layer 3 is 60-120 °;Prepared by the surface of the femoral stem 5 have bioactivity coatings 6.
When the sphere wrap angle of the artificial cartilage layer 1 and porous support layer 3 is 80-120 °, in the porous support The lower surface of layer 3 is provided with equally distributed 3-6 convex column 4 around femoral stem 5.
The convex column 4 is shaped as positive six prismsby, regular triangular prism or tapered pole, and its circumscribed circle diameter is 4-6mm, The height of convex column 4 is 5-10mm.
The porous support layer 3 is optimized by finite element method to obtain the porous mould with gradient, and aperture is 300 μm -800 μm, pass is cubic units, cellular, granatohedron, diamond units body or minimum surface, hole Rate reaches 20-85%, and porosity communication rate is more than 95%.
The femoral stem 5 is conical grip, and its taper is 1-3 °.
The material of the artificial cartilage layer 1 using it is following any one:
a:Polyvinyl alcohol polymerize with polypyrrole alkanone constituents formed by cellular hydrogel structure body, wherein both quality Than for 1:(0.01-1), the modulus of elasticity of formed cellular hydrogel structure body is 0.5-10MPa;
b:Polyvinylpyrrolidone, chitosan, hyaluronic acid or Sodium Hyaluronate are added in poly-vinyl alcohol solution;
c:Polyvinyl alcohol, nanometer hydroxyapatite, silk and deionized water mixing material;
d:Graphene oxide-hydroxyapatite-polyacrylamide-the sodium alginate obtained using Raolical polymerizable is multiple Heshui gel;
e:PLA PGA and polyglycolic acid PLA supports and the cartilage layers of organizational project culture.
The material of the porous support layer 3 using it is following any one:
a:The polycaprolactone (PCL) and hydroxyapatite HA supports of the chitosan sponge of growth factor are loaded with, wherein growing The factor be bone morphogenic protein BMP-2, TGF TGF-β, bone-inducing factor OIF, basic fibroblast growth because Any of sub- BFGF, insulin-like growth factor I GF, platelet derived growth factor PDGF;
b:The composite of nano-grade hydroxy apatite and medical macromolecular materials;
c:Ceramic porous support is included selected from aluminum oxide, zirconium oxide, silica, mullite, diopside, silicon ash In stone, janeckeite, larnite, akermanite, monticellite, bio-medical glass and calcium phosphate ceramics at least It is a kind of;
d:The metal alloy of titanium alloy or tantalum metal;
e:Polyether-ether-ketone PEEK.
The medical macromolecular materials are polyamide 6, polyamide 66 or polyethylene;The calcium phosphate ceramics are hydroxyl phosphorus Lime stone, tricalcium phosphate or fluoridated apatite.
The material of the bonding interface layer 2 is Fibrin Glue or biogum.
The bioactivity coatings 6 using sintering process, chemical plating, plating, plasma spraying method or energetic particle beam into Type method prepares the porous coating with bioactivity on the surface of femoral stem 5;Bioactivity coatings 6 are from substrate from inner toward trypsin method material Material composition changes in gradient;The material of bioactivity coatings 6 is using Hydroxyapatite nanoparticles end, bioactivity glass powder and oxygen Change composite or titanium or titanium alloy or tantalum that nano-ti powder end is formed, the powder diameter of the material of bioactivity coatings 6 is 30- 100nm, the thickness of bioactivity coatings 6 is 50-200 μm;The porosity of bioactivity coatings 6 is 10-85%.
Compared with prior art, the present invention possesses following advantage:
1) joint top layer substitutes impaired natural cartilage using soft artificial material, has excellent tribological property; Simultaneously the surface appearance feature of spheroid shape curved surface reply differential from shown when, impact more excellent fault-tolerance and Relatively low abrasion;
2) it is loose structure by joint designs, by limited according to bone trabecula or cancellous bone structure feature and material properties First method is optimized to obtain the porous mould with gradient, meets the requirement of intensity and Intracellular growth, after the implantation of joint Still be able to maintain that the biomechanical characterization of original bone, and preserve bone amount to greatest extent, avoid the occurrence of " stress shielding " and Prosthetic loosening.
3) two kinds of different fastening structures are designed according to arthropathy region, initial stage by the interference fit of femoral stem or The convex column 4 of different cross section shape is mechanically fastened, and the later stage is by inducing or promoting Gegenbaur's cell along femoral stem Grown with the hole of porous support layer, realize that bion fastens, two ways is combined to ensure prothesis implant body and nature Bone has enough interface bond strengths, improves the stability and service life of prosthese.
