CN103463531B - Use of rhizoma smilacis glabrae extract in preparation of lipid-lowering and fat-reducing medicines and health-care foods - Google Patents
Use of rhizoma smilacis glabrae extract in preparation of lipid-lowering and fat-reducing medicines and health-care foods Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines and relates to a use of rhizoma smilacis glabrae extract in preparation of lipid-lowering and fat-reducing medicines and health-care foods. The rhizoma smilacis glabrae extract comprises 5-O-caffeoylshikimic acid, astilbin, isoastilbin, neoastilbin, neoisoastilbin, taxifolin, engeletin, isoengelitin and resveratrol. An animal experiment shows that the rhizoma smilacis glabrae extract can obviously reduce mice abdominal cavity fat weight, reduce mice body weight, and reduce triglyceride and total cholesterol concentrations of mice serum. Effects of the rhizoma smilacis glabrae extract are stronger than effects of a single astilbin component. The rhizoma smilacis glabrae extract is extracted from traditional Chinese medicines, has synergism of components, has good fat-reducing effects and broadens a rhizoma smilacis glabrae application range.
Description
Technical field
The invention belongs to drug world, particularly relate to the application of a kind of Chinese medicine extract in lipid-lowering diet drug and health food.
Background technology
Along with the raising of living standards of the people, the problem such as obesity, hyperlipidemia caused because of Energy intaking too much (high fat, high-carbohydrate diet) is day by day serious.Obesity not only affects the bodily form, the more important thing is it and diabetes, the morbidity positive correlation of the diseases such as hypertension.Hyperlipidemia causes atherosclerotic principal element, and then may cause the multiple cardiovascular and cerebrovascular disease such as thrombosis and myocardial infarction.During survey data shows state-owned 11% child and 30% adult overweight, at least there is a kind of glycolipid metabolism Indexes Abnormality in the child of 42%, China facing cardiovascular disease incidence rate sharp increase risk.Therefore, medicine or the health food of researching and developing lowering blood-fat and reducing weight safely and effectively have very important social meaning.
Rhizoma Smilacis Glabrae is the rhizome of Liliaceae smilax plant smilacis glabra (Smilax glabra Roxb.), is the conventional Chinese medicine that Chinese Pharmacopoeia is included, and is also that Ministry of Public Health allows one of Chinese herbal medicine used in health food.Chemical constitution study shows Rhizoma Smilacis Glabrae mainly containing the flavonoid substance such as astilbin, engelitin; In addition, it is also containing stilbene class and phenolic acids such as resveratrol, shikimic acid, 5-O-caffeoyl shikimic acids.But at present, not yet there is the research of Rhizoma Smilacis Glabrae extract lowering blood-fat and reducing weight aspect to report.We study and find that Rhizoma Smilacis Glabrae extract can significantly reduce mouse peritoneal fat weight, alleviate Mouse Weight, reduce triglyceride and total cholesterol concentration in mice serum simultaneously, there is good functions of lowering blood-fat and reducing weight, in blood fat reducing and slimming medicine and health food, there is important using value.
Summary of the invention
The object of the invention is to provide the application of Rhizoma Smilacis Glabrae extract in preparation lipid-lowering diet drug and health food.
Specifically comprise following technical scheme:
The application of Rhizoma Smilacis Glabrae extract in preparation lipid-lowering diet drug and health food.
5-O-coffee acyl shikimic acid, astilbin, isoastilbin, neoastilbin, neoisoastilbin, Taxifolin, engelitin, isoengelitin, resveratrol is comprised in described Rhizoma Smilacis Glabrae extract;
Described Rhizoma Smilacis Glabrae extract extraction step comprises: rhizoma smilacis glabrae medicinal material is pulverized, ethanol ultrasonic extraction, decompression recycling ethanol, centrifugal rear acquisition supernatant; In supernatant, add beta-schardinger dextrin--starch-resin, filter, resin ethanol elution twice, collect eluent after shaking absorption, 40 ~ 50 DEG C of vacuum dryings after recovery ethanol, obtain Rhizoma Smilacis Glabrae extract.
Extraction step is preferably: rhizoma smilacis glabrae medicinal material pulverized 40 mesh sieves, with 10 times of volume 60% ethanol ultrasonic extraction, ethanol in 60 DEG C of reclaim under reduced pressure Extraction solvent, and centrifugal rear acquisition supernatant; In supernatant, add the 40-60 order beta-schardinger dextrin--starch-resin with the weight such as rhizoma smilacis glabrae medicinal material, filter after concussion absorption 30 min, resin 60% ethanol elution twice, collects eluent, reclaims 40 ~ 50 DEG C of vacuum dryings after ethanol, acquisition Rhizoma Smilacis Glabrae extract.
