CN103341146B - Traditional Chinese medicine preparation for treating cold and dampness type chronic rhinitis - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating cold and dampness type chronic rhinitis, which is mainly characterized in that stomach-calming poria five decoction which is prepared from licorice, magnolia officinalis, atractylodes rhizome, tangerine peel, bighead atractylodes rhizome, rhizoma alismatis, grifola, tuckahoe and cassia twig is used for blocking the pathological fluid retention of the nasal orifice to quickly remove the nose symptoms but no traditional Chinese medicine used for treating rhinitis and adopting the conception and formulation is available at present. The radix rehmanniae relieves the dry nose symptom, cortex moutan perfects the nasal microcirculation, and jasmine, forsythia and mint clear the stagnation of hot-evil; a plurality of drugs are synthesized to an efficient preparation for treating cold and dampness type chronic rhinitis; and the traditional Chinese medicine preparation has the beneficial effects of providing a specific medicine formulation for cold and dampness type chronic rhinitis and being short in treatment period, quick to become effective, sufficient and facile in medicine resources, low in cost, simple and convenient to operate, convenient to take, free of hormonal toxic side effect and capable of improving the immunity of the organism to reduce recurrence, and the traditional Chinese medicine preparation belongs to natural and environmentally-friendly medicine; and as shown in clinical verifications, the effective rate is 96.6%, so that the traditional Chinese medicine preparation is suitable for large-scale popularization and application.

Description

A kind of Chinese medicine preparation for the treatment of cold-dampness type chronic rhinitis

Technical field

The present invention relates to a kind of pharmaceutical composition for the treatment of rhinitis, particularly a kind of Chinese medicine preparation of the treatment cold-dampness type chronic rhinitis adopting herbal raw material to make.

Background technology

Chronic rhinitis is the chronic inflammatory disease of nasal mucosa and Submucosa.Its main feature is that inflammation continues more than three months or recurrent exerbation, protracted course of disease, and the intermission also can not recover normal, and without clear and definite pathogenic microorganism, with nasal obstruction in various degree, and secretions increase, tunica mucosa nasi swelling or the obstacle such as to thicken.

The traditional Chinese medical science is thought, chronic rhinitis surely belongs to " allergic rhinitis " category, has relative recording in the understanding successive dynasties document of its main etiology and pathogenesis.Wherein "Nei Jing" thinks that this is sick main relevant with seasonal weather, and also with meridians, internal organs, particularly kidney is relevant.The record that Sui Dynasty Chao Yuanfang (550-630 A.D.) is shown in " General Treatise on the Cause and Symptoms of Diseases " to be had " lung-QI connecting with the nose, it is dirty has cold, and cold air enters to take advantage of in nose, therefore makes body fluid can not from receiving ", points out that lungs cold caused by deficiency is the Important cause of disease of morbidity.In Ming Dynasty's " Compendium of medicine " " fortune allergic rhinitis has two, and one says fire attack deficiency of the lung allergic rhinitis; Two say gold helps excess of the lung allergic rhinitis ", indicate again and intimately also can fall ill.The Xue Lizhai being all the Ming Dynasty proposes lung spleen and causes empty viewpoint, contained as " internal medicine summary ": " confucian scholar's element is hardworking, aversion to wind and cold, rhinorrhea with clear discharge, and cold taboo is sneezed.More than say: this deficiency of both the splenic and pulmonary QI can not real space between skin and muscles." be all representative viewpoint.

Clinical practice is thought, the occurrence cause of primary disease has be intrinsic factor at two: one, mostly is visceral dysfunction, and mainly lung, spleen, kidney three deficiency of five ZANG-organs damage; Two is extrinsic factor, caused by the heresy invasion and attack nose key mostly being wind and cold, unusual pathogen.Exopathogenic factor and endogenous cause of ill are often combined into trouble, and temper is not filled, and nephrons virtual loss all can cause insufficiency of lung-QI, and Wei Yang is solid, and exopathogen is taken advantage of a weak point and sent out disease for this reason.Therefore, because this within primary disease, outer because mark, the clinical onset process of allergic rhinitis, i.e. acute attack stage and interval catabasis.Based on the diseases caused by exogenous pathogenic factor domination of pathogen during stage of attack, the interval catabasis then dirty virtual loss of common lung spleen kidney three and feel exopathogen again.Exopathogen then mainly ailment said due to cold or exposure, headed by exopathogen invasion and attack ailment said due to cold or exposure, manyly press from both sides as sick with cold, wetting phase, positive what is called " rheumatism is the length of all kinds of diseases and ailments ".