Brief description of the drawings
Fig. 1 is the structural representation of the biomimetic prosthetic hip joint with interior growth function;
Fig. 2 is the structure principle chart of biomimetic prosthetic hip joint, wherein, Fig. 2 (a) is that sphere wrap angle is 80-120 ° of structure; Fig. 2 (b) spheres wrap angle is 60-80 ° of structure.
Embodiment
With reference to Figure of description and embodiment, the present invention is described in detail, and the present embodiment is with skill of the present invention Implemented under premised on art scheme, but protection scope of the present invention is not limited to following embodiments.
A kind of biomimetic prosthetic hip prosthesis with interior growth function belongs to half hip resurfacing.According to the CT of patient or MRI image, primarily determine that generation area and the scope of cartilage lesion, and a thickness (clinical research statistical form person of good sense for cartilage layers Between 0.5-2.5mm, everyone result is not quite similar the thickness of body nature cartilage, need to be obtained by corresponding detection means Take), complete the reconstruction of the 3 D anatomical appearance model of hip joint, you can it is determined that the biomimetic prosthetic hip joint with interior growth function The artificial cartilage layer of prosthese and the thickness of porous support.In addition, the position of Using prosthesis installation is drafted in the region based on lesion.
As shown in Figure 1, 2, Bionic Design, the present invention one are carried out according to the institutional framework in human body natural joint and material characteristics Biomimetic prosthetic hip joint of the kind with interior growth function, using three-decker:Top layer is artificial cartilage layers 1, using artificial cartilage Or tissue engineering bone/cartilage substitutes nature cartilage to characterize excellent bio-tribology performance;Bottom is porous support layer 3, for imitating Raw subchondral bone or trabecular bone structure, closely even avoid the generation of stress shielding with reduction with it on modulus of elasticity, Mechanical strength needed for can also meeting during human normal or extreme sport, in addition, to the support for being loaded with relevant growth factors It is implanted into Gegenbaur's cell, induced cell growth, realizes mechanical type with fastening means that bion is combined to strengthen Using prosthesis Stability afterwards;It is bonding interface layer 2 between top layer and bottom, the methods of relying primarily on biogum ensures both interface cohesions Intensity, with avoid under arms during occur Relative sliding, peel off phenomena such as and influence the service life of prosthese.For example, every layer Selected materials can be:Artificial cartilage layer 1 is selected:Polyvinylpyrrolidone, chitosan, hyaluronic acid are added in poly-vinyl alcohol solution Or Sodium Hyaluronate;And porous support layer 3 selects the metal alloy such as titanium alloy or tantalum metal.In order to ensure between top layer and bottom Interface bond strength, the technology such as coating or spraying need to be used to adhere to one layer of hydroxyapatite etc. in the outer surface of porous support layer 3 Active coating, then again by fastening the two the methods of Fibrin Glue or biogum.
With the development of modern test technology, the understanding of morphology and anatomical structure for hip joint is more and more clear, Different hip joint surface geometry patterns influences notable on the contact mechanics of friction surface.Current most of artificial hip prosthesis With correlative study using joint-friction pair as standard ball-type, but three-dimensional parameterized reconstruction is carried out for natural joint, and it is right Contour mimicry learns bulb surface topography picture like rotational ellipsoid, and spheroid shape surface in reply differential from, impact etc. With more excellent fault-tolerance and relatively low abrasion during situation, therefore, hip prosthesis surface of friction pair geometrical morphology is designed as Rotation ellipsoid type surface.Spheroid shape surface is that above-below direction is using human body both sides late-segmental collapse line i.e. frontal axis as major axis Vertical axis is short axle.The a length of 40-60mm of major axis of the ellipsoidal surfaces of underlying porous support, bottom have identical ellipsoid with top layer Ellipticity (difference/major axis of major and minor axis) is 0-10%, and the thickness of top layer artificial cartilage is 0.5-2.5mm.For example, porous scaffold surface Short axle when being 50mm, when the ellipticity of ellipsoidal surfaces is 3.85%, then major axis is 52mm.
Because wear particle triggers the bone dissolving of Periprosthetic and absorbs, so as to cause prosthese aseptic loosening, joint vacation The service life of stability and prosthese after body implantation is closely related.As shown in Fig. 2 in order to ensure biomimetic prosthetic hip prosthesis Stability after implantation at initial stage, when the model that patient's cartilage lesion region is smaller, and optional sphere wrap angle is 60-80 °, pass through Interference fit between femoral stem 5 and Drilling ensures the fastening initially installed, as shown in Fig. 2 (b);When patient's diseased region Domain is larger, in 80-120 ° of coverage, then the prosthese of bigger sphere wrap angle may be selected.And contacted with femoral head Prosthese inner surface circumferentially direction devises 3-6 equally distributed convex columns 4, to prevent prosthese from bearing moment of torsion Consequence is rotated and collapsed etc. under being acted on etc. load.The convex column 4 is entity, is connected with porous support layer 3 transversal Face can be regular hexagon, equilateral triangle or circle etc., and its circumscribed circle diameter is 4-6mm, and space structure can be positive six prismsby, positive three Prism or tapered pole etc., it is highly 5-10mm, as shown in Fig. 2 (a).
