CN103316538A - Concentrating system for plasma - Google Patents
Concentrating system for plasma Download PDFInfo
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- CN103316538A CN103316538A CN201310246629XA CN201310246629A CN103316538A CN 103316538 A CN103316538 A CN 103316538A CN 201310246629X A CN201310246629X A CN 201310246629XA CN 201310246629 A CN201310246629 A CN 201310246629A CN 103316538 A CN103316538 A CN 103316538A
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- pump
- upgrading unit
- cartridge filter
- concentrating
- blood plasma
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Abstract
The invention discloses a concentrating system for plasma. The concentrating system comprises a charging bucket, a first pump and a cartridge filter, wherein the input end of the first pump is connected with the output end of the charging bucket, and the output end of the first pump is connected with the input end of the cartridge filter; the output end of the cartridge filter is connected with the input end of a concentrating cell group which is composed of at least two concentrating cells; the concentrated liquid outlet of the concentrating cell group is connected with a spray-drying device; by adopting the concentrating system, the animal plasma is directly subjected to multi-stage concentration by the concentrating cells and then is discharged from the concentrated liquid outlet of the concentrating cell group and subjected to spray drying; compared with the prior art, by adopting the continuous feeding and discharging working mode, the concentrating time is effectively saved and the production efficiency is improved; furthermore, the blockage of the cartridge filter and a film assembly of the concentrating system caused by the circulating concentrated plasma are avoided, and the running stability and the reliability of the device are effectively improved.
Description
Technical field
The present invention relates to chemical technology field, be specifically related to a kind of concentration systems of blood plasma.
Background technology
Contain the bioactivators such as rich in protein, enzyme, vitamin in the animal blood plasma, can be used for producing multiple biochemical product, be used widely in food, medicine and feed processing and other fields etc.Because the water content of animal blood plasma up to about 93%, therefore needs it is carried out concentrate drying before the preparation biochemical product, to reach the purpose that reduces reagent consumption and energy resource consumption.At present, it mainly is the circulation concentration systems that adopts batch-type, utilize ultrafiltration or nanofiltration that animal blood plasma is concentrated, then make SDPP by spray-drying, but when adopting the concentrated blood plasma of circulation concentration systems of batch-type, the fresh plasma of each batch is concentrated to interrupt, and every batch of blood plasma all adopts circulation concentrated, and the process time is long, and efficient is low, moreover, the anti-coagulants that is accompanied by in concentration process in the blood plasma runs off, so that the celloglobulin in the blood plasma separates out, and the cartridge filter in the concentration systems that causes circulating, the membrane module of upgrading unit easily stops up, not only cause the interruption of production technology, also can affect effect and the service life of system equipment.
Summary of the invention
The purpose of this invention is to provide a kind of efficient, the plasma extraction system that stable, reliability is high.
For achieving the above object, the technical solution used in the present invention is: a kind of concentration systems of blood plasma, comprise batch can, the first pump and cartridge filter, the input of described the first pump connects the output of batch can, the first delivery side of pump connects the input of cartridge filter, it is characterized in that: the output of described cartridge filter connects the input of upgrading unit group, and described upgrading unit group is made of two upgrading units at least, and the concentrated solution outlet of upgrading unit group is connected with spray-drying installation.
The beneficial effect that technique scheme produces is: animal blood plasma directly carries out multistage concentrated by the upgrading unit group, then discharge from the concentrated solution outlet of upgrading unit group and carry out spray-drying, compare than prior art, the present invention adopts the mode of operation of continuous feed, discharging, effectively save concentration time, enhance productivity, simultaneously, the obstruction that the concentrated blood plasma of avoiding circulating causes the membrane module of cartridge filter and concentration systems, stability and the reliability of the operation of Effective Raise device.
Description of drawings
Fig. 1 is structural representation of the present invention.