The medicine of current market treatment chronic rhinitis, Western medicine is mainly with shrinking the medicine of nose bleeding pipe if ephedrine, Loratadine are as cetirizine, steroid hormone spray etc., and these are all symptomatic treatments, do not effect a radical cure source of disease, and have side effect in various degree; Also have treatment by Chinese herbs in addition, because of the little and etiological treatment of side effect, effect is better, and relevant herbal species is more at present, but does not have symptomatic treatment because only treating source of disease, does not reach the effect for the treatment of both the principal and secondary aspects of a disease; Particularly very clear and definite medicine be there is no for rhinitis that is cold, wetting phase clip-like condition.

Summary of the invention

Technical problem to be solved by this invention be for cold-dampness type chronic rhinitis provide a kind of strengthening the body resistance, improve body constitution basis on YIN and YANG balance regulating is carried out to patient, heat clearing away of inducing sweat, improve nasal cavity microcirculation, block the Chinese medicine preparation that nose key pathologic body fluid stops gathering.

For solving the problems of the technologies described above, the technical solution adopted in the present invention is a kind of Chinese medicine preparation for the treatment of cold-dampness type chronic rhinitis, it is characterized in that crude drug and proportioning thereof.

Described crude drug proportioning is made up of the crude drug of following weight portion.

Ramulus Cinnamomi 9-11 part, Radix Paeoniae Alba 9-11 part, Rhizoma Zingiberis Recens 9-11 part, Fructus Jujubae 9-11 part, Radix Glycyrrhizae 9-11 part, Cortex Magnoliae Officinalis 9-11 part, Rhizoma Atractylodis 9-11 part, Pericarpium Citri Reticulatae 9-11 part, Rhizoma Atractylodis Macrocephalae 9-11 part, Rhizoma Alismatis 9-11 part, Polyporus 9-11 part, Poria 11-13 part, melon shell 9-11 part, Bulbus Allii Macrostemonis 9-11 part, Fructus Aurantii Immaturus 9-11 part, Radix Bupleuri 9-11 part, Cortex Moutan 9-11 part, Radix Rehmanniae 9-11 part, Fructus Xanthii 9-11 part, Flos Magnoliae 11-13 part, Radix Saposhnikoviae 9-11 part, Herba Asari 7-9 part, Radix Astragali 28-32 part.

Preferred weight part proportioning of described crude drug and proportioning thereof is.

Ramulus Cinnamomi 10 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae, Cortex Magnoliae Officinalis 10 parts, Rhizoma Atractylodis 10 parts, Pericarpium Citri Reticulatae 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Alismatis 10 parts, Polyporus 10 parts, 12 parts, Poria, 10 parts, melon shell, Bulbus Allii Macrostemonis 10 parts, Fructus Aurantii Immaturus 10 parts, Radix Bupleuri 10 parts, Cortex Moutan 10 parts, 10 parts, the Radix Rehmanniae, Fructus Xanthii 10 parts, Flos Magnoliae 12 parts, Radix Saposhnikoviae 10 parts, Herba Asari 4 parts, the Radix Astragali 30 parts.

The present invention can conventionally concoct as required and make Chinese medicine decoction, electuary, granule, powder, watered pill, tablet, mixture and oral liquid etc.

