CN103432106B - Bacteriostatic skin ointment and preparation method - Google Patents
Bacteriostatic skin ointment and preparation method Download PDFInfo
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- CN103432106B CN103432106B CN201310338452.6A CN201310338452A CN103432106B CN 103432106 B CN103432106 B CN 103432106B CN 201310338452 A CN201310338452 A CN 201310338452A CN 103432106 B CN103432106 B CN 103432106B
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Abstract
The invention relates to a bacteriostatic skin ointment which comprises the following components in parts by mass: 14-24 parts of cetearyl alcohol, 3-7 parts of vaseline, 3-7 parts of liquid paraffin, 17-23 parts of borneol fenchol, 4.5-8.5 parts of glycerol, 1.5-2.1 parts of lauryl sodium sulfate, 0.08-0.12 parts of ethylparaben, and 100 parts of water. A preparation method comprises the steps of placing cetearyl alcohol, the vaseline, the liquid paraffin and borneol fenchol in a container, conducting a water bath at 74 DEG C, heating, melting, keeping the constant temperature for 0.5h, placing sodium lauryl sulfate, glycerol and the distilled water in another container, heating to 73 DEG C, mixing an oil phase, heating in the water bath to 60-80 DEG C, mixing, heating to 60-80 DEG C, adding ethylparaben, dissolving, adding an aqueous phase solution to an oil phase solution slowly, and continuously stirring till the skin ointment is formed. The skin ointment is hormone-free and good in itch relieving effect, and a preparation technology is simple, easy to popularize and low in cost.
Description
Technical field
The present invention relates to a kind of skin bacteria inhibitor---skin ointments being principal agent with oxalic acid borneol acetate saponification resultant Borneolum Syntheticum fenchol.The invention still further relates to the preparation method of described skin ointments.
Background technology
Antibacterial for skin has a large amount of documents and patent report, and the medicine of existing listing, and such as oxychloroquine, dapsone and reaction such as to stop at the new selection that old medicine all can be used as skin bacteria inhibitor, have also been obtained concern and the research of a lot of researcher.Application number is that the application for a patent for invention of CN200510106633.1 provides one and is used for the treatment of dermopathic medical stone emulsifiable paste and preparation method thereof; Application number is that the patent of invention of CN200810072492.X provides that a kind of what derive from plant is main antibacterial with Aloe, Radix Arnebiae (Radix Lithospermi), Margarita powder, Nidus Vespae, medicine oil and substrate etc.Antibacterial cream-the husband of example skin of drug combination and health, Bei Meikang, miconazole nitrate etc. are all widely used clinically.But, most antibacterial of present report is all synergy, and namely two or several principal agent drug combination, relatively make complexity, cost is high and side effect is large, it is not a lot of for being modified to main single principal agent skin bacteria inhibitor with Chinese herbal medicine monomer, just less appears in the newspapers for ointment.
Oxalic acid borneol acetate is a kind of monomer that australene and anhydrous oxalic acid are obtained by reacting under catalyst action, and its saponification resultant Borneolum Syntheticum fenchol has well antibacterial, anti-infection effect.The vertical more ointment for treating hemorrhoid (hemorrhoid medicine dedicated) of the medicine being principal agent with Borneolum Syntheticum anise alcohol and Borneolum Syntheticum can anti-bacteria infect, prevent scorching become swell and ache, promote crissum blood circulation, recover anus muscular function, anti-inguinal bubo infects and the scorching generation etc. becoming anal fistula, internal hemorrhoid external hemorrhoid mixed hemorrhoid anal fissure constipation be widely used in preoperative and postoperative and the scorching degeneration treatment of swelling and ache.Theoretical basis has been established in the research that it is also the various antibacterial of master for further research excavation Borneolum Syntheticum anise alcohol that the exploitation of vertical ointment for treating hemorrhoid of healing is gone on the market.
Summary of the invention
First technical problem to be solved by this invention, is just to provide a kind of for antibacterial skin ointments.
Second technical problem to be solved by this invention, is just to provide the preparation method of above-mentioned skin ointments.
The skin ointments adopting preparation method of the present invention to prepare, makes simple cost low, and not containing hormone, side effect is little and antipruritic effect is good.
Solve above-mentioned first technical problem, the technical solution used in the present invention is:
For an antibacterial skin ointments, it is characterized in that: be made up of following component and mass percent:
Cetostearyl alcohol 14 ~ 24
Vaseline 3 ~ 7
Liquid paraffin 3 ~ 7
Borneolum Syntheticum fenchol 17 ~ 23
Glycerol 4.5 ~ 8.5
Sodium lauryl sulphate 1.5 ~ 2.1
Ethyl hydroxybenzoate 0.08 ~ 0.12
Distilled water adds to 100.
