Summary of the invention
The invention provides a kind of external-applied ointment and preparation method for the treatment of decubital ulcer, external-applied ointment of the present invention has effect of blood circulation promoting and blood stasis dispelling, granulation promoting pain relieving, closing in skin moistening, can improve the blood circulation of patient bedridden in long term pressurized tissue, skin care, promote the growth of new granulation tissue, expelling pus and promoting granulation is effective, promotes decubitus wound quickly-healing.
For achieving the above object, being implemented as follows of technical scheme of the present invention:
Treat an external-applied ointment for decubital ulcer, raw material composition and the parts by weight of making described external-applied ointment effective ingredient are:
41~71 parts, 51~76 parts of Pueraria lobota Bud leaves of 51~81 parts of Radix Hedysari of 56~86 parts of Folium Tetrastigmatis planicauliss of Gypsum Fibrosum Preparatum
34~66 parts of 36~66 portions of Herba Sedi Lineariss of 39~69 portions of Concha Meretricis Seu Cyclinaes of 41~71 parts of Rhizoma Polygoni coriaceis of herb Potentillae cryptotaeniae
26~44 parts of 29~51 parts of Radix Ocimi Pilosis of 31~56 parts of Cortex cercis chinensiss of 32~61 parts of Pericarpium Trapae of Lasiosphaera Seu Calvatia
11~31 parts of 13~36 parts of Borneolum Syntheticums of 16~41 parts of Calaminas of 21~43 parts of Herba Lycopodii serratis of Herba Incarvilleae sinensis.
Raw material composition and the parts by weight of making described external-applied ointment effective ingredient are:
45~66 parts, 55~72 parts of Pueraria lobota Bud leaves of 55~75 parts of Radix Hedysari of 60~80 parts of Folium Tetrastigmatis planicauliss of Gypsum Fibrosum Preparatum
39~60 parts of 40~60 portions of Herba Sedi Lineariss of 44~65 portions of Concha Meretricis Seu Cyclinaes of 45~65 parts of Rhizoma Polygoni coriaceis of herb Potentillae cryptotaeniae
30~40 parts of 34~48 parts of Radix Ocimi Pilosis of 35~50 parts of Cortex cercis chinensiss of 38~55 parts of Pericarpium Trapae of Lasiosphaera Seu Calvatia
15~26 parts of 18~30 parts of Borneolum Syntheticums of 20~35 parts of Calaminas of 25~38 parts of Herba Lycopodii serratis of Herba Incarvilleae sinensis.
Raw material composition and the parts by weight of making described external-applied ointment effective ingredient are:
50~60 parts, 58~68 parts of Pueraria lobota Bud leaves of 60~70 parts of Radix Hedysari of 65~75 parts of Folium Tetrastigmatis planicauliss of Gypsum Fibrosum Preparatum
45~55 parts of 45~55 portions of Herba Sedi Lineariss of 50~60 portions of Concha Meretricis Seu Cyclinaes of 50~60 parts of Rhizoma Polygoni coriaceis of herb Potentillae cryptotaeniae
33~38 parts of 38~45 parts of Radix Ocimi Pilosis of 40~48 parts of Cortex cercis chinensiss of 43~50 parts of Pericarpium Trapae of Lasiosphaera Seu Calvatia
18~23 parts of 22~27 parts of Borneolum Syntheticums of 25~32 parts of Calaminas of 28~35 parts of Herba Lycopodii serratis of Herba Incarvilleae sinensis.
Raw material composition and the parts by weight of making described external-applied ointment effective ingredient are:
55 parts, 62 parts of Pueraria lobota Bud leaves of 65 parts of Radix Hedysari of 70 parts of Folium Tetrastigmatis planicauliss of Gypsum Fibrosum Preparatum
50 parts of 50 portions of Herba Sedi Lineariss of 55 portions of Concha Meretricis Seu Cyclinaes of 55 parts of Rhizoma Polygoni coriaceis of herb Potentillae cryptotaeniae
35 parts of 42 parts of Radix Ocimi Pilosis of 44 parts of Cortex cercis chinensiss of 46 parts of Pericarpium Trapae of Lasiosphaera Seu Calvatia
20 parts of 25 parts of Borneolum Syntheticums of 28 parts of Calaminas of 31 parts of Herba Lycopodii serratis of Herba Incarvilleae sinensis.
