CN103462023A - Herbal diet therapy composition with function of tonifying spleen and lung and preparation method thereof - Google Patents
Herbal diet therapy composition with function of tonifying spleen and lung and preparation method thereof Download PDFInfo
- Publication number
- CN103462023A CN103462023A CN2013104390685A CN201310439068A CN103462023A CN 103462023 A CN103462023 A CN 103462023A CN 2013104390685 A CN2013104390685 A CN 2013104390685A CN 201310439068 A CN201310439068 A CN 201310439068A CN 103462023 A CN103462023 A CN 103462023A
- Authority
- CN
- China
- Prior art keywords
- lung
- therapeutic composition
- extract
- spleen
- function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a herbal diet therapy composition with a function of tonifying spleen and lung. The herbal diet therapy composition is prepared from the following raw materials in parts by weight: 15-35 parts of ginseng extract, 10-25 parts of honey-fried licorice root extract, 10-25 parts of poria cocos extract, 10-20 parts of rhizoma zingiberis extract, 10-25 parts of pericarpium citri reticulatae extract and 0-25 parts of almond extract. The invention also relates to a preparation method of the herbal diet therapy composition with the function of tonifying spleen and lung. The herbal diet therapy composition capable of tonifying spleen and lung is provided by combining modern advanced science and technology on the basis of the traditional Chinese medicine diet theory and the medicine food homology theory. The herbal diet therapy composition has the advantages of significant effect, high safety, no toxic and side effects and the like; meanwhile, the taste can be improved; the dosage is reduced; the quality index is accurately controlled; the herbal diet therapy composition is convenient to take and carry.
Description
Technical field
The present invention relates to a kind of medicine-food two-purpose food therapeutic composition, particularly relate to a kind of have strengthening the spleen and tonifying the lung the draft food therapeutic composition of function and the preparation method of said composition.
Background technology
Lung is positioned in the heart, and its major function is main gas, and department breathes, and main a surname sends out and leads to the water channel of calumniating, and Pi is source of generating QI and blood, and required functional activities of the body fluid in lung, lean on the essence of water and grain of spleen transporting to support, that is so-called earth generating metal in the five-element.Therefore, the prosperity and decline of functional activities of the body fluid in lung, to depend on to a great extent the power of spleen transportation capabilities: the strong fortune of temper, people's smooth breathing, thorax is full, and voice are loud and clear; Otherwise, the loose essence of spleen, lung also therefore and impaired, produces all chronic diseases marked by deficiency of vital energy.Therefore control first real spleen of lung, make the foundation of acquired constitution healthy and vigorous, all diseases of lung also thereupon more.
Making a general survey of numerous herbal medicine that enter lung channel, mostly be and induce sweat, declare respectful, is main and tuberculosis is just asthenia in origin and asthenia in superficiality.Therefore, control lung Ruo Sheben and ask mark, very easily recurrence after often healing, or touching difficulty is more.Just due to Pi and lung, on physiology He on pathology, close relationship like this is arranged.Take from and control Pi so control tuberculosis, reach the purpose of effecting a permanent cure.Strengthening the spleen and tonifying the lung the draft food therapeutic composition of function and be difficult to reach the food therapy effect of expectation in view of having on market, the inventor, through research for many years, has invented a kind of novel draft food therapeutic composition.
Summary of the invention
Technical problem to be solved by this invention is according to Traditional Chinese Medicine food therapy theory and integration of drinking and medicinal herbs theory, provide a kind of have strengthening the spleen and tonifying the lung the draft food therapeutic composition of function and the preparation method of said composition.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of have strengthening the spleen and tonifying the lung the draft food therapeutic composition of function, by the draft food therapeutic composition raw material of following weight proportion, formed:
Preferably, the draft food therapeutic composition raw material by following weight proportion forms:
Selection of land more is comprised of the draft food therapeutic composition raw material of following weight proportion:
Preferably, have that to strengthening the spleen and tonifying the lung the draft food therapeutic composition of function be capsule or tablet.