Principal agent Borneolum Syntheticum fenchol preparation method of the present invention is as follows:
Getting oxalic acid borneol acetate 362 g puts in beaker, add 400 mL20 %NaOH solution under agitation gradually, stir post-heating to 60 DEG C water-bath 1 h, after saponification completes, first add appropriate distilled water washing twice, progressively add alkali in 20 % dilute hydrochloric acid He unnecessary again, until pH value 6-7, impurity is removed in finally washing.
The preparation method of above-mentioned skin ointments is as follows:
Get oil-phase component cetostearyl alcohol, vaseline, liquid paraffin, Borneolum Syntheticum fenchol put in container, water-bath 74 DEG C of heating and melting, keep steady temperature 0.5 h; Water intaking phase constituent sodium lauryl sulphate, glycerol, distilled water put another vessel in heating to steady temperature 73 DEG C; Heating in water bath to 60-80 DEG C after oil phase mixing, aqueous phase mixing post-heating to 60-80 DEG C; Adding ethyl hydroxybenzoate is added to inside aqueous phase, is slowly added in oil phase liquid by aqueous phase liquid after dissolving, is constantly stirred to sizing and get final product.
Skin ointments of the present invention is external skin ointment, its using method be get that appropriate this product dab is smeared according to skin symptom, wiping in affected part, every day 1 ~ 2 time.
Beneficial effect: the present invention obtains one not containing hormone, antipruritic effect well with Borneolum Syntheticum anise alcohol for principal agent design, has the skin ointments of good bacteriostasis.Compared with other existing similar skin preparation, due to the present invention with the medicine gone on the market for principal agent, lower Side effect has theoretical foundation; In addition, in addition substrate and oil phase be made into ointment can overcome the clever ointment of existing micro-painting can only for the shortcoming of hemorrhoid, the present invention is containing any hormone, and antipruritic effect can use popularization well on larger skin.In aqueous phase, sodium lauryl sulphate, glycerol etc. are all good skin attachment agent, maintenance drug effect long-acting while can lubricating moisturizing again.Further, this present invention is simple, easily promote, and cost is low, has good economic benefit and social benefit.
Detailed description of the invention
Embodiment one
The preparation of oxalic acid borneol acetate saponification resultant Borneolum Syntheticum fenchol
Getting oxalic acid borneol acetate 362 g puts in beaker, add 20 %NaOH solution 400 mL under agitation gradually, after stirring, at 60 DEG C of water-bath 1 h, after saponification completes, first add appropriate distilled water and carry out washing twice, more progressively add dilute hydrochloric acid (concentrated hydrochloric acid: water=1:5) and neutralize unnecessary alkali to neutral, washing removes impurity, until pH value 6-7 again.
The preparation of skin ointments, component and quality proportioning are:
Cetostearyl alcohol 19.0
Vaseline 5.0
Liquid paraffin 5.0
Borneolum Syntheticum fenchol 20.0
Glycerol 6.5
Sodium lauryl sulphate 1.8
Ethyl hydroxybenzoate 0.1
Distilled water adds to 100.0.
Get oil-phase component cetostearyl alcohol, vaseline, liquid paraffin, Borneolum Syntheticum fenchol put in container, water-bath 60-80 DEG C of heating and melting, keep steady temperature 10 min; Water intaking phase constituent sodium lauryl sulphate, glycerol, distilled water put another vessel in heating to steady temperature 60-80 DEG C, keep steady temperature 10 min; Add inside ethyl hydroxybenzoate aqueous phase, after dissolving, aqueous phase liquid is slowly added in oil phase liquid, be constantly stirred to sizing and get final product.
Embodiment two
The preparation of oxalic acid borneol acetate saponification resultant Borneolum Syntheticum fenchol is with embodiment one.
The preparation of skin ointments, component and quality proportioning are:
Cetostearyl alcohol 24.0
Vaseline 7.0
Liquid paraffin 7.0
Borneolum Syntheticum fenchol 23.0
Glycerol 8.5
Sodium lauryl sulphate 2.1
Ethyl hydroxybenzoate 0.12
Distilled water adds to 100.
Get oil-phase component cetostearyl alcohol, vaseline, liquid paraffin, Borneolum Syntheticum fenchol put in container, heating in water bath melts, and keeps 80 DEG C, maintenance steady temperature 5 min; Water intaking phase constituent sodium lauryl sulphate, glycerol, distilled water keep steady temperature 5min, add ethyl hydroxybenzoate, slowly added in oil phase liquid by aqueous phase liquid after dissolving, be constantly stirred to sizing and get final product about putting another vessel in heating to 80 DEG C.
Embodiment three
The preparation of oxalic acid borneol acetate saponification resultant Borneolum Syntheticum fenchol is with embodiment one.
