CN103432600A - Antibacterial medical ultrasonic coupling agent and preparation method thereof - Google Patents
Antibacterial medical ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN103432600A CN103432600A CN2013103743726A CN201310374372A CN103432600A CN 103432600 A CN103432600 A CN 103432600A CN 2013103743726 A CN2013103743726 A CN 2013103743726A CN 201310374372 A CN201310374372 A CN 201310374372A CN 103432600 A CN103432600 A CN 103432600A
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000007822 coupling agent Substances 0.000 title abstract description 22
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 24
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 23
- 229960000907 methylthioninium chloride Drugs 0.000 claims abstract description 23
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 23
- 238000003756 stirring Methods 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000012153 distilled water Substances 0.000 claims abstract description 10
- 230000006837 decompression Effects 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 28
- 229920002125 Sokalan® Polymers 0.000 claims description 24
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 18
- 229960001631 carbomer Drugs 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 238000013329 compounding Methods 0.000 claims description 13
- 238000002604 ultrasonography Methods 0.000 claims description 13
- 238000004090 dissolution Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 230000008961 swelling Effects 0.000 claims description 8
- 229920002873 Polyethylenimine Polymers 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 17
- 239000000243 solution Substances 0.000 description 14
- 239000000047 product Substances 0.000 description 11
- 239000011248 coating agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 8
- 239000000499 gel Substances 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 230000001808 coupling effect Effects 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000012085 test solution Substances 0.000 description 6
- 206010011409 Cross infection Diseases 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 4
- 206010029803 Nosocomial infection Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000001408 fungistatic effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002558 medical inspection Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 239000006916 nutrient agar Substances 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 229960002233 benzalkonium bromide Drugs 0.000 description 1
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229960002152 chlorhexidine acetate Drugs 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
The invention relates to an antibacterial medical ultrasonic coupling agent and a preparation method thereof. The antibacterial medical ultrasonic coupling agent is prepared from the following raw materials according to weight percentage: 1%-2% of polyethyleneimine quaternary ammonium salt, 1%-2% of polyethylene glycol, 0.05%-0.1% of methylene blue and the balance being distilled water. The preparation method of the ultrasonic coupling agent provided by the invention comprises the steps of mixing all the raw materials with water proportionally, and then stirring while heating to dissolve and swell the raw materials, and finally, removing bubbles under vacuum decompression, thereby obtaining the light blue gel product. The ultrasonic coupling agent provided by the invention has a broad-spectrum antibacterial property, and is good in biocompatibility, biodegradable, low in cost and stable in performance, and is prepared from few raw materials and prepared by simple preparation process.
Description
technical field:
The present invention relates to a kind of antibacterial medical ultrasound compounding agent, the present invention also further provides the preparation method of this couplant, belongs to medical inspection reagent technical field.
technical background:
B ultrasonic is the detecting instrument of wide clinical application, and medical ultrasonic coupling agent used while carrying out medical inspection is for being coated on the skin that detects position, eliminating the air between instrument probe and skin.Therefore require that ultrasonic coupling agent has easy coating, easy-clear, non-stimulated, denseness is moderate, do not damage the characteristics such as instrument probe.In the use procedure of ultrasonic coupling agent, can occur that the cross infection of dermatosis, particularly skin have wound and ultrasonographic cross infection problem while contacting mucosa.In " medical ultrasonic coupling agent standard " that the people such as Niu Fengqi draft, according to the biological assessment concept requirement, " under short time (24h) contact conditions, product is to the skin no cytotoxicity, without sensitization, non-stimulated." the 6th requirement of China's " Regulations of sterilization management ", apparatus and the articles for use of all contact skin of medical and health organization, mucosa must reach the sterilization requirement, to prevent and to reduce the chance of Hospital Infection.
But widely used in the market is all common ultrasonic coupling agent, does not possess sterilizing function, easily produces cross infection.In addition, on market, in existing a small amount of antimicrobial form ultrasonic coupling agent, antibacterial is mainly chlorhexidine acetate, povidone iodine, chlorhexidine iodine, parachlorometaxylenol, benzalkonium bromide etc.On the one hand, these antibacterial do not have biocompatibility, skin irritation or anaphylaxis in use occur; On the other hand, these antibacterial do not have biodegradable, once, in use by infiltration or because misoperation enters in body, do not gone out by metabolism when stop is longer in vivo, produce certain toxic and side effects.
