CN103341147B - Traditional Chinese medicine preparation for treating cold and dampness-clip hot allergic rhinitis and chronic rhinitis - Google Patents
Traditional Chinese medicine preparation for treating cold and dampness-clip hot allergic rhinitis and chronic rhinitis Download PDFInfo
- Publication number
- CN103341147B CN103341147B CN201310305307.8A CN201310305307A CN103341147B CN 103341147 B CN103341147 B CN 103341147B CN 201310305307 A CN201310305307 A CN 201310305307A CN 103341147 B CN103341147 B CN 103341147B
- Authority
- CN
- China
- Prior art keywords
- parts
- rhinitis
- radix
- chinese medicine
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 53
- 206010039083 rhinitis Diseases 0.000 title claims abstract description 34
- 201000009151 chronic rhinitis Diseases 0.000 title claims abstract description 27
- 206010039085 Rhinitis allergic Diseases 0.000 title claims abstract description 26
- 201000010105 allergic rhinitis Diseases 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 238000011282 treatment Methods 0.000 claims abstract description 20
- 229940079593 drug Drugs 0.000 claims abstract description 19
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 9
- 238000009835 boiling Methods 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 206010037660 Pyrexia Diseases 0.000 claims description 13
- 241000628997 Flos Species 0.000 claims description 8
- 239000009636 Huang Qi Substances 0.000 claims description 8
- 241000222640 Polyporus Species 0.000 claims description 8
- 239000009670 cang er zi wan Substances 0.000 claims description 8
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 8
- 241000219112 Cucumis Species 0.000 claims description 7
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 claims description 7
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims description 7
- 239000010135 fructus aurantii immaturus Substances 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 208000024891 symptom Diseases 0.000 abstract description 5
- 230000036039 immunity Effects 0.000 abstract description 4
- 230000004089 microcirculation Effects 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 230000001575 pathological effect Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000000903 blocking effect Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 238000012795 verification Methods 0.000 abstract description 2
- 241000132012 Atractylodes Species 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 241000222684 Grifola Species 0.000 abstract 1
- 235000010254 Jasminum officinale Nutrition 0.000 abstract 1
- 240000005385 Jasminum sambac Species 0.000 abstract 1
- 241001673966 Magnolia officinalis Species 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 206010028740 Nasal dryness Diseases 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 208000027406 nose symptom Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- 210000001331 nose Anatomy 0.000 description 11
- 239000007788 liquid Substances 0.000 description 10
- 238000002386 leaching Methods 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 8
- 206010028748 Nasal obstruction Diseases 0.000 description 7
- 208000026935 allergic disease Diseases 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 5
- 206010039101 Rhinorrhoea Diseases 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 210000002850 nasal mucosa Anatomy 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 208000037920 primary disease Diseases 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000003928 nasal cavity Anatomy 0.000 description 3
- 230000000306 recurrent effect Effects 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- 206010003645 Atopy Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000005946 Xerostomia Diseases 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 208000037976 chronic inflammation Diseases 0.000 description 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 2
- 206010013781 dry mouth Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 208000010753 nasal discharge Diseases 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000002636 symptomatic treatment Methods 0.000 description 2
- 210000004876 tela submucosa Anatomy 0.000 description 2
- 239000009571 yupingfeng Substances 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 241001251949 Xanthium sibiricum Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000028004 allergic respiratory disease Diseases 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229960001803 cetirizine Drugs 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000008563 guizhi decoction Substances 0.000 description 1
- 239000008361 herbal raw material Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 229940029329 intrinsic factor Drugs 0.000 description 1
- 229960003088 loratadine Drugs 0.000 description 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000492 nasalseptum Anatomy 0.000 description 1