Chronic rhinitis is the chronic inflammatory disease of nasal mucosa and Submucosa, its main feature is that inflammation continues more than three months or recurrent exerbation, protracted course of disease, intermission also can not recover normal, and without clear and definite pathogenic microorganism, with nasal obstruction in various degree, secretions increase, tunica mucosa nasi swelling or the obstacle such as to thicken.Chronic rhinitis, the histamine's medium primarily of IgE mediation after referring to atopic individuals contact allergen discharges, and has the nasal mucosa non-infectious inflammatory disease that panimmunity competent cell and cytokine etc. participate in; Its essential condition occurred has 3: 1. namely specific antigen causes the material of organism immune response, 2. atopic individuals and so-called individual variation, allergic constitution, and 3. specific antigen and spy answer both type individualities to meet; Many scholars think that chronic rhinitis is relevant with anaphylactogen with the immunologic function of human body; Chinese medicine thinks that chronic rhinitis, allergic rhinitis are mainly due to insufficiency of lung-QI in fact, instability of surface, and pathogen is taken advantage of a weak point, and violate and nose key, pathogen conflicting with vital QI, lung qi must not lead to tune, and body fluid stops gathering, and nose key is jammed, then to sending out as primary disease; Or the heat-transformation because primary disease recurrent exerbation is strongly fragrant, or the heresy of cold-damp is experienced because patient's body constitution belongs to wooden fiery class, be directed at intermingling cold and heat type; Therefore this formula Rhizoma Atractylodis Macrocephalae, the Radix Astragali, the YUPINGFENG SAN tonifying the lung of Radix Saposhnikoviae allotment is dispeled the wind and enhancing human body immunity power; With Ramulus Cinnamomi, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Fructus Jujubae, the guizhi decoction YIN and YANG balance regulating of Radix Glycyrrhizae allotment, assist YUPINGFENG SAN enhancing human body immunity power, with Fructus Xanthii, Flos Magnoliae clearing the nasal passage, priming is to nose.

The maximum feature of formula of the present invention is that blocking nose key pathologic body fluid with the stomach Siberian cocklebur soup of Radix Glycyrrhizae, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Alismatis, Polyporus, Poria, Ramulus Cinnamomi allotment stops gathering, with Rapid reversal sniffle, also do not take the Chinese patent medicine of this thinking and formula treatment rhinitis at present; Wherein the Radix Rehmanniae alleviates dryness in the nasal cavity symptom, and Cortex Moutan improves nasal cavity microcirculation; All medicines share the efficient prescription becoming treatment cold-dampness type chronic rhinitis.

Chinese medicine preparation of the present invention is used for the treatment of chronic rhinitis, allergic rhinitis, and disease is seen: sneeze, flow clear nasal mucus, prolonged and repeated nasal obstruction, and body of the tongue is light red, white and thin fur.

The invention has the beneficial effects as follows and pharmaceutical formulation and preparation method are targetedly proposed to cold-dampness type chronic rhinitis, short treating period, instant effect, medicine medicine source is rich and easy to get, sheerly natural green medicine, cheap, easy and simple to handle, taking convenience, without hormones toxic and side effects, also can improve immunity of organisms, reduce recurrence; Through clinical verification, effective percentage reaches 96.6%, is applicable to large-scale popularization and uses.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described, and following examples are intended to the present invention instead of limitation of the invention further are described, should not limit the scope of the invention with this.

Embodiment 1.

Take each crude drug by weight: Ramulus Cinnamomi 900g, Radix Paeoniae Alba 900g, Rhizoma Zingiberis Recens 900g, Fructus Jujubae 900g, Radix Glycyrrhizae 900g, Cortex Magnoliae Officinalis 900g, Rhizoma Atractylodis 900g, Pericarpium Citri Reticulatae 900g, Rhizoma Atractylodis Macrocephalae 900g, Rhizoma Alismatis 900g, Polyporus 900g, Poria 1100g, melon shell 900g, Bulbus Allii Macrostemonis 900g, Fructus Aurantii Immaturus 900g, Radix Bupleuri 900g, Cortex Moutan 900g, Radix Rehmanniae 900g, Fructus Xanthii 900g, Flos Magnoliae 1100g, Radix Saposhnikoviae 900g, Herba Asari 700g, Radix Astragali 2800g; Put into cooker to add 114kg clear water and soak 30 minutes, then boil boiling with big fire, then decoct 30 minutes with little fire, cross leaching liquid and obtain 99.7kg decoction liquor; And then medicinal residues are rejoined the decoction of 91.2kg clear water, decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 81.5kg decoction liquor; And then medicinal residues are rejoined the decoction of 91.2kg clear water, then decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 80.9kg decoction liquor; Then merge the decoction liquor of 3 times, leave standstill 12 hours, finally by decoction liquor evaporation and concentration to 45.6kg, namely obtain a kind of Chinese medicine preparation 45.6kg treating cold-dampness type chronic rhinitis of the present invention.

