CN103300449B - 具有降低的乙醛血症风险的乙醇组合物 - Google Patents
具有降低的乙醛血症风险的乙醇组合物 Download PDFInfo
- Publication number
- CN103300449B CN103300449B CN201310226344.XA CN201310226344A CN103300449B CN 103300449 B CN103300449 B CN 103300449B CN 201310226344 A CN201310226344 A CN 201310226344A CN 103300449 B CN103300449 B CN 103300449B
- Authority
- CN
- China
- Prior art keywords
- ethanol
- deuterated
- beverage
- deuterated ethanol
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 230000001476 alcoholic effect Effects 0.000 title description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 549
- LFQSCWFLJHTTHZ-LIDOUZCJSA-N ethanol-d6 Chemical compound [2H]OC([2H])([2H])C([2H])([2H])[2H] LFQSCWFLJHTTHZ-LIDOUZCJSA-N 0.000 claims abstract description 435
- 235000013361 beverage Nutrition 0.000 claims abstract description 98
- 235000019441 ethanol Nutrition 0.000 claims description 211
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 229910052805 deuterium Inorganic materials 0.000 claims description 25
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 23
- 238000000855 fermentation Methods 0.000 claims description 12
- 230000004151 fermentation Effects 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims 3
- 235000013599 spices Nutrition 0.000 claims 3
- 238000000034 method Methods 0.000 abstract description 42
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 21
- 230000000694 effects Effects 0.000 abstract description 18
- 206010019133 Hangover Diseases 0.000 abstract description 17
- 206010016825 Flushing Diseases 0.000 abstract description 3
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 54
- 208000024891 symptom Diseases 0.000 description 24
- 235000013334 alcoholic beverage Nutrition 0.000 description 21
- 239000004615 ingredient Substances 0.000 description 16
- 235000013405 beer Nutrition 0.000 description 15
- 230000002829 reductive effect Effects 0.000 description 13
- 235000000346 sugar Nutrition 0.000 description 13
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 description 12
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 12
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 11
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 11
- 238000011010 flushing procedure Methods 0.000 description 11
- 230000000670 limiting effect Effects 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 11
- 240000007594 Oryza sativa Species 0.000 description 10
- 235000007164 Oryza sativa Nutrition 0.000 description 10
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 10
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 10
- 235000009566 rice Nutrition 0.000 description 10
- 230000009467 reduction Effects 0.000 description 8
- 235000013522 vodka Nutrition 0.000 description 8
- 239000008186 active pharmaceutical agent Substances 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 7
- 230000004060 metabolic process Effects 0.000 description 7
- 230000035945 sensitivity Effects 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000005445 isotope effect Effects 0.000 description 6
- 230000000155 isotopic effect Effects 0.000 description 6
- 235000015096 spirit Nutrition 0.000 description 6
- 235000014101 wine Nutrition 0.000 description 6
- 206010019233 Headaches Diseases 0.000 description 5
- 206010028813 Nausea Diseases 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 238000010171 animal model Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 230000036765 blood level Effects 0.000 description 5
- 231100000869 headache Toxicity 0.000 description 5
- 230000008693 nausea Effects 0.000 description 5
- 235000020083 shōchū Nutrition 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 206010014935 Enzyme abnormality Diseases 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 240000005979 Hordeum vulgare Species 0.000 description 4
- 235000007340 Hordeum vulgare Nutrition 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 208000029650 alcohol withdrawal Diseases 0.000 description 4
- 235000020054 awamori Nutrition 0.000 description 4