The preparation of skin ointments, component and quality proportioning are:
Cetostearyl alcohol 14.0
Vaseline 3.0
Liquid paraffin 3.0
Borneolum Syntheticum fenchol 17.0
Glycerol 4.50
Sodium lauryl sulphate 1.5
Ethyl hydroxybenzoate 0.08
Distilled water adds to 100.
Get oil-phase component cetostearyl alcohol, vaseline, liquid paraffin, Borneolum Syntheticum fenchol put in container, heating in water bath melts, and keeps 60 DEG C, maintenance steady temperature 10 min; Water intaking phase constituent sodium lauryl sulphate, glycerol, distilled water keep steady temperature 10 min, add ethyl hydroxybenzoate, slowly added in oil phase liquid by aqueous phase liquid after dissolving, be constantly stirred to sizing and get final product about putting another vessel in heating to 60 DEG C.
Claims (4)
1. for an antibacterial skin ointments, it is characterized in that: be made up of following component and mass percent:
Cetostearyl alcohol 14 ~ 24
Vaseline 3 ~ 7
Liquid paraffin 3 ~ 7
Borneolum Syntheticum fenchol 17 ~ 23
Glycerol 4.5 ~ 8.5
Sodium lauryl sulphate 1.5 ~ 2.1
Ethyl hydroxybenzoate 0.08 ~ 0.12
Distilled water adds to 100;
The preparation method of described principal agent Borneolum Syntheticum fenchol is: get oxalic acid borneol acetate 362 g and put in beaker, add 400 mL20 %NaOH solution under agitation gradually, stir post-heating to 60 DEG C water-bath 1 h, after saponification completes, first add appropriate distilled water washing twice, progressively add alkali in 20 % dilute hydrochloric acid He unnecessary again, until pH value 6-7, impurity is removed in finally washing.
2. according to claim 1 for antibacterial skin ointments, it is characterized in that: be made up of following component and mass percent:
Cetostearyl alcohol 19.0
Vaseline 5.0
Liquid paraffin 5.0
Borneolum Syntheticum fenchol 20.0
Glycerol 6.5
Sodium lauryl sulphate 1.8
Ethyl hydroxybenzoate 0.1
Distilled water adds to 100.
3., as claimed in claim 1 or 2 for a preparation method for antibacterial skin ointments, comprise the following steps:
Get oil-phase component cetostearyl alcohol, vaseline, liquid paraffin, Borneolum Syntheticum fenchol put in container, water-bath 60-80 DEG C of heating and melting, keep steady temperature 5-15 min; Water intaking phase constituent sodium lauryl sulphate, glycerol, distilled water put another vessel in heating to steady temperature 60-80 DEG C, keep steady temperature 5-15 min; Add inside ethyl hydroxybenzoate aqueous phase, after dissolving, aqueous phase liquid is slowly added in oil phase liquid, be constantly stirred to sizing and get final product.
4. preparation method according to claim 3, is characterized in that:
Described oil phase bath temperature is 74 DEG C, keeps 10 min, and described aqueous phase bath temperature is 73 DEG C, keeps 10 min.
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| CN201310338452.6A CN103432106B (en) | 2013-08-06 | 2013-08-06 | Bacteriostatic skin ointment and preparation method |
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| CN201310338452.6A CN103432106B (en) | 2013-08-06 | 2013-08-06 | Bacteriostatic skin ointment and preparation method |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1165013A (en) * | 1997-03-13 | 1997-11-19 | 常子元 | Bornyl alcohol hemorrhoid ointment |
| CN101401783A (en) * | 2007-09-16 | 2009-04-08 | 杨喜鸿 | Percutaneous absorption agent containing Ailamode, preparation method and medical uses thereof |
| CN102241567A (en) * | 2011-04-29 | 2011-11-16 | 南宁辰康生物科技有限公司 | One-step method for synthesizing fenchol with turpentine |
-
2013
- 2013-08-06 CN CN201310338452.6A patent/CN103432106B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1165013A (en) * | 1997-03-13 | 1997-11-19 | 常子元 | Bornyl alcohol hemorrhoid ointment |
| CN101401783A (en) * | 2007-09-16 | 2009-04-08 | 杨喜鸿 | Percutaneous absorption agent containing Ailamode, preparation method and medical uses thereof |
| CN102241567A (en) * | 2011-04-29 | 2011-11-16 | 南宁辰康生物科技有限公司 | One-step method for synthesizing fenchol with turpentine |
Non-Patent Citations (3)
| Title |
|---|
| Screening of antibacterial activities of twenty-one oxygenated monoterpnes;Kotan R et al.;《 Z Natruforsch C.》;20070831;第62卷(第7-8期);摘要 * |
| 合成正龙脑的研制;李世新等;《林产化学与工业》;19841231(第4期);10-19 * |
| 吴世敏.葑醇.《简明精细化工大辞典》.1996,745. * |
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