As above have strengthening the spleen and tonifying the lung the preparation method of draft food therapeutic composition of function, said method comprising the steps of:
Step 1, ginseng, honey-fried licorice root, Poria cocos, rhizoma zingiberis, dried orange peel and the almond of weighing constant weight are as raw material respectively;
Step 2, raw material are added respectively to different extraction vessels, and the distilled water to adding respectively 10~20 times of raw-material weights in extraction vessel is then extracted under 80 ℃~100 ℃ temperature conditions, after 2h~3h, extract is carried out to plate-frame filtering, obtain first extract and first filter residue;
Step 3, the distilled water to adding 10~20 times of first filter residue weight in first filter residue is then extracted under 80 ℃~100 ℃ temperature conditions, after 2h~3h, extract is carried out to plate-frame filtering, obtains secondary raffinate and secondary filter residue; Preferably, step 3 repeats 1~2 time.
Step 4, merge the extract of the different material of acquisition in step 2 and step 3, and described extract, through vacuum-concentrcted, spray-drying, makes corresponding draft food therapeutic composition raw material;
Step 5, the weight proportion required according to formula fully mixes various draft food therapeutic composition raw materials, and encapsulated or compressing tablet also carries out sterilizing.
Preferably, in step 2, to the distilled water that adds respectively 15 times of draft food therapeutic composition raw material weights in extraction vessel.
Preferably, in step 2, under 85 ℃~90 ℃ temperature conditions, extracted.
The invention has the beneficial effects as follows: the present invention is on Traditional Chinese Medicine food therapy theory and integration of drinking and medicinal herbs theoretical foundation, in conjunction with modern advanced science and technology, a kind of draft food therapeutic composition that can strengthening the spleen and tonifying the lung is provided, there is successful, safe, the advantage such as without any side effects, can improve taste, reduce dose, accurately control quality index, conveniently take and carry simultaneously.
The present invention is on dietary therapy of Chinese medicine principle basis, for modern human body constitution, and selected integration of drinking and medicinal herbs material, the science compatibility, make with extra care and form through the modern pharmaceutical technology, and material easily gathers and successful.Ginseng, distinguish the flavor of sweet, micro-hardship, and slightly warm in nature, return spleen, lung, the heart, kidney channel, has and reinforce vital energy, reinforce the spleen to benefit the lung, promote the production of body fluid and nourish blood, calm the nerves the effects such as kidney-nourishing; Honey-fried licorice root, bitter, cold in nature, return lung, kidney, large intestine channel, there is removing water retention by purgation, the effects such as dispersing swelling and dissipating binds; The Poria cocos flavor is sweet, light, and property is flat, the thoughts of returning home, and lung, spleen, kidney channel, have clearing damp and promoting diuresis, invigorating the spleen, the effect of the peaceful heart; Rhizoma zingiberis, flavor is hot, hot in nature, returns spleen, stomach, kidney, the heart, lung channel, has warming spleen and stomach for dispelling cold, and Hui Yang promotes blood circulation, the effects such as warming lung to reduce watery phlegm; Dried orange peel, bitter, suffering, warm in nature, return lung, the spleen channel, there is regulating qi-flowing for strengthening spleen, the effect such as eliminating dampness and eliminating phlegm; The almond bitter, slightly warm in nature, return lung, large intestine channel, has a sending down abnormally ascending relieving cough and asthma, and the effect such as relax bowel.In we, the people participates in the rhizoma zingiberis compatibility, can mend fire in Chongyang; Radix Glycyrrhizae and Poria cocos compatibility, the water pouring of can earthing up; Dried orange peel and almond compatibility, can nurse one's health lung qi.These five kinds of mutual compatibilities of raw material, the performance water pouring is mended fire, holds up sun to press down cloudy, the effect of strengtheninging the spleen and tonifying the lung.The present invention adopts the modern pharmaceutical technology, and product is made to capsule or tablet, for edible this product of the public provides convenience.
