CN103330785B - Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney - Google Patents

Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney Download PDF

Info

Publication number
CN103330785B
CN103330785B CN201310214830.XA CN201310214830A CN103330785B CN 103330785 B CN103330785 B CN 103330785B CN 201310214830 A CN201310214830 A CN 201310214830A CN 103330785 B CN103330785 B CN 103330785B
Authority
CN
China
Prior art keywords
parts
radix
nourishing
kidney
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201310214830.XA
Other languages
Chinese (zh)
Other versions
CN103330785A (en
Inventor
李宏良
王守旭
郑家富
孙守国
赵冰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Huiyinbi Group Anhui Pharmaceutical Co., Ltd.
Original Assignee
ANHUI HUATUO TRADITIONAL CHINESE MEDICINE Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ANHUI HUATUO TRADITIONAL CHINESE MEDICINE Co Ltd filed Critical ANHUI HUATUO TRADITIONAL CHINESE MEDICINE Co Ltd
Priority to CN201310214830.XA priority Critical patent/CN103330785B/en
Publication of CN103330785A publication Critical patent/CN103330785A/en
Application granted granted Critical
Publication of CN103330785B publication Critical patent/CN103330785B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

The invention discloses a preparation method for a medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney. The medicament is composed of, by weight, 30-80 parts of radix astragali, 80-150 parts of Chinese angelica, 20-60 parts of radix codonopsis, 40-80 parts of donkey-hide gelatin, 30-60 parts of antler gelatin, 20-50 parts of lycium chinensis, 30-60 parts of prepared rehmannia roots, 50-80 parts of white peony roots, 20-30 parts of paper mulberry fruit, 30-50 parts of pyrola, 25-35 parts of longan aril, 10-20 parts of cane sugar, 20-30 parts of soluble starch and 15-25 parts of dextrin. The medicament is advantaged by definite, significant and rapid therapeutic effects and short treatment course. The medicament overcomes the defects of long treated period of medicaments with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney in the prior art. The medicament has no side effects and no adverse reactions.