- 208000002173 dizziness Diseases 0.000 description 4
- 230000004149 ethanol metabolism Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 235000015203 fruit juice Nutrition 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 239000000825 pharmaceutical preparation Substances 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 206010001598 Alcohol intolerance Diseases 0.000 description 3
- 108700028369 Alleles Proteins 0.000 description 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 3
- 102000009645 Mitochondrial Aldehyde Dehydrogenase Human genes 0.000 description 3
- 108010009513 Mitochondrial Aldehyde Dehydrogenase Proteins 0.000 description 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 3
- 241000209140 Triticum Species 0.000 description 3
- 235000021307 Triticum Nutrition 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 235000019987 cider Nutrition 0.000 description 3
- 201000004101 esophageal cancer Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 235000019997 soju Nutrition 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- LFQSCWFLJHTTHZ-CBTSVUPCSA-N 1,1-dideuterioethanol Chemical compound [2H]C([2H])(C)O LFQSCWFLJHTTHZ-CBTSVUPCSA-N 0.000 description 2
- IKHGUXGNUITLKF-VMNATFBRSA-N 1-deuterioethanone Chemical compound [2H]C(C)=O IKHGUXGNUITLKF-VMNATFBRSA-N 0.000 description 2
- 108010060263 Adenosine A1 Receptor Proteins 0.000 description 2
- 102000030814 Adenosine A1 receptor Human genes 0.000 description 2
- 240000006439 Aspergillus oryzae Species 0.000 description 2
- 235000002247 Aspergillus oryzae Nutrition 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 244000017020 Ipomoea batatas Species 0.000 description 2
- 235000002678 Ipomoea batatas Nutrition 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000000112 Myalgia Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 230000007529 anxiety like behavior Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 235000019996 baijiu Nutrition 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 235000019990 fruit wine Nutrition 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 208000013465 muscle pain Diseases 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 235000015205 orange juice Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- LXJXRIRHZLFYRP-VKHMYHEASA-L (R)-2-Hydroxy-3-(phosphonooxy)-propanal Natural products O=C[C@H](O)COP([O-])([O-])=O LXJXRIRHZLFYRP-VKHMYHEASA-L 0.000 description 1
- LFQSCWFLJHTTHZ-VMNATFBRSA-N 1-deuterioethanol Chemical compound [2H]C(C)O LFQSCWFLJHTTHZ-VMNATFBRSA-N 0.000 description 1
- NBBJYMSMWIIQGU-WFVSFCRTSA-N 1-deuteriopropan-1-one Chemical compound [2H]C(=O)CC NBBJYMSMWIIQGU-WFVSFCRTSA-N 0.000 description 1
- WVCHIGAIXREVNS-UHFFFAOYSA-N 2-hydroxy-1,4-naphthoquinone Chemical compound C1=CC=C2C(O)=CC(=O)C(=O)C2=C1 WVCHIGAIXREVNS-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 240000004246 Agave americana Species 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 description 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 1
- LXJXRIRHZLFYRP-VKHMYHEASA-N D-glyceraldehyde 3-phosphate Chemical compound O=C[C@H](O)COP(O)(O)=O LXJXRIRHZLFYRP-VKHMYHEASA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 235000007238 Secale cereale Nutrition 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 206010047924 Wheezing Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000013532 brandy Nutrition 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 235000020057 cognac Nutrition 0.000 description 1
- 239000000039 congener Substances 0.000 description 1
- 239000010636 coriander oil Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 150000001975 deuterium Chemical group 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 229960002563 disulfiram Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000010643 fennel seed oil Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019264 food flavour enhancer Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000015038 fortified wine Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 230000009395 genetic defect Effects 0.000 description 1
