CN103446512B - External traditional Chinese medicine composition for treating leucoderma and preparation method thereof - Google Patents
External traditional Chinese medicine composition for treating leucoderma and preparation method thereof Download PDFInfo
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Abstract
The invention discloses external traditional Chinese medicine composition for treating leucoderma and a preparation method thereof. The external traditional Chinese medicine composition comprises, by weight, 18-22 parts of thin bambusa chungii, 48-55 parts of galangal, 14-18 parts of cortex pseudolaricis and 13-17 parts of salicylic acid. The preparation method of the external traditional Chinese medicine composition comprises the following steps of (1) selecting materials, wherein raw materials are selected according to the proportion of the raw materials, and the raw materials are rinsed cleanly and aired; (2) carrying out medicine processing, wherein the galangal are smashed into fine grains and mixed with the thin bambusa chungii, the cortex pseudolaricis and the salicylic acid, rice wine which is 50+/-5 degrees is added in the mixture based on the proportion 1:(3-4) of the weight of the composition to the rice wine to carry out immersion for 30-35 days; (3) carrying out filtration, wherein finally the immersed medicine materials are taken out, filtered and put into bottles to carry out sterilization, and thus traditional Chinese medicine liquid is formed. The external traditional Chinese medicine composition can quickly remove vitligo, chloasma and malar rash on the surface of the skin, enable the skin to recover quickly, and has the advantages of being quick in effect performance, low in cost, safe, reliable, convenient to use, low in recurrence rate and simple in preparation.
Description
Technical field
The invention belongs to tcm field, be specifically related to one and treat leukodermic external application Chinese medicine and preparation method thereof.
Background technology
Vitiligo, is also called " vitiligo ", is a kind of common multiple pigmented dermatosis.This disease forms white macula for feature with local or general property depigmentation, is around normal skin.Decolouring speckle differs in size from several millimeters to several centimetres, and in progressive stage, skin lesion can expand gradually, and constantly has new decolouring speckle to occur.The patient that the colour of skin is more shallow, white macula can be not obvious, but dark-complexioned people, color contrast is then very distinct.Under wood lamp, vitiligo position and surrounding skin have obviously boundary.Vitiligo can involve any position of health, usual Bilateral Symmetry distribution.The probability that hair bleaches is 10% ~ 60%.Leukodermic sickness rate is very high, has 1-2 people's morbidities in every 100 people of China.Wherein half just started to occur skin lesion before 20 years old, and the people of about 1/5 has family history.Although vitiligo can not threat to life, have a strong impact on the image of patient, employment, marriage, destruction mental health, even directly destroyed patient's dream, bring very large psychic pain to patient.
Vitiligo pathogenic factor more complicated, concrete mechanism is also indefinite.Modern medicine is thought several possibility: neurocyte dysfunction produces the virose material of melanocyte, the immune system dysfunction of health is attacked and is destroyed the defect of melanocyte or melanocyte self, some are formed to self virose by-product in melanogenesis process, patients with vitiligo may have certain genetic defect in addition, melanocyte is easily destroyed, thus causes leukodermic generation.Treat leukodermic method in the market and medicine various, effect is different, usual whole body therapeutic application heavy metal or hormonal medicaments treatment, because containing hormone or heavy metal component, autopath is more, and life-time service easily causes skin aging fibrosis, and most curative effect can not be satisfactory, and treatment cost is high, general patient is difficult to bear.