This lipid-lowering diet drug also comprises pharmaceutically acceptable adjuvant, as starch, cyclodextrin etc.Can need to add conventional adjuvant according to dosage form.
These lowering blood-fat and reducing weight health product can need to add conventional adjuvant according to the preparation of health product, make various dosage form.This is routine techniques, repeats no more.
The invention has the beneficial effects as follows: (1) raw material adopts natural Chinese medicine raw material, safer.(2) weight reduction with drugs prepared of this Rhizoma Smilacis Glabrae extract is effective, has expanded the purposes of Rhizoma Smilacis Glabrae.(3) astilbin shows to have functions of lowering blood-fat and reducing weight through zoopery, result also shows that Rhizoma Smilacis Glabrae extract functions of lowering blood-fat and reducing weight is stronger simultaneously, show that other compositions in astilbin and Rhizoma Smilacis Glabrae extract have synergistic function on lowering blood-fat and reducing weight, tool has an unexpected effect.
For essence of the present invention is better described, further illustrate by the experiment of Rhizoma Smilacis Glabrae extract lowering blood-fat and reducing weight and result below.
Rhizoma Smilacis Glabrae extract: Rhizoma Smilacis Glabrae pulverized 40 mesh sieves, with 10 times of volume 60% ethanol ultrasonic extraction, 60
oethanol in C reclaim under reduced pressure Extraction solvent, centrifugal rear acquisition supernatant.In supernatant, add the 40-60 order beta-schardinger dextrin--starch-resin with the weight such as rhizoma smilacis glabrae medicinal material, filter after concussion absorption 30 min, resin 60% ethanol elution twice, collects eluent, reclaims 40 ~ 50 DEG C of vacuum dryings after ethanol, acquisition Rhizoma Smilacis Glabrae extract.
Fig. 1 is the high-efficient liquid phase chromatogram (HPLC) of this Rhizoma Smilacis Glabrae extract.HPLC system used is Waters 600, is equipped with dual wavelength detector and online degas system.Chromatographic column is Agilent Zorbax SB C18 post (250 mm × 4.6 mm i.d., 5 μm).Mobile phase is acetonitrile (A) and 0.1% aqueous acetic acid (B).Linear gradient program is 0 – 15min, 16 – 21% A; 15 – 40 min, 21 – 40% A.Flow velocity is 1 mL/min.Sample size is 10 μ L, and determined wavelength is 291 nm.In figure, peak 1 is 5-O-coffee acyl shikimic acid; peak 3 is astilbin; peak 2,5,6 is astilbin isomer (isoastilbin, neoastilbin, neoisoastilbin); peak 4 is Taxifolin; peak 7,8 is engelitin and isoengelitin; peak 9 is resveratrol, and each molecular structure of compounds is shown in Fig. 2.Peak 2,3,4,5,6,7,8 is chromocor compound, their peak area sums is substituted into astilbin standard curve, calculates general flavone content in extract (in astilbin).Analysis result shows that in extract, astilbin proportion is very large, is about 50%.
Its lowering blood-fat and reducing weight effect experimental is as follows:
Astilbin: purity >98%, purchased from Shanghai Tongtian Biotechnology Co., Ltd..
Fetch earth Poria extract 1 part, adds beta-schardinger dextrin-two parts, improves its water solublity after mixing.Get astilbin 1 part, add beta-schardinger dextrin-two parts, mixing.
70 4 week age Female ICR mice be divided at random 7 groups (I, II, III, IV, V, VI and VII group), often organize 10.Wherein, matched group based on I group, feeding normal feedstuff; II group is high fat matched group, feeding high lipid food; III, IV and V feeding high lipid food, and add Rhizoma Smilacis Glabrae extract in drinking water, in wherein total flavones, total flavones concentration is respectively 1 mg/ml(III group), 2 mg/ml(IV group) and 4 mg/ml(V group); VI and VII group feeding high lipid food, and add astilbin in drinking water, concentration is respectively 1 mg/ml(VI group), 2 mg/ml(VII groups).Described high lipid food consists of 85% normal feedstuff+10% Adeps Sus domestica+5% sucrose.All mice free choice feedings and drinking-water, raise 8 weeks, weigh weekly.After experiment terminates, from Culling heart blood, separation of serum, analyzes triglyceride and cholesterol concentration in mice serum; Dissect fatty tissue, spleen, kidney, liver etc. in animal collection mouse peritoneal organize and weigh.