The specific embodiment
Below in conjunction with embodiment, principle of the present invention and feature are described, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1
Having in embodiment 1 strengtheninged the spleen and tonifying the lung the draft food therapeutic composition of function, the draft food therapeutic composition raw material of following weight proportion, consists of:
Have and strengthening the spleen and tonifying the lung the preparation method of draft food therapeutic composition of function and comprise the following steps:
Step 1, respectively the ginseng of weighing constant weight, honey-fried licorice root, Poria cocos, rhizoma zingiberis, dried orange peel and almond pulverized respectively after as raw material;
Step 2, add respectively extraction vessel by raw material, and the distilled water to adding respectively 10 times of raw-material weights in extraction vessel is then extracted under 100 ℃ of temperature conditions, after 3h, extract is carried out to plate-frame filtering, obtains first extract and first filter residue;
Step 3, the distilled water to adding 10 times of first filter residue weight in first filter residue is then extracted under 100 ℃ of temperature conditions, after 3h, extract is carried out to plate-frame filtering, obtains secondary raffinate and secondary filter residue;
Step 4, the extract obtained in step 2 and step 3 is merged, described extract, through vacuum-concentrcted, spray-drying, makes corresponding draft food therapeutic composition raw material (being respectively ginseng extract, Radix Glycyrrhizae Preparata extract, tuckahoe extracts, Rhizoma Zingiberis extract, dried orange peel extracts, almond extract).
Step 5, the weight proportion required according to embodiment 1 formula fully mixes various draft food therapeutic composition raw materials, encapsulated and carry out sterilizing.
Embodiment 2
Having in embodiment 2 strengtheninged the spleen and tonifying the lung the draft food therapeutic composition of function, the draft food therapeutic composition raw material of following weight proportion, consists of:
Have and strengthening the spleen and tonifying the lung the preparation method of draft food therapeutic composition of function and comprise the following steps:
Step 1, respectively ginseng, honey-fried licorice root, Poria cocos and the rhizoma zingiberis of weighing constant weight, after being pulverized respectively as raw material;
Step 2, add respectively extraction vessel by raw material, and the distilled water to adding respectively 15 times of raw-material weights in extraction vessel is then extracted under 80 ℃ of temperature conditions, after 2h, extract is carried out to plate-frame filtering, obtains first extract and first filter residue;
Step 3, the distilled water to adding 15 times of first filter residue weight in first filter residue is then extracted under 80 ℃ of temperature conditions, after 2h, extract is carried out to plate-frame filtering, obtains secondary raffinate and secondary filter residue; Step 3 repeats once.
Step 4, the extract obtained in step 2 and step 3 is merged, described extract, through vacuum-concentrcted, spray-drying, makes corresponding draft food therapeutic composition raw material (being respectively ginseng extract, Radix Glycyrrhizae Preparata extract, tuckahoe extracts, Rhizoma Zingiberis extract).
Step 5, the weight proportion required according to embodiment 2 formulas fully mixes various draft food therapeutic composition raw materials, and compressing tablet also carries out sterilizing.
Embodiment 3
Having in embodiment 3 strengtheninged the spleen and tonifying the lung the draft food therapeutic composition of function, the draft food therapeutic composition raw material of following weight proportion, consists of:
Have and strengthening the spleen and tonifying the lung the preparation method of draft food therapeutic composition of function and comprise the following steps:
Step 1, respectively the ginseng of weighing constant weight, honey-fried licorice root, Poria cocos, rhizoma zingiberis, dried orange peel and almond pulverized respectively after as raw material;
Step 2, add respectively extraction vessel by raw material, and the distilled water to adding respectively 20 times of raw-material weights in extraction vessel is then extracted under 90 ℃ of temperature conditions, after 3h, extract is carried out to plate-frame filtering, obtains first extract and first filter residue;
Step 3, the distilled water to adding 20 times of first filter residue weight in first filter residue is then extracted under 90 ℃ of temperature conditions, after 3h, extract is carried out to plate-frame filtering, obtains secondary raffinate and secondary filter residue;
Step 4, the extract obtained in step 2 and step 3 is merged, described extract, through vacuum-concentrcted, spray-drying, makes corresponding draft food therapeutic composition raw material (being respectively ginseng extract, Radix Glycyrrhizae Preparata extract, tuckahoe extracts, Rhizoma Zingiberis extract, dried orange peel extracts, almond extract).
