CN103385937A - Traditional Chinese medicine preparation for preventing and treating herpes zoster and postherpetic neuralgia and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for preventing and treating herpes zoster and postherpetic neuralgia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for preventing and treating herpes zoster and postherpetic neuralgia and a preparation method thereof. The traditional Chinese medicine preparation comprises the following active components in parts by weight: 5-15 parts of ground beetle, 2-7 parts of scorpion, 10-20 parts of radix paeoniae alba and 2-7 parts of liquorice. The traditional Chinese medicine preparation has the functions of tonifying yin and nourishing blood, expelling and removing stasis, activating meridians to stop pain and the like, is used for treating herpes zoster and postherpetic neuralgia, and can be prepared as concentrated water pills, concentrated water honeyed pills, small honeyed pills and big honeyed pills.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine preparation of preventing and treating herpes zoster and post-herpetic neuralgia and preparation method thereof.
Background technology
Herpes zoster (Herpeszoster, HZ) is to infect by varicella zoster virus (VZV) a kind of herpes and the neuralgia viral dermatosis as feature of trooping to occur that peripheral nerve distributes cause.Still have the part virus lays dormant because of herpes in neuroganglion after disappearing, cause being invaded position pain occurs, be referred to as post-herpetic neuralgia (postherpetic neuralgia, PHN), multiplely be born in the old people.The clinical course of HZ is changeable, usually symptom is lighter in child and adult, there is eruption in the infected dermatotome of most of patients, approximately PHN can occur in 10～20% HZ patient, need in early days to need timely and effective treatment in pathological changes, otherwise can lose afterwards lasting neuralgia, its skin of getting involved occurs that pain or rest pain reached more than 3 months.Pain can arrive extremely pain on the lenient side, and this pain continues, pain interruption or that minimum Induced by Stimulation is arranged.As a pertinacious disease of department of dermatologry, PHN brings huge physiology misery and psychological burden to the patient, badly influences patient's quality of life.The therapeutic goal of HZ is to alleviate acute stage pain, and persistent period of skin lesion is shortened in the diffusion of restriction skin lesion, prevents or alleviates PHN and other acute or chronic complicating diseases thereof.
HZ belongs to the categories such as Chinese medicine " herpes zoster ", " herpes zoster ".Chinese medicine thinks, HZ is due to feelings will internal injury, and liver is lost bar and reaches, damage temper, and dysfunction of the spleen in transportation, drinking and eating irregularly, cause incoordination between the liver and spleen, and stagnation of QI damp-stagnancy, heat-transformation fire-transformation follow through outer, and the fiery wound of damp and hot poison causes in skin.From the beginning of mostly being damp and hot tired the resistance in skin; Be that the noxious dampness fire is contained mid-term, the skin of burning; Be burning hot impairment of YIN late period, blockage of meridian, and residual poison is not to the greatest extent.
At present, the western medical treatment method is divided into get involved treatment, immunodeficiency patient's the treatment of HZ of HZ treatment, enantiopathy cytotoxic drug drug resistance for the treatment of, child and teen-age HZ, trimester of pregnancy HZ of antiviral therapy, glucocorticoid therapy, neuralgic treatment topical therapeutic, naturopathy, PHN treatment, cranial nerve.Anti-herpesvirus medicament commonly used has acyclovir, valaciclovir and famciclovir, high dose glucocorticoid class medicine, PHN patient's persistence, violent pain often need be taken tricyclic antidepressant, antuepileptic, opioid analgesics etc., but may cause the untoward reaction of whole body, and can only alleviate moderate pain; Chinese traditional treatment HZ adopts Coryza Treated by Syndrome Differentiation, and the one, with blood circulation promoting and blood stasis dispelling, the 2nd, eliminating evil collateral dredging method, the 3rd, righting method.The medicine that adopts has sedative, insects collateral dredging medicine and for the medication of accompanied symptoms and site of pathological change.
Summary of the invention
One of the object of the invention is to provide the Chinese medicine preparation of a kind of HZ of control and PHN.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine preparation of preventing and treating herpes zoster and post-herpetic neuralgia, its active ingredient is counted by weight: 5～15 parts of Eupolyphaga Seu Steleophagas, 2～7 parts of Scorpios, 10～20 parts of the Radix Paeoniae Albas, 2～7 parts, Radix Glycyrrhizae.
In embodiment, described active ingredient is: 9.5～10.5 parts of Eupolyphaga Seu Steleophagas, 4.5～5.5 parts of Scorpios, 14.5～15.5 parts of the Radix Paeoniae Albas, 4.5～5.5 parts, Radix Glycyrrhizae therein.