Table one is different disposal group Mouse Weight and feeding time relation.Known by table one, high fat control group mice body weight increases significantly faster than normal feedstuff matched group, and weight differences has statistical significance (p<0.05).Compared with high fat matched group, in drinking water, add Rhizoma Smilacis Glabrae extract significantly can reduce Mouse Weight increase, weight differences has statistical significance (p<0.05), and concentration is higher, and effect is more remarkable.Compared with high fat matched group, add astilbin and also can reduce Mouse Weight, but weight differences not statistically significant (p>0.05).Table two is different disposal group mice at the average food ration of the 3rd week and the 7th week and amount of drinking water.As shown in Table 2, compared with high fat matched group, in drinking water, add food ration and amount of drinking water that Rhizoma Smilacis Glabrae extract or astilbin can not reduce mice, illustrate that each group of Mouse Weight increases and differently not caused by food ration.
After mice is dissected, get abdominal cavity fat, liver, kidney and spleen and weigh, statistical result is in table three.Experimental result shows, compared with normal feedstuff group, high fat control group mice abdominal cavity fat weight significantly increases (p<0.05).Compared with high fat matched group, in drinking water, add Rhizoma Smilacis Glabrae extract significantly can reduce mouse peritoneal fat weight (p<0.05).Compared with high fat matched group, add astilbin and also can reduce mouse peritoneal fat weight, but no significant difference (p>0.05).Liver, kidney and spleen weighing results to show between each group without significant difference, illustrate that Rhizoma Smilacis Glabrae extract and astilbin are all dirty without impact on mice device, do not affect mice health.
Triglyceride in serum and T-CHOL index determining result show (table four), and compared with normal feedstuff group, high fat control group mice triglyceride in serum and total cholesterol concentration significantly raise (p<0.05).Compared with high fat matched group, in drinking water, add Rhizoma Smilacis Glabrae extract significantly can reduce triglyceride and total cholesterol concentration (p<0.05) in mice serum.Compared with high fat matched group, add astilbin and also can reduce triglyceride and total cholesterol concentration in mice serum, but no significant difference (p>0.05).
Above experimental result shows, Rhizoma Smilacis Glabrae extract can significantly reduce mouse peritoneal fat weight, alleviates Mouse Weight, and reduce triglyceride and total cholesterol concentration in mice serum, difference has statistical significance (p<0.05) simultaneously.And astilbin one-component, although can alleviate Mouse Weight, reduce triglyceride and total cholesterol concentration in mice serum, difference is not significantly (p>0.05) yet.
HPLC analysis result shows in Rhizoma Smilacis Glabrae extract; except main containing except astilbin; also containing flavone components such as astilbin isomer, Taxifolin, engelitin and isoengelitins, in addition also containing phenolic acid and stilbene constituents such as 5-O-coffee acyl shikimic acid, resveratrols.In these compositions, astilbin shows to have functions of lowering blood-fat and reducing weight through zoopery, result also shows that Rhizoma Smilacis Glabrae extract functions of lowering blood-fat and reducing weight is stronger simultaneously, show that other compositions in astilbin and Rhizoma Smilacis Glabrae extract have synergistic function on lowering blood-fat and reducing weight, give Rhizoma Smilacis Glabrae extract better functions of lowering blood-fat and reducing weight, effect is better than wherein main component astilbin one-component.Rhizoma Smilacis Glabrae is that health ministry allows one of Chinese herbal medicine used in health food, and therefore Rhizoma Smilacis Glabrae extract has broad application prospects at lowering blood-fat and reducing weight health product and pharmaceutical preparations.
Table one different feeding time Mouse Weight table (meansigma methods ± SE, n=10)
Matched group based on I group, II group is high fat matched group, and III, IV and V add Rhizoma Smilacis Glabrae extract 1 mg/ml(III respectively), 2 mg/ml(IV) and 4 mg/ml(V); VI and VII group adds astilbin 1 mg/ml(VI respectively) and 2 mg/ml(VII).
athere were significant differences compared with Basal control group (p<0.05);
bthere were significant differences compared with high fat matched group (p<0.05).
The average food ration of table two mice and amount of drinking water (meansigma methods ± SD, n=7)
Matched group based on I group, II group is high fat matched group, and III, IV and V add Rhizoma Smilacis Glabrae extract 1 mg/ml(III respectively), 2 mg/ml(IV) and 4 mg/ml(V); VI and VII group adds astilbin 1 mg/ml(VI respectively) and 2 mg/ml(VII).
athere were significant differences compared with Basal control group (p<0.05);
bthere were significant differences compared with high fat matched group (p<0.05).