Patent documentation application number CN200910172799.1 discloses " one treats leukodermic medicine for external use ", and it is made up of Fructus Mume, Radix Angelicae Dahuricae root, green Pericarpium Granati, Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Cacumen Platycladi, Fructus Psoraleae, green Fructus Solani melongenae, Folium Ilicis Purpureae, Semen Cuscutae, clobetasol propionate, laurocapram, chloroform, 90% ethanol.During making, a. with alcohol-pickled 5 ~ 7 day, filters the 10 taste raw materials such as Fructus Mume to form traditional Chinese medicine liquid; B. with chloroform, his rope of propanoic acid chlorine third is dissolved; C. his rope lysate of propanoic acid chlorine third and laurocapram are added in traditional Chinese medicine liquid; D. distilled water diluting is added.After but the chloroform contained in pharmaceutical compositions and sodium mix, easily develop blast after judder, there is potential safety hazard; And this medicine for external use mention coating in the description after need day illumination to shine within 5 minutes, to make chloroform slowly decompose to enter skin, if this explanation does not have solar time chloroform not have effect for the treatment of, simultaneously this medicine for external use also inconvenience use at night.
Patent documentation application number CN201010108321.5 discloses " one treats leukodermic medicine ", and its prescription is: Flos Impatientis 15 ~ 25g, Galla Chinensis 45 ~ 55g, Pericarpium Granati 45 ~ 55g, Fructus Mume 25 ~ 35g, Fructus Psoraleae 45 ~ 55g, Moschus 4 ~ 6g, the Radix Angelicae Dahuricae 45 ~ 55g, Fructus Atriplicis Sibiricae 65 ~ 75g, Radix Polygoni Multiflori Preparata 65 ~ 75g, Radix Angelicae Pubescentis 45 ~ 55g, Semen Astragali Complanati 45 ~ 55g; Its preparation method is for pick decontamination by said medicine, and clear water is cleaned, and pull out, dry, slow fire dries, and grind, mixing is put together, with 60% ethanol 1500 milliliters, soaks 15, filters and obtain solution.This prescription have employed Fructus Psoraleae, and price comparison is expensive, and treatment cost is higher, and general patient is difficult to bear.
In sum, vitiligo origin cause of formation more complicated, and pathogeny and therapy mechanism still not very clear, some medicine also also exists drug effect can not be lasting, have a rebound after drug withdrawal, the shortcoming that must uninterruptedly take for a long time, some Drug therapy expense is higher, there is potential safety hazard in therapeutic process, increase financial burden to patient.Therefore, need to play the advantage of Chinese medicine, study new effectively, the therapy of vitiligo medicine for external use of low cost.
Summary of the invention
The object of the invention is the defect for existing in existing Drug therapy, a kind of effective fast, with low cost, safe and reliable, easy to use, preparation simply leukodermic external medicine composition for the treatment of and preparation method thereof is provided.
For reaching this object, the present invention treats leukodermic external application Chinese medicine, and this Chinese medicine composition is by weight ratio: fine powder Bambusa cerosissima McClure 18 ~ 22 parts, Rhizoma Alpiniae Officinarum 48 ~ 55 parts, Cortex Pseudolaricis 14 ~ 18 parts, salicylic acid 13 ~ 17 parts.
Preferably, the proportioning of described raw material thing is: fine powder Bambusa cerosissima McClure 20 parts, Rhizoma Alpiniae Officinarum 50 parts, Cortex Pseudolaricis 15 parts, salicylic acid 15 parts.
Further, add 50 ± 5 degree of rice wine in described raw material thing, the ratio of composition material thing weight and rice wine is 1:(3 ~ 4).
The invention also discloses and a kind ofly prepare the method for the treatment of leukodermic external application Chinese medicine, comprise the following steps:
(1) draw materials: choose crude drug by raw material thing proportioning, wash clean and dry;
(2) concoct; Fine powder Bambusa cerosissima McClure, Rhizoma Alpiniae Officinarum are broken into particulate, mix with Cortex Pseudolaricis, salicylic acid, composition weight and rice wine weight are in 1:(3 ~ 4) ratio adds 50 ± 5 degree of rice wine and soaks, soak 30 ~ 35 days;
(3) filter: the medical material finally taking out immersion, filter, bottling sterilizing, forms traditional Chinese medicine liquid.