Description

The preparation method of the medicine of a kind of benefiting QI and nourishing blood, nourishing the liver and kidney
Technical field
The invention belongs to field of medicaments, be specifically related to the preparation method of medicine of a kind of benefiting QI and nourishing blood, nourishing the liver and kidney.
Background technology
The medicament categories of benefiting QI and nourishing blood, nourishing the liver and kidney is various in the market, and medicament composing prescription proportioning is different, and drug effect is different, but really reach the also few of therapeutic effect, uncertain therapeutic efficacy is cut, medication excessive cycle, but also there is certain side effect, harmful effect is caused to health.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacy, have no side effect, the preparation method of the medicine of benefiting QI and nourishing blood that the medication cycle is short, nourishing the liver and kidney.
The technical solution used in the present invention is as follows:
1, the process for preparing medicine of a kind of benefiting QI and nourishing blood, nourishing the liver and kidney, it is characterized in that, the weight portion of this medicine material composition is: Radix Astragali 30-80, Radix Angelicae Sinensis 80-150, Radix Codonopsis 20-60, Colla Corii Asini 40-80, Colla cornus cervi 30-60, Fructus Lycii 20-50, Radix Rehmanniae Preparata 30-60, Radix Paeoniae Alba 50-80, Fructus Broussonetiae 20-30, Herba Pyrolae 30-50, Arillus Longan 25-35, Flos Cleistocalycis Operculati 5-9, sucrose 10-20, soluble starch 20-30, dextrin 15-25;
Preparation method comprises the following steps:
(1) Radix Astragali, Radix Angelicae Sinensis, Radix Codonopsis, Fructus Lycii, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Broussonetiae, Herba Pyrolae, Arillus Longan, Flos Cleistocalycis Operculati are dropped in multi-function extractor, decoct with water three times, first time adds 6-10 times of water gaging, decoct 1-3 hour, boiling is per hour afterwards makes a call to 1 circulation 5-10 minute, vapour pressure 0.05-0.1Mpa, temperature 98-100 DEG C; Second time adds 5-8 times of water gaging, decocts 1-3 hour, and boiling is per hour afterwards makes a call to 1 circulation 5-10 minute; Third time adds 4-6 times of water gaging, decocts 1-3 hour, and boiling is per hour afterwards makes a call to 1 circulation 5-10 minute; Merge three decoction liquor filters, cross 200-300 order gauze, filtrate is concentrated into relative density 1.10-1.20 at 80-85 DEG C, centrifugal filtration, the concentrator that input is clean, continuing at 80-85 DEG C, be concentrated into relative density is 1.20-1.30, receive cream, 200-300 order filters, and obtains extractum;
(2) sucrose is pulverized, cross 80-100 mesh sieve, stand-by;
(3) more than preheating one-step-granulating method to 70 DEG C, by sucrose, soluble starch and dextrin one-step-granulating method carry out mixing 10-15 minute, by Colla Corii Asini, Colla cornus cervi adds the water heated and stirred 5-10 minute of 2-4 times amount, make Colla Corii Asini, Colla cornus cervi melts completely, 100-200 order filters, add extractum again to stir, then spray granulation, in pelletization, inlet temperature 80-90 DEG C, outlet temperature 50-60 DEG C, Granulation time 3-4 hour, pellet moisture≤4.0%, with the sieved sieve of reciprocating vibration, upper screen cloth 12-15 order, lower screen cloth 50-60 order, bulky grainization slurry sprays into and carries out granulation grain graininess with fine powder again according to aforesaid operations, obtain a kind of benefiting QI and nourishing blood, the granule of nourishing the liver and kidney.
The preparation method of the medicine of a kind of benefiting QI and nourishing blood according to claim 1, nourishing the liver and kidney, it is characterized in that, the weight portion of this medicine material composition is: the Radix Astragali 68, Radix Angelicae Sinensis 136, Radix Codonopsis 34, Colla Corii Asini 64, Colla cornus cervi 58, Fructus Lycii 34, Radix Rehmanniae Preparata 48, the Radix Paeoniae Alba 68, Fructus Broussonetiae 25, Herba Pyrolae 46, Arillus Longan 30, Flos Cleistocalycis Operculati 6, sucrose 18, soluble starch 24, dextrin 22.
In formula of the present invention, the Radix Astragali: invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting; Radix Angelicae Sinensis: enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation; Radix Codonopsis: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Fructus Lycii: the liver and the kidney tonifying; Radix Rehmanniae Preparata: moist, beneficial essence of enriching blood fills out marrow; The Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant; Fructus Broussonetiae: the kidney invigorating liver heat removing, improving eyesight, diuresis; Herba Pyrolae: tonify deficiency kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation; Arillus Longan: invigorating the heart and spleen, nourishing blood to tranquillize the mind.The present invention is by scientific and reasonable compatibility, bring out the best in each other, the granule prepared has effect of benefiting QI and nourishing blood, nourishing the liver and kidney, be used for the treatment of QI and blood deficiency, suffer from a deficiency of the kidney cause have a dizzy spell, spiritlessness and weakness, sore waist and aching in the waist and the back, lustreless complexion, the disease such as spontaneous perspiration, insomnia forgetfulness of losing heart.Curative effect of medication of the present invention is definite, and therapeutic effect is remarkable, instant effect, short treating period, overcomes the shortcoming of current benefiting QI and nourishing blood, nourishing the liver and kidney drug medication cycle length, and has no side effect completely, have no adverse reaction.
Detailed description of the invention
A medicine for benefiting QI and nourishing blood, nourishing the liver and kidney, the weight portion (gram) of this medicine material composition is: the Radix Astragali 68, Radix Angelicae Sinensis 136, Radix Codonopsis 34, Colla Corii Asini 64, Colla cornus cervi 58, Fructus Lycii 34, Radix Rehmanniae Preparata 48, the Radix Paeoniae Alba 68, Fructus Broussonetiae 25, Herba Pyrolae 46, Arillus Longan 30, Flos Cleistocalycis Operculati 6, sucrose 18, soluble starch 24, dextrin 22.
A preparation method for the medicine of benefiting QI and nourishing blood, nourishing the liver and kidney, comprises the following steps:
(1) Radix Astragali, Radix Angelicae Sinensis, Radix Codonopsis, Fructus Lycii, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Broussonetiae, Herba Pyrolae, Arillus Longan, Flos Cleistocalycis Operculati are dropped in multi-function extractor, decoct with water three times, first time adds 8 times of water gagings, decoct 2 hours, boiling is per hour afterwards plays 1 circulation 10 minutes, vapour pressure 0.08Mpa, temperature 98 DEG C; Second time adds 6 times of water gagings, decocts 1.5 hours, and boiling is per hour afterwards plays 1 circulation 8 minutes; Third time adds 4 times of water gagings, decocts 1 hour, and boiling is per hour afterwards plays 1 circulation 5 minutes; Merge three decoction liquor filters, cross 200 order gauzes, filtrate is concentrated into relative density 1.15 at 80 DEG C, centrifugal filtration, the concentrator that input is clean, continuing at 80 DEG C, be concentrated into relative density is 1.30, receives cream, and 200 orders filter, and obtain extractum;
(2) sucrose is pulverized, cross 80 mesh sieves, stand-by;
(3) preheating one-step-granulating method to 75 DEG C, by sucrose, soluble starch and dextrin one-step-granulating method carry out mixing 10 clock, by Colla Corii Asini, Colla cornus cervi adds the water heated and stirred 10 minutes of 3 times amount, make Colla Corii Asini, Colla cornus cervi melts completely, 200 orders filter, add extractum again to stir, then spray granulation, in pelletization, inlet temperature 90 DEG C, outlet temperature 55 DEG C, Granulation time 4 hours, pellet moisture≤4.0%, with the sieved sieve of reciprocating vibration, upper screen cloth 14 order, lower screen cloth 60 order, bulky grainization slurry sprays into and carries out granulation grain graininess with fine powder again according to aforesaid operations, obtain a kind of benefiting QI and nourishing blood, the granule of nourishing the liver and kidney.
Model case
Case 1
To certain, man, 36 years old, has a dizzy spell closely over the past half year, soreness of the waist and knees, weak all over, dry mouth and tougue, insomnia and dreamful sleep, pallor is simple and unadorned, forgetful night sweat, after using 2 courses for the treatment of of medicine of the present invention, symptom alleviates greatly, and after continuing to take 1 course for the treatment of, above-mentioned malaise symptoms disappears, and does not recur so far.
Case 2
China certain, man, 42 years old, dizziness and blurred vision, both sides of the chest dull pain, being irritable and getting angry easily, top-heavy, soreness of waist and knee joint, dreaminess is slept less, vexed xerostomia, red tongue, thin fur, deep-thready pulse or heavy string, suffer from above-mentioned symptom for many years, take various curative effect of medication all not remarkable, in December, 2012 starts to take medicine of the present invention, after taking 3 courses for the treatment of, malaise symptoms disappears, and does not recur so far.
Case 3
Money, female, 28 years old, in October, 2012 so far, shallow complexion, fingernail is pale, cardiopalmus loses eye dreaminess, shortness of breath and low voice, pale tongue, Hypomenorrhea, not just, trick is ice-cold for color, little exercise sensation is slow only gets up, after taking 3 courses for the treatment of of medicine of the present invention, above-mentioned malaise symptoms disappears, and does not recur so far.

