CN103446091B - Incarviatone A在制备治疗喉癌药物中的应用 - Google Patents
Incarviatone A在制备治疗喉癌药物中的应用 Download PDFInfo
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- CN103446091B CN103446091B CN201310432216.0A CN201310432216A CN103446091B CN 103446091 B CN103446091 B CN 103446091B CN 201310432216 A CN201310432216 A CN 201310432216A CN 103446091 B CN103446091 B CN 103446091B
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- incarviatone
- laryngeal carcinoma
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- 239000003814 drug Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 201000005264 laryngeal carcinoma Diseases 0.000 title claims abstract description 13
- 150000001875 compounds Chemical class 0.000 claims description 17
- 206010023825 Laryngeal cancer Diseases 0.000 abstract description 8
- 206010023841 laryngeal neoplasm Diseases 0.000 abstract description 8
- 230000012010 growth Effects 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 230000000118 anti-neoplastic effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 206010062129 Tongue neoplasm Diseases 0.000 description 1
- 206010043966 Tongue neoplasm malignant stage unspecified Diseases 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 201000006134 tongue cancer Diseases 0.000 description 1
- 208000025358 tongue carcinoma Diseases 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310432216.0A CN103446091B (zh) | 2013-09-22 | 2013-09-22 | Incarviatone A在制备治疗喉癌药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310432216.0A CN103446091B (zh) | 2013-09-22 | 2013-09-22 | Incarviatone A在制备治疗喉癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103446091A CN103446091A (zh) | 2013-12-18 |
CN103446091B true CN103446091B (zh) | 2015-11-25 |
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Application Number | Title | Priority Date | Filing Date |
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CN201310432216.0A Expired - Fee Related CN103446091B (zh) | 2013-09-22 | 2013-09-22 | Incarviatone A在制备治疗喉癌药物中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103446091B (zh) |
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2013
- 2013-09-22 CN CN201310432216.0A patent/CN103446091B/zh not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
Incarviatone A, a structurally unique natural product hybrid with a new carbon skeleton from Incarvillea delavayi, and its absolute configuration calculated electronic circular dichroic spectra{;Yun-Heng Shen等;《RSC Adv》;20120301;第2卷;4175–4180 * |
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Publication number | Publication date |
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CN103446091A (zh) | 2013-12-18 |
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Effective date of registration: 20151027 Address after: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Applicant after: Li Shulan Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: 225327 Taizhou, Jiangsu, Jiangsu Province, Yongan Town, North Yongan Road, No. 203 Patentee after: Li Shulan Address before: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Patentee before: Li Shulan |
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CB03 | Change of inventor or designer information |
Inventor after: Zhao Xinying Inventor after: Gao Yifang Inventor after: Dong Ran Inventor before: Jiang Chunping Inventor before: Huang Rong |
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Effective date of registration: 20170322 Address after: 071000 Baoding City, Hebei Province, south of the city built a new building in the main street A block No. 1201 Patentee after: Zhao Xinying Patentee after: Gao Yifang Patentee after: Dong Ran Address before: 225327 Taizhou, Jiangsu, Jiangsu Province, Yongan Town, North Yongan Road, No. 203 Patentee before: Li Shulan |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151125 Termination date: 20170922 |
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