In addition, as shown in Fig. 2 using sintering process, chemical plating, plating, plasma spraying method, high energy particle beam forming etc. Technology the surface of prosthese femoral stem 5 prepare with bioactivity bioactivity coatings 6, the bioactivity coatings 6 from substrate by In outward sprayed on material composition change in gradient.Coating material is chosen as:Hydroxyapatite nanoparticles end, bioactivity glass powder End and TiOx nano particulate composite or titanium or titanium alloy or tantalum, powder diameter 30-80nm, bioactivity coatings 6 Thickness is 50-200 μm.In view of different coating materials and processing technology will obtain different coating porosities, then coating porosity Rate is 10-85%.For example, being manufactured using sintering process, Ti, NiTi, Ti6Al4V are porous to obtain maximum pore rate 45%, but generally low In 50%;High energy particle beam forming is used to prepare porous Ti porositys as 67%;Porosity 40% is prepared using plasma spray method POROUS TITANIUM;CVD is used to prepare porous tantalum porosity as 75-85%.Pass through the convex column of prosthese or the interference of femoral stem Coordinate the mechanical type fastening at progress initial stage, and the bion stationary phase with inducing or promoting to grow in Gegenbaur's cell is combined, to protect Demonstrate,prove the stability of prosthese during one's term of military service.
The carrying joint important as human body, the flexion and extension, interior of hip joint is mainly contained in normal motion Abduction exercise, interior outward turning campaign are received, also subject to axial force caused by own body weight, is shown under different motion gaits different Scope of activities.But during actual motion, EDGE CONTACT will produce more as caused by differential from factors such as, impacts Wear particle, the service life of prosthese is had a strong impact on, therefore, the premise of range of motion in human body daily life is ensured Under, and the EDGE CONTACT between joint-friction pair is avoided as far as possible, while consider the scope of femoral head lesion region, by prosthese The cornerite on bulb surface is designed as 60-120 °, as shown in Figure 2.
The bottom of biomimetic prosthetic hip prosthesis is porous support layer 3, space loose structure be advantageous to Intracellular growth and Nutrition and the transmission of waste, but the introducing of loose structure will certainly reduce the mechanical property of solid material, therefore, meet accordingly Mechanical property under the premise of, pursue biological property it is more excellent porous stent structure it is very crucial.The structure and mechanics of porous support Performance is mainly determined that its structural parameters is mainly by aperture, pass, porosity, specific surface area, interior connectedness etc. by structure type. Therefore, the load born according to different motion gait hypozygal, optimized using finite element method and analyzed, obtain porous support not With the mechanical property parameters in region, e.g., modulus of elasticity, reflected further according to the correlation of loose structure and mechanical property parameters Penetrate, obtain the space porous support with gradient-structure of best performance.Designed porous stent structure:Aperture be 300 μm- 800μm;Pass has cubic units, cellular, granatohedron, diamond units body or minimum surface etc., and porosity reaches To 20-85%, porosity communication rate is more than 95%.
The present invention proposes a kind of biomimetic prosthetic hip joint design with interior growth function, compared with prior art, has Obvious advantage and beneficial effect:The articular prosthesis has good biomechanical property and tribological property, while can be most The preservation bone amount of limits and the biomechanical characterization for maintaining femur, and by inducing or promoting growth in Gegenbaur's cell to ensure vacation Body implant and the enough interface bond strengths of natural bone, the stability that the enhancing Using prosthesis later stage is on active service, improve making for prosthese With the life-span, meet the physiology and functional requirement of many patients.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, all designs in the present invention are managed Read with principle, any modification, equivalent substitution and improvements made etc., should be included in the scope of the protection.