Claims (2)

1. the process for preparing medicine of a benefiting QI and nourishing blood, nourishing the liver and kidney, it is characterized in that, the weight portion of this medicine material composition is: Radix Astragali 30-80, Radix Angelicae Sinensis 80-150, Radix Codonopsis 20-60, Colla Corii Asini 40-80, Colla cornus cervi 30-60, Fructus Lycii 20-50, Radix Rehmanniae Preparata 30-60, Radix Paeoniae Alba 50-80, Fructus Broussonetiae 20-30, Herba Pyrolae 30-50, Arillus Longan 25-35, Flos Cleistocalycis Operculati 5-9, sucrose 10-20, soluble starch 20-30, dextrin 15-25;
Preparation method comprises the following steps:
(1) Radix Astragali, Radix Angelicae Sinensis, Radix Codonopsis, Fructus Lycii, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Broussonetiae, Herba Pyrolae, Arillus Longan, Flos Cleistocalycis Operculati are dropped in multi-function extractor, decoct with water three times, first time adds 6-10 times of water gaging, decoct 1-3 hour, boiling is per hour afterwards makes a call to 1 circulation 5-10 minute, vapour pressure 0.05-0.1Mpa, temperature 98-100 DEG C; Second time adds 5-8 times of water gaging, decocts 1-3 hour, and boiling is per hour afterwards makes a call to 1 circulation 5-10 minute; Third time adds 4-6 times of water gaging, decocts 1-3 hour, and boiling is per hour afterwards makes a call to 1 circulation 5-10 minute; Merge three decoction liquor filters, cross 200-300 order gauze, filtrate is concentrated into relative density 1.10-1.20 at 80-85 DEG C, centrifugal filtration, the concentrator that input is clean, continuing at 80-85 DEG C, be concentrated into relative density is 1.20-1.30, receive cream, 200-300 order filters, and obtains extractum;
(2) sucrose is pulverized, cross 80-100 mesh sieve, stand-by;
(3) more than preheating one-step-granulating method to 70 DEG C, by sucrose, soluble starch and dextrin one-step-granulating method carry out mixing 10-15 minute, by Colla Corii Asini, Colla cornus cervi adds the water heated and stirred 5-10 minute of 2-4 times amount, make Colla Corii Asini, Colla cornus cervi melts completely, 100-200 order filters, add extractum again to stir, then spray granulation, in pelletization, inlet temperature 80-90 DEG C, outlet temperature 50-60 DEG C, Granulation time 3-4 hour, pellet moisture≤4.0%, with the sieved sieve of reciprocating vibration, upper screen cloth 12-15 order, lower screen cloth 50-60 order, bulky grainization slurry sprays into and carries out granulation grain graininess with fine powder again according to aforesaid operations, obtain a kind of benefiting QI and nourishing blood, the granule of nourishing the liver and kidney.
2. the preparation method of the medicine of a kind of benefiting QI and nourishing blood according to claim 1, nourishing the liver and kidney, it is characterized in that, the weight portion of this medicine material composition is: the Radix Astragali 68, Radix Angelicae Sinensis 136, Radix Codonopsis 34, Colla Corii Asini 64, Colla cornus cervi 58, Fructus Lycii 34, Radix Rehmanniae Preparata 48, the Radix Paeoniae Alba 68, Fructus Broussonetiae 25, Herba Pyrolae 46, Arillus Longan 30, Flos Cleistocalycis Operculati 6, sucrose 18, soluble starch 24, dextrin 22.
CN201310214830.XA 2013-06-03 2013-06-03 Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney Active CN103330785B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310214830.XA CN103330785B (en) 2013-06-03 2013-06-03 Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310214830.XA CN103330785B (en) 2013-06-03 2013-06-03 Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney

