CN103330590A - Multi-electrode impedance-adjustable high blood pressure endovascular treatment catheter - Google Patents
Multi-electrode impedance-adjustable high blood pressure endovascular treatment catheter Download PDFInfo
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- CN103330590A CN103330590A CN 201310252397 CN201310252397A CN103330590A CN 103330590 A CN103330590 A CN 103330590A CN 201310252397 CN201310252397 CN 201310252397 CN 201310252397 A CN201310252397 A CN 201310252397A CN 103330590 A CN103330590 A CN 103330590A
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Abstract
The invention relates to a multi-electrode impedance-adjustable high blood pressure endovascular treatment catheter, comprising a catheter body, a control handle, a connection plug and multiple electrodes; one end of the catheter body is connected with the connection plug; one end, close to the connection plug, of the catheter body is provided with the control handle, and one end, far away from the connection plug, of the catheter is provided with an electrode skeleton on which the multiple electrodes are assembled; a fixed front electrode union is formed at the end, far away from the control handle, of the electrode skeleton, and a slidable rear electrode union is formed at the end, close to the control handle, of the electrode skeleton; a drawing line for drawing the electrode skeleton is arranged in the cavity of the catheter body, and an adjusting part for adjusting the drawing line is arranged on the control handle; and one end of the drawing line is fixed on the front electrode union while the other end penetrates through the rear electrode union to be fixed on the adjusting part of the control handle. The multi-electrode impedance-adjustable high blood pressure endovascular treatment catheter adopts the drawing line for controlling the expansion of the electrode skeleton, and the attaching force between the electrodes on the electrode skeleton and a renal artery tubular wall is changed, so the electrodes are more tightly attached to a blood vessel for adjusting the impedance.
Description
Technical field
The present invention relates to a kind of hypertensive conduit of clinical treatment that is applied to, particularly relate to a kind of hypertension endovascular treatment conduit of multipole adjustable impedance.
Background technology
Hypertension is to have a strong impact on people's life quality and life-threatening common disease, also be the whole world cause dead main diseases because of, the annual whole world 7 million peoples are because of hypertension death.Domestic Epidemiological study in recent years shows, men and women's prevalence all surpasses more than 20%, China is one of the most serious country of hypertension harm in the world at present, estimate that national hyperpietic surpasses 200,000,000, in the international coverage, the whole world has 1,000,000,000 people to suffer from hypertension at present, and expecting hyperpietic in 2025 will have 30% people to suffer from hypertension, and sum reaches 1,500,000,000.This shows that hypertension has become that global range comprises that the present prevalence of China is the highest, one of the ill the most general disease of crowd, the research of hypertensive research and new treatment becomes human instant problem.
The serious consequence that hyperpietic's blood pressure increases is the infringement to the whole body vitals, and the infringement that easily causes the hearts such as coronary heart disease, apoplexy, renal failure, brain, kidney is severe complications the most, thereby its disability rate that causes and mortality rate are obviously increased.
Popular hypertension therapeutic remains Drug therapy both at home and abroad at present.Mainly be to rely on medicine on the Therapeutic Method, wherein of greatest concern and what play a major role is calcium channel blocker, angiotensin-convertion enzyme inhibitor and angiotensin ii receptor antagonist, and two class medicines are main after outstanding, and the effect of these back two class medicines is all in renin-angiotensin system.The treatment of the Long term combined medication of such medicine, will not only need to take for a long time and expensive, side effect outstanding, most importantly therapeutic effect is still undesirable.Data shows that the present hypertensive treatment rate of China and control rate only are 24.7% and 6.1%.Therefore, the hypertension drug treatment that generally believes global range still, individual variation more because of side effect, control rate is still not good, because the mortality rate that hypertension causes can be in any more.