Claims (6)

  1. A kind of 1. biomimetic prosthetic hip joint with interior growth function, it is characterised in that:It is spheroid shape curved surface including upper surface Porous support layer (3), in the femoral stem (5) of porous support layer (3) lower surface central integral chemical conversion type, in addition to artificial cartilage layer (1), porous support layer (3) is connected with artificial cartilage layer (1) by interfacial adhesion layer (2);On the porous support layer (3) Surface is using human body both sides late-segmental collapse line i.e. frontal axis as major axis, and vertical axis is short axle, a length of 40-60mm of major axis, people It is 0-10% that work cartilage layers (1) and porous support layer (3), which have identical flattening of ellipsoid, and the thickness of artificial cartilage layer (1) is 0.5-2.5mm;Prepared by the surface of the femoral stem (5) have bioactivity coatings (6), and bioactivity coatings (6) are from substrate by inner Sprayed on material composition changes in gradient outward, and the femoral stem (5) is conical grip, and its taper is 1-3 °, the interfacial adhesion layer (2) material is Fibrin Glue or biogum;
    When the sphere wrap angle of the artificial cartilage layer (1) and porous support layer (3) is 80-120 °, in the porous support The lower surface of layer (3) is provided with equally distributed 3-6 convex column (4) around femoral stem (5);
    The porous support layer (3) is optimized by finite element method to obtain the porous mould with gradient, aperture 300 μm -800 μm, pass is that cubic units, cellular, granatohedron, diamond units body or minimal surface, porosity reach To 20-85%, porosity communication rate is more than 95%.
  2. A kind of 2. biomimetic prosthetic hip joint with interior growth function according to claim 1, it is characterised in that:It is described convex Shape column (4) is shaped as positive six prismsby, regular triangular prism or tapered pole, and its circumscribed circle diameter is 4-6mm, convex column (4) height is 5-10mm.
  3. A kind of 3. biomimetic prosthetic hip joint with interior growth function according to claim 1, it is characterised in that:The people The materials of work cartilage layers (1) using it is following any one:
    a:Polyvinyl alcohol polymerize with polypyrrole alkanone constituents formed by cellular hydrogel structure body, wherein both mass ratioes are 1:(0.01-1), the modulus of elasticity of formed cellular hydrogel structure body is 0.5-10MPa;
    b:Polyvinylpyrrolidone, chitosan, hyaluronic acid or Sodium Hyaluronate are added in poly-vinyl alcohol solution;
    c:Polyvinyl alcohol, nanometer hydroxyapatite, silk and deionized water mixing material;
    d:Graphene oxide-hydroxyapatite-polyacrylamide-sodium alginate the Compound Water obtained using Raolical polymerizable Gel;
    e:PLA PGA and polyglycolic acid PLA supports and the cartilage layers of organizational project culture.
  4. A kind of 4. biomimetic prosthetic hip joint with interior growth function according to claim 1, it is characterised in that:It is described more The material of hole shelf layer (3) using it is following any one:
    a:It is loaded with the polycaprolactone (PCL) and hydroxyapatite HA supports of the chitosan sponge of growth factor, wherein growth factor For bone morphogenic protein BMP-2, TGF TGF-β, bone-inducing factor OIF, basic fibroblast growth factor Any of BFGF, insulin-like growth factor I GF, platelet derived growth factor PDGF;
    b:The composite of nano-grade hydroxy apatite and medical macromolecular materials;
    c:Ceramic porous support is included selected from aluminum oxide, zirconium oxide, silica, mullite, diopside, wollastonite, silicon At least one of sour DFP stone, larnite, akermanite, monticellite, bio-medical glass and calcium phosphate ceramics;
    d:The metal alloy of titanium alloy or tantalum metal;
    e:Polyether-ether-ketone PEEK.
  5. A kind of 5. biomimetic prosthetic hip joint with interior growth function according to claim 4, it is characterised in that:The doctor It is polyamide 6, polyamide 66 or polyethylene with high polymer material;The calcium phosphate ceramics are hydroxyapatite, tricalcium phosphate Or fluoridated apatite.
  6. A kind of 6. biomimetic prosthetic hip joint with interior growth function according to claim 1, it is characterised in that:The life Thing active coating (6) is using sintering process, chemical plating, plating, plasma spraying method or the energetic particle beam method of forming in femoral stem (5) surface prepares the porous coating with bioactivity;Bioactivity coatings (6) material using Hydroxyapatite nanoparticles end, The composite or titanium or titanium alloy or tantalum that bioactivity glass powder and TiOx nano powder are formed, bioactivity coatings (6) powder diameter of material is 30-100nm, and the thickness of bioactivity coatings (6) is 50-200 μm;Bioactivity coatings (6) Porosity is 10-85%.
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CN104758982A (en) * 2015-04-10 2015-07-08 中国人民解放军第二军医大学 Individual beta-Ti-15Mo alloy-Co-28Cr-6Mo alloy-Al2O3 ceramic acetabulum artificial bone scaffold

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