Publications (2)

Publication Number Publication Date
CN103330785A CN103330785A (en) 2013-10-02
CN103330785B true CN103330785B (en) 2015-05-27

Family

ID=49239035

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310214830.XA Active CN103330785B (en) 2013-06-03 2013-06-03 Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney

Country Status (1)

Country Link
CN (1) CN103330785B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103349708B (en) * 2013-06-07 2016-03-02 安庆乘风制药有限公司 Medicine of a kind of benefiting QI and nourishing blood, nourishing the liver and kidney and preparation method thereof
JP6605036B2 (en) * 2014-11-15 2019-11-13 广西慧宝源医▲薬▼科技有限公司 Method for preparing a medicinal composition for preventing or treating liver and kidney damage-related diseases
CN105011140A (en) * 2015-07-22 2015-11-04 安徽省雷氏农业科技有限公司 Nutrient decoction capable of tonifying qi, supplementing kidneys and nourishing stomachs
CN108452089A (en) * 2018-05-28 2018-08-28 江苏苏南药业实业有限公司 A kind of soothing the liver beauty treatment Chinese medicine composition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101536780A (en) * 2009-04-24 2009-09-23 山东华信制药集团股份有限公司 Glue tonifying food and health care food

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101536780A (en) * 2009-04-24 2009-09-23 山东华信制药集团股份有限公司 Glue tonifying food and health care food

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
刘文军等.黄芪、鹿仙草.《肾病名家传世灵验药对》.2010,第135-136页. *
国家药典委员会.《阿胶养血颗粒》.《国家食品药品监督管理局国家药品标准.新药转正标准.第80册》.2011,第84-86页. *
国家食品药品监督管理局.阿胶养血膏.《国家药品中药标准汇编(内科、气血津液分册)》.2002,第252-255页. *