- 210000000885 nephron Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine preparation for treating cold and dampness-clip hot allergic rhinitis and chronic rhinitis, which is mainly characterized in that stomach-calming poria five decoction which is prepared from licorice, magnolia officinalis, atractylodes rhizome, tangerine peel, bighead atractylodes rhizome, rhizoma alismatis, grifola, tuckahoe and cassia twig is used for blocking the pathological fluid retention of the nasal orifice to quickly eliminate the nose symptoms, but no traditional Chinese medicine used for treating rhinitis and adopting the conception and formulation is available at present. The radix rehmanniae relieves the dry nose symptom, cortex moutan perfects the nasal microcirculation, and jasmine, forsythia and mint clear the stagnation of hot-evil; a plurality of drugs are synthesized to an efficient preparation for treating cold and dampness-clip hot allergic rhinitis and chronic rhinitis; and the traditional Chinese medicine preparation has the beneficial effects of providing a specific medicine formulation for cold and dampness-clip hot allergic rhinitis and chronic rhinitis and being short in treatment period, quick to become effective, sufficient and facile in medicine resources, low in cost, simple and convenient to operate, convenient to take, free of hormonal toxic side effect and capable of improving the immunity of the organism to reduce recurrence, and the traditional Chinese medicine preparation belongs to natural and environmentally-friendly medicine; and as shown in clinical verifications, the effective rate is 92.9%, so that the traditional Chinese medicine preparation is suitable for large-scale popularization and application.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of rhinitis, particularly a kind for the treatment of cold-damp adopting herbal raw material to make presss from both sides the Chinese medicine preparation of pattern of fever allergic rhinitis, chronic rhinitis.
Background technology
Allergic rhinitis (allergic rhinitis, AR) also known as allergic rhinitis, for body increases some allergen (i.e. anaphylactogen) sensitivity and occur in the allergy of bronchia mucosal, it is also the common manifestation form of allergic airway disease.After general former by contact allergy, the allergic disease occurring in nasal mucosa mediated by IgE, belongs to anaphylaxis, i.e. immediate allergy.The rhinocnesmus that cardinal symptom shows as suddenly and repeatability is shown effect, paroxysmal sneeze, a large amount of water sample tears and nasal obstruction etc.
Chronic rhinitis is the chronic inflammatory disease of nasal mucosa and Submucosa.Its main feature is that inflammation continues more than three months or recurrent exerbation, protracted course of disease, and the intermission also can not recover normal, and without clear and definite pathogenic microorganism, with nasal obstruction in various degree, and secretions increase, tunica mucosa nasi swelling or the obstacle such as to thicken.
The traditional Chinese medical science is thought, allergic rhinitis surely belong to " allergic rhinitis " category, has relative recording in the understanding successive dynasties document of its main etiology and pathogenesis.Wherein "Nei Jing" thinks that this is sick main relevant with seasonal weather, and also with meridians, internal organs, particularly kidney is relevant.The record that Sui Dynasty Chao Yuanfang (550-630 A.D.) is shown in " General Treatise on the Cause and Symptoms of Diseases " to be had " lung-QI connecting with the nose, it is dirty has cold, and cold air enters to take advantage of in nose, therefore makes body fluid can not from receiving ", points out that lungs cold caused by deficiency is the Important cause of disease of morbidity.In Ming Dynasty's " Compendium of medicine " " fortune allergic rhinitis has two, and one says fire attack deficiency of the lung allergic rhinitis; Two say gold helps excess of the lung allergic rhinitis ", indicate again and intimately also can fall ill.The Xue Lizhai being all the Ming Dynasty proposes lung spleen and causes empty viewpoint, contained as " internal medicine summary ": " confucian scholar's element is hardworking, aversion to wind and cold, rhinorrhea with clear discharge, and cold taboo is sneezed.More than say: this deficiency of both the splenic and pulmonary QI can not real space between skin and muscles." be all representative viewpoint.
Clinical practice is thought, the occurrence cause of primary disease has be intrinsic factor at two: one, mostly is visceral dysfunction, and mainly lung, spleen, kidney three deficiency of five ZANG-organs damage; Two is extrinsic factor, caused by the heresy invasion and attack nose key mostly being wind and cold, unusual pathogen.Exopathogenic factor and endogenous cause of ill are often combined into trouble, and temper is not filled, and nephrons virtual loss all can cause insufficiency of lung-QI, and Wei Yang is solid, and exopathogen is taken advantage of a weak point and sent out disease for this reason.Therefore, because this within primary disease, outer because mark, the clinical onset process of allergic rhinitis, i.e. acute attack stage and interval catabasis.Based on the diseases caused by exogenous pathogenic factor domination of pathogen during stage of attack, the interval catabasis then dirty virtual loss of common lung spleen kidney three and feel exopathogen again.Exopathogen then mainly ailment said due to cold or exposure, headed by exopathogen invasion and attack ailment said due to cold or exposure, manyly folds as disease with cold, heat, positive so-called " ailment said due to cold or exposure is the length of all kinds of diseases and ailments ".