Step 5, the weight proportion required according to embodiment 3 formula fully mixes various draft food therapeutic composition raw materials, encapsulated and carry out sterilizing.
Embodiment 4
Having in embodiment 4 strengtheninged the spleen and tonifying the lung the draft food therapeutic composition of function, the draft food therapeutic composition raw material of following weight proportion, consists of:
Have and strengthening the spleen and tonifying the lung the preparation method of draft food therapeutic composition of function and comprise the following steps:
Step 1, respectively the ginseng of weighing constant weight, honey-fried licorice root, Poria cocos, rhizoma zingiberis, dried orange peel and almond pulverized respectively after as raw material;
Step 2, add respectively extraction vessel by raw material, and the distilled water to adding respectively 18 times of raw-material weights in extraction vessel is then extracted under 85 ℃ of temperature conditions, after 2.5h, extract is carried out to plate-frame filtering, obtains first extract and first filter residue;
Step 3, the distilled water to adding 18 times of first filter residue weight in first filter residue is then extracted under 85 ℃ of temperature conditions, after 2.5h, extract is carried out to plate-frame filtering, obtains secondary raffinate and secondary filter residue;
Step 4, the extract obtained in step 2 and step 3 is merged, described extract, through vacuum-concentrcted, spray-drying, makes corresponding draft food therapeutic composition raw material (being respectively ginseng extract, Radix Glycyrrhizae Preparata extract, tuckahoe extracts, Rhizoma Zingiberis extract, dried orange peel extracts, almond extract).
Step 5, the weight proportion required according to embodiment 4 formulas fully mixes various draft food therapeutic composition raw materials, and compressing tablet also carries out sterilizing.
Effect example 1
Liu, 16 years old, be born latter 1 year, leave over to cough because of flu and breathe heavily, and outbreak repeatedly, gynecological ailments.After going to school, tired whenever, cause morbidity.Seek time and again curing and treat, control repeatly and send out repeatly.This is the prolonged illness chronic ill, consumes the body healthy tendency of hurting sb.'s feelings, and causes disease-resistant strength and weakens, and though interim treatment is healed temporarily sick, and healthy tendency is multiple.Take product that embodiment of the present invention 1 makes to it, each 3, every day three times, after half a year, the cough shape is not reaccessed, physically fit.
Effect example 2
Mrs Xu, female, 33 years old, although focus on very much beauty and skin care in life, her colour of skin is still intensely dark, pouch, livid ring around eye, skin quality is coarse, dry, wrinkle occurs, color spot, middle age dark sore, skin lacks flexibility, and whole people looks like more than 40 year old, there is no spirit, speak feeble, poor memory, often tired out.Take the product that the embodiment of the present invention 2 makes, each 3, every day 2 times, after two weeks, complexion takes a turn for the better, and livid ring around eye disappear, and memory takes a turn for the better, and muscle power also improves; After adhering to taking three months, the flexible gloss of skin, the wrinkle color spot shoals, in high spirits.
Effect example 3
Grandson, 55 years old, cough was spat and has been had 5 or six years, and daytime, cough was lighter, can also stand, and evening, the cough aggravation, often had difficulty in going to sleep.And every weather is when turning cold, cough is just more severe, even coughs middle band and breathes heavily, and chest is also always stuffy, have a meal also not fragrant, and be really agonizing.He says in order to cure the cough of oneself, in the past few years takes medicine very much, and Chinese medicine, Western medicine have all been eaten much, but is exactly that treatment is not thorough.Take the product that the embodiment of the present invention 3 makes, each 3, every day 3 times, after January, remission, after two months, transference cure.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
According to claim 1-3 any one described have strengthening the spleen and tonifying the lung the draft food therapeutic composition of function, it is characterized in that, described have that to strengthening the spleen and tonifying the lung the draft food therapeutic composition of function be capsule or tablet.