Table three mouse peritoneal fat and the dirty index of device (meansigma methods ± SE, n=10)
Matched group based on I group, II group is high fat matched group, and III, IV and V add Rhizoma Smilacis Glabrae extract 1 mg/ml(III respectively), 2 mg/ml(IV) and 4 mg/ml(V); VI and VII group adds astilbin 1 mg/ml(VI respectively) and 2 mg/ml(VII).
athere were significant differences compared with Basal control group (p<0.05);
bthere were significant differences compared with high fat matched group (p<0.05).
Triglyceride and total cholesterol concentration (meansigma methods ± SE, n=10) in table four mice serum
Matched group based on I group, II group is high fat matched group, and III, IV and V add Rhizoma Smilacis Glabrae extract 1 mg/ml(III respectively), 2 mg/ml(IV) and 4 mg/ml(V); VI and VII group adds astilbin 1 mg/ml(VI respectively) and 2 mg/ml(VII).
athere were significant differences compared with Basal control group (p<0.05);
bthere were significant differences compared with high fat matched group (p<0.05).
Accompanying drawing explanation
Fig. 1 Rhizoma Smilacis Glabrae extract high-efficient liquid phase chromatogram
Each chromatographic peak molecular structure in Fig. 2 Rhizoma Smilacis Glabrae extract.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described, but the invention is not restricted to these embodiments.
Embodiment 1
Rhizoma Smilacis Glabrae lowering blood-fat and reducing weight capsule, prepare as follows:
(1) Rhizoma Smilacis Glabrae extract: Rhizoma Smilacis Glabrae pulverized 40 mesh sieves, with 10 times of volume 60% ethanol ultrasonic extraction, 60
oethanol in C reclaim under reduced pressure Extraction solvent, centrifugal rear acquisition supernatant.In supernatant, add the 40-60 order beta-schardinger dextrin--starch-resin with the weight such as rhizoma smilacis glabrae medicinal material, filter after concussion absorption 30 min, resin 60% ethanol elution twice, collects eluent, reclaims 40 ~ 50 DEG C of vacuum dryings after ethanol, acquisition Rhizoma Smilacis Glabrae extract.
(2) detect, containing 5-O-coffee acyl shikimic acid, astilbin, isoastilbin, neoastilbin, neoisoastilbin, Taxifolin, engelitin, isoengelitin, resveratrol through high performance liquid chromatography.In extract, general flavone content (in astilbin) is 76.6%.
(3) fetch earth Poria extract 500 grams, crosses 60 mesh sieves after pulverizing; Separately get beta-schardinger dextrin-2000g, mixing.
(4), after sterilization treatment, pelletize under humidity is 20-40% environment, granularity is between 20 ~ 40 orders.
(5) humidity be 50% with environment in encapsulated, every heavily about 0.5 g.
Embodiment 2
Rhizoma Smilacis Glabrae lowering blood-fat and reducing weight electuary, prepare by the following method:
(1) Rhizoma Smilacis Glabrae extract: Rhizoma Smilacis Glabrae pulverized 40 mesh sieves, with 10 times of volume 60% ethanol ultrasonic extraction, 60
oethanol in C reclaim under reduced pressure Extraction solvent, centrifugal rear acquisition supernatant.In supernatant, add the 40-60 order beta-schardinger dextrin--starch-resin with the weight such as rhizoma smilacis glabrae medicinal material, filter after concussion absorption 30 min, resin 60% ethanol elution twice, collects eluent, reclaims 40 ~ 50 DEG C of vacuum dryings after ethanol, acquisition Rhizoma Smilacis Glabrae extract.
(2) detect, containing 5-O-coffee acyl shikimic acid, astilbin, isoastilbin, neoastilbin, neoisoastilbin, Taxifolin, engelitin, isoengelitin, resveratrol through high performance liquid chromatography.In extract, general flavone content (in astilbin) is 76.6%.
(3) fetch earth Poria extract 500 grams, crosses 60 mesh sieves after pulverizing; Separately get beta-schardinger dextrin-2000g, instant green tea powder 500 grams, aspartame 40 grams, mixing.
(4), after sterilization treatment, pelletize under humidity is 20-40% environment, granularity is between 20 ~ 40 orders.
(5) humidity be 50% with environment in pack, every bag heavy 3.6 g.