The basic cause of essential hypertension is brought out owing to the sympathetic nerve overacfivity and is kept.Radiolabel shows that the hyperpietic exists the too much noradrenaline secretion of kidney and enters blood system.Nerve is arranged all blood vessel, renal tubules and juxtaglomerular apparatuses in the kidney after entering kidney behind the sympathetic ganglion of domination kidney, thereby renin angiotensin aldosterone system is regulated, conversely, Angiotensin II can increase adrenal gland's energy neurotransmission of central mechanism and acceleration SNE again.So, orthosympathetic effect causes blood pressure to increase.Thereby generally believe that at present the orthosympathetic activity of kidney is the major reason that causes essential hypertension.
External zoopery and clinical experiment confirm: blocking-up kidney sympathetic nerve, can not cause that not only the kidney normal function lowers, and systolic pressure and diastole are all descended, this explanation, although essential hypertension has multifactor existence, the orthosympathetic activity of domination kidney and tension force are to play an important role in hypertension existence and the progress.The surgery wide excision visceral nerve operation of previously once carrying out can reduce renin secretion, do not reduce the filtration rate of kidney blood flow and glomerule, still can keep electrolytical balance.But the operation of visceral nerve blocking-up has so widely caused the complication of very high peri-operation period, and because of the sickness rate of lacking of proper care of other viscera functions after visceral nerve is removed widely also very high.The kidney transfer operation of clinical more enforcement at present then can illustrate well, remove the kidney nerve after, kidney still can keep the stable of power and water solution matter.Also observe in zoopery, when hypertension, the sympathetic nervous system of kidney and body is closely related.Therefore, if can be optionally in one organ level blocking-up renin-angiotensin system, then can interrupt the effect of the rising blood pressure of renin-angiotensin system, simultaneously, because the reduction of renin-angiotensin system vaso-active substance, it is also weakened the orthosympathetic activation effect of whole body, thereby keeping under the complete prerequisite of renal function systemic blood pressure being descended, reaches the hypertensive purpose for the treatment of.Be that super-selective blocking-up kidney sympathetic nerve will make blood pressure drops, can avoid other to the unnecessary influence of bodily tissue and organ simultaneously.Our company is being devoted to this research always, and Related products such as the interior radiofrequency ablation therapy conduit of multipole hypertension blood vessel have also been developed, in order to ensure better in clinical use that in art radio frequency is disposed the time, radio frequency output can maintain best output state, reach the purpose of regulating impedance, the spy has carried out many improvement.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of multipole scalable catheter electrode and blood vessel and attach, regulate the hypertension endovascular treatment conduit of impedance.Its technical scheme is: a kind of hypertension endovascular treatment conduit of multipole adjustable impedance, comprise catheter tube, joystick, connecting pin and a plurality of electrode, one end of described catheter tube links to each other with described connecting pin, and be provided with joystick at the end by connecting pin, described catheter tube is provided with electrode skeleton away from an end of connecting pin, described a plurality of electrode is assemblied on the electrode skeleton, before forming fixing electrode away from the joystick end, electrode skeleton unites, leaning on the joystick end to form slidably at electrode skeleton unites behind the electrode, the drawing silk that the described electrode skeleton of tractive is arranged in the tube chamber of described catheter tube, the adjusting part of regulating described drawing silk is arranged on the described joystick, one end of described drawing silk is united before being fixed on described electrode, the other end of drawing silk is united after passing described electrode, is fixed on the adjusting part of described joystick.
Adjusting portion branch on the above-mentioned joystick comprises spiral rotary knob rod and tractive adjusting knob, described spiral rotary knob rod has external screw thread, be linked in the tractive adjusting knob that has female thread, the fixed position of described drawing silk on joystick is the front end of spiral rotary knob rod.
Above-mentioned a plurality of electrode cross-section distributes before and after longitudinal surface is by ring 360 degree uniform distributions.
Above-mentioned electrode is 3, and the angle between the electrode cross-section is 120 degree.
Above-mentioned electrode is 6, and the angle between the electrode cross-section is 60 degree.
Be provided with the lead of impedance measuring, temperature measuring and radio frequency output in the tube chamber of above-mentioned catheter tube, one of the lead of impedance measuring, temperature measuring and radio frequency output terminates to connecting pin, and the other end is received on the electrode through the endoceliac output input lead of catheter tube.