- 235000013531 gin Nutrition 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 235000021577 malt beverage Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 235000019520 non-alcoholic beverage Nutrition 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000001003 psychopharmacologic effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 235000019992 sake Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 235000013529 tequila Nutrition 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 235000015041 whisky Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C12/00—Processes specially adapted for making special kinds of beer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
- C12G3/05—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Non-Alcoholic Beverages (AREA)
- Alcoholic Beverages (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27487509P | 2009-08-21 | 2009-08-21 | |
| US61/274,875 | 2009-08-21 | ||
| US28086009P | 2009-11-09 | 2009-11-09 | |
| US61/280,860 | 2009-11-09 | ||
| US28352409P | 2009-12-04 | 2009-12-04 | |
| US61/283,524 | 2009-12-04 | ||
| US12/777,238 US8658236B2 (en) | 2009-08-21 | 2010-05-10 | Alcoholic compositions having a lowered risk of acetaldehydemia |
| US12/777,238 | 2010-05-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800369425A Division CN102471742B (zh) | 2009-08-21 | 2010-08-20 | 具有降低的乙醛血症风险的乙醇组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103300449A CN103300449A (zh) | 2013-09-18 |
| CN103300449B true CN103300449B (zh) | 2015-05-06 |
Family
ID=43605849
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310226344.XA Active CN103300449B (zh) | 2009-08-21 | 2010-08-20 | 具有降低的乙醛血症风险的乙醇组合物 |
| CN2010800369425A Active CN102471742B (zh) | 2009-08-21 | 2010-08-20 | 具有降低的乙醛血症风险的乙醇组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800369425A Active CN102471742B (zh) | 2009-08-21 | 2010-08-20 | 具有降低的乙醛血症风险的乙醇组合物 |
Country Status (32)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2719145T3 (es) | 2011-06-20 | 2019-07-08 | H Lundbeck As | 1-Piperazino-3-fenil-indanos deuterados para el tratamiento de la esquizofrenia |
| US9803163B2 (en) | 2012-04-05 | 2017-10-31 | Anheuser-Busch Llc | Systems for carbonating customized beverages |
| JP6362601B2 (ja) | 2012-09-18 | 2018-07-25 | オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 小胞モノアミン輸送体２の重水素化ベンゾキノリン阻害剤の製剤薬物動態 |
| US9713330B1 (en) | 2013-03-15 | 2017-07-25 | Deuteria Agrochemicals, Llc | Deuterium-enriched aldehydes |
| AU2014233179B2 (en) | 2013-03-15 | 2018-04-26 | Deuteria Agrochemicals, Llc | Deuterium-enriched aldehydes |
| MA39468B1 (fr) * | 2014-09-16 | 2020-09-30 | Roar Holding Llc | Boissons énergisantes et autres adjuvants nutritionnels issus de spiritueux à base d'agave |
| WO2016092547A1 (en) * | 2014-12-09 | 2016-06-16 | Ezekiel Golan | Alcoholic beverage substitutes |
| IL288712B2 (en) * | 2015-03-06 | 2024-01-01 | Auspex Pharmaceuticals Inc | Methods for the treatment of abnormal involuntary movement disorders |
| KR20170032815A (ko) | 2015-09-15 | 2017-03-23 | 경희대학교 산학협력단 | 신규 유산균 및 퇴행성 뇌질환 또는 인지기능의 예방, 개선 또는 치료용 조성물 |
| US10289381B2 (en) * | 2015-12-07 | 2019-05-14 | Motorola Mobility Llc | Methods and systems for controlling an electronic device in response to detected social cues |
| AU2018260727B2 (en) | 2017-04-27 | 2022-07-21 | Deuteria Beverages, Llc | Process for the preparation of deuterated ethanol from D2O |
| CA3059761A1 (en) | 2017-04-27 | 2018-11-01 | Deuteria Beverages, Llc | Process for the preparation of deuterated ethanol from d2 |
| CN109330632B (zh) * | 2018-11-09 | 2023-09-29 | 上海导向医疗系统有限公司 | 活检旋切装置 |
| US11535600B2 (en) | 2018-12-03 | 2022-12-27 | H. Lundbeck A/S | Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine |
| CA3131237A1 (en) * | 2019-02-26 | 2020-09-03 | Tsubame Bhb Co., Ltd. | Molded sintered body, and method for producing molded sintered body |
| US10582716B1 (en) | 2019-06-14 | 2020-03-10 | Lennham Pharmaceuticals, Inc. | Deuterated caffeine and uses thereof |
