CN103394382A - Microfluidic chip with optical filtering characteristics - Google Patents
Microfluidic chip with optical filtering characteristics Download PDFInfo
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- CN103394382A CN103394382A CN201310341537XA CN201310341537A CN103394382A CN 103394382 A CN103394382 A CN 103394382A CN 201310341537X A CN201310341537X A CN 201310341537XA CN 201310341537 A CN201310341537 A CN 201310341537A CN 103394382 A CN103394382 A CN 103394382A
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Abstract
The invention provides a microfluidic chip with optical filtering characteristics. According to the invention, microfluidic chip processing is directly carried out with a high-molecular polymer material with optical filtering characteristics, such that a novel microfluidic chip with optical filtering characteristics is prepared. The microfluidic chip is especially suitable for a microfluidic chip optical detection system.
Description
Technical field
The present invention relates to the micro-fluidic chip field, particularly relate to a kind of micro-fluidic chip with light-filtering characteristic.
Background technology
Optical detection is the most popular detection method in micro-fluidic chip field, and for example fluoroscopic examination, absorbance detection etc. have very extensive and important application in fields such as chemical analysis, bioanalysis, medical science detections.But present micro-fluidic optical detects often needs to possess high-precision optical system, mainly comprises various types of optical lenses, and is equipped with high-precision photoelectric sensor and detects., if some optics can be integrated on micro-fluidic chip such as devices such as optical filters, will greatly reduce light path design, volume and the cost of detecting instrument.Especially,, if filtering device directly can be processed as the material of micro-fluidic chip a part that is prepared in micro-fluidic chip integral body, no matter be on the use aspect, or on the production aspect, has important practical significance.
Summary of the invention
The present invention proposes a kind of micro-fluidic chip with light-filtering characteristic, directly use the macromolecule polymer material with light-filtering characteristic to carry out the processing of micro-fluidic chip, thereby prepare a kind of novel, micro-fluidic chip that have light-filtering characteristic, be particularly suitable for the Systems for optical inspection of micro-fluidic chip.
In order to realize above-mentioned target, the present invention proposes a kind of micro-fluidic chip with light-filtering characteristic, it is characterized in that this micro-fluidic chip is to be formed by cover plate layer, fluid channel layer and basalis bonding.Having one deck in described cover plate layer, fluid channel layer and basalis at least is to be processed by the macromolecule polymer material with light-filtering characteristic.
The invention provides a kind of micro-fluidic chip with light-filtering characteristic, it is characterized in that, described macromolecule polymer material with light-filtering characteristic comprises dimethyl silicone polymer (PDMS), polymethyl methacrylate (PMMA), Merlon (PC), polyethylene (PE), polyvinyl chloride (PVC), polystyrene (PS) etc., and the material internal doping has pigment or the dyestuff of light-filtering characteristic.
The invention provides a kind of micro-fluidic chip with light-filtering characteristic, it is characterized in that, described light-filtering characteristic comprises cut-off type, band flow-through, complete shading type.
The invention provides a kind of micro-fluidic chip with light-filtering characteristic, it is characterized in that, described doping method comprises the pressed powder of pigment or dyestuff or solution, joins in the liquid phase macromolecule polymer material, and curing molding forms.Described curing molding can be that the polymer cure under the high temperature melt state forms, and can be also to solidify and form after the solvent evaporates that will be dissolved with in the solution of polymer, can be also to impel after the monomer solution polymerization reaction take place of polymer to solidify to form.
The invention provides a kind of micro-fluidic chip with light-filtering characteristic, it is characterized in that, described microfluidic channel layer is processed with the structures such as microchannel, use existing micro-processing method to process, comprise wet etching, dry etching, laser ablation, lathe processing, mould heat pressure, mold injection etc.
The invention provides a kind of micro-fluidic chip with light-filtering characteristic, it is characterized in that, described bonding can be one or more the combination in the auxiliary bonding of thermocompression bonding, surface activation process, the auxiliary bonding of solvent, laser weld bonding, ultrasonic bonding bonding, sticking double faced adhesive tape bonding.
Use micro-fluidic chip provided by the invention, the device that can greatly simplify the micro-fluidic optical detection system forms, and macromolecule polymer material material cost and processing cost with light-filtering characteristic are very cheap, can be used for mass production, therefore be particularly suitable for production and the popularization of disposable micro-fluidic chip.
Description of drawings
Fig. 1. a kind of micro-fluidic chip with light-filtering characteristic provided by the invention.Wherein, A is the cover plate layer with light-filtering characteristic; B is the fluid channel layer with light-filtering characteristic; C is the basalis with light-filtering characteristic; D is microfluidic channel.
Fig. 2. a kind of cover plate provided by the invention has the micro-fluidic chip of light-filtering characteristic.Wherein, A is the cover plate layer with light-filtering characteristic, and B is the transparent substrates layer that is processed with microfluidic channel; C is microchannel.
Specific embodiments
The following examples are further described the present invention in connection with Figure of description.
