CN1033214C - "Weikang" capsule for treating gastric ulcer and preparing process thereof - Google Patents
"Weikang" capsule for treating gastric ulcer and preparing process thereof Download PDFInfo
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- CN1033214C CN1033214C CN 93110022 CN93110022A CN1033214C CN 1033214 C CN1033214 C CN 1033214C CN 93110022 CN93110022 CN 93110022 CN 93110022 A CN93110022 A CN 93110022A CN 1033214 C CN1033214 C CN 1033214C
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- 208000007107 Stomach Ulcer Diseases 0.000 title abstract description 12
- 239000002775 capsule Substances 0.000 title abstract description 10
- 238000000034 method Methods 0.000 title abstract description 5
- 201000005917 gastric ulcer Diseases 0.000 title description 10
- 230000008569 process Effects 0.000 title description 2
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- 230000036407 pain Effects 0.000 abstract description 5
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- 239000002253 acid Substances 0.000 abstract description 3
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a Weikang capsule for treating gastric ulcers and a preparation method thereof, and the Weikang capsule is a specific medicine for treating gastric ulcers and gastritis. The present invention comprises the components of the following proportion: 7000 portions of cuttlefish bone, 167 portions of corydalis tuber(prepared), 1050 portions of thunberg fritillary bulb, 992 portions of wetted licorice cream, 291 portions of procaine hydrochloride and a proper amount of starch. The present invention excavates the pith and marrow of the China traditional medicine, uses the combined method of the traditional Chinese and the Western medicine, and preferentially adopts the traditional Chinese medicine with the functions of activating blood circulation, regulating vital energy, clearing away heat and toxic material, making acid, stopping bleeding, relieving pain, and converging and promoting activities, and the Western medicine with the function of quick analgesia, so that the present invention is prepared. The present invention outstandingly shows the particular advantages of both symptomatic treatment and radical treatment, quick result and eradication.
Description
The present invention relates to nuclear reaction and stow a kind of service kit in the refuelling system, be used to load and unload the kingbolt of top cover of reactor pressure vessel, is a kind of main bolt mounting and dismounting equipment for pressure vessel of reactor specifically.
Nuclear power station after (general about about 1 year) operation, need be opened top cover of reactor pressure vessel through after a while, adorns and reloads, and then cover pressure vessels top cover, puts into operation again.Pressure vessels top cover is by one group of kingbolt and corresponding nut and pressure vessel bolt jail.Large nuclear power station reactor pressure vessel kingbolt is quite big, and the GNPS in building as China has 58 kingbolts, is single ended bolt, and it is of a size of M155 * 4, and length is about 2m, and heavily about 300kg, the external diameter of nut are φ 229.Usually by robot or bolt tension machine kingbolt is unscrewed, with main bolt mounting and dismounting equipment kingbolt is discharged to the hole of bracketplant from pressure vessels top cover then, or from the hole of bracketplant, the kingbolt after decontamination is cleaned is installed in the screw of pressure vessels top cover, tighten kingbolt by robot or bolt tension machine again.In the prior art, United States Patent (USP) Re33.373 (1990.10.9 second edition) discloses a kind of tool device (Tooling appratus for nuclear reactors) that improves reactor, it provides a kind of and is used for detection reaction heap reactor core cylindrical shell discharge orifice, and then stopper is embedded the remotely controlled plant of discharge orifice.This device comprises an instrument balladeur train that is used to the instrument of accepting, one is used for the supporting tool balladeur train and makes its powerful backing plate assembly of reactor core cylindrical shell guiding relatively, one is attached on the powerful backing plate assembly and with the reactor core cylindrical shell and is connected, make powerful backing plate assembly along the clamping device of reactor core tube axon to parallel suspend, be installed in and be connected with the instrument balladeur train on the powerful backing plate assembly, can driven tool balladeur train along first orientation (on, first CD-ROM drive motor that moves down), one is installed on the instrument balladeur train support stand that can rotatablely move along the arc track that matches with reactor core cylindrical shell cylinder form, be installed in driving of being connected with the rotation support stand on the instrument balladeur train and rotate second CD-ROM drive motor that support stand moves along arc track, be installed in rotation and be connected with instrument on the support stand, make the instrument can be along the radial motion of reactor core cylindrical shell with the instrument embedding or extract the 3rd CD-ROM drive motor of reactor core cylindrical shell.Wherein said instrument is an instrument hold-down arm, and it comprises releasable clamping stopper device, utilizes this device stopper can be embedded in the discharge orifice of reactor core cylindrical shell.This installs not only complex structure heaviness, and the cost height moves difficulty, need be contained in fuel manipulator crane (elevator) and go up use.Complicated operation, and main it is a kind of in order to improve the flow direction of reactor internal cooling agent, thus the repair apparatus that the plug-hole of the thermal property of reactor is used improved, can not be used for the loading and unloading of the large-scale kingbolt of reactor pressure vessel.
