CN103316538B - The concentration systems of blood plasma - Google Patents
The concentration systems of blood plasma Download PDFInfo
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- CN103316538B CN103316538B CN201310246629.XA CN201310246629A CN103316538B CN 103316538 B CN103316538 B CN 103316538B CN 201310246629 A CN201310246629 A CN 201310246629A CN 103316538 B CN103316538 B CN 103316538B
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Abstract
The invention discloses a kind of concentration systems of blood plasma, comprise batch can, first pump and cartridge filter, the input of described first pump connects the output of batch can, first delivery side of pump connects the input of cartridge filter, the output of described cartridge filter connects the input of upgrading unit group, described upgrading unit group is at least made up of two upgrading units, the concentrated solution outlet of upgrading unit group is connected with spray-drying installation, such animal blood plasma directly carries out multistage concentrated by upgrading unit group, then discharge from the concentrated solution outlet of upgrading unit group and carry out spraying dry, compare than prior art, the present invention adopts continuous feed, the mode of operation of discharging, effective saving concentration time, enhance productivity, simultaneously, the blocking that the membrane module of concentrated blood plasma to cartridge filter and concentration systems of avoiding circulating causes, the stability of effective raising plant running and reliability.
Description
Technical field
The present invention relates to chemical technology field, be specifically related to a kind of concentration systems of blood plasma.
Background technology
Containing bioactivators such as rich in protein, enzyme, vitamins in animal blood plasma, can be used for producing multiple biochemical product, be used widely in fields etc. such as food, medicine and feed manufacturing.Because the water content of animal blood plasma is up to about 93%, therefore need to carry out concentrate drying to it before preparing biochemical product, to reach the object reducing reagent consumption and energy resource consumption.At present, mainly adopt the circulation concentration systems of batch-type, ultrafiltration or nanofiltration is utilized to concentrate animal blood plasma, then SDPP is obtained by spraying dry, but when adopting the circulation concentration systems of batch-type to concentrate blood plasma, the fresh plasma of each batch is concentrated to interrupt, and often criticize blood plasma and all adopt circulation concentrated, process time is long, efficiency is low, moreover, run off along with the anti-coagulants in blood plasma in concentration process, celloglobulin in blood plasma is separated out, cause the cartridge filter in circulation concentration systems, the membrane module of upgrading unit easily blocks, not only cause the interruption of production technology, also can the effect of influential system equipment and service life.
Summary of the invention
The object of this invention is to provide a kind of efficient, the plasma extraction system that stable, reliability is high.
For achieving the above object, the technical solution used in the present invention is: a kind of concentration systems of blood plasma, comprise batch can, the first pump and cartridge filter, the input of described first pump connects the output of batch can, first delivery side of pump connects the input of cartridge filter, it is characterized in that: the output of described cartridge filter connects the input of upgrading unit group, and described upgrading unit group is at least made up of two upgrading units, and the concentrated solution outlet of upgrading unit group is connected with spray-drying installation.
The beneficial effect that technique scheme produces is: animal blood plasma directly carries out multistage concentrated by upgrading unit group, then discharge from the concentrated solution outlet of upgrading unit group and carry out spraying dry, compare than prior art, the present invention adopts the mode of operation of continuous feed, discharging, effective saving concentration time, enhances productivity, simultaneously, the blocking that the membrane module of concentrated blood plasma to cartridge filter and concentration systems of avoiding circulating causes, effectively improves stability and the reliability of plant running.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Detailed description of the invention
A kind of concentration systems of blood plasma, comprise batch can 10, first pump 20 and cartridge filter 30, the input of described first pump 20 connects the output of batch can 10, the output of the first pump 20 connects the input of cartridge filter 30, the output of described cartridge filter 30 connects the input of upgrading unit group, described upgrading unit group is at least made up of two upgrading units, and the concentrated solution outlet of upgrading unit group is connected with spray-drying installation.Operation principle of the present invention is: dropped into by animal blood plasma in batch can 10, be delivered to cartridge filter 30 through the first pump 20 and carry out primary filter, to retain particle larger in blood plasma, ensure the safe operation of the upgrading unit group of postorder, the blood plasma leached through cartridge filter 30 enters upgrading unit group and directly carries out multistage concentrated, then discharge from the concentrated solution outlet of upgrading unit group and carry out spraying dry, according to the thickening efficiency of blood plasma, fresh blood plasma can be added according to certain speed continuously in batch can 10, with ensure concentration technology continue carry out.Compared with prior art, the present invention adopts the mode of operation of continuous feed, discharging, namely in cancellation prior art, concentrate got back to circulation in batch can and carrying out the technique of secondary concentration, and employing directly enters secondary after elementary concentrating, three inferior upgrading units concentrate, spraying dry is entered after the blood plasma continuous discharge concentrated, effective saving concentration time, enhance productivity, simultaneously, the blocking that the membrane module of concentrated blood plasma to cartridge filter and concentration systems of avoiding circulating causes, effectively improves stability and the reliability of plant running.
As further preferred version: as shown in Figure 1, described upgrading unit group comprises elementary upgrading unit 40 and secondary concentration unit 50, elementary upgrading unit 40 comprises the second pump 41 and elementary concentrated film device 42, secondary concentration unit 50 comprises the 3rd pump 51 and secondary concentration film device 52, the input of described second pump 41 is connected with the output of cartridge filter 30, the output of the second pump 41 is connected with the input of elementary concentrated film device 42, the input of described 3rd pump 51 is connected with the elementary concentrated solution outlet 421 of elementary concentrated film device 42, the output of the 3rd pump 51 is connected with the input of secondary concentration film device 52, the secondary concentration liquid outlet 521 of described secondary concentration film device 52 is connected with spray-drying installation, that is each upgrading unit comprises pump and concentrated film device, delivery side of pump is connected with the input of concentrated film device, when making blood plasma enter concentrated film device, there is certain pressure, ensure the concentrated speed of blood plasma and the stable operation of concentration systems.