Embodiment 2.

Take each crude drug by weight: Ramulus Cinnamomi 1kg, Radix Paeoniae Alba 1kg, Rhizoma Zingiberis Recens 1kg, Fructus Jujubae 1kg, Radix Glycyrrhizae 1kg, Cortex Magnoliae Officinalis 1kg, Rhizoma Atractylodis 1kg, Pericarpium Citri Reticulatae 1kg, Rhizoma Atractylodis Macrocephalae 1kg, Rhizoma Alismatis 1kg, Polyporus 1kg, Poria 1.2kg, melon shell 1kg, Bulbus Allii Macrostemonis 1kg, Fructus Aurantii Immaturus 1kg, Radix Bupleuri 1kg, Cortex Moutan 1kg, Radix Rehmanniae 1kg, Fructus Xanthii 1kg, Flos Magnoliae 1.2kg, Radix Saposhnikoviae 1kg, Herba Asari 0.8kg, Radix Astragali 3kg; Put into a watt cylinder and add 126kg clear water, soak after 30 minutes, boil boiling with big fire, then decoct 30 minutes with little fire, cross leaching liquid and obtain 114.5kg decoction liquor; Then medicinal residues are rejoined 100.8kg clear water to decoct, then decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 91.9kg decoction liquor; And then medicinal residues are rejoined the decoction of 100.8kg clear water, then use slow fire boiling 25 minutes after boiling, cross leaching liquid and obtain 91.2kg decoction liquor; Then merge the decoction liquor of 3 times, leave standstill 12 hours, finally by decoction liquor evaporation and concentration to 50.4kg, namely obtain a kind of Chinese medicine preparation 50.4kg treating cold-dampness type chronic rhinitis of the present invention.

Embodiment 3.

Take each crude drug by weight: Ramulus Cinnamomi 1.1kg, Radix Paeoniae Alba 1.1kg, Rhizoma Zingiberis Recens 1.1kg, Fructus Jujubae 1.1kg, Radix Glycyrrhizae 1.1kg, Cortex Magnoliae Officinalis 1.1kg, Rhizoma Atractylodis 1.1kg, Pericarpium Citri Reticulatae 1.1kg, Rhizoma Atractylodis Macrocephalae 1.1kg, Rhizoma Alismatis 1.1kg, Polyporus 1.1kg, Poria 1.3kg, melon shell 1.1kg, Bulbus Allii Macrostemonis 1.1kg, Fructus Aurantii Immaturus 1.1kg, Radix Bupleuri 1.1kg, Cortex Moutan 1.1kg, Radix Rehmanniae 1.1kg, Fructus Xanthii 1.1kg, Flos Magnoliae 1.3kg, Radix Saposhnikoviae 1.1kg, pungent 0.9kg, Radix Astragali 3.2kg; Put into a watt cylinder and add 138kg clear water, soak after 30 minutes, boil boiling with big fire, then decoct 30 minutes with little fire, cross leaching liquid and obtain 121.5kg decoction liquor; Then medicinal residues are rejoined 110.4kg clear water to decoct, then decoct 25 minutes with little fire after boiling, cross leaching liquid and obtain 99.9kg decoction liquor; And then medicinal residues are rejoined the decoction of 110.4kg clear water, then use slow fire boiling 25 minutes after boiling, cross leaching liquid and obtain 99.2kg decoction liquor; Then merge the decoction liquor of 3 times, leave standstill 12 hours, finally by decoction liquor evaporation and concentration to 55.2kg, namely obtain a kind of Chinese medicine preparation 55.2kg treating cold-dampness type chronic rhinitis of the present invention.