Also Published As

Publication number Publication date
CN103330785A (en) 2013-10-02

Similar Documents

Publication Publication Date Title
CN102379972A (en) Medicament for treating leukotrichia and calvities and preparation method thereof
CN102846846A (en) Donkey-hide gelatin paste and preparation method thereof
CN103330785B (en) Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney
CN104998063A (en) Anti-fatigue pharmaceutic preparation
CN1415329A (en) Compund paste of donkey-skin gelatin for enriching the blood
CN102657740B (en) Chinese medicinal composition for turning grey hairs to black hairs and preparation method thereof
CN100540041C (en) A kind of promoting intelligence and strengthening brain preparation and preparation method thereof
CN103301245B (en) The medicine of a kind of benefiting QI and nourishing blood, nourishing the liver and kidney
CN105724651A (en) Process for making folium ilicis cornutae and folium ligustrum lucidum tea paste
CN103349708B (en) Medicine of a kind of benefiting QI and nourishing blood, nourishing the liver and kidney and preparation method thereof
CN101239177A (en) Chinese medicinal composition for curing alopecia, generating hair and blackening hair and its manufacturing method
CN104001022A (en) Traditional Chinese medicine for treating pediatric hyperkinetic syndrome and preparation method thereof
CN106109690A (en) Medicine for the alopecia that treatment is caused by deficiency of the liver and kindey
CN102475831A (en) Bombyx health care product and preparation method for same
CN104189592A (en) Traditional Chinese medicine preparation for treating teenager white hair
CN103690798B (en) Medicinal composition for treating teenager leukotrichia and baldness
CN106389767A (en) Deafness left-benefiting loadstone pill
CN106561890A (en) Liver-protecting lipid-lowering flower tea and preparation method thereof
CN105746805A (en) Tea having functions of maintaining beauty and keeping young
CN103961433A (en) Internal medicine for treating leucoderma and preparation method thereof
CN1132095A (en) Nurishing tonic for building body
CN104069402B (en) A kind of Chinese medicine composition and its preparation method and application of hair growth, white hair
CN1415328A (en) Stilbene paste capsule of rising white blood cell for curing disease of leucopenia
CN1143504A (en) Instant granule for curing gastric ulcer and producing technique thereof
CN105727234A (en) Traditional Chinese medicine composition for treating alopecia as well as preparation method and application of traditional Chinese medicine composition

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee
CP01 Change in the name or title of a patent holder

Address after: 236800 No. 23, Lixin Road, Qiaocheng District, Anhui, Bozhou

Patentee after: HUATUO MEDICINES CO., LTD.

Address before: 236800 No. 23, Lixin Road, Qiaocheng District, Anhui, Bozhou

Patentee before: Anhui Huatuo Traditional Chinese Medicine Co., Ltd.

PE01 Entry into force of the registration of the contract for pledge of patent right

Denomination of invention: Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney

Effective date of registration: 20161206

Granted publication date: 20150527

Pledgee: Agricultural Bank China Limited by Share Ltd Bozhou Qiaocheng branch

Pledgor: HUATUO MEDICINES CO., LTD.

Registration number: 2016990001068

PLDC Enforcement, change and cancellation of contracts on pledge of patent right or utility model
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20180201

Address after: 237200 Anhui city of Lu'an province Heng Mountain County town of Mount Holyoke LeightonWebworks factory

Patentee after: Huiyinbi Group Anhui Pharmaceutical Co., Ltd.

Address before: 236800 No. 23, Lixin Road, Qiaocheng District, Anhui, Bozhou

Patentee before: HUATUO MEDICINES CO., LTD.

PC01 Cancellation of the registration of the contract for pledge of patent right
PC01 Cancellation of the registration of the contract for pledge of patent right

Date of cancellation: 20180807

Granted publication date: 20150527

Pledgee: Agricultural Bank China Limited by Share Ltd Bozhou Qiaocheng branch

Pledgor: HUATUO MEDICINES CO., LTD.

Registration number: 2016990001068

PE01 Entry into force of the registration of the contract for pledge of patent right
PE01 Entry into force of the registration of the contract for pledge of patent right

Denomination of invention: Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney

Effective date of registration: 20190618

Granted publication date: 20150527

Pledgee: Anhui Mount Holyoke rural commercial bank Limited by Share Ltd

Pledgor: Huiyinbi Group Anhui Pharmaceutical Co., Ltd.

Registration number: 2019340000308

PC01 Cancellation of the registration of the contract for pledge of patent right
PC01 Cancellation of the registration of the contract for pledge of patent right

Date of cancellation: 20191106

Granted publication date: 20150527

Pledgee: Anhui Mount Holyoke rural commercial bank Limited by Share Ltd

Pledgor: Huiyinbi Group Anhui Pharmaceutical Co., Ltd.

Registration number: 2019340000308

PE01 Entry into force of the registration of the contract for pledge of patent right
PE01 Entry into force of the registration of the contract for pledge of patent right

Denomination of invention: Preparation method for medicament with functions of reinforcing qi and nourishing blood, and nourishing liver and kidney

Effective date of registration: 20200102

Granted publication date: 20150527

Pledgee: Huishang Bank Co., Ltd. Lu'an Huoshan sub branch

Pledgor: Huiyinbi Group Anhui Pharmaceutical Co., Ltd.

Registration number: Y2019340000248