In embodiment, described active ingredient is: 10 parts of Eupolyphaga Seu Steleophagas, 5 parts of Scorpios, 15 parts of the Radix Paeoniae Albas, 5 parts, Radix Glycyrrhizae therein.
In embodiment, the Chinese medicine preparation of described control herpes zoster and post-herpetic neuralgia is the medicine pill of control herpes zoster and post-herpetic neuralgia therein.
Another object of the present invention is to provide the preparation method of the medicine pill of above-mentioned control herpes zoster and post-herpetic neuralgia.
The technical scheme that realizes above-mentioned purpose is as follows.
A kind of preparation method of preventing and treating the medicine pill of herpes zoster and post-herpetic neuralgia, the active ingredient of this medicine pill is by weight, 5～15 parts of Trionyx sinensis Wiegmann worms, 2～7 parts of Scorpios, 10～20 parts of the Radix Paeoniae Albas, 2～7 parts, Radix Glycyrrhizae, described preparation method comprises the following steps:
(1) described Eupolyphaga Seu Steleophaga, scorpion powder are broken into the medical material fine powder, mix, and be standby;
(2) the described Radix Paeoniae Alba, Radix Glycyrrhizae, use water extraction, and extracting solution filters, and merges, and concentrates to obtain clear paste, and be standby;
(3) get the described medical material fine powder of step (1), take the described clear paste of step (2) as binding agent, method for making is moulded in employing or general method for making is made concentrated watered pill, drying, and polishing, obtain; Or (3) get step (2) clear paste in 60～70 ℃ of vacuum dryings, mix homogeneously with the described medical material fine powder of step (1) after being ground into dry extract, and be binding agent with ethanol or Mel, adopt and mould method for making or the general condensed water honeyed pill of making, drying, polishing, obtain.
A kind of preparation method of preventing and treating the medicine pill of herpes zoster and post-herpetic neuralgia, the active ingredient of this medicine pill is by weight, 5～15 parts of Trionyx sinensis Wiegmann worms, 2～7 parts of Scorpios, 10～20 parts of the Radix Paeoniae Albas, 2～7 parts, Radix Glycyrrhizae, described preparation method comprises the following steps:
(1) described Eupolyphaga Seu Steleophaga, Scorpio mix, and are ground into the medical material fine powder, and be standby;
(2) described Radix Glycyrrhizae powder is broken into the medical material impalpable powder, and is standby;
(3) described Radix Paeoniae Alba extracting in water, extracting solution filters, and merges, and concentrates to obtain clear paste, and is standby.
(4) with step (a 1) medical material fine powder, take the described clear paste of step (3) as binding agent, method for making is moulded in employing or general method for making is made concentrated pill, drying, and with the described Radix Glycyrrhizae impalpable powder of step (2) coating, polishing, obtain; Or get the described medical material fine powder of step (1), and add (3) clear paste, mix, dry, pulverize into the medical material fine powder, be binding agent with Mel, adopt and mould method for making or the general concentrated pill of making, drying, then use the described Radix Glycyrrhizae impalpable powder of step (2) coating, polishing, obtain.
In embodiment, the described extracting method of step (2) is therein:, with water extraction 1-3 time, add 9-11 at every turn and doubly measure, extract 1-3 hour, collect extracting solution, and filtration, merging filtrate, when reclaim under reduced pressure is concentrated into 60 ℃, relative density is the clear paste of 1.25-1.35.
A kind of preparation method of preventing and treating the medicine pill of herpes zoster and post-herpetic neuralgia, the active ingredient of this medicine pill is by weight, 5～15 parts of Eupolyphaga Seu Steleophagas, 2～7 parts of Scorpios, 10～20 parts of the Radix Paeoniae Albas, 2～7 parts, Radix Glycyrrhizae, described preparation method comprises the following steps:
(1) described Eupolyphaga Seu Steleophaga, Scorpio, the Radix Paeoniae Alba, Radix Glycyrrhizae mix, and are ground into the medical material fine powder, and be standby;
(2) get the described medical material fine powder of step (1), take refined honey as binding agent, method for making is moulded in employing or general method for making is made small honey pill or big honeyed pills.