Above-mentioned catheter tube is divided into the leading portion body near the back segment body of joystick and close electrode, and the back segment body adopts the polymer of high rigidity, and leading portion adopts the low polymeric material of hardness number, and heat fuses and connects two sections.
Above-mentioned drawing silk adopts the rubber-like tinsel to make.
The present invention adopts joystick, is convenient to propelling movement, tractive or rotation, with regulate that conduit moves in blood vessel and towards; But the drawing silk of tractive electrode skeleton is set in catheter tube, the drawing silk of adjusting on joystick part in can the tractive catheter tube, can change the outer swollen power of electrode skeleton, thereby the electrode and the renal artery tube wall that change on the body front end electrode skeleton attach power, it is tighter to make it attach blood vessel, regulates impedance; The present invention is mainly used in bilateral kidney sympatholytic, and the blocking-up sympathetic nerve excites kidney to produce the effect of justacrine feritin-angiotensin, makes blood pressure drops; But this conduit is monitored renal artery vascular tissue temperature, is measured the function of renal artery tissue local impedance in art, it is organized anti-regulatory function and can ensure when radio frequency is disposed in the art, and radio frequency output can maintain best output state; Its multipole configuration is the sympatheticoparalytic effect of enhancing ring renal artery and safety better.
Description of drawings.
Fig. 1 is the overall structure sketch map of the hypertension endovascular treatment conduit of the swollen multipole adjustable impedance of opening of the present invention.
Fig. 2 is the front segment structure sketch map of the hypertension endovascular treatment conduit of the not swollen multipole adjustable impedance of opening of the present invention.
Fig. 3 is the back segment structural representation of the hypertension endovascular treatment conduit of multipole adjustable impedance of the present invention.
Fig. 4 is after drawing silk of the present invention is subjected to tractive, the outer swollen internal structure sketch map of electrode skeleton.
Fig. 5 is the outer swollen structural representation of electrode skeleton of the present invention.
Fig. 6 be multiple electrode catheter of the present invention when the transverse section, electrode is at the distribution situation figure of blood vessel.
Fig. 7 be multiple electrode catheter of the present invention when longitudinal surface, electrode is at the distribution situation figure of blood vessel.
Among the figure: the output input lead 9-spiral rotary knob rod 10-tractive adjusting knob 11-connecting pin 12-catheter tube 13-joystick of associating 5-leading portion body 6-drawing silk 7-back segment body 8-body intracavity behind the associating 4-electrode before the 1-electrode 2-electrode skeleton 3-electrode.
The specific embodiment:
Referring to accompanying drawing, the present invention includes catheter tube 12, joystick 13, connecting pin 11 and a plurality of electrode 1, one end of described catheter tube 12 links to each other with described connecting pin 11, and be provided with joystick 13 at the end by connecting pin 11, described catheter tube 12 is provided with electrode skeleton 2 away from an end of connecting pin 11, a plurality of electrodes 1 are assemblied on the electrode skeleton 2, before forming fixing electrode away from joystick 13 ends, electrode skeleton 2 unites 3, lean on joystick 13 ends to form slidably at electrode skeleton 2 and unite 4 behind the electrode, the drawing silk 6 that the described electrode skeleton of tractive is arranged in the tube chamber of described catheter tube 12, the adjusting part 9,10 of regulating described drawing silk is arranged on the described joystick 13, and drawing silk 6 adopts the tinsel with favorable elasticity to make, the one end unites 3 before being welded on fixing electrode, the other end of drawing silk 6 passes electrode skeleton 2 and slidably unites 4 behind the electrode, is fixed on the adjusting part 9,10 of described joystick.