The specific embodiment
A kind of concentration systems of blood plasma, comprise batch can 10, the first pump 20 and cartridge filter 30, the input of described the first pump 20 connects the output of batch can 10, the output of the first pump 20 connects the input of cartridge filter 30, the output of described cartridge filter 30 connects the input of upgrading unit group, described upgrading unit group is made of two upgrading units at least, and the concentrated solution outlet of upgrading unit group is connected with spray-drying installation.Operation principle of the present invention is: animal blood plasma is dropped in the batch can 10, be delivered to cartridge filter 30 through the first pump 20 and carry out primary filter, to hold back particle larger in the blood plasma, guarantee the safe operation of the upgrading unit group of postorder, the blood plasma that leaches through cartridge filter 30 enters the upgrading unit group and directly carries out multistage concentrated, then discharge from the concentrated solution outlet of upgrading unit group and carry out spray-drying, thickening efficiency according to blood plasma, can add continuously fresh blood plasma in the batch can 10 according to certain speed, with guarantee concentration technology continue carry out.Compared with prior art, the present invention adopts the mode of operation of continuous feed, discharging, namely cancel in the prior art and concentrate to be got back to the technique that loops secondary concentration in the batch can, and employing directly enters secondary after elementary concentrating, three inferior upgrading units concentrate, entering spray-drying behind the concentrated good blood plasma continuous discharge gets final product, effectively save concentration time, enhance productivity, simultaneously, the obstruction that the concentrated blood plasma of avoiding circulating causes the membrane module of cartridge filter and concentration systems, stability and the reliability of the operation of Effective Raise device.
As further preferred version: as shown in Figure 1, described upgrading unit group comprises elementary upgrading unit 40 and secondary upgrading unit 50, elementary upgrading unit 40 comprises the second pump 41 and elementary concentrated film device 42, secondary upgrading unit 50 comprises the 3rd pump 51 and the concentrated film device 52 of secondary, the input of described the second pump 41 is connected with the output of cartridge filter 30, the output of the second pump 41 is connected with the input of elementary concentrated film device 42, the input of described the 3rd pump 51 is connected with the elementary concentrated solution outlet 421 of elementary concentrated film device 42, the output of the 3rd pump 51 is connected with the input of the concentrated film device 52 of secondary, the secondary concentrated solution outlet 521 of the concentrated film device 52 of described secondary is connected with spray-drying installation, that is to say that each upgrading unit comprises pump and concentrated film device, delivery side of pump is connected with the input of concentrated film device, have certain pressure when concentrating film device so that blood plasma enters, guarantee the concentrated speed of blood plasma and the stable operation of concentration systems.
Further, elementary filtrate (liquid 422 and the secondary filtrate (liquid 522 of described upgrading unit group lead to collection processing system implementing, and as shown in Figure 1, elementary filtrate and secondary filtrate are compiled and flowed to same pipeline, make things convenient for like this centralized collection of filtrate to process, improve process efficiency.
Further, the filtering accuracy of described cartridge filter 30 is 5～50 μ m, can and clean suspended particulate larger in the water of concentration systems, colloid, microorganism etc. with blood plasma like this is trapped in the cartridge surface and hole of cartridge filter 30, for the stable operation of postorder upgrading unit group is given security, avoid simultaneously the membrane component in the upgrading unit group to stop up, be conducive to prolong the service life of membrane component.
Further, membrane component in the described upgrading unit group is the NF membrane of rolling, and the NF membrane of rolling is directly bought in market and got final product, the convenient realization, according to the physicochemical property of blood plasma, the molecular cut off of the membrane component in the preferred described upgrading unit group is 200-500D.
Claims (6)
1. the concentration systems of a blood plasma, comprise batch can (10), the first pump (20) and cartridge filter (30), the input of described the first pump (20) connects the output of batch can (10), the output of the first pump (20) connects the input of cartridge filter (30), it is characterized in that: the output of described cartridge filter (30) connects the input of upgrading unit group, described upgrading unit group is made of two upgrading units at least, and the concentrated solution outlet of upgrading unit group is connected with spray-drying installation.
2. the concentration systems of described blood plasma according to claim 1, it is characterized in that: described upgrading unit group comprises elementary upgrading unit (40) and secondary upgrading unit (50), elementary upgrading unit (40) comprises the second pump (41) and elementary concentrated film device (42), secondary upgrading unit (50) comprises the 3rd pump (51) and the concentrated film device (52) of secondary, the input of described the second pump (41) is connected with the output of cartridge filter (30), the output of the second pump (41) is connected with the input of elementary concentrated film device (42), the input of described the 3rd pump (51) is connected with the elementary concentrated solution outlet (421) of elementary concentrated film device (42), the output of the 3rd pump (51) is connected with the input of the concentrated film device (52) of secondary, and the secondary concentrated solution outlet (521) that described secondary concentrates film device (52) is connected with spray-drying installation.