The purpose of this invention is to provide a kind of light and handy, conveniently moving simple in structure freely, simple to operate safe, cheap, and can load and unload the main bolt mounting and dismounting equipment for pressure vessel of reactor of large-scale kingbolt.
The present invention is achieved in that a kind of main bolt mounting and dismounting equipment for pressure vessel of reactor, it comprises a vertical frame, a kingbolt that is located at the vertical frame bottom is deposited bracketplant, be installed in the kingbolt loading and unloading device on the vertical frame, one is located on the vertical frame and is connected with kingbolt loading and unloading device, make it can and move horizontally the conveyer device of kingbolt being sent into bracketplant or from bracketplant, taking out kingbolt along the upper and lower slip of vertical frame, and with the supporting electric control box of the driving mechanism of conveyer device.Wherein, said vertical frame is provided with four ends and has sliding muscular spasm pain relieving, hemostasis, the protection ulcer surface.Thereby reach therapeutical effect.
Since this product self-application, do not found side effect.
Be most preferred embodiment of the present invention below, be made up of following composition: 7000 parts of Endoconcha Sepiaes, 167 parts of Rhizoma Corydalis (system), 1050 parts of Bulbus Fritillariae Thunbergiis, 992 parts of Radix Glycyrrhizae extractum, 291 parts of procaine hydrochlorides, starch are an amount of; Changing a kind of literary style is that proportioning raw materials is divided into: Endoconcha Sepiae: Rhizoma Corydalis (system) is fixed: Bulbus Fritillariae Thunbergii: Radix Glycyrrhizae extractum: procaine hydrochloride=7000: 1167: 1050: 992: 291; Processing step is: with 30000 is example;
1, Chinese crude drug pre-treatment
(1) with Endoconcha Sepiae, gradually Bulbus Fritillariae Uninbracteatae cleans, rinsing, oven dry, pulverized 90 mesh sieves.
(2) Rhizoma Corydalis is cleaned, rinsing, concoct with the vinegar cooking method, 90 mesh sieves were pulverized in oven dry.
(3) with Radix Glycyrrhizae extractum, oven dry is pulverized, and crosses 90 mesh sieves.
(4) procaine hydrochloride is pulverized 90 mesh sieves.
2, adjust
Measure above-mentioned medicated powder by prescription, put mixing in the mixer.
3, packing
With the medicated powder of mixing, clean the polishing packing by every 0.35g Capsules of packing into.
Laboratory report and contrast difference are as follows
Material: one, German bismuth aluminate compound, commercially available product, the big pharmaceutical factory of Germany central authorities produces.
Lot number: 200315
Two, gastric ulcer treating powder, Jin Cheng pharmaceutical factory, Shenyang provides.Lot number: 910101
Three, animal: the male and female rat is provided by animal housing of Sanitation and Anti Epidemic Station, Liaoning Prov..