Chinese medicine preparation of the present invention is comprised of Eupolyphaga Seu Steleophaga, Scorpio, the Radix Paeoniae Alba, Radix Glycyrrhizae, has tonifying YIN and nourishes blood, removing blood stasis eliminating stagnation, removing obstruction in the collateral to relieve pain effect.Can be used for clinically preventing and treating HZ and PHN thereof, have good effect, instant effect, an advantage such as treatment time is short and side effect is little.Confirm through Preliminary Clinical Observation, Chinese prescription of the present invention grinds that obvious effective rate for oral administration is 86.2% into powder, effective percentage is 13.8%, total effective rate is 100%, and the average natural law of pain relieving is 2.1 days.The average natural law of fully recovering is 4.6 days, and without PHN, occurs.The preliminary analgesia pharmacology test card of pill is bright, and this product has obvious analgesic activity (with model group, comparing P＜0.01).
Chinese medicine preparation of the present invention also can be ground into powder for oral administration, but there is the shortcoming that abnormal flavour is large and consumption is made troubles to the patient greatly, therefore, be made into pill (comprising concentrated watered pill, condensed water honeyed pill, small honey pill and big honeyed pills) and can overcome this shortcoming, increase the adaptability of patient's medication.
The specific embodiment
Embodiment 1:
The active component of the medicine pill of the described control herpes zoster of the present embodiment and post-herpetic neuralgia composed as follows:
Eupolyphaga Seu Steleophaga 500g Scorpio 250g Radix Paeoniae Alba 750g Radix Glycyrrhizae 250g.
The preparation method of this medicine pill is as follows:
(1) Eupolyphaga Seu Steleophaga, Scorpio, dry, pulverize into fine powder, sieves, and mix homogeneously, obtain the medical material fine powder;
(2) Radix Paeoniae Alba, Radix Glycyrrhizae extracting in water secondary, add 10 times of water at every turn, extract 2h, filters, and merging filtrate, filtrate decompression is condensed into relative density 1.25～1.35(60 ℃) thick paste;
(3) mix with above-mentioned thick paste, adopt and mould method for making or general method for making pill, drying, polishing, obtain concentrated watered pill.
Embodiment 2:
The active component of the medicine pill of the described control herpes zoster of the present embodiment and post-herpetic neuralgia composed as follows:
Eupolyphaga Seu Steleophaga: 435g Scorpio 217g Radix Paeoniae Alba 652g Radix Glycyrrhizae 217g
The preparation method of this medicine pill is as follows:
(1) Eupolyphaga Seu Steleophaga, Scorpio, dry, pulverize into fine powder, sieves, and mix homogeneously, obtain the medical material fine powder;
(2) Radix Glycyrrhizae powder is broken into impalpable powder;
(3) Radix Paeoniae Alba extracting in water secondary, add 10 times of water at every turn, extract 2h, filters, and merging filtrate, filtrate decompression is condensed into relative density 1.25～1.35(60 ℃) thick paste;
(4) in step (1) Chinese crude drug fine powder and step (3) thick paste and appropriate refined honey mix, adopt the conventional method pill, drying;
(5) with Radix Glycyrrhizae impalpable powder coating, polishing, obtain the condensed water honeyed pill.
Embodiment 3:
The active component of the medicine pill of the described control herpes zoster of the present embodiment and post-herpetic neuralgia composed as follows:
Eupolyphaga Seu Steleophaga 250g Scorpio 125g Radix Paeoniae Alba 375g Radix Glycyrrhizae 125g.
The preparation method of this medicine pill is as follows:
(1) above-mentioned Eupolyphaga Seu Steleophaga, Scorpio, the Radix Paeoniae Alba, Radix Glycyrrhizae, be ground into fine powder, sieve, and mix homogeneously;
(2) above-mentioned 100g powder adds refined honey 70～90g, and method for making is moulded in employing or general method for making is made small honey pill, drying, and polishing, obtain small honey pill.
Embodiment 4:
The active component of the medicine pill of the described control herpes zoster of the present embodiment and post-herpetic neuralgia composed as follows: Eupolyphaga Seu Steleophaga 250g Scorpio 125g Radix Paeoniae Alba 375g Radix Glycyrrhizae 125g.
The preparation method of this medicine pill is as follows:
Above 4 kinds of Chinese medicines, be ground into fine powder, sieves.The 100g powder adds refined honey 70～90g and makes big honeyed pills, obtains.