The medicine of current market treatment allergia chronic rhinitis, Western medicine is mainly with shrinking the medicine of nose bleeding pipe if ephedrine, Loratadine are as cetirizine, steroid hormone spray etc., these are all symptomatic treatments, do not effect a radical cure source of disease, and have side effect in various degree; Also have treatment by Chinese herbs in addition, because of the little and etiological treatment of side effect, effect is better, and relevant herbal species is more at present, but does not have symptomatic treatment because only treating source of disease, does not reach the effect for the treatment of both the principal and secondary aspects of a disease; Particularly very clear and definite medicine be there is no for cold, that heat folds situation rhinitis.
Summary of the invention
Technical problem to be solved by this invention be for cold-damp folder pattern of fever allergia chronic rhinitis provide a kind of strengthening the body resistance, improve body constitution basis on YIN and YANG balance regulating is carried out to patient, heat clearing away of inducing sweat, improve nasal cavity microcirculation, block the Chinese medicine preparation that nose key pathologic body fluid stops gathering.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is a kind of Chinese medicine preparation for the treatment of cold-damp folder pattern of fever allergic rhinitis, chronic rhinitis, it is characterized in that crude drug proportioning and preparation method thereof.
Described crude drug proportioning is made up of the crude drug of following weight portion.
Ramulus Cinnamomi 9-11 part, Radix Paeoniae Alba 9-11 part, Rhizoma Zingiberis Recens 9-11 part, Fructus Jujubae 9-11 part, Radix Glycyrrhizae 9-11 part, Cortex Magnoliae Officinalis 9-11 part, Rhizoma Atractylodis 9-11 part, Pericarpium Citri Reticulatae 9-11 part, Rhizoma Atractylodis Macrocephalae 9-11 part, Rhizoma Alismatis 9-11 part, Polyporus 9-11 part, Poria 11-13 part, melon shell 9-11 part, Bulbus Allii Macrostemonis 9-11 part, Fructus Aurantii Immaturus 9-11 part, Radix Bupleuri 9-11 part, Cortex Moutan 9-11 part, Radix Rehmanniae 9-11 part, Fructus Xanthii 9-11 part, Flos Magnoliae 11-13 part, Radix Saposhnikoviae 9-11 part, Radix Astragali 14-16 part, Fructus Gardeniae 9-11 part, Herba Menthae 9-11 part, Fructus Forsythiae 11-13 part.
Described preparation method is taken each raw material medicaments in part by weight proportioning, with the water soaking 30 minutes of crude drug gross weight 5 times, then boils boiling with big fire, then decocts 30 minutes with little fire, filter and collect decoction liquor; And then medicinal residues are rejoined the soak by water of crude drug gross weight 4 times, with slow fire boiling 25 minutes after boiling, filter and collect decoction liquor, so repeatedly extract 2 times; Then merge the decoction liquor of 3 times, leave standstill 12 hours, finally decoction liquor is concentrated into 2 times of crude drug gross weight.
Preferred weight part proportioning of described crude drug proportioning is.
Ramulus Cinnamomi 10 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae, Cortex Magnoliae Officinalis 10 parts, Rhizoma Atractylodis 10 parts, Pericarpium Citri Reticulatae 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Alismatis 10 parts, Polyporus 10 parts, 12 parts, Poria, 10 parts, melon shell, Bulbus Allii Macrostemonis 10 parts, Fructus Aurantii Immaturus 10 parts, Radix Bupleuri 10 parts, Cortex Moutan 10 parts, 10 parts, the Radix Rehmanniae, Fructus Xanthii 10 parts, Flos Magnoliae 12 parts, Radix Saposhnikoviae 10 parts, the Radix Astragali 15 parts, Fructus Gardeniae 10 parts, Herba Menthae 10 parts, Fructus Forsythiae 12 parts.