Embodiment 3
The functional observation of the lowering blood-fat and reducing weight electuary of preparation
Example 2 lowering blood-fat and reducing weight electuary is tried out through 8 volunteers, and 6 female 2 men, body weight is 60-80kg.Every day two bags, 15 days on probation, the situation such as period inquiry volunteer appetite, spirit, sleep, defecation, record volunteer body weight change situation.8 volunteers all feed back the trial employment period does not affect appetite, spirit, sleep, defecation etc., and weighing body weight result all reflects effectively, and the scope of losing weight is 0.5-2 kg.Exemplary:
Yuan ×, female, 30 years old, before on probation, body weight was 65.4 kg, tried out body weight after 15 days and was kept to 64.2 kg; Rear drug withdrawal 10 days, weight maintenance is 64.2 kg; Take electuary again 15 days, body weight reduces to 63.2 kg, and after drug withdrawal, weight maintenance does not rebound.
Claims (3)
1. Rhizoma Smilacis Glabrae extract is as the application of sole active agent in preparation lipid-lowering diet drug and health food; Described Rhizoma Smilacis Glabrae extract contains 5-O-coffee acyl shikimic acid, astilbin, isoastilbin, neoastilbin, neoisoastilbin, Taxifolin, engelitin, isoengelitin, resveratrol.
2. apply as claimed in claim 1, it is characterized in that described Rhizoma Smilacis Glabrae extract extraction step comprises: rhizoma smilacis glabrae medicinal material is pulverized, ethanol ultrasonic extraction, decompression recycling ethanol, centrifugal rear acquisition supernatant; In supernatant, add beta-schardinger dextrin--starch-resin, filter, resin ethanol elution twice, collect eluent after shaking absorption, 40 ~ 50 DEG C of vacuum dryings after recovery ethanol, obtain Rhizoma Smilacis Glabrae extract.
3. apply as claimed in claim 2, it is characterized in that described extraction step: rhizoma smilacis glabrae medicinal material pulverized 40 mesh sieves, with 10 times of volume 60% ethanol ultrasonic extraction, ethanol in 60 DEG C of reclaim under reduced pressure Extraction solvent, centrifugal rear acquisition supernatant; In supernatant, add the 40-60 order beta-schardinger dextrin--starch-resin with the weight such as rhizoma smilacis glabrae medicinal material, filter after concussion absorption 30 min, resin 60% ethanol elution twice, collects eluent, reclaims 40 ~ 50 DEG C of vacuum dryings after ethanol, acquisition Rhizoma Smilacis Glabrae extract.
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| CN103961603B (en) * | 2014-03-14 | 2017-04-19 | 广西正堂药业有限责任公司 | Traditional Chinese medicine preparationcapable of reducing blood fat and freeing vessels |
| CN106138127A (en) * | 2016-08-15 | 2016-11-23 | 锦州医科大学 | There is gland calyx Herba astilbes chinensis extract and the application thereof improving and preventing and treating obesity effect |
| CN106492069B (en) * | 2016-12-09 | 2019-10-11 | 南方医科大学南方医院 | Chinese medicine composition and the application for preventing and treating chronic pelvic inflammatory disease |
| CN106974287A (en) * | 2017-05-08 | 2017-07-25 | 中山森谱生物科技有限公司 | A kind of functional food containing Rhizoma Smilacis Glabrae extract and preparation method thereof |
| CN108373489A (en) * | 2018-03-16 | 2018-08-07 | 成都格利普生物科技有限公司 | The isolation and purification method of Astilbe chinensis glycoside isomers in smilax |
| CN108404004A (en) * | 2018-04-17 | 2018-08-17 | 江西中医药大学 | A kind of Rhizoma Smilacis Glabrae extract and its preparation method and application |
| CN108675978B (en) * | 2018-05-28 | 2021-06-01 | 江西农业大学 | Method for preparing high-purity taxifolin by taking rhizoma smilacis glabrae as raw material |
| CN112641894B (en) * | 2020-01-19 | 2022-06-17 | 北京中医药大学 | A new Chinese medicinal composition for regulating lipid metabolism and improving gastrointestinal dysfunction |
| CN113813277A (en) * | 2021-10-19 | 2021-12-21 | 广州白云山敬修堂药业股份有限公司 | Use of a composition comprising astilbin and/or its isomers in the manufacture of a medicament for the treatment of psoriasis |
| CN114452261A (en) * | 2021-12-31 | 2022-05-10 | 湖南茯神科技有限公司 | Preparation method and application of rhizoma smilacis glabrae alcohol extract oral tablet |
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