CN103341132A - 一种抗疟药胶囊及其制备方法 - Google Patents

一种抗疟药胶囊及其制备方法 Download PDF

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CN103341132A
CN103341132A CN2013103010814A CN201310301081A CN103341132A CN 103341132 A CN103341132 A CN 103341132A CN 2013103010814 A CN2013103010814 A CN 2013103010814A CN 201310301081 A CN201310301081 A CN 201310301081A CN 103341132 A CN103341132 A CN 103341132A
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CN103341132B (zh
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李建华
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Hainan Xinhe Bioengineering Co., Ltd.
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Suzhou Tianling Chinese Traditional Medicine Slice Co Ltd
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Abstract

本发明涉及一种抗疟药胶囊及其制备方法，该抗疟药以质量份计含有以下成分：马鞭草20～30份，荆芥穗17～25份，丹参8～13份，莪术4～10份，落得打10～15份，赤芍药7～13份，当归8～12份，红花3～8份，桑叶4～9份，银华1～6份，淀粉25～44份，羧甲基淀粉钠5.8～10份，硬脂酸镁1.2～2份。本发明提供的抗疟药能够治疗血热气虚、经候涩滞不通、肢体麻木、肌热生疮、浑身疼倦等症状，并且该药制成了胶囊，能够提高口服生物利用度。

Description

一种抗疟药胶囊及其制备方法
技术领域
本发明涉及药物领域，尤其涉及一种抗疟药胶囊及其制备方法。
背景技术
引起人类疟疾的原虫有四种，即间日疟原虫、蛋形疟原虫、三日疟原虫及恶性疟原虫。疟原虫生活史可分为有性生殖和无性生殖两个阶段，前者在雌性按蚊体内进行，后者在人体内进行。人体内的无性生殖又分原发性红细胞外期、继发性红细胞外期、红细胞内期等阶段。各种抗疟药通过影响疟原虫生活史的不同发育阶段而发挥其抗疟效果。目前还有很大一部分国家和地区受到疟原虫的危害。
市场上用于治疗抗疟药的胶囊品种不多，人们不能有针对性地选择抗疟药，不能满足需求。
发明内容
解决的技术问题：针对市场上胶囊类抗疟药品种的不足，本发明提供一种抗疟药胶囊及其制备方法。
技术方案：一种抗疟药胶囊，以质量份计含有以下成分：
马鞭草                                               20～30份
荆芥穗                                               17～25份
丹参                                                 8～13份
莪术                                                 4～10份
落得打                                               10～15份
赤芍药                                               7～13份
当归                                                 8～12份
红花                                                 3～8份
桑叶                                                 4～9份
银华                                                 1～6份
淀粉                                                 25～44份
羧甲基淀粉钠                                         5.8～10份
硬脂酸镁                                             1.2～2份。
上述所述的一种抗疟药胶囊，以质量份计含有以下成分：
马鞭草                                               24份
荆芥穗                                               20份
丹参                                                 10份
莪术                                                 6.5份
落得打                                               12.3份
赤芍药                                               9.6份
当归                                                 11份
红花                                                 6份
桑叶                                                 7.5份
银华                                                 3.3份
淀粉                                                 34.6份
羧甲基淀粉钠                                         7.9份
硬脂酸镁                                             1.6份。
上述所述的一种抗疟药胶囊的制备步骤如下：
第一步：将马鞭草、荆芥穗、丹参、莪术、落得打、赤芍药、当归、红花、桑叶、银华、淀粉和羧甲基淀粉钠分别过筛后在搅拌机中搅拌均匀；
第二步：再向搅拌机中加入浓度为5%的羧甲基淀粉钠溶液，搅拌30min制成软材，过18目筛制粒，在80℃下干燥3h，过4目筛整粒；
第三步：最后加入硬脂酸镁，混合均匀后装胶囊。
有益效果：本发明提供的一种抗疟药胶囊及其制备方法，该抗疟药中的马鞭草具有活血散瘀，截疟，解毒，利水消肿的功效；荆芥穗具有 解表散风，透疹的功效；丹参具有活血散淤、消肿止血、消炎止痛、调经止痛、安神静心的功效；莪术具有行气破血，消积止痛的功效；落得打具有清热利湿，解毒消肿的功效；赤芍药具有行瘀、止痛、凉血、消肿的功效。诸药配伍，制得的抗疟药能够治疗血热气虚、经候涩滞不通、肢体麻木、肌热生疮、浑身疼倦等症状，并且该药制成了胶囊，能够提高口服生物利用度。
具体实施方式
实施例1
本实施例提供一种抗疟药胶囊，以质量份计含有以下成分：
马鞭草                                               20份
荆芥穗                                               17份
丹参                                                 8份
莪术                                                 4份
落得打                                               10份
赤芍药                                               7份
当归                                                 8份
红花                                                 3份
桑叶                                                 4份
银华                                                 1份
淀粉                                                 25份
羧甲基淀粉钠                                         5.8份
硬脂酸镁                                             1.2份。
一种抗疟药胶囊的制备步骤如下：
第一步：将马鞭草、荆芥穗、丹参、莪术、落得打、赤芍药、当归、红花、桑叶、银华、淀粉和羧甲基淀粉钠分别过筛后在搅拌机中搅拌均匀；
第二步：再向搅拌机中加入浓度为5%的羧甲基淀粉钠溶液，搅拌30min制成软材，过18目筛制粒，在80℃下干燥3h，过4目筛整粒；
第三步：最后加入硬脂酸镁，混合均匀后装胶囊。
本实施例制得的颗粒较好，内容物为0.262g。照中国药典2000版二部附录XC第二法规定的溶出度测定方法，15分钟溶出度为95%。
实施例2
本实施例提供一种抗疟药胶囊，以质量份计含有以下成分：
马鞭草                                               30份
荆芥穗                                               25份
丹参                                                 13份
莪术                                                 10份
落得打                                               15份
赤芍药                                               13份
当归                                                 12份
红花                                                 8份
桑叶                                                 9份
银华                                                 6份
淀粉                                                 44份
羧甲基淀粉钠                                         10份
硬脂酸镁                                             2份。
一种抗疟药胶囊的制备步骤如下：
第一步：将马鞭草、荆芥穗、丹参、莪术、落得打、赤芍药、当归、红花、桑叶、银华、淀粉和羧甲基淀粉钠分别过筛后在搅拌机中搅拌均匀；
第二步：再向搅拌机中加入浓度为5%的羧甲基淀粉钠溶液，搅拌30min制成软材，过18目筛制粒，在80℃下干燥3h，过4目筛整粒；
第三步：最后加入硬脂酸镁，混合均匀后装胶囊。
本实施例制得的颗粒较好，内容物为0.228g。照中国药典2000版二部附录XC第二法规定的溶出度测定方法，15分钟溶出度为96%。
实施例1
本实施例提供一种抗疟药胶囊，以质量份计含有以下成分：
马鞭草                                               24份
荆芥穗                                               20份
丹参                                                 10份
莪术                                                 6.5份
落得打                                               12.3份
赤芍药                                               9.6份
当归                                                 11份
红花                                                 6份
桑叶                                                 7.5份
银华                                                 3.3份
淀粉                                                 34.6份
羧甲基淀粉钠                                         7.9份
硬脂酸镁                                             1.6份。
一种抗疟药胶囊的制备步骤如下：
第一步：将马鞭草、荆芥穗、丹参、莪术、落得打、赤芍药、当归、红花、桑叶、银华、淀粉和羧甲基淀粉钠分别过筛后在搅拌机中搅拌均匀；
第二步：再向搅拌机中加入浓度为5%的羧甲基淀粉钠溶液，搅拌30min制成软材，过18目筛制粒，在80℃下干燥3h，过4目筛整粒；
第三步：最后加入硬脂酸镁，混合均匀后装胶囊。
本实施例制得的颗粒较好，内容物为0.236g。照中国药典2000版二部附录XC第二法规定的溶出度测定方法，15分钟溶出度为98%。
以上对本发明实施例所提供的一种抗疟药胶囊及其制备方法进行了详细介绍，对于本领域的一般技术人员，依据本发明实施例的思想，在具体实施方式及应用范围上均会有改变之处，综上所述，本说明书内容不应理解为对本发明的限制。

