CN103328460B - 糖基-cf2-丝氨酸和糖基-cf2-苏氨酸的衍生物 - Google Patents

糖基-cf2-丝氨酸和糖基-cf2-苏氨酸的衍生物 Download PDF

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CN103328460B
CN103328460B CN201180062006.6A CN201180062006A CN103328460B CN 103328460 B CN103328460 B CN 103328460B CN 201180062006 A CN201180062006 A CN 201180062006A CN 103328460 B CN103328460 B CN 103328460B
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CN103328460A (zh
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G·德利库尔-戈德弗鲁瓦
H·菲永
T·马丁
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Tfchem SARL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
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  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
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  • Pain & Pain Management (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
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  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN201180062006.6A 2010-12-22 2011-12-22 糖基-cf2-丝氨酸和糖基-cf2-苏氨酸的衍生物 Expired - Fee Related CN103328460B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP103064937 2010-12-22
EP10306493 2010-12-22
PCT/EP2011/073822 WO2012085221A1 (en) 2010-12-22 2011-12-22 Derivatives of glyco-cf2-serine and glyco-cf2-threonine

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CN103328460A CN103328460A (zh) 2013-09-25
CN103328460B true CN103328460B (zh) 2015-03-25

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CN201180062006.6A Expired - Fee Related CN103328460B (zh) 2010-12-22 2011-12-22 糖基-cf2-丝氨酸和糖基-cf2-苏氨酸的衍生物

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US (1) US9175044B2 (enExample)
EP (1) EP2655353B9 (enExample)
JP (1) JP5934246B2 (enExample)
CN (1) CN103328460B (enExample)
BR (1) BR112013015869A2 (enExample)
CA (1) CA2822097C (enExample)
MX (1) MX2013007292A (enExample)
NZ (1) NZ613333A (enExample)
RU (1) RU2013133788A (enExample)
WO (1) WO2012085221A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3530663B1 (en) * 2013-01-14 2021-08-11 Sunshine Biopharma Inc. Process for preparing gem-difluorinated c-glycoside compounds
CN106459122B (zh) * 2014-03-17 2019-12-03 Tf化学公司 用于生物材料和微生物的保存和保护的糖肽衍生物
EP4281466A1 (en) 2021-01-20 2023-11-29 Tfchem Cyclic glycoaminoacid derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1671723A (zh) * 2002-07-25 2005-09-21 鲁昂国家应用科学学院 新的偕二氟化化合物、其制备方法及其应用
WO2007125203A1 (fr) * 2006-05-03 2007-11-08 Institut National Des Sciences Appliquees De Rouen (Insa) Composes c-glycopeptides gem-difluores, leur preparation et leur utilisation notamment pour la preservation de materiaux biologiques.
CN101090910A (zh) * 2004-12-02 2007-12-19 鲁昂国家应用科学学院 偕二氟化c－糖肽、其制备方法及其用于保存生物材料和/或在冷冻外科中的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0224799D0 (en) * 2002-10-25 2002-12-04 Amersham Plc Improved complex compositions
FR2900154B1 (fr) 2006-04-25 2008-07-04 Inst Nat Sciences Appliq Nouveaux composes c-glycosides gem-difluores derives de la podophyllotoxine, leur preparation et leurs applications.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1671723A (zh) * 2002-07-25 2005-09-21 鲁昂国家应用科学学院 新的偕二氟化化合物、其制备方法及其应用
CN101090910A (zh) * 2004-12-02 2007-12-19 鲁昂国家应用科学学院 偕二氟化c－糖肽、其制备方法及其用于保存生物材料和/或在冷冻外科中的用途
WO2007125203A1 (fr) * 2006-05-03 2007-11-08 Institut National Des Sciences Appliquees De Rouen (Insa) Composes c-glycopeptides gem-difluores, leur preparation et leur utilisation notamment pour la preservation de materiaux biologiques.

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Publication number Publication date
MX2013007292A (es) 2014-01-31
JP5934246B2 (ja) 2016-06-15
WO2012085221A1 (en) 2012-06-28
BR112013015869A2 (pt) 2017-07-04
NZ613333A (en) 2015-01-30
RU2013133788A (ru) 2015-01-27
EP2655353B1 (en) 2015-03-04
JP2014501750A (ja) 2014-01-23
EP2655353A1 (en) 2013-10-30
CN103328460A (zh) 2013-09-25
CA2822097C (en) 2020-06-09
CA2822097A1 (en) 2012-06-28
US9175044B2 (en) 2015-11-03
EP2655353B9 (en) 2015-08-05
US20130171180A1 (en) 2013-07-04

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