CN103432491A - 药物组合物 - Google Patents
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Abstract
本发明涉及一种治疗咳嗽的中西药结合的组合物,其中西药为氢溴酸右美沙芬,中药的原料药的重量配比如下:半夏14份,鱼腥草9份,桃仁10份,白前7份,麻黄6份,淫羊藿12份,枸杞20份,麦冬15份,陈皮6份,五味子12份,蝉蜕8份,贝母14份,肉桂7份,黄芩3份,薄荷4份,百部8份,金银花16份,当归7份,山楂20份,车前子8份,冰片7份,氢溴酸右美沙芬和中药的重量比例大约为1:40。
Description
技术领域
本发明涉及一种治疗咳嗽的中西药结合的组合物。
背景技术
肺系疾患的主要证候之一就是咳嗽。纵观历史,历代医家对于咳嗽都有不同见解。《黄帝内经》提出“五脏六腑皆令人咳,非独肺也”的论证”。《景岳全书》又论“咳嗽一证,窃见诸家立论大繁,皆不得其要,多致后人临证莫知所从,所以治难得效”。张景岳将咳嗽证由分为外感、内伤两类。《河间六书》中又提及“寒暑燥湿风火六气,皆令人咳”。咳嗽既是病又是证候,任何年龄均可发病,冬春季节多见。咳嗽的病因有外感、内伤之别,风、寒、暑、湿、燥、火六淫之邪侵袭肺系引起的咳嗽,为外感咳嗽,外邪中又以风、寒、热咳嗽居多,并常以风为先号,挟寒或挟热、挟燥犯肺,发生风寒或风热、风燥等咳嗽;由于肺脏亏虚与其他脏腑功能失调影响到肺而引起的咳嗽,为内伤咳嗽。临床上常内伤、外感咳嗽互见并互为因果。正如《医学心语·咳嗽》所说:“肺体属金,譬若钟然,钟非叩不鸣,风寒暑湿燥火六淫之邪自外击之则鸣,劳欲情志,饮食炙煿之火自内攻之则亦鸣”。
咳嗽以八纲辨证为纲,首辨外感与内伤,以外感咳嗽多见,以宣发肺气为基本原则。汪受传将小儿外感咳嗽分为风寒和风热两大证型,韩新民将其分为风寒、风热和风燥三大证型,其中风寒咳嗽以疏风散寒、宣肺止咳为治法,以金沸草散加减; 风热咳嗽以疏散风热、宣肺止咳为治法,以桑菊饮加减; 风燥咳嗽以疏风清肺、润肺止咳为治法,以清燥救肺汤加减。钟华等则依据小儿体质辨治外感咳嗽,将其分为四型即正常质儿、痰湿质儿、气虚质儿和阴虚质儿,正常质儿以疏散外邪、宣肺止咳为治法,以杏苏散、桑菊饮及麻杏石膏汤等为主方; 痰湿质儿以健脾燥湿、化痰止咳为治法,以麻杏二陈汤为主方; 气虚质儿以疏风宣肺、化痰止咳、佐以健脾益气为治法,在风寒或风热基本方上酌情加用白术、黄芪等益气药,或六君子汤加射干、鱼腥草、连翘、桔梗等。
CN102078558A公开了一种治疗咳嗽的药物组合物,其中原料药的重量配比如下:钩藤30份,天竺黄40份,桔梗10份,砂仁50份,陈皮50份,茯苓10份,薄荷50份,甘草20份,牛黄7份。
CN101991802A公开了一种治疗感冒咳嗽的中药制剂,其含有金银花30份,陈皮30份,茵陈25份,百部35份,甘草30份,苦杏仁25份,柏子仁25份,贝母20份,桔梗30份,大枣20份,干艾叶15份及适量的蜂蜜。
氢溴酸右美沙芬是瑞士Hoffman Roche公司于1950年通过对吗啡结构改造人工合成的右旋性吗啡喃衍生物,作为异构体,其左旋性化合物有镇痛作用,右旋物即美沙芬没有镇痛作用而具有明显的镇咳作用。动物和临床研究表明,美沙芬是一种有效的中枢镇咳药,主要作用于延髓咳嗽中枢,镇咳作用与相同剂量的可待因相当,且不抑制呼吸中枢,无成瘾性,在尿中以美沙芬原形或去甲基代谢物右吗喃被排泄,其毒性低、不良反应少,因此广泛用于各种原因引起的咳嗽。
CN1565525A公开了一种中西药复方糖锭制剂,其由中药浸膏、西药、糖、香精和食用矿物油组成,其中中药浸膏为枇杷叶浸膏或草珊瑚浸膏,西药选自美沙芬溴氢酸、苯佐卡因或盐酸氨溴索。
发明内容
本发明提供了一种用于治疗咳嗽的中西药结合的药物组合物,其中由西药和中药组成,西药为氢溴酸右美沙芬,中药的原料药的重量配比如下:
半夏14份,鱼腥草9份,桃仁10份,白前7份,麻黄6份,淫羊藿12份,枸杞20份,麦冬15份,陈皮6份,五味子12份,蝉蜕8份,贝母14份,肉桂7份,黄芩3份,薄荷4份,百部8份,金银花16份,当归7份,山楂20份,车前子8份,冰片7份。
氢溴酸右美沙芬和中药的重量比例为1:40。