| WO2021086983A1 (en) | 2019-10-29 | 2021-05-06 | TMRW Life Sciences, Inc. | Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions |
| EP4154257A4 (en) | 2020-05-18 | 2023-12-06 | TMRW Life Sciences, Inc. | HANDLING AND TRACKING BIOLOGICAL SAMPLES FOR CRYOGENIC STORAGE |
| USD963194S1 (en) | 2020-12-09 | 2022-09-06 | TMRW Life Sciences, Inc. | Cryogenic vial carrier |
| CA3200508A1 (en) | 2020-12-10 | 2022-06-16 | TMRW Life Sciences, Inc. | Specimen holder with wireless transponder for attachment to specimen collection body |
| EP4252009B1 (en) | 2021-01-13 | 2025-03-05 | TMRW Life Sciences, Inc. | System to pick and/or place specimen containers |
| US12194046B2 (en) | 2021-03-09 | 2025-01-14 | Lennham Pharmaceuticals, Inc. | D9-caffeine compositions and uses thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1143308A (zh) * | 1994-01-06 | 1997-02-19 | Hyd探索发展有限公司 | 预防疾病发生的食品及其制备方法 |
| WO2005065631A2 (en) * | 2003-05-23 | 2005-07-21 | Ioan Nedelcu | Cosmetic and hygiene products containing deuterium-depleted water |
| CN101124313A (zh) * | 2005-02-08 | 2008-02-13 | 伍德福德联合有限公司 | 富含1h216o的酒精饮料 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5156408A (en) * | 1974-11-08 | 1976-05-18 | Piasu Chem Co | Karubonsanno jusuisokaesuteruno seizohoho |
| DE3413085A1 (de) | 1984-04-06 | 1985-10-24 | Henkell & Co, 6200 Wiesbaden | Verfahren zum herabsetzen des alkoholgehalts alkoholhaltiger getraenke, insbesondere wein und schaumwein |
| US4612196A (en) | 1984-08-23 | 1986-09-16 | Miller Brewing Company | Preparation of low alcohol beverages by reverse osmosis |
| US5223269A (en) | 1989-08-31 | 1993-06-29 | Andrejs Liepins | Methods and composition for the treatment of hypertension |
| HU208084B (en) * | 1991-10-31 | 1993-08-30 | Hyd Kutato Fejlesztoe Kft | Process for producing compositions suitable for curing tumorous diseases |
| JPH05156408A (ja) * | 1991-11-29 | 1993-06-22 | Nippon Steel Corp | 溶接性に優れた高強度マルテンサイトステンレス鋼とその製造方法 |
| DE4343838C2 (de) | 1993-12-22 | 1998-07-09 | Lohmann Therapie Syst Lts | Deuteriertes Arzneimittel in transdermaler Applikation und Verfahren zu seiner Herstellung |
| ATE205055T1 (de) | 1994-01-06 | 2001-09-15 | Hyd Kutato Fejleszto Ktf | Nahrungsmittel zur verhinderung der entwicklung von erkrankungen und verfahren zur herstellung dieser nahrungsmittel |
| JP3696884B2 (ja) | 1994-03-25 | 2005-09-21 | アイソテクニカ、インコーポレーテッド | ジュウテリウム化による薬物の効能の増強 |
| GB2293100A (en) | 1994-09-15 | 1996-03-20 | Medeva Europ Ltd | Pharmaceutical compositions with deuterium oxide |
| KR100387229B1 (ko) | 1995-11-01 | 2003-08-21 | 삼성전자주식회사 | 영상부호화장치 |
| US6376531B1 (en) | 1998-11-13 | 2002-04-23 | Rupert Charles Bell | Method of treatment using deuterium compounds |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| DE10361313B4 (de) | 2003-12-19 | 2008-04-10 | Südzucker AG Mannheim/Ochsenfurt | Alkoholarme Biere oder bierähnliche Erfrischungsgetränke mit Palatinose |
| CA2624179A1 (en) * | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7713773B2 (en) * | 2005-11-02 | 2010-05-11 | Solopower, Inc. | Contact layers for thin film solar cells employing group IBIIIAVIA compound absorbers |
| US20080301122A1 (en) * | 2007-05-31 | 2008-12-04 | Amadeus S.A.S. | Searching techniques |
| US20090046823A1 (en) * | 2007-08-14 | 2009-02-19 | Texas Instruments Incorporated | Neutron generating device |
-
2010
- 2010-05-10 US US12/777,238 patent/US8658236B2/en active Active
- 2010-08-20 NZ NZ598452A patent/NZ598452A/xx unknown
- 2010-08-20 DK DK10810684.0T patent/DK2467465T3/en active
- 2010-08-20 AP AP2012006133A patent/AP3676A/xx active
- 2010-08-20 GE GEAP201012620A patent/GEP20146057B/en unknown
- 2010-08-20 RS RS20170789A patent/RS56120B1/sr unknown
- 2010-08-20 JP JP2012525737A patent/JP5862965B2/ja active Active
- 2010-08-20 SM SM20170397T patent/SMT201700397T1/it unknown
- 2010-08-20 PL PL10810684T patent/PL2467465T3/pl unknown
- 2010-08-20 SG SG2012011862A patent/SG178521A1/en unknown
- 2010-08-20 CN CN201310226344.XA patent/CN103300449B/zh active Active
