Summary of the invention
Still there is demand in the Chinese medicine composition that therefore, people have better curative effect for treatment nodules of the breast.Up to the present, not yet find to destroy the data of novelty of the present invention, present inventor people, by clinical practice, has collected a large amount of clinical observation materials, has obtained treatment nodules of the breast is had to the Chinese medicine composition of better curative effect, thereby completed the present invention.
The object of the invention is to provide a kind of nodules of the breast health Chinese medicine composition and preparation method, and evident in efficacy, cure rate is high, short treating period, and low price, is difficult for the Chinese medicine preparation recurring.
One of technical solution of the present invention: a kind of nodules of the breast health Chinese medicine composition, the each ingredients weight parts of described Chinese medicine composition is as follows:
200-400 parts of Spica Prunellaes, 200-400 parts of Radix Bupleuri, 100-300 parts of Radix Curcumaes, 100-300 parts of Rhizoma Cyperis, 50-200 parts of Folium Citri tangerinae, 100-300 parts of Radix Salviae Miltiorrhizaes, 50-150 parts, Flos Carthami, 100-200 parts of Radix Paeoniae Rubra, 30-100 parts, Semen Persicae, 50-150 parts of the Radix Aucklandiae, 50-150 parts of Rhizoma Corydalis, 50-150 parts of Herba Leonuris, 50-150 parts of 50-150 parts of Herba Taraxacis and Fructus Forsythiaes.
The each ingredients weight parts of preferred described Chinese medicine composition is as follows:
300 parts of Spica Prunellaes, 300 parts of Radix Bupleuri, 200 parts of Radix Curcumaes, 200 parts of Rhizoma Cyperis, 100 parts of Folium Citri tangerinae, 200 parts of Radix Salviae Miltiorrhizaes, 80 parts, Flos Carthami, 150 parts of Radix Paeoniae Rubra, 50 parts, Semen Persicae, 100 parts of the Radix Aucklandiae, 80 parts of Rhizoma Corydalis, 100 parts of Herba Leonuris, 100 parts of 90 parts of Herba Taraxacis and Fructus Forsythiaes.
Described Chinese medicine composition dosage form is said any peroral dosage form on pharmaceutics.
Described peroral dosage form is oral liquid, capsule, granule, pill, mixture, fluid extract, soft extract, powder.
Two of technical solution of the present invention: described a kind of nodules of the breast health Chinese medicine composition, its capsule preparation method thereof:
The half of getting Rhizoma Cyperi and Radix Salviae Miltiorrhizae weight portion, mixed powder is broken into segmentation, for subsequent use; Take by weight ratio Spica Prunellae, Radix Bupleuri, Radix Curcumae, Rhizoma Cyperi, Folium Citri tangerinae, Flos Carthami, Radix Paeoniae Rubra, Semen Persicae, the Radix Aucklandiae, Rhizoma Corydalis, Herba Leonuri, Herba Taraxaci, Fructus Forsythiae and remaining Rhizoma Cyperi and Radix Salviae Miltiorrhizae amount to 14 taste medical materials add 6-8 times of water soakings 0.5-1.0 hours, decoct 1.5-2 hours, filter to get filtrate, medicinal residues add 4-6 times of water gagings and decoct for the second time, decoct 1.5-2 hours, filter to get filtrate, cast out filtering residue merging filtrate, be concentrated into thick extractum; Thick extractum mixes with the segmentation of Rhizoma Cyperi and Radix Salviae Miltiorrhizae, does wetting agent with 85% ethanol, granulates, and 60 DEG C are dry, granulate, and fill capsule, packaging, to obtain final product.
Three of technical solution of the present invention: the application of described Chinese medicine composition in the Chinese medicine preparation of preparation treatment nodules of the breast.
Pharmaceutical formulation of the present invention is the clinical practice through for many years, in conjunction with Basic Theories of Chinese Medicine and modern scientific research method, investigates further and develops, and meticulously screens raw material of Chinese medicine:
Spica Prunellae: bitter, acrid, cold.Return Liver Channel.Effect clearing away liver-fire, detoxicating and resolving stagnation of pathogens.
Radix Bupleuri: bitter, pungent, be slightly cold.Return lung, spleen, Liver Channel.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
Flos Carthami: pungent, temperature.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving.
Radix Curcumae: pungent, bitter, cold.Return liver, gallbladder, heart channel.
Rhizoma Cyperi: pungent, micro-hardship, flat.Return liver, tri-jiao channel.Depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving.
Folium Citri tangerinae: hardship, flat.Return liver, kidney channel.Regulate the flow of vital energy, eliminating stagnation, pain relieving.
Radix Salviae Miltiorrhizae: bitter, be slightly cold.Return liver, heart channel.Blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, relieving restlessness is calmed the nerves.
