CN103415503B - 1-氨基-3-羟基-环丁烷-1-甲酸衍生物的制备 - Google Patents

1-氨基-3-羟基-环丁烷-1-甲酸衍生物的制备 Download PDF

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Publication number
CN103415503B
CN103415503B CN201280012007.4A CN201280012007A CN103415503B CN 103415503 B CN103415503 B CN 103415503B CN 201280012007 A CN201280012007 A CN 201280012007A CN 103415503 B CN103415503 B CN 103415503B
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China
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compound
palladium
amino
preparation
acid
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Chinese (zh)
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CN103415503A (zh
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S.M.费尔韦
M.罗兰斯加德
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GE Healthcare Ltd
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GE Healthcare Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0404Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CN201280012007.4A 2011-03-08 2012-03-07 1-氨基-3-羟基-环丁烷-1-甲酸衍生物的制备 Active CN103415503B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161450177P 2011-03-08 2011-03-08
US61/450,177 2011-03-08
US61/450177 2011-03-08
PCT/EP2012/053867 WO2012120025A1 (en) 2011-03-08 2012-03-07 Preparation of a 1-amino-3-hydroxy-cyclobutane-1-carboxylic acid derivative

Publications (2)

Publication Number Publication Date
CN103415503A CN103415503A (zh) 2013-11-27
CN103415503B true CN103415503B (zh) 2015-09-16

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CN201280012007.4A Active CN103415503B (zh) 2011-03-08 2012-03-07 1-氨基-3-羟基-环丁烷-1-甲酸衍生物的制备

Country Status (14)

Country Link
US (1) US9242924B2 (enExample)
EP (1) EP2683684B1 (enExample)
JP (1) JP5938422B2 (enExample)
KR (1) KR101904565B1 (enExample)
CN (1) CN103415503B (enExample)
AU (1) AU2012224634B2 (enExample)
BR (1) BR112013020627B1 (enExample)
CA (1) CA2828975C (enExample)
DK (1) DK2683684T3 (enExample)
ES (1) ES2657894T3 (enExample)
MX (1) MX341089B (enExample)
NO (1) NO2683684T3 (enExample)
RU (1) RU2596829C2 (enExample)
WO (1) WO2012120025A1 (enExample)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4314700A (en) 1999-04-28 2000-11-17 Banyu Pharmaceutical Co., Ltd. Processes for the preparation of piperidylmethylpyridine derivatives
JP4744163B2 (ja) * 2005-02-28 2011-08-10 広栄化学工業株式会社 ビピリジン類の製造方法
TW200736203A (en) * 2005-11-18 2007-10-01 Glaxo Group Ltd New pleuromutilin derivative and its use
CA2629227C (en) 2005-11-29 2014-02-25 Nihon Medi-Physics Co., Ltd. Precursor compound of radioactive halogen-labeled organic compound
JP5518337B2 (ja) * 2006-12-27 2014-06-11 日本メジフィジックス株式会社 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法
MX2010010012A (es) 2008-03-11 2010-10-20 Incyte Corp Derivados de azetidina y ciclobutano como inhibidores de jak.
JP5718233B2 (ja) 2008-10-20 2015-05-13 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ 甲状腺刺激ホルモン受容体(tshr)の低分子量アゴニスト
JP2012532834A (ja) 2009-07-11 2012-12-20 バイエル ファーマ アクチエンゲゼルシャフト シクロアルキル基を用いる放射性標識方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Highly Efficient and Diastereoselective Synthesis of (+)-Lineatin;Ramon Alibes et al.;《Organic letters》;20040406;第6卷(第9期);1449-1452 *
Synthesis of [F-18]-1-amino-3-fluorocyclobutane-1- carboxylic acid (facbc): a pet tracer for tumor delineation;Timothy M. Shoup et al.;《 Journal of labeled compounds and radiopharmaceuticals》;19991231;第42卷;215-225 *

Also Published As

Publication number Publication date
EP2683684A1 (en) 2014-01-15
CA2828975A1 (en) 2012-09-13
US9242924B2 (en) 2016-01-26
BR112013020627B1 (pt) 2019-12-03
WO2012120025A1 (en) 2012-09-13
MX2013010254A (es) 2013-11-18
DK2683684T3 (en) 2018-02-05
NO2683684T3 (enExample) 2018-06-02
JP2014514268A (ja) 2014-06-19
KR20140049975A (ko) 2014-04-28
CA2828975C (en) 2019-07-09
BR112013020627A2 (pt) 2016-10-04
RU2013139061A (ru) 2015-04-20
US20130345468A1 (en) 2013-12-26
AU2012224634B2 (en) 2016-09-08
ES2657894T3 (es) 2018-03-07
MX341089B (es) 2016-08-08
EP2683684B1 (en) 2018-01-03
CN103415503A (zh) 2013-11-27
JP5938422B2 (ja) 2016-06-22
KR101904565B1 (ko) 2018-10-04
RU2596829C2 (ru) 2016-09-10

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