Each raw material thing of external application Chinese medicine of the present invention has following character and effect:
1, fine powder Bambusa cerosissima McClure: nature and flavor bitter in the mouth, cold in nature, have the relieving restlessness that clears away heart-fire, relieve summer heat, dampness removing, effect of promoting the production of body fluid to quench thirst, tradition is applied to controls erythra, calentura excessive thirst.
2, Rhizoma Alpiniae Officinarum: warm in nature, acrid in the mouth is nontoxic; Return spleen, stomach warp; There is the function of warming spleen and stomach for dispelling cold, regulating QI to relieve pain; Cure mainly coldness and pain in the epigastrium, vomiting singultus, dysentery, colic of cold type, beriberi, the disease such as dysphagic.
3, Cortex Pseudolaricis: pungent, temperature, poisonous; Return lung meridian; There is Anti-Puritic and insecticidal effect; Cure mainly trick tinea, local neurodermatitis, eczema, leprosy dysentery head.
4, salicylic acid: have outstanding " exfoliation, unclogging " ability, can desalinate pigmented spots, reduce pore, remove fine wrinkles and improve Exposure to Sunlight, itself is also used as Cidex-7, infects for local hyperkeratosis and skin fungus.
The primary efficacy of above-mentioned external application Chinese medicine ingredients:
One, dispeiling pathogenic wind and removing dampness, itch-stopping bactericidal
Active substance in medicine has warm skin cold expelling, dispeiling pathogenic wind and removing dampness, soothing the channels and quicking the network vessels, changes effect of blood blood stasis dispelling, the microcirculation of lesions position skin can be improved, increase the photosensitization of skin, activate TYR enzymatic activity, promote melanic synthesis in skin, increase pigmentation; With the addition of Fungicidal substance simultaneously, promote the immunity of human body.
Two, desalinate pigment, enhance metabolism
Active substance in medicine can promote local hyperkeratosis, desalination pigment, impel skin surface to wither to scab, in hair follicle stimulating external root sheath, the melanocyte of non-activity is converted into activated melanocyte, for the melanin regeneration at skin lesion place provides source, promotes melanocyte metabolism, prevent melanocyte autoclasia, make metabolism of pigment recover normal, thus dispel white macula, chloasma, the butterfly spot of skin surface, make skin recover normal.
Therefore, external application Chinese medicine of the present invention can dispel rapidly white macula, chloasma, the butterfly spot of skin surface, makes skin recover rapidly normal, have effective fast, with low cost, safe and reliable, easy to use, relapse rate is low, prepare simple advantage.
Detailed description of the invention
Below in conjunction with embodiment, external application Chinese medicine of the present invention and preparation method thereof is described in further detail.
Embodiment 1
The raw material thing weight of external application Chinese medicine is: fine powder Bambusa cerosissima McClure 20 parts, Rhizoma Alpiniae Officinarum 50 parts, Cortex Pseudolaricis 15 parts, salicylic acid 15 parts.
The preparation method of this group Traditional Chinese medicinal prescription is:
(1) choose fine powder Bambusa cerosissima McClure 20g, Rhizoma Alpiniae Officinarum 50g, Cortex Pseudolaricis 15g, salicylic acid 15g by raw material thing weight, wash clean and dry;
(2) fine powder Bambusa cerosissima McClure, Rhizoma Alpiniae Officinarum are broken into particulate, with, Cortex Pseudolaricis, salicylic acid mix, then the 50 degree of rice wine adding 300g soak, and soak 30 days;
(3) finally take out the medical material of immersion, filter, bottling sterilizing, forms traditional Chinese medicine liquid.
Embodiment 2
The raw material thing weight of external application Chinese medicine is: fine powder Bambusa cerosissima McClure 18 parts, Rhizoma Alpiniae Officinarum 55 parts, Cortex Pseudolaricis 14 parts, salicylic acid 13 parts.
