CN103370101A - 用于治疗hiv相关性腹泻的方法和组合物 - Google Patents

用于治疗hiv相关性腹泻的方法和组合物 Download PDF

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Publication number
CN103370101A
CN103370101A CN2011800637391A CN201180063739A CN103370101A CN 103370101 A CN103370101 A CN 103370101A CN 2011800637391 A CN2011800637391 A CN 2011800637391A CN 201180063739 A CN201180063739 A CN 201180063739A CN 103370101 A CN103370101 A CN 103370101A
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CN
China
Prior art keywords
days
crofelemer
day
experimenter
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800637391A
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English (en)
Chinese (zh)
Inventor
W.福布斯
E.博尔泰
S.金
P.查图维迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salix Pharmaceuticals Inc
Napo Pharmaceuticals Inc
Original Assignee
Napo Pharmaceuticals Inc
Salix Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45994461&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN103370101(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Napo Pharmaceuticals Inc, Salix Pharmaceuticals Ltd filed Critical Napo Pharmaceuticals Inc
Priority to CN201711077144.7A priority Critical patent/CN107595836A/zh
Publication of CN103370101A publication Critical patent/CN103370101A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CN2011800637391A 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物 Pending CN103370101A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711077144.7A CN107595836A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40862210P 2010-10-31 2010-10-31
US61/408,622 2010-10-31
US40933510P 2010-11-02 2010-11-02
US61/409,335 2010-11-02
US41624910P 2010-11-22 2010-11-22
US61/416,249 2010-11-22
US201161434379P 2011-01-19 2011-01-19
US61/434,379 2011-01-19
PCT/US2011/058549 WO2012058664A1 (en) 2010-10-31 2011-10-31 Methods and compositions for treating hiv-associated diarrhea

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201711077144.7A Division CN107595836A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物

Publications (1)

Publication Number Publication Date
CN103370101A true CN103370101A (zh) 2013-10-23

Family

ID=45994461

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2011800637391A Pending CN103370101A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物
CN201711077144.7A Pending CN107595836A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201711077144.7A Pending CN107595836A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物

Country Status (20)

Country Link
US (4) US8962680B2 (cg-RX-API-DMAC10.html)
EP (1) EP2632550B1 (cg-RX-API-DMAC10.html)
JP (2) JP6063385B2 (cg-RX-API-DMAC10.html)
CN (2) CN103370101A (cg-RX-API-DMAC10.html)
AU (1) AU2011320155B2 (cg-RX-API-DMAC10.html)
BR (1) BR112013010774A2 (cg-RX-API-DMAC10.html)
CA (1) CA2816416C (cg-RX-API-DMAC10.html)
DK (1) DK2632550T3 (cg-RX-API-DMAC10.html)
EC (1) ECSP13012650A (cg-RX-API-DMAC10.html)
ES (1) ES2635435T3 (cg-RX-API-DMAC10.html)
HK (1) HK1249036A1 (cg-RX-API-DMAC10.html)
HU (1) HUE035393T2 (cg-RX-API-DMAC10.html)
MX (1) MX348184B (cg-RX-API-DMAC10.html)
PE (1) PE20140036A1 (cg-RX-API-DMAC10.html)
PH (1) PH12013500857A1 (cg-RX-API-DMAC10.html)
PL (1) PL2632550T3 (cg-RX-API-DMAC10.html)
PT (1) PT2632550T (cg-RX-API-DMAC10.html)
RU (1) RU2597746C2 (cg-RX-API-DMAC10.html)
WO (1) WO2012058664A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201303136B (cg-RX-API-DMAC10.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070254050A1 (en) 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
PT2529626T (pt) 2006-05-01 2018-02-27 Napo Pharmaceuticals Inc Composições e métodos para tratamento ou prevenção do cancro do cólon
NZ572049A (en) 2006-05-01 2012-08-31 Napo Pharmaceuticals Inc Method for treatment of constipation-predominant irritable bowel syndrome
WO2012058664A1 (en) 2010-10-31 2012-05-03 Salix Pharmaceuticals, Ltd. Methods and compositions for treating hiv-associated diarrhea
JP2016505561A (ja) * 2012-12-07 2016-02-25 サリックス ファーマスーティカルズ，リミテッド Ｈｉｖ関連下痢を治療する方法および組成物
US11389424B2 (en) 2017-03-09 2022-07-19 Napo Pharmaceuticals, Inc. Methods and compositions for treating chemotherapy-induced diarrhea
AU2018275685B2 (en) 2017-05-31 2025-04-17 Napo Pharmaceuticals, Inc. Methods and compositions for treating bile acid diarrhea, diarrhea associated with small intestine resection or gallbladder removal, and short bowel syndrome
JP2020525407A (ja) 2017-05-31 2020-08-27 ナポ ファーマシューティカルズ インク．Ｎａｐｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 先天性下痢障害を治療するための方法及び組成物
JP2022523564A (ja) 2019-03-04 2022-04-25 アイオーカレンツ， インコーポレイテッド 機械学習を使用するデータ圧縮および通信
MX2022016367A (es) * 2020-06-19 2023-01-30 Napo Pharmaceuticals Inc Metodos y composiciones para el tratamiento de la diarrea inducida por quimioterapia.
WO2022115481A1 (en) * 2020-11-24 2022-06-02 Napo Pharmaceuticals, Inc. Methods and compositions for treating post-acute infection gastrointestinal disorders