Treat a preparation method for the external-applied ointment of decubital ulcer, comprise following processing step:
(1) Folium Tetrastigmatis planicaulis, Pueraria lobota Bud leaf, Herba Sedi Linearis, Herba Incarvilleae sinensis, Herba Lycopodii serrati are decocted with water 3 times, each 1~2 hour, merge 3 times decocting liquid, be condensed into the thick paste that at 45~50 DEG C, relative density is 1.12~1.16, for subsequent use;
(2) Gypsum Fibrosum Preparatum, herb Potentillae cryptotaeniae, Concha Meretricis Seu Cyclinae, Radix Hedysari, Lasiosphaera Seu Calvatia, Pericarpium Trapae, Radix Ocimi Pilosi, Calamina, Rhizoma Polygoni coriacei and Borneolum Syntheticum are mixed to rear pulverizing, grind into powder, cross 100 order fine powders, for subsequent use;
(3) get Cortex cercis chinensis and immerse 2-3 hour in the yellow wine doubly measured of 3-4, take out, dry, grind into powder, cross 200 order fine powders, for subsequent use;
(4) will after the fine powder mix homogeneously of making in the thick paste of making in step (1) and step (2), step (3), add Oleum Sesami, uniform stirring becomes thick paste shape, obtains the external-applied ointment for the treatment of decubital ulcer of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Gypsum Fibrosum Preparatum: sweet, pungent, puckery, cold.Attach to the lung and stomach meridians.Removing dampness, granulation promoting, sore, hemostasis.External treatment ulcer being unable to heal, eczema pruritus, burn due to hot liquid or fire, traumatic hemorrhage.
Folium Tetrastigmatis planicaulis: acid; Puckery; Flat.Return Liver Channel.Promoting tissue regeneration and ulcer healing.Main ulcer of the lower limb; Wound.
Radix Hedysari: sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.
Pueraria lobota Bud leaf: sweet; Flat.Removing food stagnancy; Removing toxic substances; Sore.Staple food is long-pending; Dysentery; Eczema; Burn and scald.
Herb Potentillae cryptotaeniae: sweet; Temperature.Return lung, large intestine, stomach, Liver Channel.Heat-clearing and toxic substances removing, sore hemostasis, eliminating stasis to stop pain.Main cough, dysentery, enteritis, carbuncle furuncle, scalds, aphtha of the mouth and tongue, osteomyelitis, bone tuberculosis, scrofula, hemorrhoid, venom, metrorrhagia, menorrhagia, postpartum hemorrhage, traumatic hemorrhage, stomachache, toothache, sternalgia, lumbago, traumatic injury." Xinhua's book on Chinese herbal medicine outline " carries: " be the key medicine of traumatic injury.”
Rhizoma Polygoni coriacei: hardship; Cold in nature.Heat-clearing and toxic substances removing.Main hygropyretic dysentery; Diarrhoea; Carbuncle; Hemorrhoid; Gingival swelling and pain; Erosion of the oral mucosa; Burn; Venom." Guangxi medicine is planted register " carries: " heat clearing away, convergence, goes to amass, and enrich blood puerperal.Control the intestines and stomach damp and hot, bloody dysentery, erosion of the oral mucosa, carbuncle, hemorrhoid, burn.”
Concha Meretricis Seu Cyclinae: salty in the mouth; Cold nature.Return lung, kidney, stomach warp.Removing heat from the lung and dissipating phlegm; Hard masses softening and resolving; Inducing diuresis to remove edema; Relieving gastric hyperacidity to alleviate stomachache; Sore removing dampness.Main phlegm-heat cough; Goiter; Sucutaneous nodule; Hypochondriac pain; Damp and hot edema; Stranguria with turbid discharge leukorrhagia; Stomachache pantothenic acid; Ecthyma eczema.Modern medicine study confirmation, Concha Meretricis Seu Cyclinae is used for phlegm-fire cough, pain in chest and hypochondrium, sputum mixed with blood, scrofula goiter, stomachache acid regurgitation, external treatment eczema, scalds.
Herba Sedi Linearis: heat clearing away, detumescence, removing toxic substances.Control laryngopharynx swelling and pain, carbuncle, furuncle, erysipelas, scalds venom, jaundice, dysentery." Bencao Tujing " carries: " rotten grinding as cream, to paste sore due to scald and burn poison.”