Its preparation method is: choose fine powder Bambusa cerosissima McClure 18g, Rhizoma Alpiniae Officinarum 55g, Cortex Pseudolaricis 14g, salicylic acid 13g by raw material thing weight, washes clean and dries; Then after Rhizoma Alpiniae Officinarum being broken into particulate, mix with fine powder Bambusa cerosissima McClure, Cortex Pseudolaricis, salicylic acid, then the 50 degree of rice wine adding 400g soak, and soak 32 days; Finally take out the medical material of immersion, filter, bottling sterilizing, forms traditional Chinese medicine liquid.
Embodiment 3
The raw material thing weight of external application Chinese medicine is: fine powder Bambusa cerosissima McClure 22 parts, Rhizoma Alpiniae Officinarum 48 parts, Cortex Pseudolaricis 16 parts, salicylic acid 14 parts.
Its preparation method is: choose fine powder Bambusa cerosissima McClure 22g, Rhizoma Alpiniae Officinarum 48g, Cortex Pseudolaricis 16g, salicylic acid 14g by raw material thing weight, washes clean and dries; Then after Rhizoma Alpiniae Officinarum being broken into particulate, mix with fine powder Bambusa cerosissima McClure, Cortex Pseudolaricis, salicylic acid, then the 50 degree of rice wine adding 350g soak, and soak 35 days; Finally take out the medical material of immersion, filter, bottling sterilizing, forms traditional Chinese medicine liquid.
Below by partial clinical case, further illustrate the beneficial effect of Chinese medicine composition of the present invention.
1, physical data
Patient 220 example, male 95 example, women 125 example, 15 ~ 25 years old 40 age example, 25 ~ 35 years old 65 example, 35 ~ 45 years old 67 example, more than 45 years old 48 example.Be limitation vitiligo, facial skin lesion patient 95 example, extremity patient 73 example, metastomium patient 52 example, the course of disease is the shortest 8 months, the longest 8 years.
2, Therapeutic Method
Select the formula external application Chinese medicine of above-described embodiment 1, every day, each painting once, coated skin affected part sooner or later, was massaged into skin surface heating, till rubescent with hands.
3, criterion of therapeutical effect
Criterion of therapeutical effect organizes the vitiligo curative effect judging standard (draft) of first national scientific seminar in 1993 and group committee member enlarged meeting in 1994 discussion with reference to Chinese combination of Chinese and Western medicine Society of Dermatology and Venereology pigmented dermatosis:
Recovery from illness: white macula all disappears, recovers normal skin tone;
Effective: white macula partial disappearance or reduce, the area recovering normal skin tone accounts for skin lesion area >=50%;
Effective: white macula partial disappearance or reduce, the area recovering normal skin tone accounts for skin lesion area >=10% ,≤50%;
Invalid: white macula is unchanged or reduce, the area recovering normal skin tone accounts for skin lesion area≤10%.
4. therapeutic effect
Treat in reality in clinical smelting, through observing, in the external application Chinese medicine process of outer painting formula of the present invention (as embodiment 1,2,3), skin surface can be withered and be scabbed, a week cicatrix can automatically take off, Reusability, the lighter's 3-6 months skin recovers normal, and severe one is slightly long for the course for the treatment of, and overall treatment time is 3 ~ 12 months, therapeutic effect is all obvious, and concrete condition refers to table 1.
The routine Vitiligo table of table 1220
As can be seen from the above table, in above-mentioned treatment, treat after 3 ~ 12 months, this group 220 example, cure 68 examples, cure rate 30.9%; Effective 72 examples, obvious effective rate 32.7%; Effective 67 examples, effective percentage 30.5%; Invalid 13 examples, inefficiency 5.9%; Total effective rate reaches 94.1%; External application Chinese medicine instant effect of the present invention is described, cure rate is high, has no side effect, and safety is good.