The present invention can conventionally concoct as required and make Chinese medicine decoction, electuary, granule, powder, watered pill, tablet, mixture and oral liquid etc.
Chronic rhinitis is the chronic inflammatory disease of nasal mucosa and Submucosa, its main feature is that inflammation continues more than three months or recurrent exerbation, protracted course of disease, intermission also can not recover normal, and without clear and definite pathogenic microorganism, with nasal obstruction in various degree, secretions increase, tunica mucosa nasi swelling or the obstacle such as to thicken.Allergic rhinitis, the histamine's medium primarily of IgE mediation after referring to atopic individuals contact allergen discharges, and has the nasal mucosa non-infectious inflammatory disease that panimmunity competent cell and cytokine etc. participate in; Its essential condition occurred has 3: 1. namely specific antigen causes the material of organism immune response, 2. atopic individuals and so-called individual variation, allergic constitution, and 3. specific antigen and spy answer both type individualities to meet; Many scholars think that chronic rhinitis is relevant with anaphylactogen with the immunologic function of human body; Chinese medicine thinks that chronic rhinitis, allergic rhinitis are mainly due to insufficiency of lung-QI in fact, instability of surface, and pathogen is taken advantage of a weak point, and violate and nose key, pathogen conflicting with vital QI, lung qi must not lead to tune, and body fluid stops gathering, and nose key is jammed, then to sending out as primary disease; Or the heat-transformation because primary disease recurrent exerbation is strongly fragrant, or the heresy of cold-damp is experienced because patient's body constitution belongs to wooden fiery class, be directed at intermingling cold and heat type; Therefore this formula Rhizoma Atractylodis Macrocephalae, the Radix Astragali, the YUPINGFENG SAN tonifying the lung of Radix Saposhnikoviae allotment is dispeled the wind and enhancing human body immunity power; With Ramulus Cinnamomi, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Fructus Jujubae, the guizhi decoction YIN and YANG balance regulating of Radix Glycyrrhizae allotment, assist YUPINGFENG SAN enhancing human body immunity power, with Fructus Xanthii, Flos Magnoliae clearing the nasal passage, priming is to nose.
The maximum feature of formula of the present invention is that blocking nose key pathologic body fluid with the stomach Siberian cocklebur soup of Radix Glycyrrhizae, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Alismatis, Polyporus, Poria, Ramulus Cinnamomi allotment stops gathering, with Rapid reversal sniffle, also do not take the Chinese patent medicine of this thinking and formula treatment rhinitis at present; Wherein the Radix Rehmanniae alleviates dryness in the nasal cavity symptom, and Cortex Moutan improves nasal cavity microcirculation, and Fructus Gardeniae, Fructus Forsythiae, Herba Menthae etc. are hot and suffocating clearly; All medicines share the efficient prescription becoming treatment cold-damp folder pattern of fever allergia chronic rhinitis.
Chinese medicine preparation of the present invention is used for the treatment of: chronic rhinitis, allergic rhinitis, and disease is seen: sneeze, flow yellow nasal mucus, prolonged and repeated nasal obstruction, or xerostomia is bitter, and body of the tongue is light red, yellow, greasy and thin fur.
Usage and consumption are: each serving with 30ML mono-day 3 times, be a course for the treatment of with 30 days.
The invention has the beneficial effects as follows that chronic rhinitis, proposes pharmaceutical formulation and preparation method targetedly to cold-damp folder pattern of fever allergic rhinitis, short treating period, instant effect, medicine medicine source is rich and easy to get, sheerly natural green medicine, cheap, easy and simple to handle, taking convenience, without hormones toxic and side effects, also can improve immunity of organisms, reduce recurrence; Through clinical verification, effective percentage reaches 92.9%, is applicable to large-scale popularization and uses.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, and following examples are intended to the present invention instead of limitation of the invention further are described, should not limit the scope of the invention with this.