Embodiment 5:
The medicine pill analgesic activity experimentation of control herpes zoster and post-herpetic neuralgia
The present invention is through the experimental study of preliminary analgesia pharmacodynamics, show that it has obvious analgesic activity, we adopt following principal agent for substantially square: 5～15 parts of Eupolyphaga Seu Steleophagas, 2～7 parts of Scorpios, 10～20 parts of the Radix Paeoniae Albas, 2～7 parts, Radix Glycyrrhizae, prepare sample by following prescribed dose formula respectively, the drug effect of relatively easing pain result, and according to the method for the method for making 1 of concentrated pill in pill of the present invention, make the concentrated pill fine powder, ease pain the pharmacodynamics amount effect ratio.Its research method and result are as follows:
The impact of the different prescription of the medicine pill sample of 1 control herpes zoster and post-herpetic neuralgia on lumbar injection glacial acetic acid induced mice writhing response
1.1 experiment purpose
Observe the analgesic activity of the medicine pill different process sample of control herpes zoster and post-herpetic neuralgia to mice.
1.2 experiment material
1.2.1 the preparation of test sample sample
The preparation of sample one:
Prescription: Eupolyphaga Seu Steleophaga 150g Scorpio 75g Radix Paeoniae Alba 225g Radix Glycyrrhizae 75g
Method for making: get Eupolyphaga Seu Steleophaga, scorpion powder is broken into fine powder; The Radix Paeoniae Alba, Radix Glycyrrhizae extracting in water secondary, add respectively at every turn and extract 10 times of water of medical material amount, extracts 1.5h, filters, and filtrate is condensed into relative density 1.35～1.40(60 ℃) thick paste, vacuum drying, pulverize, and adds above-mentioned medical material fine powder, obtains.
The preparation of sample two:
Prescription: Eupolyphaga Seu Steleophaga 207g Scorpio 28g Radix Paeoniae Alba 249g Radix Glycyrrhizae 41g
Method for making: get Eupolyphaga Seu Steleophaga, scorpion powder is broken into fine powder; The Radix Paeoniae Alba, Radix Glycyrrhizae extracting in water secondary, add respectively at every turn and extract 10 times of water of medical material amount, extracts 1.5h, filters, and filtrate is condensed into relative density 1.35～1.40(60 ℃) thick paste, vacuum drying, pulverize, and adds above-mentioned medical material fine powder, obtains.
The preparation of sample three:
Prescription: Eupolyphaga Seu Steleophaga 91g Scorpio 127g Radix Paeoniae Alba 182g Radix Glycyrrhizae 127g
Method for making: method for making: get Eupolyphaga Seu Steleophaga, scorpion powder is broken into fine powder; The Radix Paeoniae Alba, Radix Glycyrrhizae extracting in water secondary, add respectively at every turn and extract 10 times of water of medical material amount, extracts 1.5h, filters, and filtrate is condensed into relative density 1.35～1.40(60 ℃) thick paste, vacuum drying, pulverize, and adds above-mentioned medical material fine powder, obtains.
Sample one, two, three, equal oral administration, 20g on the one.Grind to form fine powder during use, weigh, according to dosage with distilled water, be mixed with desired concn, 4 ℃ of Refrigerator stores.
1.2.2 reference substance
Paracetamol tablets, Shantou metal and stone pharmacy head factory, 0.3g/ sheet, lot number 120417.
Somedon, long-range medicine (China) company limited, every 0.365g, lot number 110913.
According to dosage with distilled water, be mixed with desired concn during use, 4 ℃ of Refrigerator stores.
1.2.3 reagent
Glacial acetic acid, Guangzhou Chemical Reagent Factory, lot number 20130301-2.
1.2.4 instrument
JJ3000 animal electronic scale, G﹠amp; G company product; BS224S electronic balance (1/0,000), German SARTORIUS product; The mouse writhing scope, according to those skilled in the art's common practise self-control.
1.2.5 animal
SPF level NIH mice, male and female half and half, body weight 18～22g, provided by Guangdong Medical Lab Animal Center, laboratory animal production licence number SCXK (Guangdong) 2008-0002, Quality of Experimental Animals quality certification № 44007200001196.Zoopery environment: the SPF of Academy of Traditional Chinese Medicine, Guangdong Province level Animal Lab., facility occupancy permit SYXK(Guangdong) 2010-0059.
1.3 experimental technique
1.3.1 animal grouping
Get 60 of SPF level NIH mices, male and female half and half, be divided at random 6 groups by body weight, be respectively three groups, the medicine pill sample of two groups, medicine pill sample, control herpes zoster and post-herpetic neuralgia of one group, medicine pill sample, control herpes zoster and the post-herpetic neuralgia of matched group, paracetamol tablets group, somedon group, control herpes zoster and post-herpetic neuralgia.
