CN103432186A - Preparation method for field bindweed particle - Google Patents
Preparation method for field bindweed particle Download PDFInfo
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- CN103432186A CN103432186A CN2013103860289A CN201310386028A CN103432186A CN 103432186 A CN103432186 A CN 103432186A CN 2013103860289 A CN2013103860289 A CN 2013103860289A CN 201310386028 A CN201310386028 A CN 201310386028A CN 103432186 A CN103432186 A CN 103432186A
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- convolvuli arvensis
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Abstract
The invention belongs to the technical field of Chinese herb preparations, and particularly relates to a preparation method for a field bindweed particle. The preparation method comprises the following steps of collecting the part of the field bindweed over the ground, air-drying, and smashing to 80-120 meshes to obtain the field bindweed powder; then carrying out reflux leaching with ethyl alcohol for at least two times, then filtering while hot, removing the residues, combining the filtrate, concentrating, drying, and smashing so as to obtain the field bindweed extractive; uniformly mixing 0.2-0.5 part of field bindweed extractive, 1-8 parts of xylitol, 0.1-2.0 parts of lactose, 0.15-1.5 parts of dextrin, and 0.2-0.7 part of sodium carboxymethyl starch, sieving by a 80-mesh sieve, and granulating with 0.2-0.6 part of PVPK30 solution. The prepared field bindweed particle has good taste, is easy to absorb, is convenient to take, has no side effects of the western medicines, is beneficial to the spleen, stomach and kidney, and is suitable for hypertensive patients who take the medicine for a long term.
Description
technical field
The invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind of preparation method of Herba seu Flos Convolvuli arvensis granule.
background technology
Herba seu Flos Convolvuli arvensis belongs to the Convolvulaceae Flos Calystegiae sepii and belongs to, perennial voluble herb plant, and in 5～July of florescence, very drought-enduring cold-resistant, resistance is very good, often is born in farmland and wasteland, all fine in very arid place growth.The Herba seu Flos Convolvuli arvensis another name draws aster, open country to lead a cow, climing, the bent joint rattan of car, Chinese Flos Calystegiae sepii etc., and herb summer, autumn gather or cutting is dried, simple and easy to get.
Record Herba seu Flos Convolvuli arvensis in " China's book on Chinese herbal medicine ", acrid in the mouth, warm in nature, poisonous, return kidney channel, function cures mainly, dispelling wind for relieving itching, pain relieving, main air pain of dampness syndrome, toothache, neurodermatitis.But bright grass is toxic, searches for food in a large number and may cause dysentery.Herb is containing Beta-methyl hippocastanum leather element; Aerial parts is containing flavonoid glycoside, and glycoside unit is Quercetin, nimbecetin, normal alkane, n-alkanol, α-Amyrin, campesterol, stigmasterol and cupreol; Under ground portion is containing caffeic acid, Cuscohygrine.The pure extractum of its aerial parts, can make anesthetized cat blood pressure drops 25-50%, continues 1 hour, and decompression principle is to flesh, expands in vitro rabbit ear blood vessel, makes heart rate slack-off.Pituitrin is caused to hypertensive rabbit, and intravenous injection alcohol extractum, can make blood pressure recover normal.With it anesthetized cat (coronary sinus method), can increase coronary flow 33%.From the total alkaloids wherein raised, hypotensive effect is arranged equally, but on coronary flow without impact.The herb hyoscine, have the effect of regulating menstruation blood, invigorating spleen and reinforcing stomach, diuresis.Above record explanation Herba seu Flos Convolvuli arvensis has hypotensive activity preferably, and because it belongs to natural plant composition, the property of medicine is mild, and invigorating spleen and reinforcing stomach, is attributed to kidney channel, and suitable hyperpietic's long-term taking is without any side effects.Still the related preparations that the Herba seu Flos Convolvuli arvensis of not take in the market is principal agent.
summary of the invention
The object of the present invention is to provide a kind of preparation method for the treatment of hypertensive Herba seu Flos Convolvuli arvensis granule.
The present invention is by the following technical solutions:
A kind of preparation method of Herba seu Flos Convolvuli arvensis granule comprises the following steps: gather 5-7 month Herba seu Flos Convolvuli arvensis aerial parts, dry, be crushed to the 80-120 order and obtain the Herba seu Flos Convolvuli arvensis powder; Then with the ethanol lixiviate at least twice that refluxed, filtered while hot after lixiviate, remove filtering residue, filtrate merges, concentrated, dry, pulverize to obtain the Herba seu Flos Convolvuli arvensis extract; 0.2 ~ 0.5 part of Herba seu Flos Convolvuli arvensis extract and 1 ~ 8 part of xylitol, 0.1 ~ 2.0 part of lactose, 0.15 ~ 1.5 part of dextrin, 0.2 ~ 0.7 part of Sodium Hydroxymethyl Stalcs were mixed to 80 mesh sieves, with 0.2 ~ 0.6 part of PVP K30 solution (mass concentration 10-15%), granulate and get final product.