Model case:
Case 1: Zhang, female, 22 years old, workman, face finds white macula 2 years, fail to respond to any medical treatment in local clinic, come to go to a doctor, ask that it is without family history, be coated with external application Chinese medicine medicinal liquid of the present invention, every day, each painting once, coated skin affected part sooner or later, was massaged into skin surface heating, till rubescent with hands.In medication process, skin surface is withered scabs, and after 1 week, cicatrix starts automatically to take off, further consultation after 2 months, and face only remaining a slice is not healed, and be coated with continuously with further consultation after 4 months, white patch on the face disappears, and is coated with continuously again with after 1 month, fully recovers, and follows up a case by regular visits to that so far there are no recurs.
Case 2: Huang, man, 45 years old, peasant, extremity position, extremity near-end white macula 5 years, remove hospital admission, be diagnosed as vitiligo, but through multi-treatment, poor effect, comes to go to a doctor, according to the state of an illness, be coated with external application Chinese medicine medicinal liquid of the present invention, every day, each painting once, coated skin affected part sooner or later, skin surface heating is massaged into, till rubescent with hands.In medication process, skin surface is withered scabs, and after 1 month, cicatrix starts automatically to take off; Further consultation after 2 months, has part stain to occur, skin lesion little individually has started to disappear; Continuous painting further consultation after 4 months, on extremity white macula only remaining a slice do not heal, the white macula of basic 50% disappears; Be coated with continuously again with after 2 months, white macula all disappears, and is almost recovered; Continue again painting again and used 1 month, recovery from illness, recurrence of following up a case by regular visits to that so far there are no.
It should be noted that, these are only preferred embodiment of the present invention, do not departing under concept thereof of the present invention, any minor variations do the present invention and equivalent replacement, all belong to protection scope of the present invention.
Claims (3)
1. treat a leukodermic external medicine composition, it is characterized in that: this Chinese medicine composition is fine powder Bambusa cerosissima McClure 18 ~ 22 parts, Rhizoma Alpiniae Officinarum 48 ~ 55 parts, Cortex Pseudolaricis 14 ~ 18 parts, salicylic acid 13 ~ 17 parts by weight ratio.
2. the leukodermic external medicine composition for the treatment of according to claim 1, is characterized in that: described Chinese medicine composition is fine powder Bambusa cerosissima McClure 20 parts, Rhizoma Alpiniae Officinarum 50 parts, Cortex Pseudolaricis 15 parts, salicylic acid 15 parts by weight ratio.
3. prepare a method for the leukodermic external medicine composition for the treatment of as claimed in claim 1, it is characterized in that comprising the following steps:
(1) draw materials: choose crude drug by raw material thing proportioning, wash clean and dry;
(2) concoct; Fine powder Bambusa cerosissima McClure, Rhizoma Alpiniae Officinarum are broken into particulate, mix with Cortex Pseudolaricis, salicylic acid, composition weight and rice wine weight are in 1:(3 ~ 4) ratio adds 50 ± 5 degree of rice wine and soaks, soak 30 ~ 35 days;
(3) filter: the medical material finally taking out immersion, filter, bottling sterilizing, forms traditional Chinese medicine liquid.
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| CN114028513B (en) * | 2021-11-23 | 2023-04-25 | 完美（广东）日用品有限公司 | Hippophae rhamnoides leaf composition for improving psoriasis and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601722A (en) * | 2008-06-12 | 2009-12-16 | 苗丽华 | The manufacture method of the liquid of curing vitiligo |
| CN101766779A (en) * | 2010-02-09 | 2010-07-07 | 闫明 | Compound medicine for vitligo treatment and preparation method thereof |
| CN101810812A (en) * | 2010-03-11 | 2010-08-25 | 闫明 | Use of rhizoma galangae effect part for preparing medicament for treating leucoderma |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601722A (en) * | 2008-06-12 | 2009-12-16 | 苗丽华 | The manufacture method of the liquid of curing vitiligo |
| CN101766779A (en) * | 2010-02-09 | 2010-07-07 | 闫明 | Compound medicine for vitligo treatment and preparation method thereof |
| CN101810812A (en) * | 2010-03-11 | 2010-08-25 | 闫明 | Use of rhizoma galangae effect part for preparing medicament for treating leucoderma |
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