According to claim 1-4 any one described have strengthening the spleen and tonifying the lung the preparation method of draft food therapeutic composition of function, said method comprising the steps of:
Step 1, ginseng, honey-fried licorice root, Poria cocos, rhizoma zingiberis, dried orange peel and the almond of weighing constant weight are as raw material respectively;
Step 2, raw material are added respectively to extraction vessel, and the distilled water to adding respectively 10~20 times of raw-material weights in extraction vessel is then extracted under 80 ℃~100 ℃ temperature conditions, after 2h~3h, extract is carried out to plate-frame filtering, obtain first extract and first filter residue;
Step 3, the distilled water to adding 10~20 times of first filter residue weight in first filter residue is then extracted under 80 ℃~100 ℃ temperature conditions, after 2h~3h, extract is carried out to plate-frame filtering, obtains secondary raffinate and secondary filter residue;
Step 4, merge the extract obtained in step 2 and step 3, and described extract, through vacuum-concentrcted, spray-drying, makes corresponding draft food therapeutic composition raw material;
Step 5, the weight proportion required according to formula fully mixes various draft food therapeutic composition raw materials, and encapsulated or compressing tablet also carries out sterilizing.
According to claim 5 have strengthening the spleen and tonifying the lung the preparation method of draft food therapeutic composition of function and it is characterized in that, step 3 repeats 1~2 time.
According to claim 5 have strengthening the spleen and tonifying the lung the preparation method of draft food therapeutic composition of function and it is characterized in that, in step 2, to the distilled water that adds respectively 15 times of draft food therapeutic composition raw material weights in extraction vessel.
According to claim 5 have strengthening the spleen and tonifying the lung the preparation method of draft food therapeutic composition of function and it is characterized in that, in step 2, under 85 ℃~90 ℃ temperature conditions, extracted.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310439068.5A CN103462023B (en) | 2013-09-24 | 2013-09-24 | A kind of have strengthening the spleen and tonifying the lung draft food therapeutic composition of function and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310439068.5A CN103462023B (en) | 2013-09-24 | 2013-09-24 | A kind of have strengthening the spleen and tonifying the lung draft food therapeutic composition of function and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103462023A true CN103462023A (en) | 2013-12-25 |
CN103462023B CN103462023B (en) | 2016-05-11 |
Family
ID=49787257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310439068.5A Expired - Fee Related CN103462023B (en) | 2013-09-24 | 2013-09-24 | A kind of have strengthening the spleen and tonifying the lung draft food therapeutic composition of function and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103462023B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104745416A (en) * | 2015-02-23 | 2015-07-01 | 酒口袋(上海)投资控股有限公司 | Healthcare white spirit for tonifying Qi and strengthening spleen and preparation method thereof |
CN107397017A (en) * | 2017-08-15 | 2017-11-28 | 汕头市鼎铭堂健康食品有限公司 | A kind of alternative ginger tea formula of draft and preparation method thereof |
CN112516276A (en) * | 2020-10-15 | 2021-03-19 | 湖北思达康中药科技有限公司 | Traditional Chinese medicine for preventing novel coronavirus pneumonia, preparation process thereof and traditional Chinese medicine beverage |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102078578A (en) * | 2009-12-01 | 2011-06-01 | 付志成 | Traditional Chinese medicine composition for treating enuresis due to spleen-lung vital energy deficiency |
CN103211939A (en) * | 2013-04-15 | 2013-07-24 | 陈雪莉 | Traditional Chinese medicine granule for strengthening spleen and tonifying lung |