As accompanying drawing 3,4, shown in 5, adjusting portion branch on the joystick of present embodiment comprises spiral rotary knob rod 9 and tractive adjusting knob 10, one end of drawing silk unites 3 before being fixed on electrode, the other end is united the front end that is fixed on the spiral rotary knob rod 9 on the joystick after 4 after passing described electrode, spiral rotary knob rod 9 has external screw thread, be linked in the tractive adjusting knob 10 that has female thread, the tractive adjusting knob 10 that is positioned at the outside is fixed, and when rotating tractive outward when regulating turn-knob 10, tractive drawing silk 6 reaches the effect of retraction with regard to being pulled for the spiral rotary knob rod of the helical screw sample of the inside 9, thereby electrode skeleton 2 is expanded, and it is tighter to attach blood vessel; When the counter-rotation tractive adjusting knob 10, the spiral rotary knob rod 9 of the inside is released, thereby discharges drawing silk 6 tension force, reaches to adjust electrode skeleton 2, and the outer swollen power of control skeleton is regulated the effect that electrode 1 and blood vessel attach degree.Adjusting on the joystick 13 part can also comprise other modes, for example bite type etc.
The body of this conduit can adopt tinsel to strengthen the net composite plastic and make, the catheter tube front end is multielectrode signal of telecommunication output and collecting part, and the output input lead of the input and output of electrode signal in catheter tube and in the joystick is connected to the connecting pin at body rear portion.
Shown in accompanying drawing 6,7, electrode skeleton 2 employing NiTi flat filaments are made, and a plurality of electrode cross-sections on it vertically are each electrode front and back and distribute by ring 360 degree uniform distributions.Electrode is 3, and the angle between the electrode cross-section is 120 degree.Electrode also can be 6, and the angle between the electrode cross-section is 60 degree.
Shown in accompanying drawing 1,3, each electrode all disposes temperature measuring, impedance measuring and radio frequency output and loads.
Termination electrode is made by platinum, platinumiridio, silver or other metals with excellent conductive performance, and thermal resistor wire, radio frequency output lead, impedance measuring lead can adopt the wire producing with insulating properties.One end of the lead of impedance measuring is welded on termination electrode, then the NiTi flat filament skeleton 2 by electrode, be welded at last in the connecting pin 11 through the output input lead 8 of the body intracavity of catheter tube and joystick.One end of each thermal resistor wire is fixed in the termination electrode, then by electrode skeleton 2, be welded at last in the connecting pin 11 through the output input lead 8 of the body intracavity of catheter tube and joystick.One end of radio frequency output lead is welded on the termination electrode, then by electrode skeleton 2, be welded at last in the connecting pin 11 through the output input lead 8 of the body intracavity of catheter tube and joystick.
As accompanying drawing 2, shown in 3, catheter tube is divided into the leading portion body 5 near the back segment body 7 of joystick and close electrode, back segment body 7 adopts the polymer of high rigidity to make, and quality is harder, is convenient to operation, leading portion body 5 adopts the low polymeric material of hardness number, quality is softer, is convenient to bending, and heat fuses two sections bodys of connection and gets final product.
The method that this conduit percutaneous puncture Wicresoft gets involved, the intravascular intracavity arrives renal artery, when impedance is suitable, the bilateral renal arteries tube wall is imposed the high frequency current in short bursts, sympathetic nerve on the renal artery wall is destroyed, and sympathetic nerve interrupts for the domination of kidney, and feritin-angiotensin is reduced for a long time, thereby blood pressure drops reaches the hypertensive effect for the treatment of.
Experiment in the animal body: after femoral arteriography has been put the hemostasis conduit, send 8F guiding catheter through this hemostasis conduit, X line DSA observes the front end that confirms guiding catheter down and arrives in the renal artery, then, hypertension endovascular treatment conduit is sent into through the 8F guiding catheter, X line DSA observes down, notices that termination electrode arrives the renal artery proper site.Jointing is handled the tractive button to radiofrequency generator, makes the catheter end electrode attach the renal artery inwall, measures the impedance of renal artery inwall, and adjusting and setting impedance is 100 Europe mothers, and 80 volts of voltages are 50 seconds between power 30 watt-hours; Measure renal artery place's temperature and impedance.The renal artery circle is implemented to melt at 120 degree places, interval.After one side finishes, finish the same operation in the offside renal artery then.After finished both sides, radiofrequency catheter withdrawed from, and withdrawed from externally via guide wire, and local point of puncture hemostasis wrapping finishes operation.Guiding catheter is withdrawed from the collection of hypertension endovascular treatment conduit, withdraw from the hemostasis conduit, point of puncture compressing blood.