3. the concentration systems of described blood plasma according to claim 2, it is characterized in that: elementary filtrate (liquid (422) and the secondary filtrate (liquid (522) of described upgrading unit group lead to collection processing system implementing.
4. the concentration systems of described blood plasma according to claim 1 and 2, it is characterized in that: the filtering accuracy of described cartridge filter (30) is 5～50 μ m.
5. the concentration systems of described blood plasma according to claim 1 and 2, it is characterized in that: the membrane component in the described upgrading unit group is the NF membrane of rolling.
6. the concentration systems of described blood plasma according to claim 1 and 2, it is characterized in that: the molecular cut off of the membrane component in the described upgrading unit group is 200-500D.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310246629.XA CN103316538B (en) | 2013-06-20 | 2013-06-20 | The concentration systems of blood plasma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310246629.XA CN103316538B (en) | 2013-06-20 | 2013-06-20 | The concentration systems of blood plasma |
Publications (2)
| Publication Number | Publication Date |
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| CN103316538A true CN103316538A (en) | 2013-09-25 |
| CN103316538B CN103316538B (en) | 2015-11-18 |
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| CN201310246629.XA Active CN103316538B (en) | 2013-06-20 | 2013-06-20 | The concentration systems of blood plasma |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106866810A (en) * | 2017-04-01 | 2017-06-20 | 合肥禹王膜工程技术有限公司 | Low ash content plasma protein tubular membrane concentration technology |
| CN112473184A (en) * | 2020-11-25 | 2021-03-12 | 临沂吉宇蛋白有限公司 | Plasma filtering and concentrating device and method |
Citations (6)
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|---|---|---|---|---|
| JPS5762222A (en) * | 1980-10-03 | 1982-04-15 | Asahi Chem Ind Co Ltd | Preparation of concentrated solution of platelet, its device and part |
| JP2000161848A (en) * | 1998-11-24 | 2000-06-16 | Sumitomo Chem Co Ltd | Spray drying method and spray drier |
| CN101613734A (en) * | 2009-08-17 | 2009-12-30 | 张吉越 | The preparation method of plasma polypeptide |
| CN201728060U (en) * | 2010-07-22 | 2011-02-02 | 甘肃省膜科学技术研究院 | Film separating device for purifying, condensing and desalting inulin |
| CN103039693A (en) * | 2013-01-09 | 2013-04-17 | 合肥工业大学 | Preparation method of modified livestock and poultry plasma protein powder |
| CN203342531U (en) * | 2013-06-20 | 2013-12-18 | 安徽普朗膜技术有限公司 | Plasma concentration system |
-
2013
- 2013-06-20 CN CN201310246629.XA patent/CN103316538B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5762222A (en) * | 1980-10-03 | 1982-04-15 | Asahi Chem Ind Co Ltd | Preparation of concentrated solution of platelet, its device and part |
| JP2000161848A (en) * | 1998-11-24 | 2000-06-16 | Sumitomo Chem Co Ltd | Spray drying method and spray drier |
| CN101613734A (en) * | 2009-08-17 | 2009-12-30 | 张吉越 | The preparation method of plasma polypeptide |
| CN201728060U (en) * | 2010-07-22 | 2011-02-02 | 甘肃省膜科学技术研究院 | Film separating device for purifying, condensing and desalting inulin |
| CN103039693A (en) * | 2013-01-09 | 2013-04-17 | 合肥工业大学 | Preparation method of modified livestock and poultry plasma protein powder |
| CN203342531U (en) * | 2013-06-20 | 2013-12-18 | 安徽普朗膜技术有限公司 | Plasma concentration system |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106866810A (en) * | 2017-04-01 | 2017-06-20 | 合肥禹王膜工程技术有限公司 | Low ash content plasma protein tubular membrane concentration technology |
| CN106866810B (en) * | 2017-04-01 | 2020-07-31 | 合肥禹王膜工程技术有限公司 | Tubular membrane concentration process for low-ash plasma protein |
| CN112473184A (en) * | 2020-11-25 | 2021-03-12 | 临沂吉宇蛋白有限公司 | Plasma filtering and concentrating device and method |
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| Publication number | Publication date |
|---|---|
| CN103316538B (en) | 2015-11-18 |
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