Embodiment 1.
Take each crude drug by weight: Ramulus Cinnamomi 900g, Radix Paeoniae Alba 900g, Rhizoma Zingiberis Recens 900g, Fructus Jujubae 900g, Radix Glycyrrhizae 900g, Cortex Magnoliae Officinalis 900g, Rhizoma Atractylodis 900g, Pericarpium Citri Reticulatae 900g, Rhizoma Atractylodis Macrocephalae 900g, Rhizoma Alismatis 900g, Polyporus 900g, Poria 1100g, melon shell 900g, Bulbus Allii Macrostemonis 900g, Fructus Aurantii Immaturus 900g, Radix Bupleuri 900g, Cortex Moutan 900g, Radix Rehmanniae 900g, Fructus Xanthii 900g, Flos Magnoliae 1100g, Radix Saposhnikoviae 900g, Radix Astragali 1400g, Fructus Gardeniae 900g, Herba Menthae 900g, Fructus Forsythiae 1100g; Put into cooker to add 107kg clear water and soak 30 minutes, then boil boiling with big fire, then decoct 30 minutes with little fire, cross leaching liquid and obtain 95.7kg decoction liquor; And then medicinal residues are rejoined the decoction of 85.6kg clear water, decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 79.5kg decoction liquor; And then medicinal residues are rejoined the decoction of 85.6kg clear water, then decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 79.3kg decoction liquor; Then merge the decoction liquor of 3 times, leave standstill 12 hours, finally by decoction liquor evaporation and concentration to 42.8kg, namely obtain a kind of Chinese medicine preparation 42.8kg treating cold-damp folder pattern of fever allergic rhinitis, chronic rhinitis of the present invention.
Embodiment 2.
Take each crude drug by weight: Ramulus Cinnamomi 100g, Radix Paeoniae Alba 100g, Rhizoma Zingiberis Recens 100g, Fructus Jujubae 100g, Radix Glycyrrhizae 100g, Cortex Magnoliae Officinalis 100g, Rhizoma Atractylodis 100g, Pericarpium Citri Reticulatae 100g, Rhizoma Atractylodis Macrocephalae 100g, Rhizoma Alismatis 100g, Polyporus 100g, Poria 120g, melon shell 100g, Bulbus Allii Macrostemonis 100g, Fructus Aurantii Immaturus 100g, Radix Bupleuri 100g, Cortex Moutan 100g, Radix Rehmanniae 100g, Fructus Xanthii 100g, Flos Magnoliae 120g, Radix Saposhnikoviae 100g, Radix Astragali 150g, Fructus Gardeniae 100g, Herba Menthae 100g, Fructus Forsythiae 120g; Put into a watt cylinder to add 13.050kg clear water and soak 30 minutes, then boil boiling with big fire, then decoct 30 minutes with little fire, cross leaching liquid and obtain 10.91kg decoction liquor; And then medicinal residues are rejoined the decoction of 10.44kg clear water, then decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 9.83kg decoction liquor; And then medicinal residues are rejoined the decoction of 10.44kg clear water, then decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 9.78kg decoction liquor; Then merge the decoction liquor of 3 times, leave standstill 12 hours, finally by decoction liquor evaporation and concentration to 5.22kg, namely obtain a kind of Chinese medicine preparation 5.22kg treating cold-damp folder pattern of fever allergic rhinitis, chronic rhinitis of the present invention.
Embodiment 3.