上述中药的制备方法为取以上原料药,放入容器中,加冷水漫过药面,浸泡15~20分钟,再加水没过药面约8厘米,进行煎煮。未沸前采用武火煎煮,沸后用文火煎煮20~30分钟;第二次煎煮,水沸后文火煎煮15~20分钟。两次煎煮去渣取汁,合并。
申请人意外地发现,氢溴酸右美沙芬和上述中药的组合物对于治疗咳嗽具有协同效果,组合物对于咳嗽的治疗效果远远好于单一的氢溴酸右美沙芬或上述中药,具有预料不到的技术效果。
具体实施方式
实施例1
药物组合物中西药为氢溴酸右美沙芬2.5克
中药的原料药的重量配比如下,共计100克:
半夏14份,鱼腥草9份,桃仁10份,白前7份,麻黄6份,淫羊藿12份,枸杞20份,麦冬15份,陈皮6份,五味子12份,蝉蜕8份,贝母14份,肉桂7份,黄芩3份,薄荷4份,百部8份,金银花16份,当归7份,山楂20份,车前子8份,冰片7份。
氢溴酸右美沙芬和中药的重量比例为1:40。
中药的制备方法为取以上原料药,放入容器中,加冷水漫过药面,浸泡15~20分钟,再加水没过药面约8厘米,进行煎煮。未沸前采用武火煎煮,沸后用文火煎煮20~30分钟;第二次煎煮,水沸后文火煎煮15~20分钟。两次煎煮去渣取汁,合并。
对照品1
氢溴酸右美沙芬
对照品2
半夏14份,鱼腥草9份,桃仁10份,白前7份,麻黄6份,淫羊藿12份,枸杞20份,麦冬15份,陈皮6份,五味子12份,蝉蜕8份,贝母14份,肉桂7份,黄芩3份,薄荷4份,百部8份,金银花16份,当归7份,山楂20份,车前子8份,冰片7份。
对照品3
CN102078558A公开的治疗咳嗽的药物组合物,其中原料药的重量配比如下:钩藤30份,天竺黄40份,桔梗10份,砂仁50份,陈皮50份,茯苓10份,薄荷50份,甘草20份,牛黄7份。
对照品4
CN1565525A公开的中西药复方糖锭制剂,其中中药浸膏为枇杷叶浸膏,西药选自美沙芬溴氢酸,二者重量比例为20:1。
实验例2:对二氧化硫烟雾致小鼠咳嗽模型的镇咳作用
将18-22 g的小鼠随机分为7组,模型对照组给予灌胃生理盐水,受试组给予灌胃实施例1和对照品1-4所述药物样品,阳性对照组给予诃子汤水提物,连续给药5天。于末次给药后30分钟,将小鼠置密闭玻璃箱内,定量喷入硫磺燃烧生成的烟雾诱导致咳,记录小鼠咳嗽潜伏期和3分钟内咳嗽次数,结果受试组实施例1平均咳嗽潜伏期均延长45秒以上、平均咳嗽次数明显减少,受试组对照品1-4平均咳嗽潜伏期均延长10秒以上、平均咳嗽次数较多,表明本发明药物样品有明显镇咳作用,优于诃子甘桔汤水提物和对照品1-4。实验结果如表1所示。
注:与模型组比较,*P<0.05,**P<0.01
实施例3临床治疗效果:
疗效标准:疗效判断主要依据为咳嗽症状是否消失。用药15天为1个疗程。具体疗效分以下三级:治愈——咳嗽症状全部消失;好转——咳嗽症状明显减轻;无效——用药1个疗程后,咳嗽症状毫无消失。
效果:用本发明药物治疗咳嗽患者44例,治疗1个疗程,其中治愈43例,好转1例,治愈率为97.7%,有效率为100%。
典型病例:
武某,男,60岁,农民。2011年9月就诊。患者自述,犯咳嗽病已有一年多。症状咳嗽气短,咽痛,舌尖红。采用本发明药物,先服10天,症状明显好转,后续服5天,痊愈。2个月追访,未见复发。
Claims (1)
1.一种药物组合物,其中由西药和中药组成,西药为氢溴酸右美沙芬,中药的原料药的重量配比如下:
半夏14份,鱼腥草9份,桃仁10份,白前7份,麻黄6份,淫羊藿12份,枸杞20份,麦冬15份,陈皮6份,五味子12份,蝉蜕8份,贝母14份,肉桂7份,黄芩3份,薄荷4份,百部8份,金银花16份,当归7份,山楂20份,车前子8份,冰片7份,
氢溴酸右美沙芬和中药的重量比例大约为1:40。
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CN104116982A (zh) * | 2014-08-01 | 2014-10-29 | 四川兴科蓉药业有限责任公司 | 含有甲砜霉素的药物组合物 |
CN104116982B (zh) * | 2014-08-01 | 2017-01-04 | 新乡医学院 | 含有甲砜霉素的药物组合物 |
CN113559070A (zh) * | 2021-08-18 | 2021-10-29 | 叶洪艳 | 一种适用于宠物咳嗽的药物制备方法 |
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