Lasiosphaera Seu Calvatia: pungent, flat.Removing heat from the lung and relieving sorethroat, removing toxic substances, hemostasis.Control sore throat pharyngalgia, cough with aphonia, spits blood, epistaxis, traumatic hemorrhage." detailed outline " carries: " lung heat clearing, loose heat in blood, removing toxic substances." can cough by clearing away lung-heat, sore throat, epistaxis, all diseases of aphonia.”
Pericarpium Trapae: puckery; Property is put down.Relieving diarrhea with astringents; Hemostasis; Sore; Removing toxic substances.Main having loose bowels; Dysentery; Gastric ulcer; Have blood in stool; Proctoptosis; Hemorrhoid; Furuncle." detailed outline is picked up any lost article from the road " carries: " control women's head-ornaments impetigo.”
Cortex cercis chinensis: bitter in the mouth is flat, nontoxic.Promoting blood circulation to restore menstrual flow, subduing swelling and detoxicating.Control anemofrigid-damp arthralgia, women's amenorrhea, vim and vigour pain, sore throat, drenches disease, carbuncle, tinea scabies, traumatic injury, snake bite and insect sting." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " control bones and muscles pain, anemofrigid-damp arthralgia, apathy, paralysis flaccidity is soft, warm muscle, only lumbago, controls married woman's cold in blood stomachache.”
Radix Ocimi Pilosi: bitter in the mouth; Property is put down.Removing dampness sore.Main bullous impetigo." the good book on Chinese herbal medicine of helping " carries: " main children's's bullous impetigo, ashing applies it.”
Herba Incarvilleae sinensis: temperature, bitter, sweet.Regulating menstruation and activating blood, wind-damp dispelling, antiinflammatory profit ear, beneficial arteries and veins.Seed is for otitis media; Root is used for weak, and dizziness is uncomfortable in chest, abdominal distention, cough, menoxenia; Leaf is for cough." Chinese herbal medicine handbook is commonly used in Heilungkiang " carries: " control dry wet pelt rash, trichomonal vaginitis, scabies, gums rots and inflammation of external auditory meatus, and ashing is embrocated.Menoxenia, rheumatic arthralgia, bones and muscles pain, decoct soup fumigation and wash method.”
Herba Lycopodii serrati: bitter, micro-sweet, flat.Slightly poisonous.Heat-clearing and toxic substances removing; Eliminating dampness and astringing sores; Hemostasis analgesic therapy dissipating blood stasis; Detumescence.Main pneumonia; Lung abscess; Over-strained hemoptysis; Hemorrhoidal hemorrhage; Leucorrhea; Traumatic injury; Toxic swelling; Water hygral expansion; Ulcer does not close up for a long time; Burn and scald." conventional Chinese herbal medicine formula " carries: " hemostasis of bringing down a fever, reducing swelling and alleviating pain.Control lung-heat and spit blood, abscess, festers, wound disunion of a specified duration.”
Calamina: sweet; Flat; Temperature; Nontoxic.Return liver, spleen, lung meridian.Improving eyesight removing nebula; Removing dampness is antipruritic; Expelling pus and promoting granulation.Main conjunctival congestion and swelling pain; Marginal blepharitis eye; Many tear keeps in dark place; Nebula film bulbar conjunctiva polyp; Ulcer being unable to heal; Skin eczema; Pudendum pruritus due to damp pathogen." detailed outline " carries: " hemostasis, detumescence poison, granulation promoting, improving eyesight, removing nebula is moved back red, and removing dampness is except rotten.Control all diseases in order with Borneolum Syntheticum point.”
Borneolum Syntheticum: control apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.Borneolum Syntheticum leads to all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain." detailed outline " carries: " treat sore throat, headache, breath, toothache, typhoid fever protrusion of the tongue, children's's pox falls into.Logical all keys, loose stagnated fire." modern medicine study confirmation, Borneolum Syntheticum has the functions such as the refreshment of having one's ideas straightened out, clearing heat for detumescence, pain relieving.”