1.3.2 dosage setting
Paracetamol tablets, indicate take the clinical consumption per day of 1.8g every day as basis according to package insert,, with reference to dosage conversion method " body surface area ratio " conversion animal clinical equivalent dosage in " herbal pharmacology research methodology ", use this clinical equivalent dosage as paracetamol tablets pharmacodynamics in Mice test dose.Paracetamol tablets pharmacodynamics in Mice test dose is 234.00mgkg
-1, according to dosage prepare 4 ℃ of Refrigerator stores during experiment with distilled water.
Somedon, take package insert 6 (2.19g) clinical consumption per days sign every day as basis,, with reference to dosage conversion method " body surface area ratio " conversion animal clinical equivalent dosage in " herbal pharmacology research methodology ", use this clinical equivalent dosage as somedon pharmacodynamics in Mice test dose.Somedon pharmacodynamics in Mice test dose is 284.70mgkg
-1, according to dosage prepare 4 ℃ of Refrigerator stores during experiment with distilled water.
The medicine pill sample one, two, three of control herpes zoster and post-herpetic neuralgia, clinical principium is drafted 20g ball every day, use this clinical consumption per day as basis,, with reference to dosage conversion method " body surface area ratio " conversion mice clinical equivalent dosage in " herbal pharmacology research methodology ", be 2.60gkg
-1.According to dosage be mixed with desired concn with distilled water during experiment, 4 ℃ of Refrigerator stores.
1.3.3 experiment statistics method
All measurement datas are added and subtracted standard deviation with mean
Expression.The relatively employing one factor analysis of variance (One-WayANOVA) of mean between many groups, between group, mean compares in twos, adopts the SNK method when variance is neat; Adopt Dunnett ' sT3 method during heterogeneity of variance.Completed α=0.05 by SPSSl5.0 software.
1.3.4 medication
Each dosage group of test sample medicine and positive control drug be gastric infusion according to dosage, administration volume 20mlkg
-1, every day 1 time, matched group gives distilled water 20mlkg with the method gavage
-1.
1.3.5 assay method
Get 60 of SPF level NIH mices, male and female half and half, be divided at random 6 groups by body weight, be respectively three groups, the medicine pill sample of two groups, medicine pill sample, control herpes zoster and post-herpetic neuralgia of one group, medicine pill sample, control herpes zoster and the post-herpetic neuralgia of matched group, paracetamol tablets group, somedon group, control herpes zoster and post-herpetic neuralgia, 10 every group.Each administration group is gastric infusion 20mLkg according to dosage
-1, matched group gives the equal-volume distilled water with the method gavage, every day 1 time, 5d continuously.Before the last administration, water 12h is can't help in the equal fasting of each treated animal.1h after the last administration, every Mus ip0.7% glacial acetic acid 10mLkg-1, record the writhing number of times of mice in 20min, relatively the difference of each administration group and matched group.
1.4 experimental result
Table 1 shows, with matched group, compares, and sample one, two, three groups of mouse writhing number of times significantly reduce (P＜0.01).On the analgesic activity degree, sample one〉sample two〉sample three.
The impact of the medicine pill of table 1 control herpes zoster and post-herpetic neuralgia on lumbar injection glacial acetic acid induced mice writhing response
1.5 experiment conclusion
Prescription sample one, two, three all has analgesic activity preferably, prescription sample one on effect degree〉prescription sample two〉prescription sample three.
The impact of a pair of lumbar injection glacial acetic acid of the medicine pill sample induced mice writhing response of 2 control herpes zoster and post-herpetic neuralgia
2.1 experiment purpose
Observe the dose-effect relationship of a pair of mice analgesic activity of medicine pill sample of control herpes zoster and post-herpetic neuralgia.
2.2 experiment material
2.2.1 the preparation of the medicine pill test sample sample of control herpes zoster and post-herpetic neuralgia
Prescription: Eupolyphaga Seu Steleophaga 150g Scorpio 75g Radix Paeoniae Alba 225g Radix Glycyrrhizae 75g
Method for making: above four flavors, Eupolyphaga Seu Steleophaga, scorpion powder are broken into fine powder; The Radix Paeoniae Alba, Radix Glycyrrhizae extracting in water secondary, add respectively at every turn and extract 10 times of water of medical material amount, extracts 1.5h, filters, filtrate is condensed into relative density 1.35～1.40(60 ℃) thick paste, vacuum drying, pulverize, and with above-mentioned medical material fine powder, mixes, pill according to a conventional method, drying, polishing, obtain.