To sum up analyze, develop and a kind ofly there is biocompatibility, biodegradable, the simple antibacterial medical ultrasound compounding agent of preparation technology and there is larger clinical value and the stronger market competitiveness.
summary of the invention:
The invention provides a kind of antibacterial medical ultrasound compounding agent, there is good biocompatibility, the characteristics such as biodegradable, technique is simple, with low cost, stable performance.
The present invention also further provides a kind of preparation method of antibacterial medical ultrasound compounding agent, is applicable to suitability for industrialized production.
a kind of antibacterial medical ultrasound compounding agent provided by the invention, by following raw materials by weight, made:
Carbomer 1%, triethanolamine 0.6%, polymine quaternary ammonium salt (1～2) %, Polyethylene Glycol (1～2) %, methylene blue (0.05～0.1) %, essence 0.02%, surplus is distilled water.
the preparation method of antibacterial medical ultrasound compounding agent of the present invention comprises the following steps:
(1) will in carbomer, add water, heating stirring to make the carbomer swelling;
(2) by the polymine quaternary ammonium salt, Polyethylene Glycol, methylene blue and essence join in above-mentioned solution, continue to stir, and make various material dissolutions;
(3) adding the pH value of triethanolamine regulator solution is between 7.5～8.0 again, forms light blue gel, under vacuum decompression, removes bubble, obtains final products.
The viscosity of product of the present invention is at 15.4 to 24.4 Pa ● between s, denseness is suitable, and coating performance is good, and good biocompatibility is biodegradable, non-stimulated to skin, and acoustic attenuation is at 0.193 to 0.246 dB ● cm
-1● MHz
-1between, acoustic attenuation is little, leads acoustic performance good, clear picture, but the characteristics of antibiotic and sterilizing.
the present invention compares its good effect with traditional antibacterial medical ultrasound compounding agent and is:
Polymine quaternary ammonium salt with antibacterial effect has bio-compatible phase and biodegradable preferably, without skin irritation, and its has a broad antifungal spectrum, reduced to a great extent contingent cross infection problem in the ultrasonic coupling agent use procedure.
the specific embodiment:
Following examples contribute to understand this patent.
embodiment 1:
Take that to gather carbomer, polymine quaternary ammonium salt, Polyethylene Glycol (molecular weight is 5 000 g/mol), triethanolamine, methylene blue and essence be raw material, concrete percentage by weight is: carbomer (1.0%) polymine quaternary ammonium salt (1.0%), Polyethylene Glycol (1.0%), triethanolamine (0.6%), methylene blue (0.05%), essence (0.02%), surplus are distilled water.
Preparation method:
(1) get in 1.0 g carbomers and join in 96.3 mL water, heat and stir and make its swelling; (2) by 1.0 g polymine quaternary ammonium salts (molecular weight is 10 000 g/mol), 1.0 g Polyethylene Glycol, 0.05 g methylene blue and 0.02 g essence join in above-mentioned solution, continue to stir, and make various material dissolutions; (3) add 0.6 g triethanolamine, after stirring, the pH value of test solution, drip a small amount of triethanolamine as one sees fit again, take the pH value of regulator solution between 7.5～8.0, forms light blue gel; (4) remove bubble under vacuum decompression, obtain final products.
The physicochemical property of couplant:
The physicochemical property of embodiment 1 is as shown in table 1, and result shows its suitable viscosity, and acoustic attenuation is little.
The physicochemical property of table 1. embodiment 1
| Sequence number | Index | Result |
| 1 | PH value | 7.1 |
| 2 | Viscosity | 15.4 Pa.s |
| 3 | The acoustic resistance drag | 1.66 ×10 6 Pa.s.m -1 |
| 4 | Acoustic attenuation | 0.233 dB.cm -1.MHz -1 |
| 5 | The velocity of sound | 1630 m.s -1 |
Clinical application effect detects:
The couplant of embodiment 1 is carried out to the clinical practice detection, and result shows that this couplant is easy to coating, and sliding is good, to the ultrasonic probe not damaged, non-stimulated to skin, the couplant of embodiment 1 is good to the coupling effect of ultrasonic probe and skin, the clear picture obtained.
embodiment 2:
Take that to gather carbomer, polymine quaternary ammonium salt (molecular weight is 10 000 g/mol), Polyethylene Glycol (molecular weight is 5 000 g/mol), triethanolamine, methylene blue and essence be raw material, concrete percentage by weight is: carbomer (1.0%) polymine quaternary ammonium salt (1.0%), Polyethylene Glycol (1.5%), triethanolamine (0.6%), methylene blue (0.05%), essence (0.02%), surplus are distilled water.