Take each crude drug by weight: Ramulus Cinnamomi 1.1kg, Radix Paeoniae Alba 1.1kg, Rhizoma Zingiberis Recens 1.1kg, Fructus Jujubae 1.1kg, Radix Glycyrrhizae 1.1kg, Cortex Magnoliae Officinalis 1.1kg, Rhizoma Atractylodis 1.1kg, Pericarpium Citri Reticulatae 1.1kg, Rhizoma Atractylodis Macrocephalae 1.1kg, Rhizoma Alismatis 1.1kg, Polyporus 1.1kg, Poria 1.3kg, melon shell 1.1kg, Bulbus Allii Macrostemonis 1.1kg, Fructus Aurantii Immaturus 1.1kg, Radix Bupleuri 1.1kg, Cortex Moutan 1.1kg, Radix Rehmanniae 1.1kg, Fructus Xanthii 1.1kg, Flos Magnoliae 1.3kg, Radix Saposhnikoviae 1.1kg, Radix Astragali 1.6kg, Fructus Gardeniae 1.1kg, Herba Menthae 1.1kg, Fructus Forsythiae 1.3kg; Put into a watt cylinder and add 143kg clear water, soak after 30 minutes, boil boiling with big fire, then decoct 30 minutes with little fire, cross leaching liquid and obtain 129kg decoction liquor; Then medicinal residues are rejoined 114.4kg clear water to decoct, then decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 101.5kg decoction liquor; And then medicinal residues are rejoined the decoction of 114.4kg clear water, then decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 100.9kg decoction liquor; Then merge the decoction liquor of 3 times, leave standstill 12 hours, finally by decoction liquor evaporation and concentration to 57.2kg, namely obtain a kind of Chinese medicine preparation 57.2kg treating cold-damp folder pattern of fever allergic rhinitis, chronic rhinitis of the present invention.
Clinical experiment process and result as follows.
1. choose case and meet Western medicine diagnose " allergia chronic rhinitis ".
2. criterion of therapeutical effect is: recovery from illness: thin nasal discharge, rhinocnesmus disappear; Take a turn for the better: thin nasal discharge disappears, rhinocnesmus is alleviated; Do not heal: symptom is unchanged.
3. Therapeutic Method is each serving with 30ML mono-day 3 times, is a course for the treatment of with 10 days.
Clinical experiment 71 example of the present invention, wherein male 27 example, women 44 example, the oldest 57 years old, minimum 7 years old.
Wherein model case is as follows.
Case 1, revives certain, man 45 years old, for Qianjiang, Chongqing People's Armed Police, suffer from chronic rhinitis more than a year, long-term nasal obstruction is obstructed, through in many ways curing, imitate not good, gone to a doctor in June, 2009, disease sees light red tongue yellow and thin fur, xerostomia is bitter, after taking two courses for the treatment of of above-mentioned formula, stuffy nose with watery discharge all takes a turn for the better, and follow up a case by regular visits to 1 year, rhinitis does not recur again.
Case 2, Luo, man, 56 years old, live near middle school of Xinhua, Qianjiang District, long-term nose is dry, very painful, once examines as rhinitis sicca in Chongqing one Grade A hospital department of eye, gone to a doctor in April, 2011, examine as cold-damp folder pattern of fever chronic rhinitis, after taking two courses for the treatment of of above-mentioned formula, all diseases alleviate.
Case 3, Guo, man, 39 years old, live post office, Qianjiang dormitory building, gone to a doctor in August, 2011, it is many for half a year that patient suffers from chronic rhinitis, nasal obstruction, sneeze, snivel, bitter taste, light red tongue yellow, greasy and thin fur.Examined as allergic rhinitis in Qianjiang central hospital department of eye before February, deviation of nasal septum, suggestion operative treatment, patient refuses operation, and come after here takes two courses for the treatment of of above-mentioned formula, rhinitis does not recur again.
Case 4, what
certain, female, 16 years old, live stage casing, Qianjiang District Xinhua East Road, go to a doctor on August 9th, 2010, suffer from chronic rhinitis more than 1 year, existing disease sees nasal obstruction, sneeze, snivel, bitter taste, light red tongue yellow, greasy and thin fur, spirit is not good enough, examines as cold-damp folder pattern of fever chronic rhinitis, after taking two courses for the treatment of of above-mentioned formula, all diseases alleviate.
This 71 routine clinical effectiveness is: clinical cure 15 example, and take a turn for the better 51 examples, invalid 5 examples, clinical effective rate 92.9%.