- 2010-08-20 SI SI201031516T patent/SI2467465T1/sl unknown
- 2010-08-20 WO PCT/US2010/046211 patent/WO2011022682A1/en not_active Ceased
- 2010-08-20 AU AU2010284051A patent/AU2010284051B2/en active Active
- 2010-08-20 HR HRP20171225TT patent/HRP20171225T1/hr unknown
- 2010-08-20 ES ES10810684.0T patent/ES2635730T3/es active Active
- 2010-08-20 LT LTEP10810684.0T patent/LT2467465T/lt unknown
- 2010-08-20 BR BR112012003560A patent/BR112012003560A8/pt not_active Application Discontinuation
- 2010-08-20 MX MX2012002089A patent/MX2012002089A/es active IP Right Grant
- 2010-08-20 ME MEP-2017-183A patent/ME02866B/me unknown
- 2010-08-20 HU HUE10810684A patent/HUE036124T2/hu unknown
- 2010-08-20 KR KR1020127007059A patent/KR101462740B1/ko active Active
- 2010-08-20 CA CA2771166A patent/CA2771166C/en not_active Expired - Fee Related
- 2010-08-20 PT PT108106840T patent/PT2467465T/pt unknown
- 2010-08-20 CN CN2010800369425A patent/CN102471742B/zh active Active
- 2010-08-20 MY MYPI2012000628A patent/MY156177A/en unknown
- 2010-08-20 EP EP10810684.0A patent/EP2467465B1/en active Active
- 2010-08-20 EA EA201290097A patent/EA023867B1/ru unknown
-
2012
- 2012-02-19 IL IL218201A patent/IL218201A/en active IP Right Grant
- 2012-02-21 CL CL2012000448A patent/CL2012000448A1/es unknown
- 2012-03-09 CO CO12041745A patent/CO6511227A2/es not_active Application Discontinuation
- 2012-03-20 ZA ZA2012/02075A patent/ZA201202075B/en unknown
-
2014
- 2014-01-13 US US14/153,879 patent/US9044423B2/en active Active
-
2015
- 2015-05-31 US US14/726,586 patent/US9732311B2/en active Active
-
2017
- 2017-07-10 CY CY20171100731T patent/CY1119041T1/el unknown
- 2017-08-14 US US15/676,351 patent/US10047330B2/en active Active
-
2018
- 2018-08-14 US US16/103,016 patent/US10731116B2/en active Active
-
2020
- 2020-07-29 US US16/941,959 patent/US11298317B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1143308A (zh) * | 1994-01-06 | 1997-02-19 | Hyd探索发展有限公司 | 预防疾病发生的食品及其制备方法 |
| WO2005065631A2 (en) * | 2003-05-23 | 2005-07-21 | Ioan Nedelcu | Cosmetic and hygiene products containing deuterium-depleted water |
| CN101124313A (zh) * | 2005-02-08 | 2008-02-13 | 伍德福德联合有限公司 | 富含1h216o的酒精饮料 |
Non-Patent Citations (4)
| Title |
|---|
| Dehydrogenase-dependent metabolism of alcohols in gastric mucosa of deer mice lacking hepatic alcohol dehydrogenase;Gunilla Ekstrom et al.;《Biochemical Pharmacology》;19931231;第45卷(第10期);第1989-1994页 * |
| Deuterium Isotope Effects in the Oxidation of Alcohols in Vitro and in Vivo;Howard Gershman et al.;《Archives of biochemistry and biophysics》;19731231;第154卷(第2期);第659-674页 * |
| Studies on the interaction between ethanol and serotonin metabolism in rat, using deuterated ethanol and 4-methylpyrazole;Margareta Some et al.;《Biochemical Pharmacology》;20001231;第59卷(第4期);第385-391页 * |
| 倪沛洲.乙醇氧化.《有机化学》.人民卫生出版社,1999,第422页最后1段至423页第1段. * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103300449B (zh) | 具有降低的乙醛血症风险的乙醇组合物 | |
| JP6284580B2 (ja) | 非発酵ビール様発泡性飲料の製造方法 | |
| US20160066614A1 (en) | Unfermented beer-flavoured beverage containing indigestible dextrin, and bitter substance | |
| US20090196951A1 (en) | Product and Method for Alcoholic Beverage Infused with Resveratrol | |
| WO2016006316A1 (ja) | ビール様飲料 | |
| TWI862778B (zh) | 啤酒風味飲料 | |
| JP2013124243A (ja) | 血中アルコール濃度上昇抑制剤 | |
| JP7522550B2 (ja) | ビールテイストアルコール飲料 | |
| HK1171245B (en) | Alcoholic compositions having a lowered risk of acetaldehydemia | |
| US20250073180A1 (en) | Compositions comprising non-racemic mixtures of r- and s-1,3-butanediol and uses thereof | |
| JP2016210789A (ja) | 血中アルコール濃度上昇抑制剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: DEUTERIA BEVERAGES LLC Free format text: FORMER OWNER: PROTIALLC CO., LTD. Effective date: 20150414 |
|
| C14 | Grant of patent or utility model | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| GR01 | Patent grant | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20150414 Address after: Nevada Applicant after: DEUTERIA BEVERAGE,LLC Address before: Nevada Applicant before: Protia LLC |