Radix Paeoniae Rubra: bitter, be slightly cold.Return liver, heart channel.Clearing away heat and cooling blood, stasis-dispelling and pain-killing, clearing away liver-fire.
Semen Persicae: bitter, sweet, flat.Blood circulation promoting and blood stasis dispelling, intestine moistening passage.
The Radix Aucklandiae: acrid, bitter, warm.Return spleen, stomach, large intestine, liver, gallbladder meridian.Promoting the circulation of QI to relieve pain.
Rhizoma Corydalis: pungent, hardship, temperature.Return liver spleen heart channel.Invigorate blood circulation, circulation of qi promoting, pain relieving.
Herba Leonuri: pungent, bitter, be slightly cold.Return liver, the heart, urinary bladder channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.
Herba Taraxaci: hardship, sweet, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, clearing away heat-damp and promoting diuresis.
Fructus Forsythiae: bitter, micro-pungent, cold.GUIXIN, lung, small intestine meridian.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.
The present invention is from depressed liver-energy dispersing and QI regulating, eliminating carbuncle eliminating stagnation, thirty years of age of the method for promoting blood circulation to disperse blood clots and relieves pain.The present invention is taking Radix Bupleuri, Flos Carthami compatibility as monarch drug.Radix Bupleuri bitter in the mouth, pungent, be slightly cold.Return lung, spleen, Liver Channel.This product is good at discongesting the depression and stagnation of QI of Liver Channel, is that irritability is adjusted and reached, and faces the multiplex this product of all stagnation of QI due to depression of the liver of card, is the key medicine for the treatment of irritability stasis, again because of Radix Bupleuri can " declare smooth QI and blood " (" property of medicine opinion ") nodules of the breast of causing for irritability stasis, multiplex this product of prescription.Flos Carthami is pungent, temperature.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving.The pungent loose temperature of this product is logical, is the key medicine of promoting blood circulation to restore menstrual flow pain relieving, reaches the Hui that disappears, unobstructed blood vessels, the effect of pain relieving, the especially common medicine of gynecological's blood stasis disease by blood circulation promoting and blood stasis dispelling.The two compatibility, a temperature one is cool, share without the cold and heat fraud of Sheng partially.The merit of auxiliary Flos Carthami promoting blood flow to regulate menstruation simultaneously that Radix Bupleuri circulation of qi promoting is soothing the liver, the capable blood of so-called gas.For strengthening our dispersing the stagnated live-QI to relieve the stagnation of QI, effect of blood circulation promoting and dispersing pathogen accumulation, minister share with Radix Salviae Miltiorrhizae, Spica Prunellae, Rhizoma Cyperi, Radix Paeoniae Rubra, Radix Curcumae.Spica Prunellae bitter, acrid, cold, return Liver Channel, clearing away liver-fire, and detoxicating and resolving stagnation of pathogens, kind purging liver-fire is usually used in treating pathogenic fire derived from stagnation of liver-QI, and bright Tianjin is expectorant, phlegm-fire pent-up and the scrofula that arrives, nodules of the breast; Radix Salviae Miltiorrhizae hardship, be slightly cold, return liver, heart channel, blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, is Fuke Tiaojing key medicine, forefathers have " Radix Salviae Miltiorrhizae simply, common four things "; Radix Paeoniae Rubra hardship, be slightly cold, return liver, heart channel, stasis-dispelling and pain-killing, clearing away liver-fire; Rhizoma Cyperi is pungent can manage it and can fall apart, and micro-hardship is flat.Return liver, tri-jiao channel.Depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving, cures mainly the card of stagnation of QI due to depression of the liver; Radix Curcumae promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice, this product is pungent can manage it and can fall apart, can promoting blood circulation and stopping pain, again can promoting QI circulation for relieving depression, be " the gas medicine of blood system ".Help with Fructus Forsythiae, Herba Taraxaci, Herba Leonuri, the Radix Aucklandiae, Folium Citri tangerinae simultaneously and strengthen and invigorate blood circulation, circulation of qi promoting, pain relieving, effect of eliminating carbuncle.Folium Citri tangerinae is regulated the flow of vital energy, eliminating stagnation, pain relieving; Semen Persicae blood circulation promoting and blood stasis dispelling; Radix Aucklandiae promoting the circulation of QI to relieve pain, are apt to into Liver Channel, adjust China and foreign countries except circulation of qi promoting, cure mainly QI stagnation of the liver and galibladder; Rhizoma Corydalis is invigorated blood circulation, circulation of qi promoting, and pain relieving, pungent loose temperature is logical, can " stagnation of QI in promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body " be pain relieving good medicine; Herba Leonuri promoting blood flow to regulate menstruation, this product hardship is let out pungent loose, and master enters blood system, kind promoting blood flow to regulate menstruation, promoting tissue regeneration by removing blood stasis; Herba Taraxaci heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, this product is apt to into liver stomach warp, holds concurrently and can dredge strongly fragrant lactogenesis, is treatment acute mastitis key medicine; Fructus Forsythiae depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving, cures mainly the card of stagnation of QI due to depression of the liver.