1 one kinds of embodiment have PDMS micro-fluidic chip of light-filtering characteristic and preparation method thereof
As shown in Figure 1, cover plate layer A, fluid channel layer B and basalis C form by PDMS for a kind of PDMS micro-fluidic chip with light-filtering characteristic, structure.Its preparation process is as follows: at first, red ink and PDMS performed polymer (containing 90% monomer, 10% initator) are fully mixed by the volume ratio of 1: 10, stir, vacuum eliminates bubble; Use sol evenning machine to be spin-coated on three smooth smooth teflon substrates mixed liquor, thickness is 100～500 microns; After this substrate is placed in 90 ℃ of baking oven heating 1h, take out, film is peeled off from substrate, obtain three PDMS substrates with light-filtering characteristic; Use CO
2Laser engraving equipment cuts respectively and obtains cover plate layer, fluid channel layer and basalis, and the through hole of further processing hollow out on the cover plate layer is as the flow injecting mouth, in the fluid passage of fluid channel layer processing hollow out; Use finally oxygen plasma to carry out surface bombardment activation processing to three substrates, will fit after three layers of aligning, realize whole PDMS micro-fluidic chip with light-filtering characteristic.
2 one kinds of cover plate layers of embodiment have PDMS micro-fluidic chip of light-filtering characteristic and preparation method thereof
A kind of cover plate layer has the PDMS micro-fluidic chip of light-filtering characteristic, and as shown in Figure 2, cover plate layer A, fluid channel layer B and basalis C form by PDMS structure.Its preparation process is as follows: at first, get two beakers, one of them is equipped with monomer: the PDMS performed polymer of initator=10: 1, another fully mixes red ink and PDMS performed polymer (containing 90% monomer, 10% initator) by the volume ratio of 1: 10, stir, vacuum eliminates bubble; Use sol evenning machine to be spin-coated on a smooth smooth teflon substrate red ink mixed liquor, thickness is 100～500 microns, simultaneously water white performed polymer is cast in a surface and has on the metal nickel mould of bulge-structure; After above-mentioned two substrates are placed in 90 ℃ of baking oven heating 1h, take out, film is peeled off from substrate, obtain a PDMS cover plate with light-filtering characteristic, and the complete transparent substrate with MCA; Punch on cover plate finally, use oxygen plasma to carry out surface to two substrates and bombard activation processing, will fit after two-layer aligning, realize that cover plate has light-filtering characteristic and substrate is transparent PDMS micro-fluidic chip.
3 one kinds of embodiment have PMMA micro-fluidic chip of light-filtering characteristic and preparation method thereof
As shown in Figure 1, cover plate layer A, fluid channel layer B and basalis C form by PDMS for a kind of PMMA micro-fluidic chip with light-filtering characteristic, structure.Its preparation process is as follows: at first, under 150 ℃ of conditions, the liquid PMMA of blue ink and thawing is fully mixed by the volume ratio of 1: 10, stir, vacuum eliminates bubble; Mixed liquor is cast on stainless steel substrate three surface finish, that minute surface is smooth, and thickness is 100～500 microns; After this substrate is down to normal temperature, take out, film is peeled off from substrate, obtain three PMMA substrates with light-filtering characteristic; Use CO
2Laser engraving equipment cuts respectively and obtains cover plate layer, fluid channel layer and basalis, and the through hole of further processing hollow out on the cover plate layer is as the flow injecting mouth, in the fluid passage of fluid channel layer processing hollow out; Use finally thermocompression bonding method,, with 90～100 ℃ of lower thermocompression bondings after three layers of aligning, realize whole PMMA micro-fluidic chip with light-filtering characteristic.
The macromolecule polymer material with light-filtering characteristic that micro-fluidic chip with light-filtering characteristic provided by the invention uses comprises dimethyl silicone polymer (PDMS), polymethyl methacrylate (PMMA), Merlon (PC), polyethylene (PE), polyvinyl chloride (PVC), polystyrene (PS) etc., and the material internal doping has pigment or the dyestuff of light-filtering characteristic.Preparing very easy, light-filtering characteristic can adjust according to pigment or dyestuff, and material cost and processing cost are very cheap, is fit to produce in enormous quantities, and can greatly simplifies requirement to Systems for optical inspection, has foreseeable huge market application foreground.
Claims (7)
1. the micro-fluidic chip with light-filtering characteristic, is characterized in that this micro-fluidic chip is to be formed by cover plate layer, fluid channel layer and basalis bonding.
2., according to a kind of micro-fluidic chip with light-filtering characteristic claimed in claim 1, it is characterized in that, having one deck in described cover plate layer, fluid channel layer and basalis at least is to be processed by the macromolecule polymer material with light-filtering characteristic.
3. according to a kind of micro-fluidic chip with light-filtering characteristic claimed in claim 1, it is characterized in that, described macromolecule polymer material with light-filtering characteristic comprises dimethyl silicone polymer, polymethyl methacrylate, Merlon, polyethylene, polyvinyl chloride, polystyrene etc., and the material internal doping has pigment or the dyestuff of light-filtering characteristic.
4., according to claim 1 and 3 described a kind of micro-fluidic chips with light-filtering characteristic, it is characterized in that, described light-filtering characteristic comprises cut-off type, band flow-through, complete shading type.