Four, normal saline, will eagle pharmaceutical factory, Shenyang provides lot number: 910102
Scope of experiment:
One, to the experiment of stress ulcer
Get 46 of body weight 250-350 gram male and female rats and divide equally five groups, irritate the stomach health powder that German bismuth aluminate compound and Jin Cheng pharmaceutical factory produce respectively.Be 10g/1kg, organize separately to being contrast with the volume normal saline, the beginning fasting is 24 hours after the injection, can freely drink water, the samely after the 24th hour be administered once again, then rat be bundled on the plank, head is upwards stood in the water-bath of 20 ℃ of constant temperature, make the water surface be higher than rat breast xiphoid-process, take out rat after spending 20 hours, the cervical vertebra dislocation is put to death, and cuts open the belly and gets stomach, in cardia and pylorus two places ligation, fill with 1% formalin to gastric, the tailing edge greater gastric curvature was cut in 5 minutes, flushing, shakeout, calculating ulcer number and ulcer area (only remembering the area of the above ulcer of diameter 1mm) 10 rat ulcers of matched group are as a result counted 66.6 ± 6.2 of average out to, and the ulcer number of one group of Germany of two medicine 10g/kg dosage bismuth aluminate compound group is below 9, two groups of dosage, gold city stomach health is about 3, learn by statistics and handle, see Table one with the more different equal highly significant of matched group (P＜0.001), when dosage reduces to 5g/kg, effect weakens, but still has significant therapeutic effect.Matched group ulcer area average out to 36.5mm
2, German bismuth aluminate compound dosage group is at 9.5mm
2Below, stomach health dosage group is at 3.3mm
2Below.With matched group comparing difference still significantly (P＜0.01) but weaken than the effect of 10g/kg dosage group.
Conclusion: the stomach health has the effect that prevents that significantly stress ulcer from generating.
Show the experimental result group dosage number of animals gastric mucosa ulcer of a pair of stress ulcer and count ulcer area mm
2
G/kg x ± SE x ± SE matched group normal saline is with volume 10 66.6 ± 6.2 36.5 ± 1.0 German bismuth aluminate compound 10 10 9.1 ± 2.5 △ △ 9.5 ± 4.0 △ △
5??????7?????25.6±4.7△△?10.9±2.7△△
Stomach health 10 10 3.0 ± 0.2 △ △ 1.4 ± 0.5 △ △
5??????9??????7.4±1.2△△??5.9±1.4△△
△ and matched group be P＜0.01＜0.0002 relatively
Two, to the experiment of duodenal ulcer
Get body weight 200-300 and restrain 48 suspension fasting of female male rat 24 hours, freely drink water, divide equally four groups then, irritate stomach respectively in the gastric ulcer treating powder suspension 10g/kg of German bismuth aluminate compound 10g/kg and the production of Jin Cheng pharmaceutical factory and stomach health powder suspension 10g/kg and the 5g/kg that the Jin Cheng pharmaceutical factory produces, matched group is irritated stomach and is contrast with the volume normal saline.
The same again being administered once after spending 20 hours, after the last administration 2 hours, execute pylorus ligation the ether fiber crops and state, stop eating after stating, cut off the water 18 hours, and with animal place row, cut open the belly and get stomach then, cut off along greater gastric curvature, wash stomach gently, observe gastric mucosa ulcer number and ulcer area and (only remember ulcer diameter 1mm
2The area of above ulcer surface)
Matched group ulcer is counted 17.2 ± 3.7 of average out to as a result, and two medicine 10g/kg dosage group ulcer numbers are on average at 2.6-2.8, and most animals does not have ulcer to take place, and the ulcer number that stomach health group ulcer number is less than German bismuth aluminate compound sees Table two.Matched group ulcer area average out to 18.4 ± 7.2mm
2, two 10g/kg dosage groups are all at 7.3mm
2Below, stomach health dosage group ulcer area is less than the ulcer area of German bismuth aluminate compound dosage group, and the ulcer number and the ulcer area of stomach health 5g/kg dosage group all are higher than 10g/kg dosage group, but lack than matched group, see Table two.
The experimental result of table two pair duodenal ulcer
Dosage is moving, and (x ± SE) ulcer area group thing ulcer is counted 1mm
2More than (x ± SE)
(g/kg) count ulcer and count mm
2German bismuth aluminate compound 10 16 2.6 ± 1.0 △ 2.1 in normal saline co-content 9 17.2 ± 3.7 3.8 ± 0.7 18.4 ± 7.2 ± 0.7 7.3 ± 2.0 stomach health powder, 10 16 2.1 ± 0.4 △ 1.9 ± 0.1 4.2 ± 0.8
5?????7???7.7±4.9???3.3±1.3??7.0±2.1
Compare P＜0.03 with matched group
Three, to the experiment of hyperchlorhydria
Get 57 of body weight 200-300g rats, divide five groups, put to death animal at last, cut open the belly and get stomach, gastric content is filtered with a little Cotton Gossypii, measure the gastric juice volume of each treated animal, and measure its pH value with acidometer by the duodenal ulcer method.