The present invention compared with prior art, has following beneficial effect:
External-applied ointment of the present invention has effect of blood circulation promoting and blood stasis dispelling, granulation promoting pain relieving, closing in skin moistening, can improve the blood circulation of patient bedridden in long term pressurized tissue, skin care, promotes the growth of new granulation tissue, and expelling pus and promoting granulation is effective, promote decubitus wound quickly-healing, external-applied ointment therapeutic effect of the present invention is remarkable, cost is low, instant effect, determined curative effect, and after curing, skin smooth is as before, pore demutation, preventing from scar.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of external-applied ointment effective ingredient of the present invention are:
Gypsum Fibrosum Preparatum 80g Folium Tetrastigmatis planicaulis 75g Radix Hedysari 72g Pueraria lobota Bud leaf 66g
Herb Potentillae cryptotaeniae 65g Rhizoma Polygoni coriacei 65g Concha Meretricis Seu Cyclinae 60g Herba Sedi Linearis 60g
Lasiosphaera Seu Calvatia 55g Pericarpium Trapae 50g Cortex cercis chinensis 48g Radix Ocimi Pilosi 40g
Herba Incarvilleae sinensis 38g Herba Lycopodii serrati 35g Calamina 30g Borneolum Syntheticum 26g.
Treat a preparation method for the external-applied ointment of decubital ulcer, comprise following processing step:
(1) Folium Tetrastigmatis planicaulis, Pueraria lobota Bud leaf, Herba Sedi Linearis, Herba Incarvilleae sinensis, Herba Lycopodii serrati are decocted with water 3 times, each 1~2 hour, merge 3 times decocting liquid, be condensed into the thick paste that at 45~50 DEG C, relative density is 1.12~1.16, for subsequent use;
(2) Gypsum Fibrosum Preparatum, herb Potentillae cryptotaeniae, Concha Meretricis Seu Cyclinae, Radix Hedysari, Lasiosphaera Seu Calvatia, Pericarpium Trapae, Radix Ocimi Pilosi, Calamina, Rhizoma Polygoni coriacei and Borneolum Syntheticum are mixed to rear pulverizing, grind into powder, cross 100 order fine powders, for subsequent use;
(3) get Cortex cercis chinensis and immerse 2-3 hour in the yellow wine doubly measured of 3-4, take out, dry, grind into powder, cross 200 order fine powders, for subsequent use;
(4) will after the fine powder mix homogeneously of making in the thick paste of making in step (1) and step (2), step (3), add Oleum Sesami, uniform stirring becomes thick paste shape, obtains the external-applied ointment for the treatment of decubital ulcer of the present invention.
Using method:
1, method and consumption: first decubital ulcer place is cleaned with aseptic cotton, be then coated with external-applied ointment 1-3 millimeters thick of the present invention on decubital ulcer face, change medicine every day one time.
2, the course for the treatment of: 3 days be a course for the treatment of, 1 course for the treatment of of the lighter, can fully recover severe one 2-3 the course for the treatment of.
3, criterion of therapeutical effect: dispel scar as effective taking skin detumescence, skin preventing from scar is recovery from illness.
Embodiment 2
Raw material composition and the weight of external-applied ointment effective ingredient of the present invention are:
Gypsum Fibrosum Preparatum 75g Folium Tetrastigmatis planicaulis 70g Radix Hedysari 68g Pueraria lobota Bud leaf 60g
Herb Potentillae cryptotaeniae 60g Rhizoma Polygoni coriacei 60g Concha Meretricis Seu Cyclinae 55g Herba Sedi Linearis 55g
Lasiosphaera Seu Calvatia 50g Pericarpium Trapae 48g Cortex cercis chinensis 45g Radix Ocimi Pilosi 38g
Herba Incarvilleae sinensis 35g Herba Lycopodii serrati 32g Calamina 27g Borneolum Syntheticum 23g.
External-applied ointment preparation method processing step and the using method of the present embodiment are identical with embodiment 1.
Embodiment 3
Raw material composition and the weight of external-applied ointment effective ingredient of the present invention are:
Gypsum Fibrosum Preparatum 70g Folium Tetrastigmatis planicaulis 65g Radix Hedysari 62g Pueraria lobota Bud leaf 55g
Herb Potentillae cryptotaeniae 55g Rhizoma Polygoni coriacei 55g Concha Meretricis Seu Cyclinae 50g Herba Sedi Linearis 50g
Lasiosphaera Seu Calvatia 46g Pericarpium Trapae 44g Cortex cercis chinensis 42g Radix Ocimi Pilosi 35g
Herba Incarvilleae sinensis 31g Herba Lycopodii serrati 28g Calamina 25g Borneolum Syntheticum 20g.
External-applied ointment preparation method processing step and the using method of the present embodiment are identical with embodiment 1.