-
2013
- 2013-09-24 CN CN201310439068.5A patent/CN103462023B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102078578A (en) * | 2009-12-01 | 2011-06-01 | 付志成 | Traditional Chinese medicine composition for treating enuresis due to spleen-lung vital energy deficiency |
CN103211939A (en) * | 2013-04-15 | 2013-07-24 | 陈雪莉 | Traditional Chinese medicine granule for strengthening spleen and tonifying lung |
Non-Patent Citations (2)
Title |
---|
刘庆林: "杏仁药对的临床应用", 《陕西中医》 * |
康锁彬等: "《张景岳医方精要》", 31 July 2004, 河北科学技术出版社 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104745416A (en) * | 2015-02-23 | 2015-07-01 | 酒口袋(上海)投资控股有限公司 | Healthcare white spirit for tonifying Qi and strengthening spleen and preparation method thereof |
CN104745416B (en) * | 2015-02-23 | 2017-01-25 | 酒口袋(上海)投资控股有限公司 | Healthcare white spirit for tonifying Qi and strengthening spleen and preparation method thereof |
CN107397017A (en) * | 2017-08-15 | 2017-11-28 | 汕头市鼎铭堂健康食品有限公司 | A kind of alternative ginger tea formula of draft and preparation method thereof |
CN112516276A (en) * | 2020-10-15 | 2021-03-19 | 湖北思达康中药科技有限公司 | Traditional Chinese medicine for preventing novel coronavirus pneumonia, preparation process thereof and traditional Chinese medicine beverage |
Also Published As
Publication number | Publication date |
---|---|
CN103462023B (en) | 2016-05-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104258045B (en) | A kind of Chinese medicine relaxed bowel and preparation method thereof | |
CN102283999B (en) | Traditional Chinese medicine preparation for treating insomnia | |
CN103689513A (en) | Health care cooking wine and preparation method thereof | |
CN106214961B (en) | Nine RHIZOMA POLYGONATI PREPARATAs of one kind and preparation method thereof | |
CN104782833A (en) | All-season health tea and preparation method thereof | |
CN102550738B (en) | Health-care tea capable of preventing radiation and improving immunity and preparation method thereof | |
CN105920200A (en) | Traditional Chinese medicine oral liquid for treating insufficiency of qi and blood | |
CN103689559A (en) | Health-preserving health food formula beneficial for improving gastrointestinal functions and preparation method thereof | |
CN103462023B (en) | A kind of have strengthening the spleen and tonifying the lung draft food therapeutic composition of function and preparation method thereof | |
CN104115962A (en) | Tea capable of delaying menopause | |
CN103330020B (en) | Health-preserving tea | |
CN105639550A (en) | Flesh Guiling jelly and preparation method thereof | |
CN104491502A (en) | Medicament for treating spontaneous perspiration and preparation method thereof | |
CN103798726A (en) | Polygonum multiflorum hot-pot flavoring capable of maintaining beauty and keeping young and production method thereof | |
CN103315085B (en) | Health-preserving tea | |
CN106109914A (en) | A kind of pharmaceutical preparation of QI invigorating toxin expelling | |
CN110235969A (en) | A kind of balance tea and preparation method thereof | |
CN104984150A (en) | Preparing technology of health maintaining porridge with blood pressure reducing effect | |
CN104606565B (en) | The Chinese medicinal capsule of Prevention and Curation ocular disease | |
CN103349108A (en) | Warming-yang and tonifying-pleen healthy team cream and preparation method | |
CN102670974A (en) | Health wine | |
CN105194258A (en) | Traditional Chinese medicine composition for treating diseases caused by kidney essence deficiency and decoction method of traditional Chinese medicine composition | |
CN105567530A (en) | Vinegar beverage having blood vessel softening effect and preparation method thereof | |
CN104606657B (en) | A kind of medicine for beautifying skin | |
CN103520410A (en) | Novel rapid osteosynthesis powder |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160511 Termination date: 20160924 |
|
CF01 | Termination of patent right due to non-payment of annual fee |