Preparation method:
(1) get in 1.0 g carbomers and join in 95.8 mL water, heat and stir and make its swelling; (2) by 1.0 g polymine quaternary ammonium salts, 1.5 g Polyethylene Glycol, 0.05 g methylene blue and 0.02 g essence join in above-mentioned solution, continue to stir, and make various material dissolutions; (3) add 0.6 g triethanolamine, after stirring, the pH value of test solution, drip a small amount of triethanolamine as one sees fit again, take the pH value of regulator solution between 7.5～8.0, forms light blue gel; (4) remove bubble under vacuum decompression, obtain final products.
The physicochemical property of couplant:
The physicochemical property of embodiment 2 is as shown in table 2, and result shows its suitable viscosity, and acoustic attenuation is little.
The physicochemical property of table 2. embodiment 2
| Sequence number | Index | Result |
| 1 | PH value | 7.3 |
| 2 | Viscosity | 16.0 Pa.s |
| 3 | The acoustic resistance drag | 1.59 ×10 6 Pa.s.m -1 |
| 4 | Acoustic attenuation | 0.246 dB.cm -1.MHz -1 |
| 5 | The velocity of sound | 1840 m.s -1 |
Clinical application effect detects:
The couplant of embodiment 2 is carried out to the clinical practice detection, and result shows that this couplant is easy to coating, and sliding is good, to the ultrasonic probe not damaged, non-stimulated to skin, the couplant of embodiment 2 is good to the coupling effect of ultrasonic probe and skin, the clear picture obtained.
embodiment 3:
Take that to gather carbomer, polymine quaternary ammonium salt (molecular weight is 10 000 g/mol), Polyethylene Glycol (molecular weight is 5 000 g/mol), triethanolamine, methylene blue and essence be raw material, concrete percentage by weight is: carbomer (1.0%) polymine quaternary ammonium salt (1.5%), Polyethylene Glycol (1.0%), triethanolamine (0.6%), methylene blue (0.10%), essence (0.02%), surplus are distilled water.
Preparation method:
(1) get in 1.0 g carbomers and join in 95.8 mL water, heat and stir and make its swelling; (2) by 1.5 g polymine quaternary ammonium salts, 1.0 g Polyethylene Glycol, 0.10 g methylene blue and 0.02 g essence join in above-mentioned solution, continue to stir, and make various material dissolutions; (3) add 0.6 g triethanolamine, after stirring, the pH value of test solution, drip a small amount of triethanolamine as one sees fit again, take the pH value of regulator solution between 7.5～8.0, forms light blue gel; (4) remove bubble under vacuum decompression, obtain final products.
The physicochemical property of couplant:
The physicochemical property of embodiment 3 is as shown in table 3, and result shows its suitable viscosity, and acoustic attenuation is little.
The physicochemical property of table 3. embodiment 3
| Sequence number | Index | Result |
| 1 | PH value | 7.4 |
| 2 | Viscosity | 15.5 Pa.s |
| 3 | The acoustic resistance drag | 1.64 ×10 6 Pa.s.m -1 |
| 4 | Acoustic attenuation | 0.238 dB.cm -1.MHz -1 |
| 5 | The velocity of sound | 1610 m.s -1 |
Clinical application effect detects:
The couplant of embodiment 3 is carried out to the clinical practice detection, and result shows that this couplant is easy to coating, and sliding is good, to the ultrasonic probe not damaged, non-stimulated to skin, the couplant of embodiment 3 is good to the coupling effect of ultrasonic probe and skin, the clear picture obtained.
embodiment 4:
Take that to gather carbomer, polymine quaternary ammonium salt (molecular weight is 10 000 g/mol), Polyethylene Glycol (molecular weight is 5 000 g/mol), triethanolamine, methylene blue and essence be raw material, concrete percentage by weight is: carbomer (1.0%) polymine quaternary ammonium salt (2.0%), Polyethylene Glycol (1.5%), triethanolamine (0.6%), methylene blue (0.05%), essence (0.02%), surplus are distilled water.