During each lixiviate, the ethanol volumetric concentration is 50 ~ 80%, and extraction time is 3 ~ 24 hours, and the feed liquid mass ratio is Herba seu Flos Convolvuli arvensis: ethanol=1:8 ~ 35.
When concentrated, temperature is below 40 ℃, controls temperature when dry below 40 ℃ or spray drying.
The present invention has extracted the effective ingredient in the Herba seu Flos Convolvuli arvensis, make a kind of Chinese medicine sugar-free granular preparation of maturation, be used for the treatment of hypertension, consider that the hyperpietic mostly is the old people, be not suitable for Excessive Intake sugar part, Sugarless type is more suitable for the old people, facilitates the hyperpietic to take, the side effects of having avoided the Western medicine long-term taking to bring.
The raw materials used Herba seu Flos Convolvuli arvensis of the present invention is easily collected, low price, and drug effect is proved, the quality standard research analysis of existing relevant medical material at present, just not yet make Chinese medicine preparation, and decoct and to take comparatively trouble, can not take full advantage of antihypertensive compositions, mouthfeel of the present invention is better, easily absorb, conveniently take, and without the side effect of Western medicine, useful taste and kidney, be applicable to the hyperpietic of long-term prescription.
the specific embodiment
Embodiment 1
The preparation method of Herba seu Flos Convolvuli arvensis granule: the medical material of getting the Herba seu Flos Convolvuli arvensis aerial parts dries, is crushed to 80 orders, then with the lixiviate 2 times that refluxed of 75% ethanol, each ethanol consumption is 10 times of Herba seu Flos Convolvuli arvensis quality, each 6h, filtered while hot after lixiviate, remove filtering residue, the Herba seu Flos Convolvuli arvensis extract is pulverized and obtained to the merging filtrate concentrate drying.Herba seu Flos Convolvuli arvensis extract 0.2kg and xylitol 1.5kg, lactose 0.1kg, dextrin 0.15kg, Sodium Hydroxymethyl Stalcs 0.3kg were mixed to 80 mesh sieves, with mass concentration 15% PVP K30 solution 0.2kg, granulate and get final product.
Embodiment 2
The preparation method of Herba seu Flos Convolvuli arvensis granule: the medical material of getting the Herba seu Flos Convolvuli arvensis aerial parts dries, is crushed to 100 orders, then with the lixiviate 2 times that refluxed of 70% ethanol, each ethanol consumption is 8 times of Herba seu Flos Convolvuli arvensis quality, each 12h, filtered while hot after lixiviate, remove filtering residue, the Herba seu Flos Convolvuli arvensis extract is pulverized and obtained to the merging filtrate concentrate drying.The Herba seu Flos Convolvuli arvensis extract 0.5kg of preparation and xylitol 2kg, lactose 0.15kg, dextrin 0.2kg, Sodium Hydroxymethyl Stalcs 0.7kg were mixed to 80 mesh sieves, with mass concentration 12% PVP K30 solution 0.6kg, granulate and get final product.
Embodiment 3
The preparation method of Herba seu Flos Convolvuli arvensis granule: the medical material of getting the Herba seu Flos Convolvuli arvensis aerial parts dries, is crushed to 120 orders, then with the lixiviate 2 times that refluxed of 80% ethanol, each ethanol consumption is 15 times of Herba seu Flos Convolvuli arvensis quality, each 3h, filtered while hot after lixiviate, remove filtering residue, the Herba seu Flos Convolvuli arvensis extract is pulverized and obtained to the merging filtrate concentrate drying.The Herba seu Flos Convolvuli arvensis extract 0.3kg of preparation and xylitol 1kg, lactose 0.15kg, dextrin 0.15kg, Sodium Hydroxymethyl Stalcs 0.4kg were mixed to 80 mesh sieves, with mass concentration 10% PVP K30 solution 0.4kg solution, granulate and get final product.
Usage of the present invention is oral, consumption: 5 grams, and a twice-daily, or follow the doctor's advice and cut down according to the circumstance by the state of an illness.
Clinical therapeutic efficacy:
Criterion of therapeutical effect: a kind ofly treat hypertensive sugar-free Herba seu Flos Convolvuli arvensis granule, judge that whether Main Basis hyperpietic blood pressure is normally stable.Medication 2 months is a course for the treatment of.Concrete curative effect is divided three grades: healings-hyperpietic blood pressure maintains normally, improvement-hyperpietic's blood pressure drops, and after invalid-one of medication course for the treatment of, blood pressure is less than decline.
Effect: by hypertension therapy patient's 20 examples of the present invention, treat a course for the treatment of, wherein cure 17 examples, 3 examples that take a turn for the better, cure rate is 85%, effective percentage is 100%.
Model case:
Case 1:
Lee, man, 58 years old.
Suffer from hypertension for many years, headache, insomnia, dreaminess etc.Ate a lot of depressor, unstable blood pressure, when medical, blood pressure, still at 120-170mmHg, gives the present embodiment 1, after one month, blood pressure is down to 100-135mmHg, within 2 months, is down to 80-120mmHg, the head do not ached, the length of one's sleep every day 7-8 hour, after half a year, with examining, adhere to taking, blood pressure maintains normal level.