The result: control animals gastric juice pH average out to 17.4 ± 0.06, and 10g/kg dosage group two medicine gastric juice all show alkalescence, about pH7.6-7.9, show two dosage groups can both be more completely in and gastric acid.5g/kg dosage group can part in and gastric acid (seeing Table three) measure its gastric juice amount (representing) and show with the 1m/100kg body weight, two dosage group gastric juice amounts and matched group be more slightly reduction.Learn by statistics and handle, difference is all not remarkable.This experiment is clear to be seen, is better than the effect of German bismuth aluminate compound in the stomach health with the gastric acid effect, but to not influence and change of gastric secretion.
The experimental result of table three pair hyperchlorhydria
Dosage moves gastric juice pH value gastric juice amount group thing (ml/100g
(g/kg) number (x ± SE) body weight) German bismuth aluminate compound 10 16 7.63 ± 0.34 △ △ 0.68 ± 0.04 in normal saline co-content 16 1.74 ± 0.06 0.08 ± 0.05
58 2.60 ± 0.18 △ △, 0.76 ± 0.03 stomach health, 10 16 7.94 ± 0.32 △ △ 0.76 ± 0.06
5????7?3.57±0.67△???0.64±0.03
△ and matched group be P＜0.01 △ △ P＜0.001 relatively
Four, to the test (providing) of gastric ulcer by 238 hospitals of PLA
My institute used Weikang capsule for curing gastric disease treatment gastric ulcer 203 examples from 1973 to 1985, obtain very good effect.
(1) clinical data: this group case all has the epigastrium history of pain of prolonged and repeated outbreak, make a definite diagnosis with gastroscopy through x-ray barium meal examination and to confirm, be the gastric ulcer person, minimum 19 years old maximum 64 years old age, 20 examples of person below 20 years old, 109 examples in 21-30 year, 48 examples in 31-40 year, 41-50 year 16 examples, 51-60 year 9 examples, 2 examples more than 61 years old.Wherein: male 182 examples, women 21 examples.The course of disease 1 year with interior person's 33 examples, 1-5 person's 88 examples, 5-10 person's 52 examples, the longest example of person's 30 examples is 38 years more than 10 years.The gastroscopy of X line barium meal: niche 94 examples, excitation disease tenderness 95 examples, pyloric cap is out of shape 14 examples.
(2) Therapeutic Method: take Weikang capsule for curing gastric disease.Usage: every day 3 times, each 5-7 grain, 28 days is a course of treatment, does not fully recover as disease, can continue second course of treatment.
(3) efficacy analysis: 1, clinical cure: x-ray barium meal examination ulcer surface direct sign or indirect sign all disappear.2, produce effects: cardinal symptom disappears.Gastroscopy ulcer trace has clear improvement.3, take a turn for the better: subjective symptoms disappears, but gastroscopy still has ulcer million.4, invalid: the equal no change of symptom and sign gastroscopy.
The contrast of table four pair gastric ulcer disease therapeutic effect
| The case load group | Cure rate % | Obvious effective rate % | Effective percentage % | Inefficiency % | Amount to |
| Stomach health group | ???157 ??77.33 | ???31 ??15.27 | ???11 ???5.41 | ????4 ??1.97 | ????203 ??100.00 |
| Matched group | ????41 ??41.00 | ???24 ??24.00 | ???21 ??21.00 | ???14 ??14.00 | ???100 ??100.00 |
Five, antineoplastic is tested
Current research result according to China Academy Of Traditional Chinese Medicine Traditional Chinese Medicine Research Institute shows, accounts in the stomach health marine animal medicine～Endoconcha Sepiae of 67% and contains natural carcinophylin (LMW-NTS) lung, skin and digestive tract cancer cell are had the obvious suppression effect.