Grind to form fine powder during use, weigh, according to dosage with distilled water, be mixed with desired concn, 4 ℃ of Refrigerator stores.
2.2.2 reference substance
Paracetamol tablets, Shantou metal and stone pharmacy head factory, 0.3g/ sheet, lot number 120417.
According to dosage with distilled water, be mixed with desired concn during use, 4 ℃ of Refrigerator stores.
2.2.3 reagent
Glacial acetic acid, Guangzhou Chemical Reagent Factory, lot number 20130301-2.
2.2.4 instrument
JJ3000 animal electronic scale, G﹠amp; G company product; BS224S electronic balance (1/0,000), German SARTORIUS product; The mouse writhing scope, according to those skilled in the art's common practise self-control.
2.2.5 animal
SPF level NIH mice, male and female half and half, body weight 18～22g, provided by Guangdong Medical Lab Animal Center, laboratory animal production licence number SCXK (Guangdong) 2008-0002, Quality of Experimental Animals quality certification № 44007200001389.Zoopery environment: the SPF of Academy of Traditional Chinese Medicine, Guangdong Province level Animal Lab., facility occupancy permit SYXK(Guangdong) 2010-0059.
2.3 experimental technique
2.3.1 animal grouping
Get 70 of SPF level NIH mices, male and female half and half, be divided into 7 groups at random by body weight, is respectively matched group, paracetamol tablets group, control herpes zoster and medicine pill sample one superelevation of post-herpetic neuralgia, high, medium and low, ultra low-volume group.
2.3.2 dosage setting
Paracetamol tablets, indicate take the clinical consumption per day of 1.8g every day as basis according to package insert,, with reference to dosage conversion method " body surface area ratio " conversion animal clinical equivalent dosage in " herbal pharmacology research methodology ", use this clinical equivalent dosage as paracetamol tablets pharmacodynamics in Mice test dose.Paracetamol tablets pharmacodynamics in Mice test dose is 234.00mgkg
-1, according to dosage prepare 4 ℃ of Refrigerator stores during experiment with distilled water.
The medicine pill sample one of control herpes zoster and post-herpetic neuralgia, clinical principium is drafted oral concentrated pill 20g every day, use this clinical consumption per day as basis,, with reference to dosage conversion method " body surface area ratio " conversion mice clinical equivalent dosage in " herbal pharmacology research methodology ", be 2.60gkg
-1.The medicine pill sample one pharmacodynamics in Mice experiment ultrahigh dose of design control herpes zoster and post-herpetic neuralgia is 10.40gkg
-1, high dose is 5.20gkg
-1, middle dosage is 2.60gkg
-1, low dosage is 1.30gkg
-1Real, ultra low-volume is 0.65gkg
-1, according to dosage be mixed with desired concn with distilled water during experiment, 4 ℃ of Refrigerator stores.
2.3.3 experiment statistics method
All measurement datas are added and subtracted standard deviation with mean
Expression.The relatively employing one factor analysis of variance (One-WayANOVA) of mean between many groups, between group, mean compares in twos, adopts the SNK method when variance is neat; Adopt Dunnett ' sT3 method during heterogeneity of variance.Completed α=0.05 by SPSSl5.0 software.
2.3.4 medication
Each dosage group of test sample medicine and positive control drug be gastric infusion according to dosage, administration volume 20mlkg
-1, every day 1 time, matched group gives distilled water 20mlkg-1 with the method gavage.
2.3.5 assay method
Get 70 of SPF level NIH mices, male and female half and half, be divided at random 7 groups by body weight, be respectively matched group, paracetamol tablets group, control herpes zoster and medicine pill sample one superelevation of post-herpetic neuralgia, high, medium and low, ultra low-volume group, 10 every group.Each administration group is gastric infusion 20mLkg according to dosage
-1, matched group gives the equal-volume distilled water with the method gavage, every day 1 time, 5d continuously.Before the last administration, water 12h is can't help in the equal fasting of each treated animal.1h after the last administration, every Mus ip0.7% glacial acetic acid 10mLkg
-1, record the writhing number of times of mice in 20min, relatively the difference of each administration group and matched group.
2.4 experimental result
Table 2 shows, compares medicine pill sample 1,5.20,2.60, the 1.30gkg of control herpes zoster and post-herpetic neuralgia with matched group
-1Dosage group mouse writhing number of times significantly reduces (P＜0.01 or P＜0.05).The medicine pill sample one of control herpes zoster and post-herpetic neuralgia is at 0.65～5.20gkg
-1The dosage range dose-effect relationship is clear and definite.