Case 2:
Remaining certain, female, 55 years old.
Weak and sickly at ordinary times, need eat hypertension pill every day and maintain blood pressure and do not increase, at ordinary times diet seldom, the neurasthenia, often insomnia, hypertension reaches 130-180mmHg, give this enforcements after 2,20 days blood pressure drop to 100-160mmHg, sleep is perfume especially also, health is hale and hearty gradually.
Case 3:
Season, man, 65 years old.
Suffer from hypertension 6 years; blood pressure 120-150mmHg, lean on FUFANG JIANGYA PIAN at ordinary times, and the Niuhuang Jiangya sheet maintains; frequent Light-headedness; give the present embodiment 3, one and a half months fluctuation of blood pressure decline, after 50 days, blood pressure is steady; remain on 90-120mmHg; brains is salubrious, and blood pressure is normally stable now, without other side effect.
Claims (3)
1. the preparation method of a Herba seu Flos Convolvuli arvensis granule, is characterized in that, comprises the following steps: gather the Herba seu Flos Convolvuli arvensis aerial parts, dry, be crushed to the 80-120 order and obtain the Herba seu Flos Convolvuli arvensis powder; Then with the ethanol lixiviate at least twice that refluxed, filtered while hot after lixiviate, remove filtering residue, filtrate merges, concentrated, dry, pulverize to obtain the Herba seu Flos Convolvuli arvensis extract; 0.2 ~ 0.5 part of Herba seu Flos Convolvuli arvensis extract and 1 ~ 8 part of xylitol, 0.1 ~ 2.0 part of lactose, 0.15 ~ 1.5 part of dextrin, 0.2 ~ 0.7 part of Sodium Hydroxymethyl Stalcs were mixed to 80 mesh sieves, with 0.2 ~ 0.6 part of PVP K30 solution, granulate and get final product.
2. the preparation method of Herba seu Flos Convolvuli arvensis granule according to claim 1 is characterized in that: during each lixiviate, the ethanol volumetric concentration is 50 ~ 80%, and extraction time is 3 ~ 24 hours, and the feed liquid mass ratio is Herba seu Flos Convolvuli arvensis: ethanol=1:8 ~ 35.
3. the preparation method of Herba seu Flos Convolvuli arvensis granule according to claim 1 and 2, is characterized in that when concentrated that temperature is below 40 ℃, controls temperature when dry below 40 ℃ or spray drying.
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| CN201310386028.9A CN103432186B (en) | 2013-08-30 | 2013-08-30 | A kind of preparation method of Herba seu Flos Convolvuli arvensis granule |
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| CN201310386028.9A CN103432186B (en) | 2013-08-30 | 2013-08-30 | A kind of preparation method of Herba seu Flos Convolvuli arvensis granule |
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| CN103432186A true CN103432186A (en) | 2013-12-11 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018099493A1 (en) * | 2016-11-29 | 2018-06-07 | 广东大鹏医药科技有限公司 | Tropaeolum majus granules and preparation method therefor |
| CN108478619A (en) * | 2018-03-23 | 2018-09-04 | 南通大学 | Total Resin glycoside extract of field bindweed and preparation method thereof and medical usage |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1338941A (en) * | 1999-02-16 | 2002-03-06 | 人机能改善中心国际有限公司 | High molecular weight extracts of 1 (convolvulus arvensis) (field bindweed) |
-
2013
- 2013-08-30 CN CN201310386028.9A patent/CN103432186B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1338941A (en) * | 1999-02-16 | 2002-03-06 | 人机能改善中心国际有限公司 | High molecular weight extracts of 1 (convolvulus arvensis) (field bindweed) |
Non-Patent Citations (1)
| Title |
|---|
| 江苏新医学院: "《中药大辞典 上册》", 31 July 1977, article "田旋花" * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018099493A1 (en) * | 2016-11-29 | 2018-06-07 | 广东大鹏医药科技有限公司 | Tropaeolum majus granules and preparation method therefor |
| CN108478619A (en) * | 2018-03-23 | 2018-09-04 | 南通大学 | Total Resin glycoside extract of field bindweed and preparation method thereof and medical usage |
| CN108478619B (en) * | 2018-03-23 | 2021-05-07 | 南通大学 | Convolvulus arvensis total resin glucoside extract, preparation method and medical application thereof |
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| CN103432186B (en) | 2015-08-12 |
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Address after: 462000 No. 6 Renmin Middle Road, Zhengzhou, Henan, Xinzheng Applicant after: Suicheng Pharmaceutical Co., Ltd. Address before: 462000 No. 6 Renmin Middle Road, Zhengzhou, Henan, Xinzheng Applicant before: Tianjin Pharmaceutical Group Xinzheng Co., Ltd. |
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Free format text: CORRECT: APPLICANT; FROM: TIANJIN PHARMACEUTICAL GROUP XINZHENG CO., LTD. TO: SUICHENG PHARMACEUTICAL CO., LTD. |
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