Further, elementary filtrate (liquid 422 and the secondary filtrate (liquid 522 of described upgrading unit group lead to collection processing system implementing, and as shown in Figure 1, elementary filtrate and secondary filtrate are collected and flowed to same pipeline, facilitate the centralized collection process of filtrate like this, improve process efficiency.
Further, the filtering accuracy of described cartridge filter 30 is 5 ~ 50 μm, like this can by larger suspended particulate, colloid, microorganism etc. the cartridge surface that is trapped in cartridge filter 30 in the water of blood plasma and cleaning concentration systems and hole, for the stable operation of postorder upgrading unit group is given security, avoid the membrane component in upgrading unit group to block simultaneously, be conducive to the service life extending membrane component.
Further, membrane component in described upgrading unit group is the NF membrane of rolling, and the NF membrane of rolling is directly commercially bought, convenient realization, according to the physicochemical property of blood plasma, the molecular cut off of the membrane component in preferred described upgrading unit group is 200-500D.
Claims (4)
1. the concentration systems of a blood plasma, comprise batch can (10), the first pump (20) and cartridge filter (30), the input of described first pump (20) connects the output of batch can (10), the output of the first pump (20) connects the input of cartridge filter (30), it is characterized in that: the output of described cartridge filter (30) connects the input of upgrading unit group, described upgrading unit group is at least made up of two-stage upgrading unit, and the concentrated solution outlet of upgrading unit group is connected with spray-drying installation; The molecular cut off of the membrane component in described upgrading unit group is 200-500D; The filtering accuracy of described cartridge filter (30) is 5 ~ 50 μm.
2. the concentration systems of blood plasma according to claim 1, it is characterized in that: described upgrading unit group comprises elementary upgrading unit (40) and secondary concentration unit (50), elementary upgrading unit (40) comprises the second pump (41) and elementary concentrated film device (42), secondary concentration unit (50) comprises the 3rd pump (51) and secondary concentration film device (52), the input of described second pump (41) is connected with the output of cartridge filter (30), the output of the second pump (41) is connected with the input of elementary concentrated film device (42), the input of described 3rd pump (51) is connected with the elementary concentrated solution outlet (421) of elementary concentrated film device (42), the output of the 3rd pump (51) is connected with the input of secondary concentration film device (52), secondary concentration liquid outlet (521) of described secondary concentration film device (52) is connected with spray-drying installation.
3. the concentration systems of blood plasma according to claim 2, is characterized in that: elementary filtrate (liquid (422) and the secondary filtrate (liquid (522) of described upgrading unit group lead to collection processing system implementing.
4. the concentration systems of blood plasma according to claim 1 or 2, is characterized in that: the membrane component in described upgrading unit group is the NF membrane of rolling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310246629.XA CN103316538B (en) | 2013-06-20 | 2013-06-20 | The concentration systems of blood plasma |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310246629.XA CN103316538B (en) | 2013-06-20 | 2013-06-20 | The concentration systems of blood plasma |
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| CN103316538A CN103316538A (en) | 2013-09-25 |
| CN103316538B true CN103316538B (en) | 2015-11-18 |
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| CN201310246629.XA Active CN103316538B (en) | 2013-06-20 | 2013-06-20 | The concentration systems of blood plasma |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106866810B (en) * | 2017-04-01 | 2020-07-31 | 合肥禹王膜工程技术有限公司 | Tubular membrane concentration process for low-ash plasma protein |
| CN112473184B (en) * | 2020-11-25 | 2022-04-08 | 临沂吉宇蛋白有限公司 | Plasma filtering and concentrating device and method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101613734A (en) * | 2009-08-17 | 2009-12-30 | 张吉越 | The preparation method of plasma polypeptide |
| CN201728060U (en) * | 2010-07-22 | 2011-02-02 | 甘肃省膜科学技术研究院 | Film separating device for purifying, condensing and desalting inulin |
| CN103039693A (en) * | 2013-01-09 | 2013-04-17 | 合肥工业大学 | Preparation method of modified livestock and poultry plasma protein powder |
| CN203342531U (en) * | 2013-06-20 | 2013-12-18 | 安徽普朗膜技术有限公司 | Plasma concentration system |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5762222A (en) * | 1980-10-03 | 1982-04-15 | Asahi Chem Ind Co Ltd | Preparation of concentrated solution of platelet, its device and part |
| JP2000161848A (en) * | 1998-11-24 | 2000-06-16 | Sumitomo Chem Co Ltd | Spray drying method and spray drier |
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- 2013-06-20 CN CN201310246629.XA patent/CN103316538B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101613734A (en) * | 2009-08-17 | 2009-12-30 | 张吉越 | The preparation method of plasma polypeptide |
| CN201728060U (en) * | 2010-07-22 | 2011-02-02 | 甘肃省膜科学技术研究院 | Film separating device for purifying, condensing and desalting inulin |
| CN103039693A (en) * | 2013-01-09 | 2013-04-17 | 合肥工业大学 | Preparation method of modified livestock and poultry plasma protein powder |
| CN203342531U (en) * | 2013-06-20 | 2013-12-18 | 安徽普朗膜技术有限公司 | Plasma concentration system |
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