The medicine pill of table 2 control herpes zoster and post-herpetic neuralgia is to the lumbar injection glacial acetic acid
The impact of induced mice writhing response
The medicine pill sample one of control herpes zoster and post-herpetic neuralgia has analgesic activity preferably, clinical plan with every day 20g be in effective dosage ranges.
The treatment of the described Chinese medicine preparation of embodiment 6 to herpes zoster
Physical data: be diagnosed as Patients with Herpes Zoster 29 examples, male's 12 examples wherein, women's 17 examples; At 45～82 years old age, account for 79% more than 50 years old; Site of pathological change: waist skin lesion dermexanthesis: 9 examples, intercostal 12 examples, extremity section 6 examples, eyelid damages dermexanthesis 2 examples.Indomethacin post herpetic neuralgia (neuralgia continues to surpass more than 5d).
Diagnostic criteria: according to " traditional Chinese medical science disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine promulgated in 1994, evaluate.1. the lump rash from the beginning of the time facial area skin be irregular or oval erythema, the water lump occurred after a few hours on erythema, increase gradually and be combined into large lump, severe patient can be the blood scar, has secondary infection person to be fester.2. low grade fever, weak symptom are often arranged, and there are pain, burn feeling in the dermexanthesis position.3. severe pain, but post herpetic neuralgia after deflorescence.
Therapeutic Method: get 10 parts of Eupolyphaga Seu Steleophagas, 5 parts of Scorpios, 15 parts of the Radix Paeoniae Albas, 5 parts, Radix Glycyrrhizae, be ground into fine powder, mix; Oral, every day 3 times, each 10g; Till continuous use is extremely fully recovered.Whether observe deflorescence, neuralgia extinction time, adverse effect and sequela.
Criterion of therapeutical effect: according to " traditional Chinese medical science disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine formulated in 1994, judge.Recovery from illness: pain, gargalesthesia disappear, skin lesion inflammation Periostracum Cicadae, and the water scar is dry, and without new rash, subjective symptoms all disappears; Produce effects: pain, gargalesthesia disappear substantially, and skin lesion disappears 〉=and 75%; Effectively: pain, gargalesthesia alleviate, and≤50% skin lesion disappears＜and 75%; Invalid: pain, gargalesthesia do not alleviate even aggravation, and skin lesion goes down＜and 50%.
Therapeutic outcome: in this group 29 examples, produce effects 25 examples, account for 86.2%; Effective 4 examples, account for 13.8%; Analgesic time is 1d the earliest, is 4d at the latest, average 2.1d; The water scar the fastest 3d that dries up, 6d at the latest, average 4.6d; The longest 7d for the treatment of time, the shortest 3d, cure rate reaches 100%.Have no part and leave over neuralgia or pigmentation.
Untoward reaction: stomach discomfort after the small number of patients clothes, vomiting, have individually diarrhoea, all need not process, and can stand.Do not find other untoward reaction.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.Should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (9)
1. a Chinese medicine preparation of preventing and treating herpes zoster and post-herpetic neuralgia, is characterized in that, its active ingredient is counted by weight: 5～15 parts of Eupolyphaga Seu Steleophagas, 2～7 parts of Scorpios, 10～20 parts of the Radix Paeoniae Albas, 2～7 parts, Radix Glycyrrhizae.
2. the Chinese medicine preparation of control herpes zoster according to claim 1 and post-herpetic neuralgia, it is characterized in that, its active ingredient is counted by weight: 9.5～10.5 parts of Eupolyphaga Seu Steleophagas, 4.5～5.5 parts of Scorpios, 14.5～15.5 parts of the Radix Paeoniae Albas, 4.5～5.5 parts, Radix Glycyrrhizae.
3. the Chinese medicine preparation of control herpes zoster according to claim 2 and post-herpetic neuralgia, is characterized in that, its active ingredient is counted by weight: 10 parts of Eupolyphaga Seu Steleophagas, 5 parts of Scorpios, 15 parts of the Radix Paeoniae Albas, 5 parts, Radix Glycyrrhizae.
4. the Chinese medicine preparation of according to claim 1-3 described control herpes zoster and post-herpetic neuralgia, is characterized in that, described Chinese medicine preparation is medicine pill.