5., according to a kind of micro-fluidic chip with light-filtering characteristic claimed in claim 3, it is characterized in that, described doping method comprises the pressed powder of pigment or dyestuff or solution, joins in the liquid phase macromolecule polymer material, and curing molding forms.Described curing molding can be that the polymer cure under the high temperature melt state forms, and can be also to solidify and form after the solvent evaporates that will be dissolved with in the solution of polymer, can be also to impel after the monomer solution polymerization reaction take place of polymer to solidify to form.
6. according to a kind of micro-fluidic chip with light-filtering characteristic claimed in claim 1, it is characterized in that, described microfluidic channel layer is processed with the structures such as microchannel, use existing micro-processing method to process, comprise wet etching, dry etching, laser ablation, lathe processing, mould heat pressure, mold injection etc.
7. according to a kind of micro-fluidic chip with light-filtering characteristic claimed in claim 1, it is characterized in that, described bonding can be one or more the combination in the auxiliary bonding of thermocompression bonding, surface activation process, the auxiliary bonding of solvent, laser weld bonding, ultrasonic bonding bonding, sticking double faced adhesive tape bonding.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104251910A (en) * | 2013-06-29 | 2014-12-31 | 黄辉 | Microfluidic chip based on optical detection and preparation method thereof |
| CN104607256A (en) * | 2014-12-31 | 2015-05-13 | 北京同方生物芯片技术有限公司 | Plasma auxiliary thermo-compression bonding micro-fluidic chip and preparation method thereof |
| CN105399051A (en) * | 2015-12-29 | 2016-03-16 | 南京洁态环保科技有限公司 | Method for packaging microfluidic chip with cyclo-olefin copolymer (COC) substrate and COC upper cover |
| CN105314591B (en) * | 2014-05-26 | 2017-05-24 | 上海量子绘景电子股份有限公司 | Micro-nano structure closed pipeline and preparation method thereof |
| CN108982435A (en) * | 2018-04-09 | 2018-12-11 | 佛山市顺德区中山大学研究院 | A kind of integration fluorescence detection device and preparation method thereof |
| CN109926112A (en) * | 2019-04-10 | 2019-06-25 | 中南大学 | The layered manufacturing method of three-dimensional microstructures polymeric micro-fluidic chip |
| CN110308086A (en) * | 2019-07-09 | 2019-10-08 | 大连海事大学 | It is a kind of based on micro-fluidic particle surface partial region fluorescent marker device and method |
| CN111129269A (en) * | 2019-12-30 | 2020-05-08 | 中国科学院长春光学精密机械与物理研究所 | Composite light conversion layer substrate for Micro-LED array device and preparation method thereof |
| CN114684782A (en) * | 2022-03-30 | 2022-07-01 | 湖南超亟检测技术有限责任公司 | Method for manufacturing blind-hole-shaped micropores based on monomolecular microarray chip substrate |
| CN114768895A (en) * | 2022-03-12 | 2022-07-22 | 北京化工大学 | Laser bonding method suitable for thermoplastic polymer material microfluidic chip |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104251910A (en) * | 2013-06-29 | 2014-12-31 | 黄辉 | Microfluidic chip based on optical detection and preparation method thereof |
| CN105314591B (en) * | 2014-05-26 | 2017-05-24 | 上海量子绘景电子股份有限公司 | Micro-nano structure closed pipeline and preparation method thereof |
| CN104607256A (en) * | 2014-12-31 | 2015-05-13 | 北京同方生物芯片技术有限公司 | Plasma auxiliary thermo-compression bonding micro-fluidic chip and preparation method thereof |
| CN105399051A (en) * | 2015-12-29 | 2016-03-16 | 南京洁态环保科技有限公司 | Method for packaging microfluidic chip with cyclo-olefin copolymer (COC) substrate and COC upper cover |
| CN108982435A (en) * | 2018-04-09 | 2018-12-11 | 佛山市顺德区中山大学研究院 | A kind of integration fluorescence detection device and preparation method thereof |
| CN109926112A (en) * | 2019-04-10 | 2019-06-25 | 中南大学 | The layered manufacturing method of three-dimensional microstructures polymeric micro-fluidic chip |
| CN110308086A (en) * | 2019-07-09 | 2019-10-08 | 大连海事大学 | It is a kind of based on micro-fluidic particle surface partial region fluorescent marker device and method |
| CN110308086B (en) * | 2019-07-09 | 2021-11-05 | 大连海事大学 | Particle surface partial-area fluorescence labeling device and method based on micro-fluidic |
| CN111129269A (en) * | 2019-12-30 | 2020-05-08 | 中国科学院长春光学精密机械与物理研究所 | Composite light conversion layer substrate for Micro-LED array device and preparation method thereof |
| CN114768895A (en) * | 2022-03-12 | 2022-07-22 | 北京化工大学 | Laser bonding method suitable for thermoplastic polymer material microfluidic chip |
| CN114684782A (en) * | 2022-03-30 | 2022-07-01 | 湖南超亟检测技术有限责任公司 | Method for manufacturing blind-hole-shaped micropores based on monomolecular microarray chip substrate |
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Application publication date: 20131120 |