Clinical experiment process and result as follows.

1. choose case and meet Western medicine diagnose " chronic rhinitis ".

2. criterion of therapeutical effect is: recovery from illness: thin nasal discharge, rhinocnesmus disappear; Take a turn for the better: thin nasal discharge disappears, rhinocnesmus is alleviated; Do not heal: symptom is unchanged.

3. Therapeutic Method is each serving using 30 ML, one day 3 times, is a course for the treatment of with 30 days.

Clinical experiment 87 example of the present invention, wherein male 43 example, women 44 example, the oldest 59 years old, minimum 7 years old.

Wherein model case is as follows.

Case 1, Lee, man 40 years old, lives city, Qianjiang District of Chongqing, suffers from chronic rhinitis more than 2 years, takes multiple anti-rhinitis Chinese patent medicine, and imitated not good, and after taking two courses for the treatment of of above-mentioned formula, stuffy nose with watery discharge all takes a turn for the better, and follow up a case by regular visits to 1 year, rhinitis does not recur again.

Case 2, Chen, female 28 years old, live Zhou Bai community, Qianjiang District road East Village, long-term nasal obstruction is obstructed, and perfume (or spice) is smelt and can not be heard, very painful, gone to a doctor in June, 2009, disease sees stuffy nose with watery discharge, light red tongue, white and thin fur is greasy, states easy catching a cold at ordinary times, examines as cold-dampness type chronic rhinitis, after taking a course for the treatment of of above-mentioned formula, all diseases alleviate.

Case 3, Qiu, female, 31 years old, live Sunlight Garden side, Qianjiang, gone to a doctor in October, 2012, patient suffers from chronic rhinitis for many years, ate Chinese and Western patent medicine and the Chinese herbal medicine of many treatment rhinitis, often play garter transfusion, long-term nose blocking barrier gas, sneeze, snivel, mouth is not bitter, treat at Qianjiang central hospital department of eye hospitalisation for surgery before more than a year, operation half a year after glucose recovery as before, through friend introduction, after taking a course for the treatment of of above-mentioned formula, nose blocking barrier gas, sneeze is all eliminated, after February, again because flu to rhinitis recurs, after taking again a course for the treatment of of above-mentioned formula, follow up a case by regular visits to half a year, rhinitis does not recur again.

This 87 routine clinical effectiveness is: clinical cure 16 example, and take a turn for the better 68 examples, invalid 3 examples, clinical effective rate 96.6%.

Claims (1)

1. treat a Chinese medicine preparation for cold-dampness type chronic rhinitis, it is characterized in that crude drug and proportioning thereof:

Described crude drug and proportioning thereof are made up of the crude drug of following weight portion:

Ramulus Cinnamomi 9-11 part, Radix Paeoniae Alba 9-11 part, Rhizoma Zingiberis Recens 9-11 part, Fructus Jujubae 9-11 part, Radix Glycyrrhizae 9-11 part, Cortex Magnoliae Officinalis 9-11 part, Rhizoma Atractylodis 9-11 part, Pericarpium Citri Reticulatae 9-11 part, Rhizoma Atractylodis Macrocephalae 9-11 part, Rhizoma Alismatis 9-11 part, Polyporus 9-11 part, Poria 11-13 part, melon shell 9-11 part, Bulbus Allii Macrostemonis 9-11 part, Fructus Aurantii Immaturus 9-11 part, Radix Bupleuri 9-11 part, Cortex Moutan 9-11 part, Radix Rehmanniae 9-11 part, Fructus Xanthii 9-11 part, Flos Magnoliae 11-13 part, Radix Saposhnikoviae 9-11 part, Herba Asari 7-9 part, Radix Astragali 28-32 part.