Experimental data shows: Endoconcha Sepiae extract is 82% to the suppression ratio of mice S-180 cancerous cell, can prolong the life of S-100 mice, and is higher 2.85 times than matched group, can be used for the prevention and the treatment of pulmonary carcinoma, haematemesis, skin carcinoma, digestive tract tumor.
Six, randomization is a matched group with general treatment (antacid spasmolytic), and healing person compares X for two groups
2=48.78, P＜0.001, difference highly significant.X ray examination group ratio, person's 94 examples that the stomach health has the niche, treatment disappearance 72 examples (76.59%) matched group has the niche person's 40 examples, treatment disappearance 16 examples (40%).Compare X for two groups
2=15.07, P＜0.001, difference highly significant.
This product is got the length of Chinese medicine and western medicine, and effect comprehensively.Glycyrrhizic acid is the effective ingredient of treatment Peptic Ulcers, has spasmolytic, and anti-gastric acid secretion effect has the effect of class desoxycortone simultaneously, but antiinflammatory and improve the gastrointestinal blood circulation.Endoconcha Sepiae contains charcoal acid calcium, the antacid that can dehumidify, and hemostasis convergence, the similar papaverine of peimine spasmolysis has the dissipating depression of QI therapeutic method to keep the adverse QI flowing downwards, and astringing to arrest bleeding helps digestion and removes the effect of grade of expanding, and Rhizoma Corydalis total alkaloids has that analgesia is relieving convulsion, stable effect is told in the town.The property circulation of procaine cortex internal organs capable of blocking Asia, thus the neurotrophy state of affected part improved, promote ulcer healing.
Seven, this product has no side effect.
Eight, clinical effectiveness is summed up
(1) gastric ulcer patient 203 examples, success rate is the highest by 98.1%, and minimum 90.3%
(2) duodenum patient 197 examples, success rate is the highest by 98.3%, and minimum 95.4%
(3) gastritis sufferer: 232 examples, success rate is the highest by 94.6%, and minimum 91.1%
(4) gastrorrhagia patient: 108 examples, success rate is the highest by 98.5%, and minimum 95%
(5) patient that has a stomach-ache: 336 examples, success rate is the highest by 96.8%, and minimum 90.5%
(6) hyperchlorhydria: 202 examples, success rate the highest 98.8% is minimum 90.5%, and total effective rate is more than 98%.
Model case
Case 1: Liu Yuying, the woman, 47 years old, Hua Feng ordnance factory, turner, stomachache, abdominal distention 11 years, pain is acute diffuses to the back.On the July 27th, 80 of the 4th hospital gastroscope inspection in the Fushun City: the antrum reddish yellow is alternate, have rotten to the corn everywhere, have a small amount of fresh hemorrhage, there is the ulcer surface of 0.8 * 0.8 centimetre of size in 12 duodenum 12 bulbs, on cover white fur, peripheral congestion and edema, oral Weikang capsule for curing gastric disease one all upper abdominal pain are clearly better, abdominal distention disappears, and around taking medicine, symptom all disappears.In gastroscope check on October 8th, 80: the gastric antrum erosion healing.Duodenal bulbar ulcer obviously dwindles, and 0.1 * 0.2 centimetre of size is only arranged, on cover thin and whitish fur, the mucous hyperemia edema disappears on every side.
Case 2: Zhang Tiejun, man 25 years old, the military region, Shenyang tank four teacher volunteers.Readme, repeated relapsing, chronic upper abdominal pain 4 years, companion's acid regurgitation abdominal distention, appetite is not good enough.Once took medicines such as gastropine, hydroxide aluminium flake, do not heal all the time.JIUYUE was done gastroscopy in General Hospital, Shenyang Military Command on 3rd in 80 years: find that there is the ulcer surface of one 0.9 * 0.8 centimetre of size in stomach angle central authorities, the ulcer bottom is smooth, on cover white fur, congestion and edema on every side, diagnosis, gastric ulcer.Promptly give 6 of oral Weikang capsule for curing gastric disease one time, continuous 5 days, bitterly, the film transference cure that expands, heighten than appetite around taking medicine, 1.2 kilograms of weight increase, gastroscope check on October 8th, 80: place, stomach angle ulcer heals fully.