Therapeutic Method of the present invention is with depressed liver-energy dispersing and QI regulating pain relieving, and promoting blood circulation to remove obstruction in the collateral eliminating stagnation is main, the Therapeutic Principle who has embodied acute mastitis for circulation of qi promotingization is strongly fragrant, the pathogenesis of dissipating phlegm and resolving masses, stasis-dispelling and pain-killing and acute mastitis matches, treating both the principal and secondary aspects of a disease, evident in efficacy.Be particularly useful for because irritability is not dredged, congestion, the stagnation of QI, blockage of main and collateral channels so that the newborn network stagnation of QI, expectorant are solidifying, the nodules of the breast of the coalescent nucleation of congestion, are also applicable to other mastopathy simultaneously.The consumption of medicine of the present invention: 5 of usage and dosages one time, 3 times on the one or follow the doctor's advice; The careful clothes of anemia of pregnant woman; There are the careful clothes of bleeding tendency person.
Detailed description of the invention
The present invention is described further by clinical observation and embodiment
Clinical observation on the therapeutic effect data
1, clinical physical data: be the actual efficacy of checking medicine of the present invention, apply medicine of the present invention and coordinate clinical treatment nodules of the breast, accept altogether patient's 100 examples for medical treatment, age distribution is as follows: 30 years old following 12 example, 30-40 years old 40 example, 40-50 years old 38 example, 50 years old above 10 example; The oldest 70 years old, minimum 24 years old of age; Unmarried 30 examples, married 70 examples.
2, diagnosis index
(1) clinical symptoms: most have a flat lump at the outside upper quadrant of breast, that lays one's hand on has beans size tough hard
Tuberosity, can have tenderness.Owe clearly on lump border, with surrounding tissue adhesion.
(2) breast can have distending pain, the often growth and decline with susceptible to anger, and month premenstrual the increasing the weight of of being everlasting, alleviates after menstruation.
3, syndrome-classification
(1) liver energy depression and phlegm stagnation: be more common between twenty and fifty women.Lump in breast, with susceptible to anger growth and decline, with feeling of oppression over the chest and distention of hypochondrium, is apt to strongly fragrant irritability, insomnia and dreamful sleep, vexed bitter taste.Tongue fur BOHUANG, stringy and rolling pulse.
(2) Chong and Ren channel disorder: be more common in middle-aged women.The lump in breast moon premenstrual increasing the weight of, through after extenuate.Weak with the soreness of waist, tired, menstruation is imbalance successively, and the few color of amount is light, or amenorrhea.Light red tongue, tongue is white, deep-thready pulse.
4, Therapeutic Method: according to the etiology and pathogenesis of nodules of the breast and feature thereof, adjust our best proportioning: 100 parts of 300 parts of Spica Prunellaes, 300 parts of Radix Bupleuri, 200 parts of Radix Curcumaes, 200 parts of Rhizoma Cyperis, 100 parts of Folium Citri tangerinae, 200 parts of Radix Salviae Miltiorrhizaes, 80 parts, Flos Carthami, 150 parts of Radix Paeoniae Rubra, 50 parts, Semen Persicae, 100 parts of the Radix Aucklandiae, 80 parts of Rhizoma Corydalis, 100 parts of Herba Leonuris, 90 parts of Herba Taraxacis and Fructus Forsythiaes.Get medicine material by above weight proportion, be prepared into capsule as embodiment 1, oral, 5 of usage and dosages one time, 3 times on the one or follow the doctor's advice 7 days is a course for the treatment of, substantially reach rehabilitation 1-3 courses for the treatment of, consolidates and can reach curative effect 1-2 courses for the treatment of.
5, efficacy evaluation result
Cure: lump in breast and pain disappear.
Take a turn for the better: lump in breast dwindles, pain relief or disappearance.
Do not heal: lump in breast and pain are unchanged.
6, therapeutic outcome.
By the conventional therapy of 1-3 courses for the treatment of, can change rapidly clinical symptoms; Cure 52 examples; Take a turn for the better: 35 examples; Invalid 13 examples; Total effective rate 87%.
Through 1-2 after treatments course for the treatment of, clinical symptoms rapidly disappears again, recovers normal; Cure 63 examples; Take a turn for the better: 29 examples; Invalid 8 examples; Total effective rate 92%.