Preparation method:
(1) get in 1.0 g carbomers and join in 94.8 mL water, heat and stir and make its swelling; (2) by 2.0 g polymine quaternary ammonium salts, 1.5 g Polyethylene Glycol, 0.05 g methylene blue and 0.02 g essence join in above-mentioned solution, continue to stir, and make various material dissolutions; (3) add 0.6 g triethanolamine, after stirring, the pH value of test solution, drip a small amount of triethanolamine as one sees fit again, take the pH value of regulator solution between 7.5～8.0, forms light blue gel; (4) remove bubble under vacuum decompression, obtain final products.
The physicochemical property of couplant:
The physicochemical property of embodiment 4 is as shown in table 4, and result shows its suitable viscosity, and acoustic attenuation is little.
The physicochemical property of table 4. embodiment 4
| Sequence number | Index | Result |
| 1 | PH value | 7.1 |
| 2 | Viscosity | 17.2 Pa.s |
| 3 | The acoustic resistance drag | 1.68 ×10 6 Pa.s.m -1 |
| 4 | Acoustic attenuation | 0.229 dB.cm -1.MHz -1 |
| 5 | The velocity of sound | 1650 m.s -1 |
Clinical application effect detects:
The couplant of embodiment 4 is carried out to the clinical practice detection, and result shows that this couplant is easy to coating, and sliding is good, to the ultrasonic probe not damaged, non-stimulated to skin, the couplant of embodiment 4 is good to the coupling effect of ultrasonic probe and skin, the clear picture obtained.
embodiment 5:
Take that to gather carbomer, polymine quaternary ammonium salt (molecular weight is 30 000 g/mol), Polyethylene Glycol (molecular weight is 5 000 g/mol), triethanolamine, methylene blue and essence be raw material, concrete percentage by weight is: carbomer (1.0%) polymine quaternary ammonium salt (2.0%), Polyethylene Glycol (1.0%), triethanolamine (0.6%), methylene blue (0.1%), essence (0.02%), surplus are distilled water.
Preparation method:
(1) get in 1.0 g carbomers and join in 95.3 mL water, heat and stir and make its swelling; (2) by 2.0 g polymine quaternary ammonium salts, 1.0 g Polyethylene Glycol, 0.1 g methylene blue and 0.02 g essence join in above-mentioned solution, continue to stir, and make various material dissolutions; (3) add 0.6 g triethanolamine, after stirring, the pH value of test solution, drip a small amount of triethanolamine as one sees fit again, take the pH value of regulator solution between 7.5～8.0, forms light blue gel; (4) remove bubble under vacuum decompression, obtain final products.
The physicochemical property of couplant:
The physicochemical property of embodiment 5 is as shown in table 5, and result shows its suitable viscosity, and acoustic attenuation is little.
The physicochemical property of table 5. embodiment 5
| Sequence number | Index | Result |
| 1 | PH value | 7.4 |
| 2 | Viscosity | 24.4 Pa.s |
| 3 | The acoustic resistance drag | 1.88 ×10 6 Pa.s.m -1 |
| 4 | Acoustic attenuation | 1710 m.s -1 |
| 5 | The velocity of sound | 1430 m.s -1 |
Clinical application effect detects:
The couplant of embodiment 5 is carried out to the clinical practice detection, and result shows that this couplant is easy to coating, and to the ultrasonic probe not damaged, non-stimulated to skin, the couplant of embodiment 5 is good to the coupling effect of ultrasonic probe and skin, the clear picture obtained.
embodiment 6:
Take that to gather carbomer, polymine quaternary ammonium salt (molecular weight is 30 000 g/mol), Polyethylene Glycol (molecular weight is 5 000 g/mol), triethanolamine, methylene blue and essence be raw material, concrete percentage by weight is: carbomer (1.0%) polymine quaternary ammonium salt (1.5%), Polyethylene Glycol (1.5%), triethanolamine (0.6%), methylene blue (0.05%), essence (0.02%), surplus are distilled water.
Preparation method:
(1) get in 1.0 g carbomers and join in 95.3 mL water, heat and stir and make its swelling; (2) by 1.5 g polymine quaternary ammonium salts, 1.5 g Polyethylene Glycol, 0.05 g methylene blue and 0.02 g essence join in above-mentioned solution, continue to stir, and make various material dissolutions; (3) add 0.6 g triethanolamine, after stirring, the pH value of test solution, drip a small amount of triethanolamine as one sees fit again, take the pH value of regulator solution between 7.5～8.0, forms light blue gel; (4) remove bubble under vacuum decompression, obtain final products.