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
US5211944A (en) 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
JP4195728B2 (ja) 1996-10-16 2008-12-10 ナポ ファーマシューティカルズ，インコーポレーテッド プロアントシアニジンポリマー止瀉組成物の腸溶製剤
WO2000047062A2 (en) * 1999-02-01 2000-08-17 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
US20040071793A1 (en) 2002-10-05 2004-04-15 Bobrowski Paul J. Oral rehydration methods and compositions
WO2005074575A2 (en) * 2004-01-30 2005-08-18 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1937655A1 (en) * 2005-06-22 2008-07-02 University of Massachusetts Hiv-1 protease inhibitors, and methods of making and using them
CA2633417A1 (en) 2005-12-15 2007-06-21 Bayer Healthcare Ag Diaryl ureas for treating virus infections
US20070254050A1 (en) 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
NZ572049A (en) * 2006-05-01 2012-08-31 Napo Pharmaceuticals Inc Method for treatment of constipation-predominant irritable bowel syndrome
PT2529626T (pt) 2006-05-01 2018-02-27 Napo Pharmaceuticals Inc Composições e métodos para tratamento ou prevenção do cancro do cólon
US20100092479A1 (en) 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
WO2011024049A2 (en) 2009-08-26 2011-03-03 Glenmark Pharmaceuticals Ltd Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations
AU2010303577B2 (en) * 2009-10-06 2015-10-22 Napo Pharmaceuticals, Inc. Methods of treating diseases with proanthocyanidin oligomers such as crofelemer
US20110087530A1 (en) 2009-10-09 2011-04-14 Visa U.S.A. Inc. Systems and Methods to Provide Loyalty Programs
WO2012058664A1 (en) 2010-10-31 2012-05-03 Salix Pharmaceuticals, Ltd. Methods and compositions for treating hiv-associated diarrhea
WO2012101008A1 (en) 2011-01-27 2012-08-02 Glenmark Pharmaceuticals Limited Process for the production of proanthocyanidin polymeric composition
MX2014007635A (es) 2011-12-22 2014-09-22 Glenmark Pharmaceuticals Ltd Composicion farmaceutica no enterica que comprende crofelemer.
JP2016505561A (ja) 2012-12-07 2016-02-25 サリックス ファーマスーティカルズ，リミテッド Ｈｉｖ関連下痢を治療する方法および組成物

Non-Patent Citations (2)

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HOLODNIY M. 等: "A Double Blind, Randomized, Placebo-Controlled Phase II Study to Assess the Safety and Efficacy of Orally Administered SP-303 for the Symptomatic Treatment of Diarrhea in Patients With AIDS.", 《THE AMERICAN JOURNAL OF GASTROENTEROLOGY》 *
马燕: "Crofelemer治疗急性传染性腹泻的Ⅱ期临床试验启动", 《国外医药(抗生素分册)》 *

Also Published As

Publication number Publication date
ZA201303136B (en) 2016-01-27
JP6063385B2 (ja) 2017-01-18
ES2635435T3 (es) 2017-10-03
HK1249036A1 (zh) 2018-10-26
PL2632550T3 (pl) 2017-10-31
EP2632550A4 (en) 2014-04-23
EP2632550A1 (en) 2013-09-04
AU2011320155A1 (en) 2013-05-09
US9585868B2 (en) 2017-03-07
US8962680B2 (en) 2015-02-24
MX348184B (es) 2017-06-02
ECSP13012650A (es) 2013-10-31
US20120107370A1 (en) 2012-05-03
PH12013500857A1 (en) 2018-01-17
BR112013010774A2 (pt) 2017-03-21
EP2632550B1 (en) 2017-05-03
US20120184605A1 (en) 2012-07-19
WO2012058664A1 (en) 2012-05-03
CA2816416C (en) 2020-02-11
PE20140036A1 (es) 2014-01-31
AU2011320155B2 (en) 2016-02-25
CN107595836A (zh) 2018-01-19
US20150190367A1 (en) 2015-07-09
RU2597746C2 (ru) 2016-09-20
JP6310971B2 (ja) 2018-04-11
RU2013123794A (ru) 2014-12-10
JP2017019806A (ja) 2017-01-26
HUE035393T2 (en) 2018-05-02
US20140294903A1 (en) 2014-10-02
CA2816416A1 (en) 2012-05-03
DK2632550T3 (en) 2017-08-07
PT2632550T (pt) 2017-08-02
JP2013540826A (ja) 2013-11-07
MX2013004873A (es) 2013-08-21

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SESSION XXXI ANNUAL CONFERENCE OF INDIAN PHARMACOLOGICAL SOCIETY DECEMBER 18-20, 1998, LUCKNOW

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20160713

Address after: California, USA

Applicant after: NAPO PHARMACEUTICALS, Inc.

Address before: North Carolina

Applicant before: Salix Pharmaceuticals, Inc.

Applicant before: NAPO PHARMACEUTICALS, Inc.

Effective date of registration: 20160713

Address after: North Carolina

Applicant after: Salix Pharmaceuticals, Inc.

Applicant after: NAPO PHARMACEUTICALS, Inc.

Address before: North Carolina

Applicant before: SALIX PHARMACEUTICALS, LTD.

Applicant before: NAPO PHARMACEUTICALS, Inc.

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20131023