Case 3: patient, Bao Min, women, 35 years old, Qing Yuan county agricultural machinery factory workman.Because of empty stomach upper abdomen dull pain, can alleviate about 1 year after the dining slightly.Recently sx comes my institute's diagnosis and treatment.Through gastroscopy: in curved greatly visible 0.7 * 0.7 centimetre of dark approximate penetrating ulcer of side of pyloric cap, the companion is congested swollen.Through treating with Weikang capsule for curing gastric disease, oral each 6, every day three times, the back Upper abdominal pain disappears all around.Check gastroscope duodenal bulbar ulcer all heals.
| The grouping of example number | Cure % | Produce effects % | Improvement % | Invalid % | Amount to % |
| Stomach health group | ???157 ??(77.33) | ????31 ??(15.27) | ????11 ??(5.41) | ?????4 ??(1.97) | ???203 ?(100.0) |
| Matched group | ????41 ??(41.00) | ????24 ??(24.00) | ????21 ??(21.00) | ????14 ??(14.00) | ???100 ?(100.0) |
Claims (2)
1. main bolt mounting and dismounting equipment for pressure vessel of reactor, it comprises a vertical frame (20), a kingbolt that is located at vertical frame (20) bottom is deposited bracketplant (2).Be installed in the kingbolt loading and unloading device (5) on the vertical frame (20), one is located at vertical frame (20) and upward and with kingbolt loading and unloading devices (5) is connected, so that it can be along on the vertical frame (20), lower slider and move horizontally and kingbolt sent into bracketplant (2) or the conveyer device (17) of taking-up kingbolt from bracketplant (2), and with the supporting electric control box (19) of the driving mechanism of conveyer device (17), it is characterized in that said vertical frame (20) is provided with the supporting leg (3) that four ends have roller, can be supported on respectively on little room floor of heap and the pressure vessels top cover, vertical frame (20) bottom be provided with can make vertical frame (20) around the pressure vessels top cover edge rotating two hand friction pulleys (4) and make vertical frame (20) firmly be parked in the auxiliary supporting leg (1) of three adjustment heights of scheduled operation position, kingbolt loading and unloading devices (5) are a lift fork, conveyer device (17) is mounted in the dolly that moves horizontally at vertical frame (20) top, it is by the motor that is installed on the vertical frame (20), gear reduction unit and feed screw nut pay (11) and drive, the lifting of lift fork is by the motor (9) that is installed on the dolly, gear reduction unit and feed screw nut pay (8) and drive, bracketplant is provided with the kingbolt binding clasp in (2), and its bottom is provided with ball.
2. according to the said a kind of main bolt mounting and dismounting equipment for pressure vessel of reactor of claim 1, it is characterized in that the feed screw nut pays is connected with pulling force sensor (7) on (8), the feed screw nut pays (8) and is connected with lift fork by pulling force sensor (7), on lift fork, be provided with two leads (18), the guide pin bushing (10) of lead (18) is contained on the dolly, also is provided with two level indicators (6) on the vertical frame (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93110022 CN1033214C (en) | 1993-01-09 | 1993-01-09 | "Weikang" capsule for treating gastric ulcer and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93110022 CN1033214C (en) | 1993-01-09 | 1993-01-09 | "Weikang" capsule for treating gastric ulcer and preparing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1087011A CN1087011A (en) | 1994-05-25 |
| CN1033214C true CN1033214C (en) | 1996-11-06 |
Family
ID=4987932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93110022 Expired - Fee Related CN1033214C (en) | 1993-01-09 | 1993-01-09 | "Weikang" capsule for treating gastric ulcer and preparing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1033214C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100350947C (en) * | 2005-12-22 | 2007-11-28 | 陈宝贵 | Medicine for treating gastric and duodenal ulcer and preparing method |
-
1993
- 1993-01-09 CN CN 93110022 patent/CN1033214C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1087011A (en) | 1994-05-25 |
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