The physicochemical property of couplant:
The physicochemical property of embodiment 6 is as shown in table 6, and result shows its suitable viscosity, and acoustic attenuation is little.
The physicochemical property of table 6. embodiment 6
| Sequence number | Index | Result |
| 1 | PH value | 7.2 |
| 2 | Viscosity | 21.9 Pa●s |
| 3 | The acoustic resistance drag | 1.75 ×10 6 Pa●s●m -1 |
| 4 | Acoustic attenuation | 0.193 dB●cm -1●MHz -1 |
| 5 | The velocity of sound | 1500 m●s -1 |
Clinical application effect detects:
The couplant of embodiment 6 is carried out to the clinical practice detection, and result shows that this couplant is easy to coating, and to the ultrasonic probe not damaged, non-stimulated to skin, the couplant of embodiment 6 is good to the coupling effect of ultrasonic probe and skin, the clear picture obtained.
experimental example 1: the antibacterial medical ultrasound compounding agent fungistatic effect detects
1.1 experiment purpose:
Detect the fungistatic effect of the prepared antibacterial medical ultrasound compounding agent of the present invention, and the product on itself and existing market is compared.
1.2 experimental apparatus and raw material:
The prepared antibacterial ultrasonic coupling agent of the emerging reality in antimicrobial form ultrasonic coupling agent, Changchun of Siemens ACUSON X150 compuscan, the present invention, the medical antibacterial sterilization type ultrasonic coupling agent of sound friend's board, the sterilization dimension board of 5cm * 5cm, aseptic eluent, cotton swab, normal saline, nutrient agar, distilled water.
1.3 experimental technique:
The method that this experiment adopts is implemented in strict accordance with " disposable use hygienic article sanitary standard GB15979-1995 ", and the embodiment 1 of below take is narrated concrete experimental technique as example.The ultrasonic coupling agent of the different proportionings that prepare in embodiment, carry out ultrasonic examination.
1.3.1 sampling
Before ultrasonic examination, at first skin of abdomen is sampled, in contrast; Carry out ultrasonic examination after 1 hour in Application Example 1, again the same abdominal part is examined to regional skin sampling.
Sampling method is implemented according to " medical institutions' disinfection technology standard-2012 edition ", be specially: with the sterilization dimension board of 5cm * 5cm, be placed on tested skin place, with 1 of the cotton swab that is soaked with the aseptic eluent that contains corresponding nertralizer, in dimension board, anyhow come and go and evenly embrocate each 5 times, and rotate cotton swab thereupon, after cutting off the hands contact site, cotton swab is dropped in the 200mL sterile saline, fully mix, obtain a normal saline sample liquid, standby inspection.
1.3.2 detect
The normal saline supernatant of getting in 1.3.1 is done colony counting for treating sample measuring liquid.Inoculate altogether 5 plates, in each plate, add 1mL to treat sample measuring liquid, then with the nutrient agar 15-20mL of the thawing that is cooled to 45 ℃ of left and right, pour mix homogeneously in each plate into.After the upset plate is put 35 ℃ ± 2 ℃ cultivation 48h after agar solidifies, calculate the clump count on flat board.
1.3.3 clump count calculates
The flat board that bacterium colony is grown in the form of sheets should not adopt; Count the bacterium colony on satisfactory flat board, be calculated as follows result:
X
1=A*K/5
In formula: X
1---total number of bacterial colonies, unit is cfu/mL;
Total number of bacterial colonies on A---5 these editions of agar culture medium;
K---dilution factor.
1.3.4 result and discussion
Should use the same method, respectively embodiment 2 to embodiment 6, the medical antibacterial sterilization type ultrasonic coupling agent of the antibacterial ultrasonic coupling agent harmony friend's board of the emerging reality in Changchun are detected, testing result is as shown in table 7, for being examined skin, the clump count of the clump count of ultrasonic examination after 1 hour before than ultrasonic examination is much lower, shows that the ultrasonic coupling agent of the various different proportionings of preparation in embodiment 1 and the ultrasonic coupling agent of two kinds of marketizations all have good antibacterial effect.The ultrasonic coupling agent of application the present embodiment carries out ultrasonic examination, clump count in ultrasonic examination after 1 hour is between 64 to 88 cfu/mL, carry out ultrasonic examination and apply the product of buying on two kinds of markets, clump count in ultrasonic examination after 1 hour all is greater than 90cfu/mL, illustrates that antibacterial medical ultrasound compounding agent of the present invention has better antibacterial effect.