Claims (2)
1. treat a Chinese medicine preparation for cold-damp folder pattern of fever allergic rhinitis, chronic rhinitis, it is characterized in that crude drug proportioning and preparation method thereof:
Described crude drug proportioning is made up of the crude drug of following weight portion:
Ramulus Cinnamomi 9-11 part, Radix Paeoniae Alba 9-11 part, Rhizoma Zingiberis Recens 9-11 part, Fructus Jujubae 9-11 part, Radix Glycyrrhizae 9-11 part, Cortex Magnoliae Officinalis 9-11 part, Rhizoma Atractylodis 9-11 part, Pericarpium Citri Reticulatae 9-11 part, Rhizoma Atractylodis Macrocephalae 9-11 part, Rhizoma Alismatis 9-11 part, Polyporus 9-11 part, Poria 11-13 part, melon shell 9-11 part, Bulbus Allii Macrostemonis 9-11 part, Fructus Aurantii Immaturus 9-11 part, Radix Bupleuri 9-11 part, Cortex Moutan 9-11 part, Radix Rehmanniae 9-11 part, Fructus Xanthii 9-11 part, Flos Magnoliae 11-13 part, Radix Saposhnikoviae 9-11 part, Radix Astragali 14-16 part, Fructus Gardeniae 9-11 part, Herba Menthae 9-11 part, Fructus Forsythiae 11-13 part,
Described preparation method is taken each raw material medicaments in part by weight proportioning, with the water soaking 30 minutes of crude drug gross weight 5 times, then boils boiling with big fire, then decocts 30 minutes with little fire, filter and collect decoction liquor; And then medicinal residues are rejoined the soak by water of crude drug gross weight 4 times, with slow fire boiling 25 minutes after boiling, filter and collect decoction liquor, so repeatedly extract 2 times; Then merge the decoction liquor of 3 times, leave standstill 12 hours, finally decoction liquor is concentrated into 2 times of crude drug gross weight.
2. a kind of Chinese medicine preparation for the treatment of cold-damp folder pattern of fever allergic rhinitis, chronic rhinitis according to claim 1, is characterized in that preferred weight part proportioning of described crude drug proportioning is:
Ramulus Cinnamomi 10 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae, Cortex Magnoliae Officinalis 10 parts, Rhizoma Atractylodis 10 parts, Pericarpium Citri Reticulatae 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Alismatis 10 parts, Polyporus 10 parts, 12 parts, Poria, 10 parts, melon shell, Bulbus Allii Macrostemonis 10 parts, Fructus Aurantii Immaturus 10 parts, Radix Bupleuri 10 parts, Cortex Moutan 10 parts, 10 parts, the Radix Rehmanniae, Fructus Xanthii 10 parts, Flos Magnoliae 12 parts, Radix Saposhnikoviae 10 parts, the Radix Astragali 15 parts, Fructus Gardeniae 10 parts, Herba Menthae 10 parts, Fructus Forsythiae 12 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310305307.8A CN103341147B (en) | 2013-07-21 | 2013-07-21 | Traditional Chinese medicine preparation for treating cold and dampness-clip hot allergic rhinitis and chronic rhinitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310305307.8A CN103341147B (en) | 2013-07-21 | 2013-07-21 | Traditional Chinese medicine preparation for treating cold and dampness-clip hot allergic rhinitis and chronic rhinitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103341147A CN103341147A (en) | 2013-10-09 |
| CN103341147B true CN103341147B (en) | 2014-12-24 |
Family
ID=49276006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310305307.8A Active CN103341147B (en) | 2013-07-21 | 2013-07-21 | Traditional Chinese medicine preparation for treating cold and dampness-clip hot allergic rhinitis and chronic rhinitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103341147B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233219A (en) * | 2015-10-30 | 2016-01-13 | 刘爱华 | Traditional Chinese medicine composition for treating chronic rhinitis |
| CN116870112B (en) * | 2023-08-28 | 2024-04-19 | 山西医科大学第一医院 | Traditional Chinese medicine preparation for treating allergic rhinitis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813904B (en) * | 2012-09-06 | 2013-10-30 | 江苏省中医院 | Compound medicine for treating anaphylactic rhinitis-asthma syndrome and preparation method and application thereof |
-
2013