Claims (8)
1. the hypertension endovascular treatment conduit of a multipole adjustable impedance, comprise catheter tube (12), joystick (13), connecting pin (11) and a plurality of electrode (1), one end of described catheter tube (12) links to each other with described connecting pin (11), and be provided with joystick (13) at the end by connecting pin (11), it is characterized in that: described catheter tube (12) is provided with electrode skeleton (2) away from an end of connecting pin, described a plurality of electrode (1) is assemblied on the electrode skeleton (2), associating (3) before electrode skeleton forms fixing electrode away from joystick (13) end, lean on joystick (13) end to form slidably at electrode skeleton (2) and unite (4) behind the electrode, the drawing silk (6) that the described electrode skeleton of tractive (2) is arranged in the tube chamber of described catheter tube (12), the adjusting part (9 of regulating described drawing silk (6) is arranged on the described joystick (13), 10), one end of described drawing silk (6) is united (3) before being fixed on described electrode, the other end of drawing silk (6) is united (4) after passing described electrode, is fixed on the adjusting part of described joystick (13).
2. the hypertension endovascular treatment conduit of multipole adjustable impedance according to claim 1, it is characterized in that: the adjusting portion branch on the described joystick comprises spiral rotary knob rod (9) and tractive adjusting knob (10), described spiral rotary knob rod (9) has external screw thread, be linked in the tractive adjusting knob (10) that has female thread, the fixed position of described drawing silk on joystick is the front end of spiral rotary knob rod (9).
3. the hypertension endovascular treatment conduit of multipole adjustable impedance according to claim 1 is characterized in that: described a plurality of electrode cross-sections distribute before and after longitudinal surface is by ring 360 degree uniform distributions.
4. the hypertension endovascular treatment conduit of multipole adjustable impedance according to claim 1, it is characterized in that: described electrode is 3, the angle between the electrode cross-section is 120 degree.
5. the hypertension endovascular treatment conduit of multipole adjustable impedance according to claim 1, it is characterized in that: described electrode is 6, the angle between the electrode cross-section is 60 degree.
6. the hypertension endovascular treatment conduit of multipole adjustable impedance according to claim 1, it is characterized in that: the lead that is provided with impedance measuring, temperature measuring and radio frequency output in the tube chamber of described catheter tube, one of the lead of impedance measuring, temperature measuring and radio frequency output terminates to connecting pin (11), and the other end is in the endoceliac output input lead of catheter tube (8) is received electrode (1).
7. the hypertension endovascular treatment conduit of multipole adjustable impedance according to claim 1, it is characterized in that: described catheter tube is divided into the leading portion body (5) near the back segment body (7) of joystick and close electrode, back segment body (7) adopts the polymer of high rigidity, leading portion body (5) adopts the low polymeric material of hardness number, and heat fuses and connects two sections bodys.
8. the hypertension endovascular treatment conduit of multipole adjustable impedance according to claim 1 is characterized in that: the making of described drawing silk employing rubber-like tinsel.
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| CN 201310252397 CN103330590A (en) | 2013-06-24 | 2013-06-24 | Multi-electrode impedance-adjustable high blood pressure endovascular treatment catheter |
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| CN 201310252397 CN103330590A (en) | 2013-06-24 | 2013-06-24 | Multi-electrode impedance-adjustable high blood pressure endovascular treatment catheter |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016055000A1 (en) * | 2014-10-11 | 2016-04-14 | 先健科技(深圳)有限公司 | Ablation catheter device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016055000A1 (en) * | 2014-10-11 | 2016-04-14 | 先健科技(深圳)有限公司 | Ablation catheter device |
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Application publication date: 20131002 |