Embodiment 4
Raw material composition and the weight of external-applied ointment effective ingredient of the present invention are:
Gypsum Fibrosum Preparatum 60g Folium Tetrastigmatis planicaulis 57g Radix Hedysari 56g Pueraria lobota Bud leaf 47g
Herb Potentillae cryptotaeniae 48g Rhizoma Polygoni coriacei 45g Concha Meretricis Seu Cyclinae 43g Herba Sedi Linearis 43g
Lasiosphaera Seu Calvatia 37g Pericarpium Trapae 38g Cortex cercis chinensis 35g Radix Ocimi Pilosi 30g
Herba Incarvilleae sinensis 26g Herba Lycopodii serrati 22g Calamina 18g Borneolum Syntheticum 15g.
External-applied ointment preparation method processing step and the using method of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection
As the external-applied ointment for the treatment of decubital ulcer, select the routine clinical observation of patients with bedsore 400, patients with bedsore is divided into two groups at random, treatment group 200 examples, wherein male's 112 examples, women's 88 examples, 30~80 years old age, 40.5 years old mean age, the course of disease 1~20 year, average 5.5 years; Severity extent: slight 46 examples, moderate 72 examples, severe 82 examples.Matched group 200 examples, wherein male's 106 examples, women's 94 examples, 32~82 years old age, 39.8 years old mean age, the course of disease 1~21 year, average 5.7 years; Severity extent: slight 61 examples, moderate 80 examples, severe 59 examples.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.
Treatment group is smeared external-applied ointment of the present invention, in the smearing ointment 1-3 of decubital ulcer place millimeters thick, within 3 days, is a course for the treatment of, changes medicine every day one time, and 1 course for the treatment of of the lighter, severe one can be fully recovered 2~3 courses for the treatment of; Matched group external Kangfuxin Liquid, smears affected part, a 3-5ml, and 2 times on the one 4 days is a course for the treatment of, and 2 courses for the treatment of of the lighter, severe one is effective 4 courses for the treatment of, and severe patient is conventionally invalid.
3, efficacy determination:
(1) effective: patients with bedsore is red and swollen obviously to be alleviated, and cicatrix disappears, the normal outdoor activity of energy;
(2) effective: patients with bedsore redness is alleviated to some extent;
(3) invalid: through 2 course of therapy, patients with bedsore does not reach effective standard.
4, result
Be coated with in the treatment group of external-applied ointment of the present invention effective 130 examples, effective 65 examples, invalid 5 examples, total effective rate 97.5%.
In matched group, effective 61 examples, effective 67 examples, invalid 72 examples, total effective rate 64%.
Above result demonstration, the total effective rate for the treatment of group is apparently higher than matched group.
Model case is given an example:
Appoint certain, female, 41 years old, Zhengzhou, henan people, because hemiplegia causes left omoplate position decubital ulcer two months at bed, through doctor fail to respond to any medical treatment and wound surface larger, after examination 1 course for the treatment of of external-applied ointment of the present invention, fully recover, follow up a case by regular visits to, without recurrence.
, man, 73 years old, Taiyuan, Shanxi people, diabetics, fester and form irregular similar round ulcer in left vola, dark approximately one horizontal finger, substrate is canescence, once treated the several months at so-and-so hospital, and controlling under the prerequisite of diabetes, rotten position was once used many Drug therapys, can not be restored always.Seek medical advice and control with my institute afterwards, external-applied ointment of the present invention is smeared in affected part, treats after 9 days lesion recovery from illness.
Bai, man, 36 years old, people from Hengshui, Hebei, the left leg of accidentally damaging when working, cause it before inner side place soft tissue fester, the initial stage treats; heavy when light when pathological changes; the left leg that goes down for a long time forms irregular ulcer, and rotten position often has purulent secretion, and focus surrounding skin is pitchy; though often treatment, poor effect.I treated at institute afterwards, smeared external-applied ointment of the present invention, treated recovery from illness afterwards in 6 days.
Tang, female, 26 years old, Zhejiang Hangzhou people, puerperal, long-term bed compressing caused decubital ulcer, had the blood crusts of 3 centimetres.Inflammation afterwards, blood crusts is around festered.Injected pioneer's enzyme element, external saline, iodine fluorine, Kangfuxin Liquid, BURN MOISTEN UNGUENTUM, Mupirocin Ointment.PLA General Hospital the first Affiliated Hospital burn plastic surgery Hao Dai peak blood crusts is good around, and blood crusts is not fallen, after start inflammation and fester, my institute had used external-applied ointment treatment of the present invention after 8 days afterwards, recovery from illness, without recurrence.