Embodiment 1: the each ingredients weight parts of described Chinese medicine composition is as follows:
300 parts of Spica Prunellaes, 300 parts of Radix Bupleuri, 200 parts of Radix Curcumaes, 200 parts of Rhizoma Cyperis, 100 parts of Folium Citri tangerinae, 200 parts of Radix Salviae Miltiorrhizaes, 80 parts, Flos Carthami, 150 parts of Radix Paeoniae Rubra, 50 parts, Semen Persicae, 100 parts of the Radix Aucklandiae, 80 parts of Rhizoma Corydalis, 100 parts of Herba Leonuris, 100 parts of 90 parts of Herba Taraxacis and Fructus Forsythiaes.
Preparation method:
The half of getting Rhizoma Cyperi and Radix Salviae Miltiorrhizae weight portion, mixed powder is broken into segmentation, for subsequent use; Take by weight ratio Spica Prunellae, Radix Bupleuri, Radix Curcumae, Rhizoma Cyperi, Folium Citri tangerinae, Flos Carthami, Radix Paeoniae Rubra, Semen Persicae, the Radix Aucklandiae, Rhizoma Corydalis, Herba Leonuri, Herba Taraxaci, Fructus Forsythiae and remaining Rhizoma Cyperi and Radix Salviae Miltiorrhizae amount to 14 taste medical materials add 6-8 times of water soakings 0.5-1.0 hours, decoct 1.5-2 hours, filter to get filtrate, medicinal residues add 4-6 times of water gagings and decoct for the second time, decoct 1.5-2 hours, filter to get filtrate, cast out filtering residue merging filtrate, be concentrated into thick extractum; Thick extractum mixes with the segmentation of Rhizoma Cyperi and Radix Salviae Miltiorrhizae, does wetting agent with 85% ethanol, granulates, and 60 DEG C are dry, granulate, and fill capsule, packaging, to obtain final product.
Embodiment 2: the each ingredients weight parts of described Chinese medicine composition is as follows:
200 parts of Spica Prunellaes, 200 parts of Radix Bupleuri, 100 parts of Radix Curcumaes, 100 parts of Rhizoma Cyperis, 50 parts of Folium Citri tangerinae, 100 parts of Radix Salviae Miltiorrhizaes, 50 parts, Flos Carthami, 100 parts of Radix Paeoniae Rubra, 30 parts, Semen Persicae, 50 parts of the Radix Aucklandiae, 50 parts of Rhizoma Corydalis, 50 parts of Herba Leonuris, 50 parts of 50 parts of Herba Taraxacis and Fructus Forsythiaes.
Preparation method is as embodiment 1.
Embodiment 3: the each ingredients weight parts of described Chinese medicine composition is as follows:
400 parts of Spica Prunellaes, 400 parts of Radix Bupleuri, 300 parts of Radix Curcumaes, 300 parts of Rhizoma Cyperis, 200 parts of Folium Citri tangerinae, 300 parts of Radix Salviae Miltiorrhizaes, 150 parts, Flos Carthami, 200 parts of Radix Paeoniae Rubra, 100 parts, Semen Persicae, 150 parts of the Radix Aucklandiae, 150 parts of Rhizoma Corydalis, 150 parts of Herba Leonuris, 150 parts of 150 parts of Herba Taraxacis and Fructus Forsythiaes.
Preparation method is as embodiment 1.
Embodiment 4: the each ingredients weight parts of described Chinese medicine composition is as follows:
200 parts of Spica Prunellaes, 400 parts of Radix Bupleuri, 100 parts of Radix Curcumaes, 300 parts of Rhizoma Cyperis, 50 parts of Folium Citri tangerinae, 300 parts of Radix Salviae Miltiorrhizaes, 50 parts, Flos Carthami, 200 parts of Radix Paeoniae Rubra, 30 parts, Semen Persicae, 150 parts of the Radix Aucklandiae, 50 parts of Rhizoma Corydalis, 150 parts of Herba Leonuris, 150 parts of 50 parts of Herba Taraxacis and Fructus Forsythiaes.
Preparation method is as embodiment 1.
Embodiment 5: the each ingredients weight parts of described Chinese medicine composition is as follows:
400 parts of Spica Prunellaes, 200 parts of Radix Bupleuri, 300 parts of Radix Curcumaes, 100 parts of Rhizoma Cyperis, 200 parts of Folium Citri tangerinae, 100 parts of Radix Salviae Miltiorrhizaes, 150 parts, Flos Carthami, 100 parts of Radix Paeoniae Rubra, 100 parts, Semen Persicae, 50 parts of the Radix Aucklandiae, 150 parts of Rhizoma Corydalis, 50 parts of Herba Leonuris, 50 parts of 150 parts of Herba Taraxacis and Fructus Forsythiaes.
Preparation method is as embodiment 1.