5. a preparation method of preventing and treating the medicine pill of herpes zoster and post-herpetic neuralgia, is characterized in that, the active ingredient of this medicine pill is by weight, 5～15 parts of Trionyx sinensis Wiegmann worms, 2～7 parts of Scorpios, 10～20 parts of the Radix Paeoniae Albas, 2～7 parts, Radix Glycyrrhizae, described preparation method comprises the following steps:
(1) described Eupolyphaga Seu Steleophaga, Scorpio mix, and are ground into the medical material fine powder, and be standby;
(2) the described Radix Paeoniae Alba, Radix Glycyrrhizae, use water extraction, and extracting solution filters, and merges, and concentrates to obtain clear paste, and be standby;
(3) get the described medical material fine powder of step (1), take the described clear paste of step (2) as binding agent, method for making is moulded in employing or general method for making is made concentrated watered pill, drying, and polishing, obtain; Or (3) get step (2) clear paste in 60～70 ℃ of vacuum dryings, mix homogeneously with the described medical material fine powder of step (1) after being ground into dry extract, and be binding agent with ethanol or Mel, adopt and mould method for making or the general condensed water honeyed pill of making, drying, polishing, obtain.
6. preparation method according to claim 5, is characterized in that, the described extracting method of step (2) is: use water extraction 1-3 time, add 9-11 at every turn and doubly measure, extract 1-3 hour, collect extracting solution, filter, merging filtrate, when reclaim under reduced pressure is concentrated into 60 ℃, relative density is the clear paste of 1.25-1.35.
7. a preparation method of preventing and treating the medicine pill of herpes zoster and post-herpetic neuralgia, is characterized in that, the active ingredient of this medicine pill is by weight, 5～15 parts of Trionyx sinensis Wiegmann worms, 2～7 parts of Scorpios, 10～20 parts of the Radix Paeoniae Albas, 2～7 parts, Radix Glycyrrhizae, described preparation method comprises the following steps:
(1) described Eupolyphaga Seu Steleophaga, Scorpio mix, and are ground into the medical material fine powder, and be standby;
(2) described Radix Glycyrrhizae powder is broken into the medical material impalpable powder, and is standby;
(3) described Radix Paeoniae Alba extracting in water, extracting solution filters, and merges, and concentrates to obtain clear paste, and is standby;
(4) with step (a 1) medical material fine powder, take the described clear paste of step (3) as binding agent, method for making is moulded in employing or general method for making is made concentrated pill, drying, and with the described Radix Glycyrrhizae impalpable powder of step (2) coating, polishing, obtain; Or get the described medical material fine powder of step (1), and add (3) clear paste, mix, dry, pulverize into the medical material fine powder, be binding agent with Mel, adopt and mould method for making or the general concentrated pill of making, drying, then use the described Radix Glycyrrhizae impalpable powder of step (2) coating, polishing, obtain.
8. preparation method according to claim 7, is characterized in that, the described extracting method of step (2) is: with water extraction 1-3 time, add 9-11 at every turn and doubly measure, extract 1-3 hour, collect extracting solution, filter, merging filtrate, when reclaim under reduced pressure is concentrated into 60 ℃, relative density is the clear paste of 1.25-1.35.
9. preparation method of preventing and treating the medicine pill of herpes zoster and post-herpetic neuralgia, the active ingredient of this medicine pill is by weight, 5～15 parts of Trionyx sinensis Wiegmann worms, 2～7 parts of Scorpios, 10～20 parts of the Radix Paeoniae Albas, 2～7 parts, Radix Glycyrrhizae, described preparation method comprises the following steps:
(1) described Eupolyphaga Seu Steleophaga, Scorpio, the Radix Paeoniae Alba, Radix Glycyrrhizae powder are broken into the medical material fine powder, mix, and be standby;
(2) get the described medical material fine powder of step (1), take refined honey as binding agent, method for making is moulded in employing or general method for making is made small honey pill or big honeyed pills.
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| CN1586501A (en) * | 2004-07-15 | 2005-03-02 | 邵丹 | Use of ground beetle in preparing medicine for treating virus infection disease |
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| CN102266454A (en) * | 2011-08-18 | 2011-12-07 | 杨少辉 | Traditional Chinese preparation for treating neuralgia caused by herpes zoster |
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| CN1586501A (en) * | 2004-07-15 | 2005-03-02 | 邵丹 | Use of ground beetle in preparing medicine for treating virus infection disease |
| CN101190322A (en) * | 2006-11-24 | 2008-06-04 | 李洋 | Traditional Chinese medicine for treating zoster post herpetic neuralgia |
| CN102266454A (en) * | 2011-08-18 | 2011-12-07 | 杨少辉 | Traditional Chinese preparation for treating neuralgia caused by herpes zoster |
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