Table 7. ultrasonic coupling agent fungistatic effect detects
Claims (2)
1. an antibacterial medical ultrasound compounding agent, by following raw materials by weight, made:
Carbomer 1%, triethanolamine 0.6%, polymine quaternary ammonium salt (1～2) %, Polyethylene Glycol (1～2) %, methylene blue (0.05～0.1) %, essence 0.02%, surplus is distilled water.
2. the preparation method of antibacterial medical ultrasound compounding agent as claimed in claim 1 comprises the following steps:
(1) will in carbomer, add water, heating stirring to make the carbomer swelling;
(2) by the polymine quaternary ammonium salt, Polyethylene Glycol, methylene blue and essence join in above-mentioned solution, continue to stir, and make various material dissolutions;
(3) adding the pH value of triethanolamine regulator solution is between 7.5～8.0 again, forms light blue gel, under vacuum decompression, removes bubble, obtains.
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| CN201310374372.6A CN103432600B (en) | 2013-08-26 | 2013-08-26 | Antibacterial medical ultrasonic coupling agent and preparation method thereof |
| KR1020167008027A KR101990185B1 (en) | 2013-08-26 | 2014-07-03 | Antibacterial medical ultrasonic coupling agent and preparation method thereof |
| PCT/CN2014/081587 WO2015027752A1 (en) | 2013-08-26 | 2014-07-03 | Antibacterial medical ultrasonic coupling agent and preparation method thereof |
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| CN104208726A (en) * | 2014-02-28 | 2014-12-17 | 张维芬 | Chitosan quaternary ammonium salt couplant and preparation method thereof |
| CN106039330A (en) * | 2016-06-16 | 2016-10-26 | 吉林医药学院 | Antibacterial medical ultrasonic coupling agent containing traditional Chinese medicine ingredients and preparation method thereof |
| CN107648621A (en) * | 2017-10-26 | 2018-02-02 | 天津华大弘毅生物科技有限公司 | A kind of irradiating preparation process of ultrasonic probe couplant |
| CN109069129A (en) * | 2016-03-04 | 2018-12-21 | 伯东株式会社 | For improving the composition, echo gel composition and ultrasonic diagnosis method of ultrasonic transmission efficiency |
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| CN105832652A (en) * | 2016-05-13 | 2016-08-10 | 沈阳赛镝医疗器械有限公司 | Ultrasonic coupling agent intermediate medium |
| CN112741671A (en) * | 2019-10-29 | 2021-05-04 | 王强 | Energy-guiding liquid for extracorporeal shock wave lithotripsy and preparation method thereof |
| CN112891567A (en) * | 2021-01-29 | 2021-06-04 | 陈卫东 | Emulsifying agent |
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| CN102247607A (en) * | 2011-08-22 | 2011-11-23 | 江西三鑫医疗科技股份有限公司 | Method for preparing bacteriostatic couplant |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208726A (en) * | 2014-02-28 | 2014-12-17 | 张维芬 | Chitosan quaternary ammonium salt couplant and preparation method thereof |
| CN104208726B (en) * | 2014-02-28 | 2017-02-08 | 潍坊医学院 | Chitosan quaternary ammonium salt couplant and preparation method thereof |
| CN109069129A (en) * | 2016-03-04 | 2018-12-21 | 伯东株式会社 | For improving the composition, echo gel composition and ultrasonic diagnosis method of ultrasonic transmission efficiency |
| CN106039330A (en) * | 2016-06-16 | 2016-10-26 | 吉林医药学院 | Antibacterial medical ultrasonic coupling agent containing traditional Chinese medicine ingredients and preparation method thereof |
| CN107648621A (en) * | 2017-10-26 | 2018-02-02 | 天津华大弘毅生物科技有限公司 | A kind of irradiating preparation process of ultrasonic probe couplant |
| CN107648621B (en) * | 2017-10-26 | 2018-11-27 | 广州华大生物科技有限公司 | A kind of irradiating preparation process of ultrasonic probe couplant |
Also Published As
| Publication number | Publication date |
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| KR20160046907A (en) | 2016-04-29 |
| WO2015027752A1 (en) | 2015-03-05 |
| CN103432600B (en) | 2015-01-28 |
| KR101990185B1 (en) | 2019-06-17 |
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