- 2013-07-21 CN CN201310305307.8A patent/CN103341147B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103341147A (en) | 2013-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103550729B (en) | A kind of Chinese medicine composition for the treatment of cough | |
| CN103356756A (en) | Traditional Chinese medicine composition for treating allergic rhinitis | |
| CN104042814A (en) | Traditional Chinese medicinal composition for treating anaphylactic rhinitis | |
| CN104857080A (en) | Nose drop for treating nasosinusitis | |
| CN103432545A (en) | Medicament for allaying fever of child and preparation method thereof | |
| CN103301439A (en) | Traditional Chinese medicine composition for treating chronic enteritis and preparation method thereof | |
| CN103251898B (en) | Traditional Chinese medicine preparation for treating dysmenorrhea | |
| CN102600426B (en) | Chinese medicinal preparation for promoting blood circulation to remove blood stasis and preparation method thereof | |
| CN103948675A (en) | Traditional Chinese medicine for treating chronic rhinitis | |
| CN102526677B (en) | Chinese medicine foot-massage composition for treating common cold due to wind-cold | |
| CN103341147B (en) | Traditional Chinese medicine preparation for treating cold and dampness-clip hot allergic rhinitis and chronic rhinitis | |
| CN103341146B (en) | Traditional Chinese medicine preparation for treating cold and dampness type chronic rhinitis | |
| CN103463344A (en) | Traditional Chinese medicinal composition for treating trigeminal neuralgia | |
| CN103463254A (en) | Traditional Chinese medicine composition for treating allergic rhinitis | |
| CN103028037A (en) | Traditional Chinese medicine prescription for treating allergic rhinitis | |
| CN103550348B (en) | Traditional Chinese medicine formula for treating chronic erosive gastritis | |
| CN106539908A (en) | A kind of Chinese medicine composition for treating allergic rhinitises and skin allergy | |
| CN102698073B (en) | Traditional Chinese medicine extract for treating allergic rhinitis | |
| CN104523911A (en) | Medicine for treating acute and chronic rhinitis | |
| CN104857414A (en) | Medicine composite for treating chronic simple rhinitis | |
| CN104771516A (en) | Traditional Chinese medicine composition for treating allergic dermatitis | |
| CN103800869A (en) | Traditional Chinese medicine composition for treating anaphylactic rhinitis | |
| CN103169940A (en) | Drug for treating facioplegia | |
| CN106309684A (en) | Pill medicine for treating allergic rhinitis and preparation method thereof | |
| CN106310096A (en) | Decoction pharmaceutical for treating allergic rhinitis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Ma Xilei Inventor before: He Benyang Inventor before: Xie Yinfang |
|
| CB03 | Change of inventor or designer information | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180208 Address after: No. 192 Qi Cun village, Qi Cun town, Central District, Zaozhuang City, Shandong Province Patentee after: Ma Xilei Address before: 409000 Chongqing city Qianjiang District Officer Ba Lu Jin Xiu Yuan 1 Building 2 unit 601 room Patentee before: Xie Yinfang |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20180920 Address after: 518000 Tian'an Community, Shatou Street, Futian District, Shenzhen City, Guangdong Province Patentee after: Shenzhen jinshijia Biological Technology Management Co.,Ltd. Address before: 277122 Qi Qi Cun 192, Qi Cun town, Shizhong District, Zaozhuang, Shandong Patentee before: Ma Xilei |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190515 Address after: 277110 Qixi Village 383, Qicun Town, Central District, Zaozhuang City, Shandong Province Patentee after: Ma Xilei Address before: 518000 Tian'an Community, Shatou Street, Futian District, Shenzhen City, Guangdong Province Patentee before: Shenzhen jinshijia Biological Technology Management Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221129 Address after: No. 209-27, Ruijing Road, Xiangcheng District, Zhangzhou City, Fujian Province, 363000 Patentee after: Zhangzhou Fuyezi Biotechnology Co.,Ltd. Address before: 277110 Qixi Village 383, Qicun Town, Central District, Zaozhuang City, Shandong Province Patentee before: Ma Xilei |
|
| TR01 | Transfer of patent right |