Claims (3)

1.一种抗疟药胶囊，其特征在于以质量份计含有以下成分：
马鞭草                                               20～30份
荆芥穗                                               17～25份
丹参                                                 8～13份
莪术                                                 4～10份
落得打                                               10～15份
赤芍药                                               7～13份
当归                                                 8～12份
红花                                                 3～8份
桑叶                                                 4～9份
银华                                                 1～6份
淀粉                                                 25～44份
羧甲基淀粉钠                                         5.8～10份
硬脂酸镁                                             1.2～2份。
2.根据权利要求1所述的一种抗疟药胶囊，其特征在于以质量份计含有以下成分：
马鞭草                                               24份
荆芥穗                                               20份
丹参                                                 10份
莪术                                                 6.5份
落得打                                               12.3份
赤芍药                                               9.6份
当归                                                 11份
红花                                                 6份
桑叶                                                 7.5份
银华                                                 3.3份
淀粉                                                 34.6份
羧甲基淀粉钠                                         7.9份
硬脂酸镁                                             1.6份。
3.如权利要求1所述的一种抗疟药胶囊的制备方法，其特征在于该方法的制备步骤如下：
第一步：将马鞭草、荆芥穗、丹参、莪术、落得打、赤芍药、当归、红花、桑叶、银华、淀粉和羧甲基淀粉钠分别过筛后在搅拌机中搅拌均匀；
第二步：再向搅拌机中加入浓度为5%的羧甲基淀粉钠溶液，搅拌30min制成软材，过18目筛制粒，在80℃下干燥3h，过4目筛整粒；
第三步：最后加入硬脂酸镁，混合均匀后装胶囊。
CN201310301081.4A 2013-07-18 2013-07-18 一种抗疟药胶囊及其制备方法 Expired - Fee Related CN103341132B (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3833334A4 (en) * 2018-08-08 2022-05-04 Karici Diagnostics Inc., CONTROLLED RELEASE FORMULATIONS FOR THE TREATMENT OF MALARIA

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
肖少卿等: ""祖国医学对疟疾的认识及治疗"", 《南京中医学院学报》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3833334A4 (en) * 2018-08-08 2022-05-04 Karici Diagnostics Inc., CONTROLLED RELEASE FORMULATIONS FOR THE TREATMENT OF MALARIA

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